Journal of Materials Chemistry B
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2026
·
IF 6.2
jing Shi,Tao Wang,mengyuan Dai,qinling Liu,Qingxin Fan,Lu Li,Sha Wan,Chen Fan,Yu Wang,Qingquan Kong
Osteoarthritis (OA) is a highly prevalent degenerative joint disease affecting over 500 million people globally, imposing substantial social and economic burdens. Current treatments, including platelet-rich plasma (PRP), are limited by rapid growth factor release, failing to achieve long-term efficacy. To address this, we developed an injectable PRP-loaded hydrogel via in situ assembly of metal-phenolic networks (MPNs), leveraging MPNs' multi-scale porous structure, adjustable mesh size, and dynamic drug interactions to enable "dynamic adhesion" and sustained growth factor release.In vitro studies with OA chondrocytes demonstrated stable PRP release for 14 days, while in vivo evaluations in OA rodent (rat) models confirmed therapeutic effects, including anti-inflammatory, antioxidant, and cartilage repair-promoting activities.This MPN-based hydrogel system validates a novel strategy for sustained PRP delivery, offering a convenient, safe, and effective approach to enhance long-term OA treatment outcomes with potential for clinical translation.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yuheng Zhao,Yuemao Dou,Shounian Ding,Xuedong Wang,Chunyang Chen
Monitoring pyrethroid residues is essential due to their environmental persistence and toxicity. However, conventional laboratory-based techniques are inadequate for real-time, on-site screening. Herein, we report the development of a novel coumarin-derived near-infrared (NIR) fluorescent probe featuring an ultralong Stokes shift of 330 nm, for the intelligent handheld detection of pyrethroids. Leveraging a twisted intramolecular charge transfer (TICT) to intramolecular charge transfer (ICT) transition mechanism, the probe achieves high-sensitivity turn-on response at 705 nm. In an optimized H 2 O/DMSO (19:1, v/v) system, the probe exhibited exceptional selectivity and anti-interference capability, with a limit of detection (LOD) of 1.33 nM. Furthermore, a portable fluorescence-to-vision transduction (FVT) integrating optoelectronic conversion and wireless communication was fabricated via 3D printing. This portable platform, connected to a smartphone via Bluetooth, enables automated data acquisition and concentration quantification. Spiked recovery assays in Kyoho grapes yielded results ranging from 98.36% to 100.83%, demonstrating high accuracy in complex matrices. This work not only provides a design strategy for ultralong Stokes shift NIR probes but also establishes a paradigm for handheld rapid analysis of pesticide.
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MINERALS ENGINEERING
·
2026
·
IF 6
Tianbei Wang,Hao Li,Bingduo Xing,Zhijian Xu,Xuecheng Zhang,Yongjun Xian
Magnetite significantly deteriorates spodumene flotation by preferentially consuming sodium oleate. • Fe 3+ activates spodumene flotation by promoting oleate adsorption through hydrolyzed Fe species. • Molecular dynamics simulations reveal stronger oleate adsorption on magnetite than on spodumene. Low-grade lithium ores are abundant and have gradually emerged as key lithium sources for the energy storage industry; however, effective ore enrichment remains a challenge. Moreover, a key consideration factor is that common iron minerals severely interfere in the lithium flotation process. In this context, this study investigates the mechanism governing the adverse effect of magnetite on spodumene flotation. Specifically, flotation tests in a magnetite–spodumene–oleate flotation system showed that sodium oleate preferentially collects magnetite (recovery >65%), and spodumene recovery significantly decreases with an increase in magnetite content. Additionally, zeta potential measurements and adsorption tests indicated that the Fe ions dissolved from magnetite do not contribute to decreases in spodumene flotation, owing to Fe 3+ addition observably activating spodumene flotation. Such activation was achieved via the formation of hydroxyl–iron complexes as bridges for enhancing oleate collector adsorption on spodumene surface. Molecular dynamics simulations confirmed that the