POLYMERS FOR ADVANCED TECHNOLOGIES
·
2015
·Vol. 26
·期 5
·449-456
·
IF 1.757
Xiangyu Liu,Jingwen He,Yile Niu,Yefei Li,Ding Hu,Xinnian Xia,Yanbing Lu,Weijian Xu
Photo-responsive block copolymer mPEG-b-poly(Tyr)-g-NB was prepared by introduction of o -nitrobenzyl ester group into the side chain of amphiphilic poly(ethylene glycol)-b-poly( α -hydroxy acids) (mPEG-b-poly(Tyr)) containing pendent alkynyl group via copper-catalyzed azide-alkyne cycloaddition reaction. The amphiphilic mPEG-b-poly(Tyr) was synthesized via the ring-opening polymerization of O -carboxyanhydrides, with monomethoxy poly(ethylene glycol) (mPEG) as macroinitiator. The molecular structure, self-assembly, and photo-controlled release of the obtained mPEG-b-poly(Tyr)-g-NB were thoroughly investigated. mPEG-b-poly(Tyr)-g-NB could self-assemble into spherical micelles in water and showed disassembly under UV light irradiation, which was demonstrated by means of UV-vis spectroscopy, scan electron microscopes, and dynamic light scattering measurement. Fluorescence emission measurements demonstrated that Nile red, encapsulated by micelles, can be released upon UV irradiation. This study provides a convenient way to construct smart poly( α -hydroxy acids)-based nanocarriers for controlled release of hydrophobic drugs. Copyright © 2015 John Wiley & Sons, Ltd.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2014
·
IF 2.354
Yanfeng Ji,Wanli Kang,Lingwei Meng,Leilei Hu,Hongbin Yang
A supramolecular recognition system was constructed based on the host–guest interaction with water-soluble β-cyclodextrinpolymer-P(AM/A-β-CD/NaA) as the host polymer and hydrophobically modified polyacrylamide-P(AM/C 18 /NaA) as the guest one. The guest polymer contains a small amount of hydrophobic octadecyl groups. High viscosity enhancement was observed when P(AM/A-β-CD/NaA) was added to P(AM/C 18 /NaA) solution, the concentration of P(AM/C 18 /NaA) was under the critical aggregation concentrations (CAC), as a result of the polymer inclusion association. The influences of salt concentration, shearing, pH values and temperature on the viscosity of mixture solution were also studied. O/W crude oil emulsion stabilized by the complex was prepared. A laser particle size analyzer and Turbiscan Lab Expert stability analyzer were employed to study their stability. The results indicated that mixture emulsion became more stable than the single amphiphilic polymer's. This is because that the net structure of elastic polymer in the continuous phase has the ability to hold oil droplets at the low concentration of P(AM/C 18 /NaA). The stability mechanism of O/W emulsion was indicated by three-stage visual rheological method. In this paper, the stability of inclusion complex is discussed, and the mechanism of the enhanced oil emulsification is further explored.
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JOURNAL OF SEPARATION SCIENCE
·
2013
·
IF 2.591
Jiangmei Li,Haiyun Zhai,Zuanguang Chen,Qing Zhou,Zhenping Liu,Zihao Su
A novel method combining molecular imprinting and SPE was developed in a capillary column for the determination of auramine O in shrimp. The capillary monolithic column was prepared by UV-initiated in situ polymerization, using auramine O as template and methacrylic acid and ethylene dimethacrylate as functional monomer and cross-linker, respectively. The properties of the prepared capillary monolithic column were investigated under the optimized conditions coupled with HPLC, and then the morphologies of the inner polymers were characterized by SEM. The calibration curve was expressed as A = 103 C + 19.8 ( r = 0.9992) with a linear range of 0.25–25.0 μg/mL, and the recoveries of auramine O at different concentrations in shrimp ranged from 90.5 to 92.4% with RSDs ranging from 2.1 to 4.4%. The capacities of the molecularly imprinted polymer and nonimprinted polymer columns were 0.722 and 0.147 μg/mg, respectively, and the LOD (S/N = 3) of auramine O in shrimp was 17.85 μg/kg. Under the selected conditions, the enrichment factors obtained were higher than 70-fold. The results indicate that the prepared molecularly imprinted capillary monolithic column was reliable and applicable to the analysis of auramine O in shrimp.
