Applied Food Research
·
2026
·Vol. 6
·期 2
·102705
·
IF 5.4
Hong Li,Yanyan Li,Ran Ding,Xintian Qiao,Zihao Guo,Ruiling Shen,Huiling Mu,Zheng Guo
A novel phospholipid derivative, PA-CG, is synthesized via a PLD-catalyzed method. • Success of PA-CG synthesis is structurally confirmed by NMR and MS analysis. • PA-CG shows superior antioxidant activity to PC and CG in DPPH, ABTS, and FRAP assays. • SPI+PA-CG combination improves the physical and oxidative stability of O/W emulsions. This work presents an efficient enzymatic synthesis of a novel phosphatidyl caffeoyl glycerol (PA-CG) via phospholipase D (PLD)-catalyzed transphosphatidylation of phosphatidylcholine (PC) with caffeoyl glycerol (CG). Under optimized conditions (CG/PC 4:1 mol/mol, water/methyl tert-butyl ether (MTBE) 0.15:1 V/V, PLD 30 U/mL, 40 °C, 3 h), the yield exceeded 95% (HPLC mol% relative to PC), and the product was confirmed by NMR and ESI-MS. PA-CG exhibited additive antioxidant activity over PC and CG in DPPH, ABTS, and FRAP assays. When combined with soy protein isolates (SPI), PA-CG outperformed SPI or SPI+PC in stabilizing oil-in-water (O/W) emulsions, evidenced by the highest emulsifying activity index, smallest and most homogeneous droplets, and lowest creaming index, attributed to its excellent amphiphilic interfacial properties. Moreover, SPI+PA-CG emulsion displayed the slowest increase in peroxide value (POV) and thiobarbituric acid reactive substances (TBARS) over time. Collectively, PA-CG is a promising dual-function antioxidant and emulsifier for food, cosmetic, and pharmaceutical applications. Download: Download high-res image (293KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Ming Wang,Yanqing Liu,Xingrui Liu,Pengkun Li,Xingjian Song,Lin Yang,Xiang Sui,Mengyao Tang,Qiang Wang,Shaowei Chen
Hydrothermal synthesis of Bi-Bi 3 TaO 7 heterostructures with mannitol • Morphological evolution from nanoflakes to nanoparticles • Enhanced visible absorption and charge separation by modulation of d-band center • Photocatalytic performance of nitrogen fixation up to 10 times that of pristine Bi 3 TaO 7 Morphology control can effectively regulate the interfacial electric field and electronic structure of photocatalytic materials, making it an important strategy for achieving efficient nitrogen fixation. In this study, a facile one-step hydrothermal method is used, with mannitol as both a reducing agent and morphology regulator, to in situ deposit metallic bismuth nanoparticles onto the surface of Bi₃TaO₇ (BTO), forming Bi-Bi₃TaO₇ (Bi-BTO) Schottky heterojunctions. The Bi-BTO samples consist of nanoparticles as compared to nanosheets for pure BTO, which not only increases the specific surface area and accessibility of catalytic active sites but also effectively regulates the interfacial contact of the Schottky heterojunction. This strengthens the built-in electric field and shifts the d-band center closer to the Fermi level. The optimized electronic structure enhances orbital coupling between the catalyst and nitrogen molecules, promoting nitrogen adsorption and activation and lowering the energy barrier for the formation of the rate-determining *NNH intermediate. Thanks to the synergistic effect of morphology engineering on the built-in electric field and d-band center, the optimal sample Bi-BTO-2 shows an excellent photocatalytic nitrogen fixation performance even without a hole scavenger, achieving an ammonia generation rate of 195 μmol·g −1 ·h −1 , 10 times that of pure BTO, with ammonia selectivity approaching 100%. This study highlights the key role of morphology engineering in regulating the interfacial properties and electronic structure of Schottky heterojunctions, providing a practical modification strategy for the design and engineering of high-performance photocatalysts for nitrogen fixation. Download: Download high-res image (176KB) Download: Download full-size image
