BIOMASS & BIOENERGY
·
2025
·
IF 5.8
Yin Wang,Mingqin Xue,Fei Ge,Wenlin Xu,Jianchun Jiang,Minghao Zhou
5-Hydroxymethylfurfural (HMF) played a crucial role in the selective hydrodeoxygenation (HDO) of 2,5-dimethylfuran (DMF). In this work, a series of Cu-MOF-based catalysts were synthesized and applied to the catalytic transfer hydrodeoxygenation (CTHDO) of HMF to produce DMF. Catalyst 2Cu/1BTC-700 exhibited the best catalytic performance, achieving a DMF yield of 95.84 % at 180 °C using isopropanol as the hydrogen donor. Results of detailed characterizations showed the excellent catalytic performance was attributed the appropriate specific surface area, acid sites, the smallest particle size and the synergistic effect between Cu 0 and Cu + species. Mechanistic studies revealed metallic Cu 0 promoted isopropanol dehydrogenation, generating active hydrogen to initiate the CTHDO reaction of HMF, while Cu + acted as Lewis acid sites promoting the activation of the C=O bond and subsequent C–OH cleavage. In addition, the catalyst also had a good reusability, which could give some insights to the high value conversion of HMF.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Dalong Qu,Nan Jiang,Yujie Sun
Electrochemical reconstruction is a well-documented phenomenon in electrocatalysis, yet it has rarely been purposefully harnessed to enhance catalyst performance in a controllable manner. In this study, we introduce a rational electrochemical reconstructing strategy using Ag as a model electrocatalyst and the electrocatalytic hydrogenation of 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) as a benchmark reaction. Through a simple yet effective electrochemical reconstruction approach, we generated preferentially oriented Ag nanoparticles (PO-Ag NPs) with more exposure of the Ag(110) facets, which exhibited significantly enhanced activity and selectivity compared to pristine Ag. The faradaic efficiency of PO-Ag NPs for HMF hydrogenation reached above 95% with a selectivity exceeding 98%. Comprehensive electrochemical, spectroscopic, and computational investigations identify the preferential adsorption of HMF on the Ag(110) facet as the primary factor contributing to the enhanced performance. Furthermore, PO-Ag NPs demonstrated excellent long-term stability, retaining high activity and selectivity over extended electrolysis cycles. These findings highlight electrochemical reconstruction as a powerful and controllable strategy for designing highly efficient electrocatalysts, with broad implications for a wide range of electrochemical transformations beyond hydrogenation.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Mahmoud Mohamed Mohamed Ahmed,Chen Cheng,El-Sayed R.E. Hassan,Jiang Yu,Guangyi Liu
The flotation separation of galena from its ores with traditional xanthate collectors needs the high alkaline media maintained by lime which production releases CO 2. In this study, a novel collector, 5-heptyl-1,3,4-oxadiazole-2-thione (HPODT), was investigated in flotation separation of galena from pyrite under a moderate alkaline pulp without addition of lime. The micro-flotation results demonstrated that at pH ∼10.0, 6 × 10 −6 mol·L −1 HPODT and octyl xanthate sodium (OXS) floated out 99.3 % and 83.8 % galena, as well as 5.3 % and 75.6 % pyrite from their mixture, respectively, deducing the much better selectivity of HPODT for flotation separation of galena against pyrite than OXS. UV spectra exhibited that under pH ∼10.0, the adsorption amount of HPODT on galena was much bigger than that on pyrite, which supported their flotation and contact angle results. In situ AFM gave out clear evidences that HPODT formed self-assembled aggregates on galena surface. XPS confirmed that the exo -S and endo -N atoms of HPODT’s oxadiazole-thione group bonded with the Pb atom(s) on galena to deliver the Pb(II)-HPODT complexes. As a big conjugated configuration, the oxadiazole-thione group possessed the weak electron-donating and strong electron-accepting ability through electron delocalization effect, which improved the selective affinity of HPODT towards Pb(II) on galena against Fe(III)/Fe(II) on pyrite.
