ACS Nano
·
2024
·
IF 15.8
Xuantong Zhou,Fene Gao,Wenyan Gao,Qingzhen Wang,Xin Li,Xinyue Li,Wenxin Li,Jing Liu,Huige Zhou,Aiping Luo,Chunying Chen,Zhihua Liu
Despite the superior efficacy of radiotherapy in esophageal squamous cell carcinoma (ESCC), radioresistance by cancer stem cells (CSCs) leads to recurrence, metastasis, and treatment failure. Therefore, it is necessary to develop CSC-based therapies to enhance radiotherapy. miR-339-5p (miR339) is involved in stem cell division and DNA damage checkpoint signaling pathways based on ESCC cohort. miR339 inhibited ESCC cell stemness and enhanced radiation-induced DNA damage by targeting USP8, suggesting that it acts as a potential CSC regulator and radiosensitizer. Considering the limited circulating periods and poor tumor-targeting ability of miRNA, a multifunctional nanoplatform based on bismuth sulfide nanoflower (Bi@PP) is developed to efficiently deliver miR339 and improve radioresistance. Intriguingly, Bi@PP encapsulates more miR339 owing to their flower-shaped structure, delivering more than 1000-fold miR339 into cells, superior to free miR339 alone. Besides being used as a carrier, Bi@PP is advantageous for dynamically monitoring the distribution of delivered miR339 in vivo while simultaneously inhibiting tumor growth. Additionally, Bi@PP/miR339 can significantly enhance radiotherapy efficacy in patient-derived xenograft models. This multifunctional platform, incorporating higher miRNA loading capacity, pH responsiveness, hypoxia relief, and CT imaging, provides another method to promote radiosensitivity and optimize ESCC treatment.
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Wenjing Li,Jinsheng Li,Youze Zeng,Dong Pan,Rina Sa,Xue Wang,Meiling Xiao,Zhe Wang,Jianbing Zhu
This study focused on enhancing the performance of anion exchange membranes (AEMs) in water electrolysis applications. Anion exchange membrane water electrolysis (AEMWE) is a crucial technology for hydrogen production, but its performance is largely determined by the key materials of the AEMs. We developed a new filler and incorporated it into poly(terphenyl piperidinium) (PTP) to address the key challenges in AEM properties, such as ion conductivity and long-term stability. The resultant composite membranes exhibited improved ionic conductivity (128.8 mS cm–1, 80 °C), enhanced resistance to swelling (<8%), and excellent alkaline stability (more than 2160 h, 60 °C in 1 M KOH). Additionally, surface modification of the filler enhanced its compatibility with the polymer matrix, thereby preventing the filler from compromising the mechanical properties of the AEMs and promoting long-term stability. Notably, the AEMWE achieved a high water electrolysis performance (2.3 A cm–2 at 2 V, 80 °C) and remarkable durability (1300 h at 0.5 A cm–2, 60 °C). Overall, this research presented a promising strategy for AEM design and applications in hydrogen production through water electrolysis.
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DOI
高影响因子
Advanced Membranes
·
2021
·
IF 0
Ao-Shuai Zhang,Shen-Hui Li,Heng Mao,Li-Hao Xu,Ming-Yu Lv,Zhi-Ping Zhao
Organophilic pervaporation (PV) mixed matrix membranes (MMMs) possess huge potential in organic wastewater treatment with merits of environmentally friendly and high-efficiency. The filler dispersion structure inside MMMs is required to explore in depth to upgrade the PV performance. In this study, an ethoxysilyl functionalized ionic liquid (IL-PTES) modified ZIF-8 nanoparticles (IL-PTES@ZIF-8) were synthesized by one-pot method, and then incorporated into the PDMS matrix to prepare MMMs for PV separation of ethyl acetate (EtOAc) from its diluted aqueous solution. The preferential adsorption performances to EtOAc by IL-PTES, especially for the functions of specific chemical groups in IL-PTES, were researched via molecular dynamicssimulation approach. Furthermore, the IL-PTES covered on ZIF-8 surface could crosslink with PDMS chains, thereby enhancing the interfacial compatibility between ZIF-8 and PDMS. Importantly, the self-aggregated IL-PTES subtly “glued” the nanoparticles together to lead IL-PTES@ZIF-8 a relatively continuous and defect-free distribution state. This condition would lead to a high-efficiency molecular pathway with less polymer phase and much relatively continuous ZIF-8 phase with high selectivity. PV results suggested that the MMMs with 15% IL-PTES@ZIF-8 loading displayed an optimal separation performance with an ultra-high separation factor of 492 (158.7% more than that of pristine PDMS membrane) and normalized EtOAc flux of 4.98 kg μm m −2 ·h −1 (2 times as much as that of pristine PDMS membrane) for separating 1 wt% EtOAc aqueous solution at 30 °C. These findings offered significant advancement toward developing high-performance MMMs enabled by the synergy of MOFs and ionic liquid.