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2025
·
IF 4.7
Zhiqiang Yu,Yufan Lan,Tenghui Li,Shucheng Huang,Wuli Han,Xiao Luo
This study constructed an S-scheme MIL( Fe )DCA (et al., 2023b (6)) /MoS 2 heterojunction for enhanced performance in degrading pollutants under a wide spectrum, benefiting from the customized d-band centers (by the built-in electric field) and the Mars–Van Krevelen cycle. Results reveal the tetracycline degradation rate of MIL( Fe )DCA (et al., 2023b (6)) /MoS₂ (~95 %) increases 1.38-fold and 11.8-fold compared to pristine MIL-Fe-DCA and MoS 2 , respectively, with better repeatability.Also, satisfactory reduction of Cr(VI) ions (75 %) and removal of coumarin (81.3 %) and ciprofloxacin hydrochloride (83 %) are observed. The catalyst exhibits rich defects, wide-spectrum solar light harvesting, efficient separation of h + ~ e − pairs and a robust redox process. It is found that the charge transfer in the S-scheme interfacial electric field elevates the d-band center towards the Fermi level, which can effectively lower water activation energy to more easily produce •OH, enhancing intermediate adsorption on the catalyst's surface, thus facilitating charge transfer and accelerating reaction kinetics. Another major emphasis is the oxygen defects induced Mars–Van Krevelen cycle, wherein adsorbed reactants, lattice oxygen, h + , •O 2 − , Fe 2+ and Fe 3+ participate in the reaction processes, which contributes to the photo-thermal conversion, achieving the synergy between photocatalysis and photothermal catalysis. This work offers a synergetic strategy involving the interfacial electric field, d-band center, and photo-thermal effect for photocatalytic water purification.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Wenmei Wuxia,Yu Chen,HuanHuan Li,Ning Ma,Lengyuan Niu,Yinyan Gong,Can Li
Zr 4+ incorporation drives a complete transition to an amorphous phase and increases the electrochemically active surface area. • Zr 4+ incorporation induces a downward shift in the core-level binding energies of Fe, Co, and Ni sites. • Optimized S-CrMnFeCoNiZr 1.5 specimen achieves overpotentials of 240/287 mV at 10/100 mA/cm 2 . • S-CrMnFeCoNiZr 1.5 specimen exhibits outstanding stability and a 16-fold enhancement in TOF relative to S-CrMnFeCoNi specimen. Developing efficient and durable electrocatalysts for oxygen evolution reaction (OER) is pivotal to advancing renewable energy conversion technologies. Herein, a series of amorphous CrMnFeCoNi-based high-entropy compounds (HECs) with varied Zr content were synthesized, and the role of Zr doping in modulating the atomic/electronic structures were investigated, as well as the OER activity. Experimental characterization reveals that Zr 4+ incorporation drives a complete transition to an amorphous phase, increases the electrochemically active surface area, and induces a downward shift in the core-level binding energies of Fe, Co, and Ni. Relative to the Zr-free analogue, the optimized catalyst S-CrMnFeCoNiZr 1.5 delivers a 57/69 mV reduction in overpotential at 10/100 mA cm −2 , exhibits a 17-fold higher turnover frequency, and maintains exceptional operational stability over 72 h. This OER activity outperforms most previously reported HECs. Density functional theory calculations corroborate these observations, demonstrating that Zr doping upshifts the d-band centers of Fe, Co, and Ni, thereby strengthening adsorption of intermediates and optimizing the free-energy profile for the rate-determining steps. Collectively, this study establishes a rigorous structure–electronic property–performance correlation and demonstrates Zr-mediated electronic modulation as a rational, scalable strategy for engineering high-entropy electrocatalysts. Download: Download high-res image (70KB) Download: Download full-size image
