Materials Today Chemistry
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2020
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IF 0
H. Wang,Y. Xia,J. Liu,Z. Ma,Q. Shi,J. Yin
Reduction of inflammation and thrombosis caused by implanted devices is critical for clinical success. To this end, the strategy based on programmable release of anti-inflammatory and anti-thrombotic agents from the widely-used polycaprolactone (PCL)/gelatin nanofiber scaffold is developed. The release of 2-O- d -Glucopyranosyl- l -ascorbic Acid (AA-2G) and heparin are controlled by reactive oxygen species (ROS)-responsive poly(ethylene glycol)-based β-thioether ester copolymer (PEGDA-EDT) and mesoporous silica nanoparticles (MSN) in the nanofiber, respectively. The in vitro assay demonstrate that the scaffolds are hemocompatible with the resistance of platelet adhesion; the control release of AA-2G prevents initial inflammation and oxidation of the blood cells, and the subsequent release of heparin entitles nanofibers with long-term anti-thrombotic capability. In addition, rapid endothelialization is obtained on the surface of nanofiber scaffolds for the further enhancement of the hemocompatibility. In vivo implant evaluation convinces that the nanofiber scaffolds possess high biocompatibility with the substantial resistance for inflammation and thrombosis. Hence, our work paves a new way to develop the anti-inflammatory and anti-thrombotic tissue-engineering substrates through programmable delivery of two or multiple drugs.
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FOOD MICROBIOLOGY
·
2022
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IF 6.374
Jian Chen,Rendi Yang,Yongzheng Wang,Shigenobu Koseki,Linglin Fu,Yanbo Wang
In this study, we found the inhibitory effect of d -Tryptophan ( d -Trp) on the bacterial growth and spoilage potential of P. fluorescens and S. baltica . The effectiveness of d -Trp in bacterial growth inhibition was highly dependent on environmental NaCl concentrations. The growth/no growth models were developed to clarify the relationship between salt and d -Trp concentrations for optimal growth-inhibitory effect. It showed that higher levels of NaCl (>3.5%) with d -Trp (>15 mM) are required for growth inhibition. The d -Trp treatment combined with NaCl also retarded the psychrotrophic growth and reduced the respiratory active bacteria at low temperature, indicating that the inhibitory effect of d -Trp might be associated with the tolerance to osmotic and cold stress. Furthermore, the treatment d -Trp combined NaCl (artificial seawater) on salmon fillets was investigated. During refrigerated storage, the d -Trp treated salmon fillet either inoculated with S. baltica or P. fluorescen maintained remained a relatively low level of total volatile basic nitrogen (TVBN) (below 30 mg N/100 g during 8-days storage) and delayed increase of low total viable bacteria counts (TVC) with a longer lag phase of 2 days.
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Advanced Composites and Hybrid Materials
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2022
·Vol. 5
·期 4
·2801-2816
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IF 11.806
Cui Zhixiang,Marcelle Sansi seukep alix,Zhao Mingliang,Wu Jiahui,Liu Xianhu,Si Junhui,Wang Qianting
With the rapid development of the chemical industry, large amounts of industrial organic pollutants have constituted a huge threat to the ecological environment. The 3-D porous TPU/TiO 2 /PDA composite foam with outstanding oil/water separation and photocatalytic performances was successfully prepared. Its morphology, chemical composition, surface wettability, mechanical properties, oil/water separation, and photocatalytic performances had been systematically studied by SEM, FTIR, XRD, XPS, Raman, XPS, TGA, contact angle instrument, and ultraviolet spectrophotometer. The results showed that TPU/TiO 2 /PDA composite foam can remove water and oil for various oil/water mixtures and emulsion with outstanding separation performance only under the gravitational force. The water and oil separation flux can reach 21,035 L/m 2 ·h and 14,500 L/m 2 ·h, respectively. The highest separation efficiency reach to 99.6% for petroleum ether/water. It also can continuously separate the oil and water from various water/oil mixtures with the assistance of the pump; after 10 cycles, it maintains large separation efficiency of 98.5%. Moreover, the RhB removal rate reached up to 96% only after irradiation 1 h under UV light. These results manifested that the prepared multifunctional TPU/TiO 2 /PDA composite foams have great application prospect in oil/water separation fields, providing a new idea for fabricating 3-D porous composite foams with multifunctionality. A novel type of 3-D porous TPU/TiO 2 /PDA composite foam with multifunctional applications was successfully designed and prepared. It exhibits excellent performance for oil/water separation and photocatalytic degradation of organic dye. Graphical abstract
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Xiaofei Zhou,Guijuan Wei,Chang Liu,Qian Zhao,Hui Gao,Wenbo Wang,Xixia Zhao,Xin Zhao,Honglei Chen
