INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Wangli Dai,Lin Zhou,Saiqi Gu,Wenjie Wang,Zheng Xu,Xuxia Zhou,Yuting Ding
Novel chitosan films incorporating epigallocatechin gallate (EGCG) were prepared and demonstrated the ideal physical and mechanical properties required of candidate food packaging materials alongside desirable antioxidant and antibacterial activity. Compared with traditional chitosan films, chitosan films incorporated with EGCG were thicker, had higher tensile strength and water solubility, and had lower elongation at break, moisture content, degree of swelling, and water contact angles. Although EGCG-containing films were slightly darker in color than pure chitosan films, they exhibited a greater inhibitory effect on light-induced oxidation with obviously improved UV–vis barrier capability and opacity. Scanning electron microscopy results suggested that EGCG-incorporated samples had a rougher surface structure. This was further confirmed by atomic force microscopy and indicated that the addition of EGCG facilitated the formation of protective barriers through the interaction between the film and food surface. FTIR spectroscopy confirmed that EGCG interacted with chitosan by intermolecular hydrogen bonding and effectively improved the thermal stability of chitosan films. Notably, the incorporation of EGCG significantly enhanced the antioxidant and antibacterial activity of chitosan films. Hence, chitosan films incorporating EGCG have potential applications in the food industry as a novel active packaging material, especially in preventing food oxidation and spoilage in perishable foods.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiaoyi Tang,Siyi Wang,Zhihui Zhang,Zijie Li,Lin Wang,Liyong Yuan,Bairong Wang,Jian Sun,Lirong Zheng,Hongqing Wang,Weiqun Shi
Efficient removal of 137 Cs from various radioactive wastewater and contaminated environment is much meaningful for nuclear energy sustainable development and public health. Herein we used chitosan (CS) to induce the self-assembly of graphene oxide (GO) into a hydrogel (GO/CS) possessing a three-dimensional macroporous structure and produced a type of ternary composite hydrogel/aerogel named GO/CS/Cu-PBA by in situ growing potassium copper hexacyanoferrate(II) (Cu-PBA) nanoparticles onto the GO/CS via simple leaching. The adsorption behaviors of Cs + by GO, Cu-PBA, and GO/CS/Cu-PBA in various matrice was systematically studied and compared. It was found that the GO/CS/Cu-PBA exhibited satisfactory sorption capacity for Cs + (64.7 mg/g) and ultrafast kinetics. In addition, a fixed-bed column system could be employed for the cleanup of Cs + from contaminated groundwater. Further FT-IR, XRD, XPS, and EXAFS analyses clarified the interaction mechanism between Cs + and GO/CS/Cu-PBA. Highly selective fixation of Cs + by Cu-PBA was accompanied by the release of K + /Cu 2+ and a crystalline phase transition. The adsorption of Cs + by GO was mainly correlated with the electrostatic attraction by –COO − and C-OH groups. The confinement of Cu-PBA by GO/CS aerogel is of much potential for the practical treatment of cesium-containing radioactive wastewater.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Bo Zhu,Jie Shi,Huanchao Sun,Lixin Xia,Weisen Fang,Hongjian Li,Wanshun Liu,Baoqin Han
Chitosan and its water-soluble derivatives have been widely used in biomaterials, but their disadvantages have hindered their widespread application. In this study, butyryl chitosan, a liposoluble chitosan derivative, was prepared by introducing butyryl groups into chitosan molecules through an acylation reaction. The synthesis conditions were optimised, the reaction was more efficient and simpler than previously reported strategies. Two butyryl chitosan with degrees of substitution greater than two were synthesised. Chemical characterisations confirmed that the hydroxyl and primary amine groups in the backbone of chitosan were converted into amide and ester groups, respectively. The butyryl chitosan films have advantages such as high mechanical properties, long biodegradation time, proper surface charge, good cytocompatibility, and histocompatibility. Butyryl chitosan