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DOI
Frontiers in Chemistry
·
2021
·
IF 5.221
Li Yu,Wang Dan,Xu Guanchen,Qiao Li,Li Yong,Gong Hongyu,Shi Lei,Li Dongwei,Gao Meng,Liu Guoran,Zhang Jingjing,Wei Wenhui,Zhang Xingshuang,Liang Xiu
Air and water pollution poses a serious threat to public health and the ecological environment worldwide. Particulate matter (PM) is the major air pollutant, and its primary sources are processes that require high temperatures, such as fossil fuel combustion and vehicle exhaust. PM0.3 can penetrate and seriously harm the bronchi of the lungs, but it is difficult to remove PM0.3 due to its small size. Therefore, PM0.3 air filters that are highly efficient and resistant to high temperatures must be developed. Polyimide (PI) is an excellent polymer with a high temperature resistance and a good mechanical property. Air filters made from PI nanofibers have a high PM removal efficiency and a low air flow resistance. Herein, zeolitic imidazolate framework-8 (ZIF-8) was used to modify PI nanofibers to fabricate air filters with a high specific surface area and filtration efficiency. Compared with traditional PI membranes, the ZIF-8/PI multifunction nanofiber membranes achieved super-high filtration efficiency for ultrafine particles (PM0.3, 100%), and the pressure drop was only 63 Pa. The filtration mechanism of performance improvement caused by the introduction of ZIF-8/PI nanofiber membrane is explored. Moreover, the ZIF-8/PI nanofiber membranes exhibited excellent thermal stability (300 C) and efficient water–oil separation ability (99.85%).
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高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 22
·6687-6703
·
IF 6.177
Furong Cao,Yun Wang,Xing Wang,Wenjuan Zhang,Gregory A. Solan,Rui Wang,Yanping Ma,Xiang Hao,Wen-Hua Sun
Five types of N-(2-(diphenylphosphino)ethyl)-2-R-5,6,7,8-tetrahydroquinolin-8-amines (R = H L1, Me L2, iPr L3, Cl L4, Ph L5) along with one example of an N-isopropyl-5,6,7,8-tetrahydroquinolin-8-amine (L6) have been prepared and employed as neutral ligand supports for zinc(II) chloride complexes, LZnCl2 (Zn1–Zn6). All zinc compounds were characterized by multinuclear NMR spectroscopy (1H/13C/31P) and elemental analysis, while the structures of Zn2 and Zn5 were further studied by single crystal X-ray diffraction: distorted tetrahedral geometries with the diphenylphosphine moieties non-coordinated were a feature. Pre-treatment of Zn1–Zn5 with two equivalents of either LiCH2SiMe3 or LiN(SiMe3)2 led to catalysts displaying good to exceptionally high activity for the ring opening polymerization (ROP) of ε-caprolactone (ε-CL) at 50 °C. For example, Zn4/2LiCH2SiMe3 displayed a TOF of 2.1 × 104 h−1 with 71% conversion seen within 10 minutes with the ε-CL : Zn molar ratio at 5000 : 1; the resulting polycaprolactone (PCL) comprised predominately cyclic structures along with lower levels of trimethylsilylmethyl-capped linear PCL. By comparison, Zn1–Zn5 on treatment with two equivalents of LiN(SiMe3)2 at the same high monomer to zinc ratio, led to catalysts exhibiting an order of magnitude higher activity. Zn1/2LiN(SiMe3)2 in the presence of BnOH exhibited a remarkable TOF of 1.35 × 105 h−1 with 90% monomer conversion within two minutes. In these cases, a distinct selectivity towards linear polymers capped with CH3O end-groups (derived from the quenching solvent) was observed with cyclic polyesters only observable with larger amounts of ε-CL. As a general observation, the 2-R substituent on the chelating ligand showed noticeable effects on the efficiency and on the molecular weight of the PCLs, with 2-Cl-containing Zn4 in combination with LiCH2SiMe3 and BnOH affording the highest molecular weight PCL of the study (9.57 × 104 g mol−1). Based on the microstructural properties of the PCL, distinct mechanisms (viz., coordination–insertion and ring expansion) have been proposed to account for the mode of propagation mediated by Zn/2LiCH2SiMe3 and Zn/2LiN(SiMe3)2. In addition, a zinc silylamido L1−HZn[N(SiMe3)2] (Zn7) species has been tentatively assigned (obtained via deprotonation of L1 with Zn[N(SiMe3)2]2), that proved inactive for the ROP of ε-CL but displayed good activity for ROP of rac-LA.