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CARBOHYDRATE RESEARCH
·
2024
·
IF 2.4
Qianqian Zhang,Tong Wan,Guocheng Jin,Shiai Xu
The objective of this study is to develop a drug carrier to overcome the inherent drawbacks of 5-Fluorouracil (5-Fu), including low bioavailability, short half-life, and systemic toxicity. In the present work, mesoporous silica nanoparticles (MSNs) capped by chitosan (CS) to encapsulate 5-Fu (5-Fu MSNs/CS) were fabricated by the sol-gel process, ultrasonic impregnation, and emulsion cross-linking. The 5-Fu MSNs/CS microspheres exhibit pH-responsive drug release and remarkable drug encapsulation capacity, as well as perfect sphericity, high specific surface area (680.62 cm 2 /g), and uniform particle size (2.64 ± 0.05 μm). The drug-loading content and encapsulation efficiency are 14.12 ± 0.53 % and 82.21 ± 2.13 %, respectively. The cumulative release of 5-Fu from MSNs/CS microspheres is fast and sustained at pH 5.0 (89.56 ± 0.97 %) compared to that at pH 7.4 (57.88 ± 0.91 %) in 96 h, and it is Fickian diffusion controlled. In conclusion, the MSNs/CS microspheres prepared in this study could be potential carriers for 5-Fu delivery.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 7
·3273
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IF 4.9
Tianxu Liu,Muyuan Ma,Yonglin Wu,Ismail Muhammad Asif,Daosen Chen,Lichong Liu,Minghui Zhang,Yijie Chen,Bin Li,Ling Wang
As the major polysaccharide in brown algae, fucoidan possesses broad biological abilities and has been reported to improve gastrointestinal health. Functional dyspepsia, a common non-organic disease, is a complex of symptoms mainly characterized by pathogenesis, such as visceral hypersensitivity, gastric dysmotility, and inflammation. To date, the effects of fucoidan in regulating functional dyspepsia with visceral sensitivity remains unclear. In the current study, iodoacetamide was employed to establish a mouse model of visceral hypersensitivity. Meanwhile, fucoidan was orally administrated for fourteen days. Indicators were conducted to evaluate the potential of fucoidan as the ingredient of complementary and alternative medicine for functional dyspepsia, such as levels of serum hormones, expression of receptors, and gut microbial profile. The results show that oral administration of fucoidan led to significant reductions in the secretion of 5-hydroxytryptamine, cortisol, and corticosterone. Additionally, it decreased the expression of 5-hydroxytryptamine-3receptors, with regulation of 5-hydroxytryptamine metabolism and improvement of gut microbial imbalance. The above results suggest fucoidan could ameliorate visceral hypersensitivity by modulating 5-HT metabolism and microbiota. The current findings indicate that fucoidan has potential as a biological component in the adjuvant treatment of functional dyspepsia and for its expanded utilization in the food and medical fields.
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PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Zhisheng Zhou,Xing Hu,Xinyue Hong,Jie Zheng,Xia Liu,Deming Gong,Guowen Zhang
5−Hydroxymethyl−2−furaldehyde (5-HMF) is a kind of by-product produced in food processing, which may cause latent hazard to human health. Here, the interaction of 5-HMF with human serum albumin (HSA) was studied by multi-spectroscopic methods, multivariate curve resolution-alternating least squares (MCR−ALS) and molecular docking . The formation of 5-HMF−HSA complex was confirmed by MCR−ALS. The fluorescence quenching mechanism of HSA by 5-HMF was static , and their binding constant was 5.25 × 10 4 L mol −1 at 298 K, the binding site of 5-HMF was located in subdomain IIA of HSA. The main forces of the interaction were hydrogen bonds and van der Waals forces . The molecular docking showed that three hydrogen bonds were formed between –CH 2 OH of 5-HMF and Lys106, Pro147 and Gln29 of HSA. The synchronous fluorescence, three-dimensional fluorescence and circular dichroism spectra showed that 5-HMF induced a structural shrinkage of HSA. Fluorescence phase diagram ascertained that the HSA conformational change was in accordance with all-or-none model. Moreover, the presence of the food nutrients (vitamin C, chlorogenic acid and phloretin) weakened the binding of 5-HMF with HSA. This study is helpful to understand the hazard mechanism of 5-HMF to human body and provides new strategies to reduce the hazard of 5-HMF.