The production of hydrogen through seawater electrolysis has recently garnered increasing concern. However, hydrogen evolution reaction (HER) by alkaline seawater electrocatalysis is severely impeded by the slow H 2 O adsorption and H* binding kinetics at industrial current densities . Herein, a face-centered cubic/hexagonal close packed (fcc/hcp) NiRu alloy heterojunction was fabricated on Ni foam (N doped NiRu-inf/NF) by a low-temperature nitrogen plasma activation. Simultaneously, nitrogen atoms are introduced into the alloy to facilitate d-p hybridization. When N doped NiRu-inf/NF is integrated into a dual-electrode cell for urea-assisted seawater electrolysis, it achieves 100 mA cm −2 with an ultra-low voltage of 1.36 V and excellent stability. Density functional theory (DFT) verifies that the robust d-p hybridization among Ni, Ru and N exhibits more energy level matching for H 2 O molecule adsorption at the Ru sites, while simultaneously reducing the interaction between H* and Ni sites in N -doped NiRu-inf.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Maoxin Zhang,Ruijuan Liao,Ao Zhang,Yi Fang,Xiaoli Song,Mingsi Xie,Chunxiu Zhang,Yuwen Feng,Haifeng Yu
A series of novel discotic liquid-crystalline donor–acceptor dyads (D-A) adjusted by changing the chain length of diester groups on perylene were synthesized based on triphenylene and perylene units which linked by a flexible linkage of 9-nonyloxy-1-amine. The mesomorphism properties and their self-assembly behaviors were studied by differential scanning calorimetry, polarized optical microscopy, one-dimensional wide-angle X-ray diffraction, small angle X-ray scattering and two-dimensional wide-angle X-ray diffraction. Charge carrier mobilities were measured by Time-of-flight device. These discotic liquid crystalline compounds exhibited highly efficient ambipolar charge-transport properties and the charge carrier mobility can reach the order of 10 −4 cm 2 v −1 s −1 by segregated donor–acceptor columns, providing potential utility of the strategy in organic optoelectronic applications.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zhe Dou,Pei-Ru Hu,Lin-Lin Song,Yi-Cheng Wang,Hao-Nan Tang,Zhen-Qi Weng,Ya-Jun Wang,Yuan-Qiang Cai
Carbonyl reductases (CRs) are promising biological macromolecules for the asymmetric synthesis of chiral secondary alcohols. A novel CR was evolved for efficient conversion of d -xylose into anti-aging ( S )-Pro-Xylane. Through extensive gene mining, an active carbonyl reductase Zm CR was identified from Zygofabospora marxiana with high reductive activity towards d -xylose-derived 1-C-(β- d -xylopyranosyl)-acetone (XPSA) and in situ cofactor regeneration capability. Using a three-round of concise engineering strategy, a hextuple mutant C85V/V128C/S129A/V161S/Y166H/T217A (M6) was identified from merely 157 mutants with specific activity of 46.00 U·mg −1 , about 306 folds of WT. The Shannon-Wiener index of M6 was 2.21, much higher than WT, indicating its extended substrate scope. M6 could efficiently catalyze the asymmetric reduction of 190 g·L −1 XPSA into ( S )-XPSP. The k cat / K M XPSA of M6 was 203.84 s −1 ·mM −1 , about 910 folds of WT. More non-bonded interactions were monitored in M6, contributing to the stabilization of reactive catalytic conformation. This study provides a promising biocatalyst for the chemoenzymatic synthesis of value-added anti-aging ( S )-Pro-Xylane from lignocellulosic d -xylose.
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PubMed
高影响因子
Nutrients
·
2025
·Vol. 17
·期 7
·1255
·
IF 5
Jingxin Chen,Genghua Ou,Wenting Gu,Jian Shi,Ruiying Lyu,Xueping Wu,Junming Wang,Chunhong Liu
Background/Objectives: Chronic alcohol overconsumption triggers alcohol liver injury, and therapeutic strategies targeting alcohol-triggered oxidative stress and hepatic inflammatory responses represent potential approaches to ameliorating alcohol-related hepatotoxicity. This study aimed to determine the hepatoprotective activity of finger citron essential oil (FCEO) in alcoholic liver disease (ALD)-afflicted rats and explore its underlying mechanisms. In order to identify the effective components, we compared the effects of FCEO and D-limonene.Methods: The regulatory effects of FCEO on metabolic enzymes were systematically evaluated through in vitro experiments. In vivo studies were conducted to investigate and compare the hepatoprotective effects of FCEO and D-limonene. Staining methods, assay kits, and Western Blot were used to determine the roles of FCEO and D-limonene in the ALD rats.Results: We found that FCEO downregulated phase I metabolic enzymes and upregulated phase II metabolic enzymes in Buffalo Rat Liver-3A (BRL-3A) cells. FCEO and/or D-limonene intervention reduced transaminase levels in ALD rats and effectively alleviated inflammatory cell infiltration and lipid droplet accumulation in their liver tissue. Additionally, FCEO and D-limonene played a regulatory role in oxidative stress and inflammation-related pathways such as the MAPK/Nrf2 and NF-κB/AMPK pathways. FCEO was superior to D-limonene as an antioxidant in alleviating alcoholic liver injury.Conclusions: This study revealed the alleviative effects and mechanisms of FCEO on alcoholic liver injury, demonstrating better efficacy compared to its monomer, thus providing a strategy for the development and utilization of finger citron resources.