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DOI
高影响因子
LUMINESCENCE
·
2022
·Vol. 37
·期 7
·1109-1119
·
IF 2.613
Yongjuan Meng,Jinling Pu,Jiamei Gan,Jianping Li
A composite of the metal–organic framework compound ZIF-8 doped with CdSe quantum dots (QDs) with sensitive and stable luminescence was synthesized, and a molecularly imprinted electrochemiluminescence (ECL) sensor was constructed based on this composite. The ZIF-8@CdSe molecularly imprinted ECL sensor combines the high sensitivity of ECL and the high selectivity of molecular imprinting to realize the sensitive and specific detection of estriol. CdSe QDs and gold nanoparticles were encapsulated within ZIF-8 to obtain the ZIF-8@CdSe QDs/GNP (ZIF@CdSe/GNP) composite. Subsequently, the GNPs were further loaded on the surface of this composite to obtain the GNP/ZIF@CdSe/GNP composite. l -Cysteine was used to immobilize the GNP/ZIF@CdSe/GNP composite on the surface of a gold electrode to obtain the GNP/ZIF@CdSe/GNP-modified gold electrode. A molecularly imprinted polymer (MIP) film was prepared on the surface of the modified electrode by electropolymerization with o -phenylenediamine as the functional monomer and estriol as the template molecule. After elution, estriol could be specifically recognized by the cavities. The readsorption of estriol by the MIP can prevent the coreactant from reaching the electrode surface through the cavities, thereby weakening ECL. A good linear relationship existed between the ∆ECL and lg C of estriol concentrations of 1 × 10 −14 to 1 × 10 −9 mol·L −1 . The detection limit was as low as 8.9 × 10 −16 mol·L −1 . The sensor was applied in the determination of estriol in serum samples with a recovery of 97.0–102%.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Hanxiao Duan,Xiang Hu,Zhirong Sun
Zeolitic imidazolate framework-8 (ZIF-8) was synthesized by solvothermal method and the adsorption pore size was adjusted by changing the amount of template agent. The ZIF-8@SiO 2 @Fe 3 O 4 derived from self-assembly of ZIF-8 and SiO 2 @Fe 3 O 4 were then synthesized and used for ceftazidime (CAZ) removal. ZIF-8 was a regular dodecahedral particle with uniform particle size. The pore diameter was 6.47 nm and the specific surface area was 1182.5 m²·g −1 in ZIF-8@SiO 2 @Fe 3 O 4 . The adsorption of CAZ on ZIF-8@SiO 2 @Fe 3 O 4 as a function of adsorption temperature, contact time, ionic strength solution pH, and humic acid concentration were investigated. The error of equilibrium adsorption capacity between model fitting and actual experiments is only 1.19%. Kinetics for CAZ removal on ZIF-8@SiO 2 @Fe 3 O 4 was found to follow pseudo-second-order kinetics. Langmuir, Freundlich and Sips isotherm fitted the adsorption data well and gave similar correlation coefficients, suggesting a single layer adsorption of CAZ on ZIF-8@SiO 2 @Fe 3 O 4 . The ZIF-8@SiO 2 @Fe 3 O 4 showed no apparent loss in CAZ adsorption after five cycles. These features indicate that the ZIF-8@SiO 2 @Fe 3 O 4 may be a promising adsorbent for CAZ removal from aqueous solution.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Mengmeng Zhang,Kun Yang,Junshuo Cui,Haibiao Yu,Yuejiao Wang,Weijun Shan,Zhenning Lou,Ying Xiong