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MOLECULAR & CELLULAR PROTEOMICS
·
2026
·
IF 6.3
Hongyu Zhang,Baojin Zhou,Jingwen Liu,Yan Ren
Background and aim Platycodin D (PD), a major bioactive saponin isolated from the traditional Chinese medicine (TCM) Platycodon grandiflorus , has shown promising therapeutic potential against non-small cell lung cancer (NSCLC). However, the functional mechanisms of PD in NSCLC progression remains unclear. This study aimed to explore the pharmacological mechanism of PD against NSCLC. Materials and methods Thermal proteome profiling (TPP) approach, molecular docking, cellular thermal shift assay (CETSA) and peptide-centric local stability assay (PELSA) were employed to identify the potential binding target of PD. Subsequent Western Blot and immunoprecipitation-Western Blot (IP-WB) experiments were conducted to investigate the downstream signaling pathways of the target. Furthermore, proteomic and ubiquitinomic profiling of PD-treated cells were performed to investigate its functions on global. Results Replication factor C subunit 4 (RFC4) was identified as a potential binding target of PD by TPP and their binding sites were further exposed by PELSA. PD-RFC4 complex promotes the degradation of Notch1 and Notch3 by reducing nuclear entry of their domains. Compared with control treatment, the differentially expressed proteins induced by PD were found to be primarily involved in ferroptosis, ubiquitination, platinum drug resistance and ribosome-related processes. The ubiquitin proteome analysis revealed that proteins associated with the Notch pathway underwent ubiquitin modifications. Conclusions PD binds to RFC4 and inhibits its activity, leading to downregulation of the Notch signaling pathway, ultimately triggering cancer cell apoptosis. PD is a natural product with potential therapeutic value for NSCLC.
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INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Yu-Qing Yang,Shen-Jing Ji,Nian-Tzu Suen
Reported are the synthesis, material characterization, and electrocatalytic hydrogen evolution reaction (HER) in acid and alkaline electrolytes for the Brewer intermetallic phase, Nb6Co7 and Mo6Co7. It was realized that the overpotential at a current density of 10 mA/cm2 (η10) for Nb6Co7 (η10 = 62 mV) and Mo6Co7 (η10 = 143 mV) are both much lower than that of using a single Co metal (η10 = 253 mV) in alkaline electrolytes. The enhancement of electrocatalytic HER activity of Nb6Co7 and Mo6Co7 can be attributed to the hypo-hyper-d-electronic interaction between Nb/Mo and Co elements. Based on the result of density functional theory calculation, alloying between Nb/Mo and Co elements will increase the antibonding state population of the Co–Co bond near the Fermi level (EF), which induces the synergistic effect to influence the adsorption energy of the H atom (ΔGH) on the surface of Nb6Co7 and Mo6Co7. Moreover, the role of the Nb element is not only a simple electron donor but is also an anchor position for the OH molecule (i.e., dual function) due to the bonding character of the Nb–Co bond near EF. It can reduce the OH position effect as well as the activation energy for water dissociation, which rationalizes the high and robust HER performance of Nb6Co7 to that of commercial Pt/C (η10 = 67 mV) in alkaline electrolytes.