was used as carrier to prepare an implantable tacrolimus sustained release film. Characterization results showed that tacrolimus existed in an amorphous state in the release film. This work embodies an innovative formulation using tacrolimus-loaded carboxymethyl chitosan amorphous solid dispersions embedded butyryl chitosan film with added advantage of sustained release, an effective blood concentration in vivo for 11 days and a systemic exposure but lower intrapatient variability in tacrolimus trough levels. This work merits sustainable tacrolimus release use by providing application-based proofs and qualifies as a potential formulation for sustainable tacrolimus release system. We expect an improvement in terms of therapeutic compliance with positive effects on allograft outcomes.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Hongxia Wang,Ludan Hu,Lin Peng,Jie Du,Miaochuan Lan,Yang Cheng,Liang Ma,Yuhao Zhang
Dual encapsulation of β-carotene (CAT) by β-cyclodextrin (CCLD) and chitosan (CS) are prepared via self-assembly process by special addition order and concentration. CCLD and CS alone could not effectively stabilize CAT, while CAT could be encapsulated in cavity of CCLD and the inclusion complex could be further strengthened by CS, due to hydrogen-bonding between CCLD and CS via groups including NH 2 and OH. The dispersion system based on dual encapsulation of CAT had outstanding shear-thinning behavior, proper pseudoplastic properties, satisfactory yield stress, excellent thermal stability and great thixotropy, illustrating high potential for 3D printing. 3D printing of CAT-encapsulated system with high-content CS on paper and bread proves its excellent extrudability and printability, with possible potential in nutrition personalization. The designed host encapsulation structure by CCLD and CS plays a guiding role in incorporating functional materials including bioactives, probiotics, enzymes, vitamins, etc., and provides a reference in innovative food technology.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2022
·
IF 4.432
Wenyan Song,Tianfeng Huang,Huajiang Zuo,Dongmei Deng,Chunyi Tang
Environmentally friendly natural materials, chitosan (CS) and tannic acid (TA), were used to prepare a composite membrane and immobilize Stenotrophomonas maltophilia on it, which was then applied for removing manganese in water. Surface morphology was investigated, and the amount of immobilized fungus on the composite membrane was probed using scanning electron microscopy (SEM). A composite membrane was prepared by grafting CS and TA on a cotton cloth, and the experimental conditions were optimized; preferential immobilization of S. maltophilia on the composite was achieved. A Mn 2+ standard calibration curve was obtained via atomic absorption spectroscopy ; the removal of manganese ions was determined and compared before and after immobilization on the composite membrane. For glutaraldehyde concentration of 8%, solution pH of 5, TA concentration of 0.05 g/mL, and temperature of 80 °C, the grafting of the TA/CS composite membrane was the best, resulting in better immobilization of S. maltophilia . SEM images showed that a large number of S. maltophilia were immobilized on the composite membrane, substantially improving the manganese removal performance. The removal rate of the manganese ions was the best and reached >70% for solution pH of 5 and Mn 2+ concentration of 0.6–1.2 mg/L.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2022
·Vol. 22
·期 7
·2100493
·
IF 5.859
Haishan Wu,Ting Guo,Jian Nan,Liu Yang,Guangfu Liao,Hyun Jin Park,Jinglei Li