hydration film thickness at the mineral–water interface decreased with the addition of oleic acid, and the degree of thinning of the hydration film at the magnetite–water interface far exceeds that at the lithium–spodumene–water interface. This resulted from magnetite inherently possessing abundant surface Fe sites binding directly and strongly with oleate, although some Fe 3+ also adsorbed on the spodumene. An interfacial adsorption energy between magnetite and sodium oleate (–4.01 kcal · mol −1 · Å -2 ) significantly exceeding that of spodumene (–1.03 kcal·mol −1 ·Å -2 ) was obtained from calculations, further proving that the structural-preferential adsorption of oleate on magnetite surface is a key factor influencing spodumene flotation. Ultimately, these findings may provide a theoretical foundation for developing strategies to mitigate the interference of iron minerals in low-grade lithium ore flotation. Download: Download high-res image (121KB) Download: Download full-size image
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Wang Lei,Shao Meiyu,Wang Huizhi,Han Chunlei,Ma Nan,Qu Wei,Liu Jun,Lin Xiangyun,Jiang Mai,Xu Xiangmei,Meng Fangang,Tang Yan,Zhang Wei
Neural electrodes capable of precise interrogation and biofunctional regulation—encompassing both long-term electrophysiological signal recording and tunable control of neuronal or pathological cell behavior via surface biofunctionalization—hold significant promise for advancing the diagnosis and treatment of neurological disorders. A critical challenge lies in mitigating the immune-mediated foreign body response, which often leads to glial scar formation that encapsulates implants like “cement,” severely compromising functionality. To address this, we develop a benzyloxycarbonyl (Cbz)-substituted poly(ornithine-alt-glycine) (OG Cbz ) interface, which inherently resists biofouling and immunogenic rejection without degrading electrical performance. Notably, substituting the Cbz group with various functional moieties not only maintains these excellent antifouling and biocompatibility properties but also imparts corresponding functionalities. As a proof-of-concept, replacing Cbz with the peptide sequence IKVAV and the antibody cetuximab successfully endows the interface with neuron-affinity and tumor cell proliferation inhibition, while retaining its inherent antifouling and anti-foreign-body reaction properties. During a six-month in vivo implantation period, the IKVAV-functionalized electrodes exhibit a significantly enhanced operational lifetime with improved electrophysiological signal fidelity. This work presents a reliable and versatile interfacial strategy for developing durable and multifunctional neural interfaces.
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Journal of Agriculture and Food Research
·
2025
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IF 6.2
Ziyang Wang,Qinqin Ouyang,Xiaolin Liang,Hongxia Li,Haiying Guo,Rong Liu
Traditional Chinese medicine polysaccharides (TCMPs) have attracted growing attention due to their multi-target and multi-level therapeutic effects in the treatment of diabetes. In this study, we systematically evaluated the antidiabetic effect of three TCMPs, including Moringa oleifera Lam. polysaccharide (MOP), Morus alba L. polysaccharide (MLP) and Lycium barbarum polysaccharide (LBP) in T2DM mouse model. Among the three, MLP exhibited the most pronounced therapeutic efficacy, markedly alleviating hyperglycemia, insulin resistance, hepatic steatosis, and pathological lesions in the liver, pancreas. Liver metabolomic profiling revealed that MLP significantly modulated key glucose and lipid metabolic pathways, particularly bile acid and glycerolipid metabolism. Furthermore, we found MLP exerted its antidiabetic action through inhibition of the mTORC1 signaling pathway, leading to suppressed lipogenesis and enhanced fatty acid oxidation. Notably, MLP-mediated mTORC1 inhibition activated the PPARα–SIRT1 axis, thereby downregulating FOXO1-driven gluconeogenesis and promoting GLUT4-mediated glucose uptake. These findings suggest that MLP exerts comprehensive antidiabetic effects by targeting mTORC1-mediated metabolic reprogramming, offering promise as a natural therapeutic agent for T2DM.