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高影响因子
Journal of Energy Chemistry
·
2025
·
IF 14.9
Xiaona Zhang,Zeyang Liu,Wenxuan Guo,Wei An,Zhaoyi Song,Yizhang Du,Tongjun Shen,Qihao Qin,Chunxia Wang,Guoyong Huang,Shengming Xu,Junjie Mao
The strong hydrogen binding affinity on Ru surfaces and their intrinsic aggregation tendency pose significant challenges to the hydrogen evolution reaction (HER) activity of Ru-based electrocatalysts. The construction of active electrocatalysts composed of partially dispersed nanoparticles (NPs) and individual single atomic sites with robust thermodynamic stability, has emerged as a viable alternative to benchmark commercial HER electrocatalyst. Herein, a multi-step strategy was designed to synthesize Ru NP @Fe SA -NC electrocatalyst and a robust interaction between uniformly dispersed Ru NPs and embedded single-atom Fe sites was uncovered, which not only regulates the particle size of Ru NPs but also controls the spin state and electronic configuration of Fe single atom. Moreover, magnetic characterization further corroborates the synergetic effect and predicts that the synergetic effect induces a high spin state of the Fe atom with unpaired electrons in the 3 d orbitals, which enhances the adsorption of intermediates and accelerates the reaction kinetics. The as obtained electrocatalyst demonstrate exceptional performance with a low overpotential of 13 mV at 10 mA cm -2 in alkaline condition. Remarkably, theoretical calculations indicates that the outstanding performance of Ru NP @Fe SA -NC stems from the Fe optimized electronic structure of the Ru site, which downshifts the d-band center, reduces the energy barriers for water dissociation and optimizes H* desorption, thereby promoting HER. This study presents an innovative approach to utilize Fe SA -NC to stabilize Ru NPs and reduce the energy barrier, contributing to an ideal HER performance.
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高影响因子
PHYTOMEDICINE
·
2026
·
IF 11.3
Tingwen Zhang,Ruihong Zou,Zheng Chen,Yawei Li,Xin Sun,Xialin Sun
Background Overuse of acetaminophen (APAP) can induce acute liver injury (ALI), and its mechanism is closely related to ferroptosis. 4′-O-β-D-glucosyl-5-O-methylvisamminol (5-O) is a natural coumarin glycoside with anti-inflammatory and antioxidant activities, but whether it can alleviate liver injury through intervention in ferroptosis and multi-dimensional mechanisms remains unclear. Purpose To explore whether 5-O can alleviate APAP-induced ALI through multiple mechanisms such as inhibiting ferroptosis, regulating inflammation, promoting lipid metabolism, and reshaping the intestinal microbiota . Methods Through in vitro and in vivo experiments, combined with CCK-8, Western blot, whole transcriptome sequencing, 16S rRNA sequencing, FMT and other techniques and methods, the mechanism of 5-O was evaluated from multiple levels such as cells, tissues, metabolism and flora. Results 5-O downregulated Tfrc/Slc39a14 in cells to reduce iron intake and upregulated Slc7a11/GPX4 to enhance antioxidant capacity. It reduced serum ALT/AST, alleviated liver tissue pathological damage, inhibited the expression of chemokines and inflammatory factors, and activated the PPARα-Fabp1/Me1 axis to promote lipid metabolism. Whole transcriptome analysis revealed that 5-O intervention was associated with upregulation of miR-30e-3p and downregulation of Tfrc, suggesting a potential role in modulating iron metabolism. Concurrently, the analysis indicated that 5-O treatment was linked to inhibition of the ferroptosis pathway and activation of the PPAR pathway. In addition, 5-O reshaped the intestinal microbiota, inhibited pro-inflammatory bacterial genera, and promoted the colonization of the probiotic Lactobacillus . Conclusion This study systematically clarified that the hepatoprotective effect of 5-O against APAP-induced liver injury is associated with a multi-dimensional network involving "ferroptosis-inflammation-metabolism-flora". The innovation lies in systematically elucidating the multi-faceted actions of a natural product, which may involve regulating ferroptosis through miR-30e-3p associated changes, cross-organ metabolic reprogramming, and microecological modulation. This work provides a candidate drug with multi-dimensional synergistic potential for the prevention and treatment of liver injury.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Tong Zhou,Xue Xia,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