With the ever-increasing of Rare Earth Elements (REEs) in various high technology applications, efficient recovery of REEs from liquid sources is becoming significantly important. In this work, ZIF-8 and UiO-66-NH 2 (U6N) are combined to form a 3D-agaric like core-shell structure hybrid material (U6N@ZIF-8-20), which exhibits good performance in REEs extraction. Due to the abundant adsorption sites of ZIF-8 and the excellent water stability of UiO-66-NH 2 , 3D-agaric like U6N@ZIF-8-20 showed quick adsorption rate (only 10 min to reach equilibrium), high adsorption capacity and selectivity for REEs from water compared to other reported adsorbents. Maximum adsorption capacities of U6N@ZIF-8-20 for neodymium (Nd(III)), europium (Eu(III)), gadolinium (Gd(III)) and erbium (Er(III)) achieved to 249.90, 295.28, 316.22 and 340.95 mg g -1 , respectively. U6N@ZIF-8-20 has superiority in selective adsorption of REEs from Cd(II), Zn(II), Cu(II), Mn(II) and Co(II) coexistence solution. The order of adsorption capacities for REEs is in agreement with the order of their electronegativity, ionic radius and charge density. Moreover, U6N@ZIF-8-20 showed better water stability and recyclability than single MOF. Overall, MOF@MOF hybrid material has efficiency in REEs separation from solutions, and has great advantage in the application of wastewater treating.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Yang Chen,Chengyin Yang,Xiaoqing Wang,Jiangfeng Yang,Jinping Li
Solvent-evaporated conversion (SEC) and steam-assisted conversion (SAC) have been developed to prepare the typical metal-organic frameworks (MOFs) Cu-BTC (HKUST-1) and ZIF-8 using a unique solvent recovery strategy using zeolite. As a green circulation medium, zeolite Na-4A loading and removal of solvent (H 2 O and EtOH) can transport solvent in the vapor phase and avoid solvent condensation, which was the defect in previous SAC syntheses of MOFs, and achieves efficient solvent recovery as well as being an economical and green synthetic process. Moreover, SEC and SAC processes exhibited different mechanisms during the multi-stage reaction and solid diffusion reaction, respectively and both can synthesize the desired products in 12 h. These two methods for MOFs preparation were characterized in detail using XRD, SEM and N 2 adsorption during the different growing stages. According to polar molecules (H 2 O and EtOH) steam-assisted in those synthesis, polar destruction molecules (H 2 O, NH 3 ) adsorption and stability of Cu-BTC and ZIF-8 was investigated.
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hui Ye,Xiao Zhang,Xijie Wang,Chuan Gao,Shurui Han,Jing Lv,Jinke An,YuZhong Zhang,Lizhi Zhao,Qingping Xin,Ligang Lin,Xiaoli Ding
Membranes are extensively utilized for protein separation and purification; however, fouling is a significant challenge and limits further practical application. Biocatalytic membranes have attracted much attention due to their potential anti-fouling and self-cleaning properties. Herein, biocatalytic nanofibrous porous membranes were fabricated through an in-situ zeolitic imidazolate frameworks (ZIF-8) anchored and trypsin incorporation strategy. Ethylene vinyl alcohol copolymer (EVAL) nanofibers, doped with Zn(Ⅱ) or ZIF-8, were fabricated via electrospinning, and then ZIF-8 layers were anchored onto the surface of the nanofibers via in-situ growth. Continuous ZIF-8 layers were observed and almost completely covered the surface of the nanofibers, providing 2.7-fold trypsin loading than ZIF-8 crystals in solution. For the biocatalytic nanofibrous membranes, the trypsin loading were both exceeded 270 µg cm −2 and the maximum reaction rate values of membranes during filtration increased by 120 % than that of free trypsin. Enhanced hydrophilicity and protein-digestive functionality contributed to high self-cleaning properties of the membranes. The biocatalytic nanofibrous membranes demonstrated 2-fold flux recovery and improved BSA resistance compared to the pristine membrane after BSA filtration. Moreover, the membranes retained high anti-fouling properties after five reuse cycles, utilizing only a simple and cost-effective washing operation. Such biocatalytic nanofibrous membranes hold great promise for enhanced anti-fouling and self-cleaning performance in water applications.