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高影响因子
Frontiers in Nutrition
·
2022
·
IF 6.59
Ma Yingjie,Long You,Li Feng,Zhang Yan,Gan Bei,Yu Qiang,Xie Jianhua,Chen Yi
In the “glucose-asparagine-linoleic acid” ternary system, a kinetic model approach was used to explore formation and elimination law of target hazards, including acrylamide (AA) and 5-hydroxymethylfurfural (5-HMF), and their related precursors and intermediate products. The results showed that the elimination of glucose and asparagine and the formation of fructose (generated from glucose isomerization), 3-deoxyglucosone (3-DG), methylglyoxal (MGO), and glyoxal (GO), AA and 5-HMF followed first-order reaction kinetics with high fit coefficients (R2 > 0.9). In addition, the kinetic reaction rate constants increased as the increasing temperature, and all models followed the Arrhenius law. Results of statistical correlations analysis suggested that at lower temperature, the generic amino acid route and the specific amino acid route may paly crucial roles for the formation of AA and 5-HMF, while at high temperature a linoleic acid pathway may be predominantly involved.
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PubMed
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 18
·7032-7040
·
IF 6.482
Xiaojia Jiang,Mingsong Zang,Fei Li,Chunxi Hou,Quan Luo,Jiayun Xu,Junqiu Liu
Recently, biological nanopore-based techniques have attracted more and more attention in the field of single-molecule detection because they allow real-time, sensitive, high-throughput analysis. Herein, we report an engineered biological nanopore sensor by introducing a macrocyclic host molecule carboxylatopillar[5]arene (CP[5]A) that acts as an aptamer into the lumen of a mutant (E111R/K147R)7 αHL nanopore for detecting highly toxic paraquat (PQ) via host–guest interactions at the single-molecule level. By taking advantage of introducing positively charged arginine (Arg) into the lumen of the αHL nanopore, our engineered nanopore sensor exhibits higher stability. More importantly, this nanopore sensor shows high sensitivity, and the limit of detection (LOD) for PQ can reach a nanomolar level of 0.37 ppb. The CP[5]A-based nanopore sensing strategy developed in this work may bring inspiration for single-molecule detection and hold great potential in public health applications.
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高影响因子
Redox Biology
·
2025
·
IF 11.9
Xiaoyue Lai,Xiaoqin Wan,Xinyu Bao,Qingyuan Yang,Wei Zhang,Yan Tan,Xiaoshi Cai,Ziyang Wang,Yujie Li,Chun Liu,Zhongfang Deng,Pan Zheng,Dingyuan Tian,Ming Chen,Hongjun Yin,Gang Xu,Qi Huang,Zhihui Zhang,Hongmei Xia,Fang Deng
Hypoxia leads to decreased synthesis of 5-Methoxytryptophan (5-MTP) in pulmonary microvascular endothelial cells by downregulating Asmt level via Hif1α induced NF-κB p50 nuclear translocation. 5-MTP can reduce the localization of Prdx6 to lysosomes and increase its protein level by reducing its lysosomal degradation through interacting with Prdx6-S32, without affecting its function of clearing lipid peroxides (LPOs), thus improving the lipid peroxidation and rescuing VE-cadherin level and endothelial barrier function.
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高影响因子
Microorganisms
·
2025
·Vol. 13
·期 12
·2874
·
IF 4.2
Wenli Quan,Shuanglian Chen,Han Li,Zhen Tang,Mohammad Nur Alam,Xun Liu
Monascuspigments (MPs) are valuable natural colorants, but their industrial production is often hampered by scarce high-yield strains and inefficient processes. In this study, a novel MPs-producing strain was isolated from red yeast rice and named asMonascus purpureusHC-5. This strain exhibited notable hydrolase activities, indicating a high efficiency in substrate utilization. In addition, using rice as the optimal substrate, the key parameters of solid-state fermentation were optimized. Response surface analysis revealed that soaking time and temperature were the most critical influencing factors. The optimal combination conditions were an inoculum size of 8.91%, a soaking time of 13.59 h, and a temperature of 32 °C. Under these optimized conditions, the MPs yield reached 2185 ± 255.7 U/g, which displayed an approximately four-fold increase compared to the initial unoptimized process. Briefly, this study identified a strain ofMonascus purpureusand optimized its solid-state fermentation conditions, which significantly increased the yield of MPs. This provides an important theoretical basis and scientific evidence for the large-scale industrial production of MPs.