The contribution of glutathione (GSH) and free amino acids degraded from GSH to the generation of pyrazines and 2,3-butanedione was illustrated during their interaction in the thermal treatment of the Amadori compound of alanine and xylose (ARP). GSH-degraded amino acids, glutamic acid (Glu), cysteine (Cys), and glycine (Gly), but not pyroglutamic acid (pGlu), could effectively capture α-dicarbonyls to facilitate the formation of pyrazines when ARP was heated with GSH. Deoxypentosones, the precursors of 2,3-butanedione, were largely consumed in the ARP–GSH model by the interaction with GSH and its degradative Cys compared with the ARP model. The addition of GSH and deoxypentosones inhibited the further degradation of deoxypentosones, resulting in less formation of 2,3-butanedione and other α-dicarbonyl compounds. Meanwhile, the reaction between GSH-degraded Cys and deoxypentosones to form sulfur-containing compounds such as thiols accelerated the consumption of deoxypentosones; thereby, the formation of 2,3-butanedione was severely interfered. However, this inhibition was compensated for by the GSH-degraded Gly through the addition between Gly and MGO and the subsequent deamination. The involvement of exogenous GSH could simultaneously boost the yields of 2,3-butanedione and pyrazines compared with those of ARP heated alone. As the degree of GSH degradation strengthened in the ARP-thermal-degraded GSH models, the yields of both pyrazines and 2,3-butanedione steadily increased.
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
·
IF 4.7
Zhiqiang Yu,Yufan Lan,Tenghui Li,Shucheng Huang,Wuli Han,Xiao Luo
This study constructed an S-scheme MIL( Fe )DCA (et al., 2023b (6)) /MoS 2 heterojunction for enhanced performance in degrading pollutants under a wide spectrum, benefiting from the customized d-band centers (by the built-in electric field) and the Mars–Van Krevelen cycle. Results reveal the tetracycline degradation rate of MIL( Fe )DCA (et al., 2023b (6)) /MoS₂ (~95 %) increases 1.38-fold and 11.8-fold compared to pristine MIL-Fe-DCA and MoS 2 , respectively, with better repeatability.Also, satisfactory reduction of Cr(VI) ions (75 %) and removal of coumarin (81.3 %) and ciprofloxacin hydrochloride (83 %) are observed. The catalyst exhibits rich defects, wide-spectrum solar light harvesting, efficient separation of h + ~ e − pairs and a robust redox process. It is found that the charge transfer in the S-scheme interfacial electric field elevates the d-band center towards the Fermi level, which can effectively lower water activation energy to more easily produce •OH, enhancing intermediate adsorption on the catalyst's surface, thus facilitating charge transfer and accelerating reaction kinetics. Another major emphasis is the oxygen defects induced Mars–Van Krevelen cycle, wherein adsorbed reactants, lattice oxygen, h + , •O 2 − , Fe 2+ and Fe 3+ participate in the reaction processes, which contributes to the photo-thermal conversion, achieving the synergy between photocatalysis and photothermal catalysis. This work offers a synergetic strategy involving the interfacial electric field, d-band center, and photo-thermal effect for photocatalytic water purification.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Chen Yuxin,Xu Xing,Zeng Jianrong,Yu Yang,Ma Yingshuai,Zhang Peilin,Zeng Tao,Zhang Haiguang,Tang Liang,Liu Runzeng,Zhu Youcai
Direct electron transfer (ETP) during peroxymonosulfate (PMS) activation enables selective, matrix-resistant organic contaminants oxidation, yet its precise control over competing radical pathways remains elusive. Here we report a nano-island-like single-atom catalyst- carbon nitride islands immobilize cobalt single atoms on reduced graphene oxide (CoN 3 C/rGO)- that leverages an island-sea architecture to direct PMS activation toward ETP. Experimental and density functional theory (DFT) analyses show an rGO induced elevation of the Co d -band center and a sharpened d z2 orbital near the Fermi level, promoting directional hybridization with PMS p orbitals and suppressing antibonding occupation. Consequently, CoN 3 C/rGO/PMS degrade bisphenol A (BPA) completely within 5 min, with ~94% contribution from ETP. Furthermore, catalytic membrane coatings enable stable 100 h continuous operation in diverse real water matrices with minimal Co leaching. Our results demonstrate a design principle-orbital-level modulation via island-sea architectures to reconcile activity and selectivity in Fenton-like systems and advance translating practical water treatment technologies based on single-atom electronic control.
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高影响因子
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