Oral administration of insulin faces multiple biological challenges, such as varied digestive environments, mucin exclusion, and low epithelial cells’ absorption. In the present study, a hyaluronic acid (HA)-coated chitosan (CS) nanoparticle (HCP) delivery system is fabricated for insulin oral delivery. It is hypothesized that the developed nanoparticles will protect insulin from digestive degradation, promote intestinal epithelial cell absorption, and exert strong in vivo hyperglycemic ability. Nanoparticles formulated by CS and sodium tripolyphosphate (TPP) are optimized to form the core nanoparticles (CNPs). HA is further applied to coat CNP (HCP) to improve stability, reduce enzymatic degradation, and promote absorption of insulin. HCP promotes insulin uptake by Caco-2 cells, absorbs less mucin, and improves intestinal absorption. Moreover, an in vivo test demonstrates that oral administration of insulin-loaded HCP exerts strong and continuous hyperthermia effect (with a pharmacological availability (PA) of 13.8%). In summary, HCP is a promising delivery platform for insulin oral administration in terms of protecting insulin during digestion, facilitating its absorption and ultimately promoting its oral bioavailability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Yue Dong,Zihao Wei,Yuming Wang,Qingjuan Tang,Changhu Xue,Qingrong Huang
This work prepared food-grade oleogel-based Pickering emulsion stabilized by ovotransferrin (OVT)–carboxymethyl chitosan (CMCS) nanoparticles (OPEOC). The analysis of emulsified phase volumes and stability index exhibited that OPEOC with different volumes of oil fraction remained stable for 2 months of storage. The prepared Pickering emulsions were used as delivery systems for curcumin. In vitro digestive studies showed that OPEOC significantly improved the degree of lipolysis and the bioaccessibility of curcumin compared to the sunflower seed oil-based oleogel. The oleogel-based Pickering emulsions fabricated in the present study had noticeable storage stability, high loading and improved bioaccessibility of nutraceuticals, which might provide new insights into the development of novel food-grade Pickering emulsions with excellent properties.
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Qais Ali Al-Maqtari,Adel Ali Saeed Al-Gheethi,Abduljalil D.S. Ghaleb,Amer Ali Mahdi,Waleed Al-Ansi,Abeer Essam Noman,Abdulqader Al-Adeeb,Aboudou Kabirou Olatoundé Odjo,Yuhang Du,Minping Wei,Weirong Yao
This study aimed to evaluate the influence of incorporating two concentrations of microcapsules containing Pulicaria jaubertii extract (MPJE) on the physicochemical, microstructure, and bioactivities properties of films based on chitosan (CH), gelatin (GEL), and CH50:GEL50 for possible use as active food packaging in the future. The MPJE treatment was compatible with the CH and/or GEL film without affecting chemical structures. Physico-mechanical results revealed that the CH50:GEL50 film showed optimal properties. The films blended with MPJE considerably improved in glass transition temperature and thermal stability. The films treated with MPJE presented high barrier property toward UV and visible light. Compared with that of the control films, the microstructure of the films loaded with MPJE had a rougher surface with homogeneous microcapsules, which increased with increasing MPJE concentration. Furthermore, mixing MPJE with CH and/or GEL led to the formation of high bioactive films with lower moisture content than the control films, suggesting that MPJE can be utilized to preserve lipid-rich foods .
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Qiuyan Zhang,Jun Tong,Wei Zhou,Zibiao Zhong,Qianchao Hu,Qiang Ma,Haitao Long,Shuangquan Wu,Xiaowen Shi,Qifa Ye
Hypothermic machine perfusion (HMP) is a preferable measure to preserve kidneys from donation after cardiac death (DCD), while the current standard perfusate is imperfect. We synthesized amphiphilic chitosan, N-alkylated-O-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (N-alkyl-O-HTCC) as additive in the perfusate, which can self-assembly into micelles in water (size 133 ± 8.48 nm) (ζ-potential 43.9 ± 2.06 mV), with good antibacterial activity for Escherichia coli and Staphylococcus aureus . The derivates can also deliver hydrophobic drug Alda-1 into kidneys through HMP, with drug loading ratio (~42.14%). The delivery system specifically activated mitochondrial acetaldehyde dehydrogenase 2 in kidneys and reduced the ischemic injury. What's more, the addition of N-alkyl-O-HTCC in HMP also activated mitochondria superoxide dismutase 2, presented nice antioxidant activity . These all helped to improve the quality of DCD kidneys. This study provides a feasible amphiphilic carrier for hydrophobic drugs, and provides efficient guidance for perfusate improvement.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Qifeng Chen,Yunjia Wang,Fushou Yin,Wenxiong Wang,Guangxue Chen,Peisheng Lin