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高影响因子
JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 19
·2303-2315
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IF 3.4
Yipeng Chen,Jiangang Zhang,Yuesheng Zhang,Wen Cao,Xiong Liu,Jianna Bao,Xianming Zhang,Wenxing Chen
Copolymerizing poly(lactide) with other materials to obtain better comprehensive performance is a effective way to expand its application range. In this work, the precursors of hydroxyl terminated (poly(L-lactide) [PLLA], poly(ε-caprolactone) [PCL], poly(D,L-lactide) [PDLLA]) were prepared, and PLLA-PCL-PDLLA copolymer were synthesized by chain extension. The effects of the proportion and molecular weight of each component and the amount of chain extender on crystallization, phase structures, mechanical properties and thermal stabilities of PLLA-PCL-PDLLA copolymer were studied in detail. Based on small-angle X-ray scattering results, the competition between crystallization and microphase separation was regulated by the composition and chain length of prepolymers. As the ratio of PLLA/PDLLA was 1:1, crystallization was prevailing and no obvious peak was observed in SAXS pattern. The tensile test results showed that as the ratio of PLLA/PDLLA increased from 1:1 to 1:5, the elongation at break of the copolymer changed from 1.8% to 343%. By using shorter length of PCL and PLLA segments in chain extension, improvement in strength and flexibility were obtained due to moderate degree of crystallization and microphase separation. This work used biodegradable materials to prepare extraordinary toughness copolymers without losing the biocompatibility, which may provide a feasible method for obtaining high toughness and biodegradable PLA-based materials. Graphical
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2022
·Vol. 45
·期 6
·1075-1088
·
IF 3.434
Wei Kaixin,Wu Xiaomei,Ma Baodi,Li Zhi,Xu Yi
A series of nickel-incorporated SBA-15 mesoporous molecular sieves (Ni-SBA-15) were prepared as support for the immobilization of his-tagged recombinant Microbacterium esterase. The Ni-SBA-15 could strongly and specific absorb the his-tagged esterase from cell disrupted supernatant. It was found that the nickel amount in Ni-SBA-15 has dramatic influence on the activity and thermo-stability of immobilized enzyme, while the kinds of nickel precursor had little effect on enzyme stability. The morphology, chemical composition and structure of the best support NiCl 2 -SBA-15 (Ni-SBA-15 prepared from NiCl 2 precursor) were characterized by various spectroscopy techniques. The immobilized esterase retained full activity of free esterase and showed high immobilized yield (> 90%) with higher thermo-stability, pH stability and organic solvent resistance compared with free enzyme. The optimum reaction temperature increased from 35 to 40 °C and the optimal reaction pH moved from 10.0 to 8.0 after enzyme immobilization. The immobilized esterase exhibited excellent storage stability and keeping 92% of the initial activity after 30 days’ storage at 25 °C. In addition, the immobilized esterase had excellent reusability for the synthesis of key chiral intermediate of d -biotin and the substrate conversion could still keep 100% after 13 cycles continuously. Finally, optical pure (4 S , 5 R )-hemiester was obtained in 80.8% isolated yield and 99% purity in the gram preparative scale.
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POLYMER
·
2021
·
IF 4.43
Wenze Li,Mengyao Wang,Huan Luo,Yanhua Niu,Yajiang Huang,Guangxian Li
A high molecular weight (H M w ) PLLA has been blended with a low molecular weight (L M w ) PDLA and its two types diblock copolymers (PEG- b -PDLA and PDMS- b -PDLA), respectively, to investigate the stereocomplex (sc) and homochiral (hc) crystallization behaviors . The miscible PEG and immiscible PDMS segments with comparable molecular weight were introduced into PDLA by bulk ring-opening polymerization method. Compared to PLLA/PDLA, the introduction of both sequences could inhibit the crystallization kinetics of sc and hc crystallites of the blends due to the dilution effect of L M w segments. The formation of sc crystallites is prior to its hc counterparts. The shorter induction period of hc crystallites of PLLA/PEG-b-PDLA blend indicates that the miscible PEG segments could promote the mobility of PLLA chains. Due to the involving of PEG chains, the spherulite exhibits coarsen and irregular texture and its lamellae show sparse string-like structure. The microphase separation between PLA and PDMS segments as evidenced by SAXS results in the increased sc nuclei and different growth mode of hc crystallites. The phase separated microdomains weakened the competition between sc and hc crystallites, and the former acts as a template for repeated assembly of the latter. X-ray analysis also reveal that sc crystallites possess much thicker lamellar thickness than hc crystallites in PLLA/PDLA and PLLA/PEG-b-PDLA blends.