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DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Lei Zhang,Yong Shi,Qinyu Xu,Jingbo Yu,Qingya Li,Lirong Huang,Xinxin Kang,Shujun Wang,Jie Qiao
Although a protective shell based on a metal-organic framework (MOF) can effectively improve the remediation of polycyclic aromatic hydrocarbons (PAHs) by microorganisms, the functional characteristics of the shell are often limited by the surface charge, chemical properties and intrinsic strain characteristics. This study explored the potential of mixed organic acids (MA) as an eco-friendly modifier for zeolite imidazolate framework-8 (ZIF-8), facilitating the formation of a biomimetic mineralized shell around Bacillus subtilis ZL09-26. The addition of MA into the ZIF-8 protective shell was found to stimulate growth and bolster cell viability. Notably, adding MA contribute resulted in a 1.98- fold enhancement of the PHE degradation efficiency. After five cycles of reuse, ZIF-8-MA@ B. subtilis ZL09-26 still maintained almost 90 % of the initial PHE degradation ability. Proteomic analysis revealed a coordinated regulation of multiple metabolic pathways that facilitated PHE uptake and degradation, including central carbon metabolism, direct PHE biodegradation, oxidative phosphorylation, aminoacyl-tRNA biosynthesis, fatty acid biosynthesis, ABC transporters, and the biosynthesis of valine, leucine, isoleucine, and lysine. This work broadens the application potential of biomineralized microorganisms, providing novel strategies for the sustainable bioremediation of xenobiotic pollutants in the environment.
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DOI
PubMed
高影响因子
Membranes
·
2024
·Vol. 14
·期 12
·272
·
IF 3.3
Yu Ma,Rui Jia,Zhen-Liang Xu,Aida Aibulatova,Xiao-Gang Jin,Yin-Xin Fang,Ming-Xiao Zhang,Sun-Jie Xu
Forward osmosis (FO) technology, known for its minimal energy requirements, excellent resistance to fouling, and significant commercial potential, shows enormous promise in the development of sustainable technologies, especially with regard to seawater desalination and wastewater. In this study, we improved the performance of the FO membrane in terms of its mechanical strength and hydrophilic properties. Generally, the water flux ( J w ) of polyisophenylbenzamide (PMIA) thin-film composite (TFC)-FO membranes is still inadequate for industrial applications. Here, hydrophilic polydopamine (PDA)@ zeolitic imidazolate frameworks-8 (ZIF-8) nanomaterials and their integration into PMIA membranes using the interfacial polymerization (IP) method were investigated. The impact of PDA@ZIF-8 on membrane performance in both pressure-retarded osmosis (PRO) and forward osmosis (FO) modes was analyzed. The durability and fouling resistance of these membranes were evaluated over the long term. When the amount of ZIF-8@PDA incorporated in the membrane reached 0.05 wt% in the aqueous phase in the IP reaction, the J w values for the PRO mode and FO mode were 12.09 LMH and 11.10 LMH, respectively. The reverse salt flux ( J s )/J w values for both modes decreased from 0.75 and 0.80 to 0.33 and 0.35, respectively. At the same time, the PRO and FO modes’ properties were stable in a 15 h test. The incorporation of PDA@ZIF-8 facilitated the formation of water channels within the nanoparticle pores. Furthermore, the J s / J w ratio decreased significantly, and the FO membranes containing PDA@ZIF-8 exhibited high flux recovery rates and superior resistance to membrane fouling. Therefore, PDA@ZIF-8-modified FO membranes have the potential for use in industrial applications in seawater desalination.
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DOI
PubMed
高影响因子
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