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高影响因子
RARE METALS
·
2025
·
IF 11
Cheng-Feng Yi,Jing-Wen Li,Jia-Rui Li,Bing-Chuan Xue,Xing Lin,Zhi-Gang Liu
en Ni 3 S 2 has emerged as a promising catalyst for the electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA), driven by its distinctive physicochemical properties. However, its practical catalytic efficiency is severely hindered by abundant electrochemically inactive surface sites and poor electronic conductivity. To overcome these challenges, an N,W-cooperative modulation of Ni 3 S 2 catalyst (N,W-Ni 3 S 2 ), featuring an engineered crystalline-amorphous heterostructure, is designed, utilizing 5,10,15,20-tetraphenylporphine (TPP) as the N source. This innovative architecture integrates W-doped crystalline Ni 3 S 2 and N-doped amorphous carbon, which synergistically enhances charge transport and induces interfacial charge polarization, substantially boosting catalytic activity. The optimized N,W-Ni 3 S 2 demonstrates unprecedented electrocatalytic performance for the oxidation of HMF to FDCA, achieving 100% HMF conversion, 97% FDCA yield, and 97% Faradaic efficiency, with over 95% retention in both FDCA yield and Faradaic efficiency across 10 consecutive cycles. Theoretical calculations and experimental results unveil that N incorporation exerts a more profound influence than W in reshaping the electronic landscape of Ni 3 S 2 , triggering an asymmetric electron redistribution at the heterogeneous interface. This unique electronic perturbation depletes the electron density around Ni active sites, creating an electron-deficient state that dramatically promotes the in situ generation of NiOOH as the true active species. Furthermore, the tailored electronic environment significantly lowers the energy barrier for the rate-determining step in the oxidation pathway, thereby enabling near-quantitative FDCA production with high efficiency. 摘要 zh Ni 3 S 2 凭借其独特的物理化学性质,已成为一种极具前景的催化剂,可用于将生物质衍生的5-羟甲基糠醛(HMF)电化学氧化为2,5-呋喃二甲酸(FDCA)。然而,其实际催化效率因大量电化学惰性表面位点和较差的电子导电性而受到严重阻碍。为解决这些问题,本研究设计了一种具有工程化晶态-非晶态异质结构的Ni 3 S 2 催化剂的氮、钨协同调控体系(N,W-Ni 3 S 2 ),并以5,10,15,20-四苯基卟啉(TPP)作为氮源。这种创新结构整合了钨掺杂的晶态Ni 3 S 2 与氮掺杂的非晶碳,二者协同增强电荷传输并诱导界面电荷极化,显著提升了催化活性。优化后的N,W-Ni 3 S 2 在HMF氧化生成FDCA的反应中表现出优异的电催化性能:HMF转化率达100%,FDCA产率达97%,法拉第效率达97%; 在10次连续循环中,FDCA产率和法拉第效率均保持在95%以上。理论计算与实验结果表明,在重构Ni 3 S 2 的电子结构方面,氮掺杂比钨掺杂的影响更为显著,可在异质界面处引发不对称的电子重新分布。这种独特的电子扰动会降低Ni活性位点周围的电子密度,形成缺电子状态,从而显著促进真正活性物种NiOOH的原位生成。此外,这种定制化的电子环境大幅降低了氧化路径中决速步的能垒,进而实现了高效且接近定量的FDCA生成。
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ELECTROCHIMICA ACTA
·
2013
·
IF 3.777
Xiaomeng Meng,Zhenning Xu,Mo Wang,Huanshun Yin,Shiyun Ai
In this paper, a simple and sensitive method was proposed for 5-methylcytosine determination based on sodium dodecyl sulfate functionalized graphene (SDS-GR) modified pyrolytic graphite electrode (PGE), where SDS-GR was synthesized by electrolyzing graphite rod in 0.01 M SDS solution containing 0.1 M KNO 3 . After electrochemical activation by cyclic voltammetry (CV), activated SDS-GR modified PGE (A-SDS-GR/PGE) was fabricated for discriminating 5-methylcytosine from other nucleic acid bases. The results indicated that SDS-GR could improve the conductivity of the electrode and promote the electron transfer rate. And the process of electrochemical activation significantly enhanced the amount of active sites and oxygenated groups on electrode surface. As a result, 5-methylcytosine, guanine, adenine and cytosine could be distinguished with different oxidation potentials in a mixture solution except the overlap of the oxidation potential of thymine and 5-methylcytosine. However, the interference caused by thymine could be eliminated because the content of it is equal to adenine. The fabricated A-SDS-GR/PGE provided an alternative route for 5-methylcytosine determination when cytosine existed.
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高影响因子
危险品化学品经营许可证（带存储）