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International Journal of Oral Science
·
2025
·Vol. 17
·期 1
·1-15
·
IF 12.2
Tao Xingyu,Zhang Hongjian,Mei Peng,Huang Jinzhou,Fang Bing,Huan Zhiguang,Wu Chengtie
Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of repairing the pulp-dentin complex defects. Although biomaterial-based strategies show remarkable progress in antibacterial, anti-inflammatory, and pulp regeneration, the important modulatory effects of nerves within pulp cavity have been greatly overlooked, making it challenging to achieve functional pulp-dentin complex regeneration. In this study, we propose an injectable bioceramics-containing composite hydrogel in combination of Li-Ca-Si (LCS) bioceramics and gelatin methacrylate matrix with photo-crosslinking properties. Due to the sustained release of bioactive Li, Ca and Si ions from LCS, the composite hydrogels possess multiple functions of promoting the neurogenic differentiation of Schwann cells, odontogenic differentiation of dental pulp stem cells, and neurogenesis-odontogenesis couples in vitro. In addition, the in vivo results showed that LCS-containing composite hydrogel can significantly promote the pulp-dentin complex repair. More importantly, LCS bioceramics-containing composite hydrogel can induce the growth of nerve fibers, leading to the re-innervation of pulp tissues. Taken together, the study suggests that LCS bioceramics can induce the innervation of pulp-dentin complex repair, offering a referable strategy of designing multifunctional filling materials for functional periodontal tissue regeneration.
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MOLECULES
·
2025
·Vol. 30
·期 12
·2536
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IF 4.6
Qiuxu An,Yuanyuan Liu,Guodong Liang,Yuewu Wang,Fengying Liang,Yunyang Bai,Chaolu Eerdun,Riqing Cheng,Haifeng Zhang,Xiaojie Lv
Curcumin exhibits compromised bioavailability upon oral administration due to its inherent limitations, including low aqueous solubility, poor membrane permeability, and chemical instability. Inspired by the efficient mechanism by which viruses penetrate mucus and cells, we constructed an electrically neutral and hydrophilic nanocarrier (C60-CPP5/Pser@CUR) using fullerene C60 as the matrix modified with cell-penetrating peptides and phosphoserine. CPP5 facilitates efficient cellular internalization of therapeutic agents, while the incorporation of phosphoserine serves as a charge reversal strategy. This design enables dynamic surface charge modulation to enhance curcumin’s trans-barrier delivery efficiency. Systematic in vitro and in vivo evaluations demonstrated that the synthesized carrier significantly improved the synergistic effects of mucus penetration and cellular uptake. The Caco-2 cellular uptake of curcumin-loaded carriers was 2.26 times higher than that of free drugs. In a single-pass intestinal perfusion study in rat models, this nanocarrier significantly enhanced the absorption of curcumin in the duodenal and colonic regions. In the in vivo experiments, compared with free curcumin, its Cmaxand AUC0–tachieved improvements of 2.60 times and 14.70 times, respectively. This virus-mimetic platform dynamically adapts to micro-environmental demands through charge reversal mechanisms, effectively overcoming sequential biological barriers and providing a robust strategy for oral delivery of hydrophobic therapeutics.
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MACROMOLECULES
·
2025
·
IF 5.2
Chuying Zhang,Haotong Guo,Na Zhang,Liming Jin,Jinbo Bai,Hang Zhao
Dielectric elastomers (DEs) can be deformed in response to an electric field. However, an excellent electro-actuated strain of DEs is usually achieved at high applied voltages, which severely limits their application range. Moreover, flexible DEs are susceptible to electromechanical breakdown, which directly affects their operational life. Herein, a novel all-organic DE composite was designed. First, isooctyl 3-mercaptopropionate (IOMP)-grafted methyl vinyl silicone (MVQ) was prepared to enhance the polarization and reduce cross-link density of macromolecular chains. Furthermore, 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTCDA) was incorporated into the MVQ–IOMP matrix. The positively charged NTCDA can capture free charges through strong electrostatic interaction, thus enhancing the breakdown strength of DEs. Ultimately, a 1 wt % NTCDA/MVQ–IOMP0.75 DE composite obtains an extremal actuated strain of 52.9% under 45.2 V/μm and a maximum actuated strain of 37.3% under its safe electric field (36.1 V/μm). Consequently, this work provides a feasible way for preparing advanced DE composites.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
He Chen,Juan Zhou,Li An,Huan Ma,Meng Li,Haixia Lei,Lei Wang,Lufei Zheng,Zenglong Chen,Xujin Wu
Clothianidin are significant toxicity toward non-target organisms, underscoring the necessity for a simple and highly sensitive biosensor for on-site detection. Herein, a pH responsive biotin-tagged horseradish peroxidase (HRP)-encapsulated nanoliposome (HRP@liposome) was synthesized and applied to a colorimetric immunosensor as signal amplification generator. In the presence of clothianidin, it competes with coated antigens for binding to biotinylated antibodies, thereby reducing the number of HRP@liposome due to biotin-streptavidin-biotin interactions. Upon addition of substrate solution, the HRP@liposome are lysed, releasing a substantial amount of HRP, which catalyzes the oxidation of substrate. Under optimal conditions, the colorimetric immunosensor exhibited a 50 % inhibition concentration of 4.75 ng mL −1 , with a limit of detection of 0.24 ng mL −1 , and a linear range of 0.24–66.23 ng mL −1 , respectively. The average recoveries were 86.1 %–103.6 % in spiked environmental and food samples. Compared with conventional enzyme-linked immunosorbent assays, the proposed immunosensor demonstrates higher sensitivity. This research provides a promising reference for rapid assessment in environmental health and food safety.