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Advanced Energy Materials
·
2020
·Vol. 10
·期 45
·2002499
·
IF 25.245
Yunzhen Wu,Panlong Zhai,Shuyan Cao,Zhuwei Li,Bo Zhang,Yanting Zhang,Xiaowa Nie,Licheng Sun,Jungang Hou
Electrochemical CO 2 reduction is regarded as a promising strategy for the sustainable conversion of greenhouse gas. However, it still remains a significant challenge to manipulate the selectivity and activity. Herein, amorphous and porous Cd modified by sulfur (P–Cd|S) is synthesized by a p-block sulfur dopant. In comparison with unmodified Cd metal, the P–Cd|S architecture exhibits superior activity for selective CO generation, indicating that the sulfur dopant enables a selectivity shift from formic acid to CO. The high selectivity of P–Cd|S is partially ascribed to the local alkalization and suppression of hydrogen evolution as indicated by the finite element analysis. In-depth mechanistic investigations by operando Raman, Infrared, and X-ray photoelectron spectroscopy in combination with theory calculations indicate that the covalently hybridized sp band system with dual collaborative sites (Cd δ + and S δ − ) gives rise to a strong interplay with CO 2 molecules and carbonaceous species, leading to the natural elimination of linear correlation among intermediates binding for d-band metals and the convenient modulation of selectivity toward CO versus HCOOH.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2018
·Vol. 53
·期 8
·1992-2005
·
IF 2.383
Huifan Liu,Fan Gong,Fashan Wei,Furao Lai,Xiaoyuan Zhang,Hui Wu
Summary Four types of carbohydrates, including Dendrobium officinale polysaccharide, Dendrobium aphyllum polysaccharide and β-glucans from yeast and barley, were examined, and their structures were found to mainly contain 1,4-linked-β- d -Glc p . Artificially simulated gastrointestinal digestion was conducted to characterise the changes of molecular weight, reducing sugars and released free monosaccharides by high-performance liquid chromatography, kits and the newly developed gas chromatography (GC)-mass spectrometry (MS)/MS analysis, which indicated that high molecular weight and complex spatial structures contributed to delayed monosaccharide release following exposure to digestive solution. The spatial structures of carbohydrates were changed during gastric digestion, but their primary structures were destroyed during intestinal digestion. Additionally, for the developed 7890A/7000 GC-TQ/MS-MS, the new analytical method was successfully used to analyse very low concentrations of monosaccharides in the simulated gastrointestinal digestive system.
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MOLECULES
·
2025
·Vol. 30
·期 4
·912
·
IF 4.6
Huiyi Shang,Juntan Wang,Bishan Guo,Haihua Zhu,Huijuan Li
Phospholipase D (PLD) plays a pivotal role in the biosynthesis of phosphatidylserine (PS), but its practical application is constrained by limitations in stability and reusability. In this study, we successfully fabricated the Fe3O4@SiO2–graphene oxide (GO) nanocomposite by chemical binding of Fe3O4@SiO2and GO. Subsequently, PLD was immobilized onto the nanocomposite via physical adsorption, with the aim of enhancing catalytic stability, reducing mass transfer resistance, and improving reusability. Under optimal conditions, the immobilization efficiency reached 84.4%, with a PLD loading capacity of 111.4 mg/gsupport. The optimal pH for PS production by immobilized PLD shifted from 6.0 to 6.5, while the optimal temperature increased from 45 °C to 50 °C. Notably, the immobilized PLD demonstrated a shorter reaction time and a higher PS yield, achieving a 95.4% yield within 90 min, compared to the free PLD (78.1% yield within 150 min), representing a 1.04-fold improvement in production efficiency. Furthermore, the immobilized PLD exhibited outstanding storage stability and thermal stability, along with remarkable reusability. Even after being reused for 10 cycles, the PS yield still stays as high as 78.3%. These findings strongly suggest that the Fe3O4@SiO2–GO immobilized PLD has the potential for the efficient production of PS.
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危险品化学品经营许可证（带存储）