Medical dressings require good antibacterial and mechanical properties. Polyvinyl alcohol based medical dressings are commercially available, and the antimicrobial properties of chitosan and cerium ions are known, and nanocellulose possesses excellent comprehensive properties, such as non-toxicity, biocompatibility, and biodegradability. In this study, polyvinyl alcohol-chitosan/cerium-nanocellulose (PVA-Cs/Ce-CNF) composite hydrogels are prepared by a freeze-thaw method and characterized by scanning electron microscope and X-ray diffraction. It is expected to improve antibacterial activity of the composite hydrogels by adding a small amount of cerium, and their biological activity will not be affected. In addition, the effects of chitosan/cerium (Cs/Ce) complexes and nanocellulose with different contents on properties are investigated. The results show that PVA-Cs/Ce-CNF composite hydrogels have a 3D, highly porous structure with distributed pores of 8–30µm, good skin viscosity, efficient ability to absorb fluid, and suitable water vapor transmission rate of 2000—2500 g m −2 day −1 . Two hydrogels in specific ratio show good strong tensile strength of 132.6 and 130.1 kPa respectively, and their elongation at break are over 400%. The PVA-Cs/Ce-CNF composite hydrogels are non-toxic, and they have inhibitory effect on Escherichia coli and Staphylococcus aureus . These results suggest that the PVA-Cs/Ce-CNF composite hydrogels have great potential as medical dressings.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Haibo Chen,Chengqi Zhao,Yu Li,Junyao Li,Wenrong Cai,Yong Kong,Zheng-Zhi Yin
Au nanoparticles (AuNPs) is first combined with d -methionine ( d -Met) through Au–S bond, and the obtained Au- d -Met was self-assembled with chitosan (CS) via electrostatic driving. Both d -Met and CS are important chiral sources, and therefore the resultant Au- d -Met/CS displays distinct chirality. Interestingly, the chirality of the Au- d -Met/CS can be reversed depending on the ratio of d -Met to CS, as revealed by circular dichroism spectra. Due to the high electrical conductivity of AuNPs as well as the intrinsic chirality of d -Met and CS, the resultant Au- d -Met/CS is used as the electrochemical chiral sensing platform for the discrimination of tryptophan (Trp) enantiomers. Although the Trp enantiomers can be successfully discriminated by the developed chiral sensing platform, the electrochemical signals of l -Trp and d -Trp can be reversed on the differential pulse voltammograms (DPVs) when different ratios of d -Met to CS are used, which can be ascribed to the reversible chirality of the Au- d -Met/CS complexes prepared by different ratios of d -Met to CS.
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Cunguo Chen,Murong Hu,Yunyun Cao,Binbin Zhu,Jiashe Chen,Yashi Li,Junyi Shao,Sen Zhou,Pengfei Shan,Chen Zheng,Zhongyu Li,Zhiming Li
Cyclic dinucleotides (CDNs) are a promising class of immune agonists that trigger the stimulator of interferon genes (STING) to activate both innate and acquired immunity. However, the efficacy of CDNs is limited by drug delivery barriers. Therefore, we developed a combined immunotherapy strategy based on injectable reactive oxygen species (ROS)-responsive hydrogels, which sustainably release 5,6-dimethylxanthenone-4-acetic acid (DMXAA) as known as a STING agonist and indocyanine green (ICG) by utilizing a high level of ROS in the tumor microenvironment (TME). The STING agonist combined with photothermal therapy (PTT) can improve the biological efficacy of DMXAA, transform the immunosuppressive TME into an immunogenic and tumoricidal microenvironment, and completely kill tumor cells. In addition, this bioreactive gel can effectively leverage local ROS to facilitate the release of immunotherapy drugs, thereby enhancing the efficacy of combination therapy, improving the TME, inhibiting tumor growth, inducing memory immunity, and protecting against tumor rechallenge.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）