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Thermal Science and Engineering Progress
·
2025
·
IF 5.4
Lin Liu,Xin Liu,Qunzhi Zhu,Jiatian He
The global energy transition is urgent, and photovoltaic (PV) power generation, as an important method of utilizing solar energy, is playing an increasingly crucial role in the global energy transformation. However, the excessively high operating temperature of PV panels remains a pressing issue. High temperatures lead to an increase in the internal resistance of PV cells, thereby reducing their energy conversion efficiency and power generation performance. In this study, a highly efficient cooling PV module with moisture-absorbing properties was fabricated using a crosslinking-vacuum freeze-drying method, with agarose modification. The moisture-absorbing hydrogel absorbs and stores moisture from the atmosphere at night, and during the day, the excess heat from the PV panel is used to evaporate the moisture, providing cooling. Laboratory and outdoor experiments were conducted to validate this approach. At a solar irradiance of 1 kW/m 2 , the cooling effect of the PV panel can achieve a temperature reduction of approximately 9 ℃, with a 2.7 % increase in maximum power output compared to a standalone PV panel. Its low cost, significant cooling effect, and good outdoor applicability indicate that this hydrogel film-based cooling solution holds potential for practical applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yini Long,Jiaming Li,Junyi Han,Jiaqi Li,Xiao Yu,Nan Li,Zhanhong Yang
Severe dendrite growth, the occurrence of side reactions, and hydrogen evolution can deteriorate the reversibility of Zn plating/stripping. Therefore, we immersed the Zn metal in an alcoholic solution of lauric acid, in-situ generating the zinc laurate layer to alleviate the challenges posed by the above problem. The different alkanoic acids form interfacial layers can effectively regulate the hydrophobicity of the Zn surface and affect the transport of Zn 2+ . Firstly, the zinc laurate layer inhibits the direct contact of active water with the Zn surface, thus preventing the occurrence of side reactions and hydrogen evolution. At the same time, the zoophilic sites of zinc laurate can induce the uniform deposition of Zn and inhibit the growth of Zn dendrites. Thus, the Zn@LA anode is able to cycle stably for more than 2000 h at 5 mA cm −2 , 1 mAh cm −2 . Even at a high depth of discharge of 57 %, the Zn@LA symmetric cell can still maintain a cycle life of 180 h. The Zn@LA//MnO 2 full cell can be cycled stably for 950 cycles at 1 A g −1 with a capacity retention of 81.8 %. This work provides another insight to improve the cycling stability of zinc ion batteries.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Siyan Yu,Rui Guo,Zhaocheng Liu,Haoxiang Jiang,Xifeng Xu,Tong Wang,Kai Wang
Colitis is a common inflammatory bowel disease, and early diagnosis is crucial for effective treatment. Gamma-glutamyltransferase (GGT) has been suggested as a potential biomarker for colitis, but current detection methods face challenges in sensitivity and specificity. Therefore, developing a sensitive and practical tool, especially one that uses serum samples, is important for improving clinical diagnosis. In this study, a novel fluorescent probe was developed to detect GGT activity in serum samples. The probe was incubated with serum from both colitis and healthy mice, and fluorescence measurements revealed significantly higher signals in the colitis group, indicating elevated GGT activity. This demonstrates the probe's high sensitivity and its potential for identifying colitis through serum detection.The findings support the clinical use of this probe for detecting GGT activity in inflammatory diseases like colitis, offering a simple and efficient diagnostic tool for early diagnosis and treatment.
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