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CHINESE CHEMICAL LETTERS
·
2015
·
IF 1.587
Hong-Yu Luo,Min Zhang,Nai-Chao Si,Min-Jia Meng,Li Yan,Wen-Jing Zhu,Chun-Xiang Li
In this study, novel molecularly imprinted open porous membranes (MIOPMs) were prepared using the Pickering HIPEs template method and molecular imprinting technology for selective adsorption and separation of methyl 4-hydroxybenzoate (M4HB). The template M4HB, functional monomers, crosslinker and plastifier 2-ethylhexyl acrylate (2-EHA) were contained in the oil phase. Hydrophobic silica nanoparticles (HNP-SiO 2 ) were employed as a stabilizer to establish stable W/O Pickering HIPEs with nonionic surfactant sorbitantrioleate (Span 85). The results of SEM and FTIR indicated that the optimal MIOPMs were prepared successfully and possessed open and interconnecting pores. Then, the MIOPMs were used as sorbents for M4HB. The correlation coefficient ( R 2 ) values for the Langmuir–Freundlich isotherm model and pseudo-second-order kinetic model fitting to the adsorption equilibrium and kinetic data respectively were all higher than 0.95. The maximum adsorption capacity and the time of rapid adsorption for MIOPM 4 were 4.146 mg g −1 and 100 min, respectively. In addition, the permeability separation factor of MIOPMs for M4HB compared to a structurally related analog methyl 2-hydroxybenzoate (M2HB) could reach 3.122.
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EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
·
2015
·Vol. 117
·期 10
·1636-1646
·
IF 1.812
Lingyi Liu,Meirong Pang,Ying Zhang
AOB-w is a water-soluble antioxidant extracted from bamboo leaves, containing four flavone C-glucosides (orientin, isoorientin, vitexin, and isovitexin) as functional components. Flavone C-glucoside esters were firstly synthesized by three lipases (CALB, RM IM, and TL IM) in organic solvent system or solvent-free system. Results indicated that C12 fatty acid ester exhibited the optimal antioxidant capacity, CALB was the most efficient lipase in both systems, and higher conversion yields were achieved in solvent-free system. Highest conversion was obtained with 1% water content for CALB and 2% water content for RM IM and TL IM. All lipases displayed absolute 6″-regioselectivities with monoester. It is required to consider both of hydrophobicity and antioxidant capacity to prepare high-efficiency oil-soluble antioxidant. Regression equations were built up to illuminate the relationship between conversion yield of flavone C-glucoside and antioxidant capacity of its corresponding ester. Highest antioxidant capacity could be achieved when conversion yield was nearly 60% for flavone C-glucosides. Based on reaction parameters of flavone C-glucosides, high-efficiency eAOB-o was prepared, which could be expected as an excellent oil-soluble antioxidant in lipids. Practical applications: Water-soluble antioxidant of bamboo leaves (AOB-w) is a natural food antioxidant extracted from bamboo leaves, with four flavone C-glucosides (orientin, isoorientin, vitexin, and isovitexin) as functional components. This study aimed to provide a practical procedure to prepare high-efficiency lipid antioxidant by enzymatic acylation. Based on the optimal parameters from the synthesis of flavone C-glucoside esters, high-efficiency oil-soluble antioxidant of bamboo leaves (eAOB-o) was prepared. eAOB-o exhibited higher antioxidant capacity than cAOB-o, which has been approved as food antioxidants in China. High-efficiency acylation products were obtained by consideration both of lipid solubility and antioxidant capacity. Based on the rule, flavone C-glucoside ester and eAOB-o were prepared.
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RSC Advances
·
2016
·Vol. 6
·期 27
·22827-22838
·
IF 3.289
Li Guan,Yanfeng Hao,Lei Chen,Meng-Lin Wei,Qin Jiang,Wen-Yuan Liu,Yan-Bo Zhang,Jie Zhang,Feng Feng,Wei Qu
A series of 4-O-substituted chrysotoxine (CTX) derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). In vitro assays indicated that four ring substituted compounds (2a, 2b, 3i and 3j) exhibited significant neuroprotective effects against Aβ25–35-induced toxicity in PC12 cells. The four compounds also inhibited self- and Cu2+-induced Aβ1–42 aggregation and acted as biometal chelators. In particular, compound 2a was a potential lead compound for AD treatment (cell viability up to 100.78% at 50 µM in Aβ25–35-treated PC12 cells, 51.88% and 58.03% inhibition at 25 µM for self- and Cu2+-induced Aβ1–42 aggregation, respectively). A metal chelating experiment showed that compound 2a had a moderate interaction with Cu2+ and Al3+. Moreover, western blot analysis showed that compound 2a attenuated Aβ-induced tau protein hyperphosphorylation at Ser199/202 and Ser396 sites. Furthermore, compound 2a could efficiently cross the blood-brain barrier (BBB) by a parallel artificial membrane permeability assay (PAMPA). In summary, these results suggested that compound 2a was a promising multifunctional compound for AD therapy.
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FOOD HYDROCOLLOIDS
·
2016
·
IF 3.858
Jin Feng,Chunfang Lin,Hua Wang,Songbai Liu
In this study, stable sodium carboxymethyl cellullose (CMC-Na) coated niosomal vesicles was successfully prepared through an electrostatic deposition method. The interaction of CMC-Na with two types of gemini alkyl O -glucosides based vesicles was thermodynamically characterized by means of isothermal titration calorimetry (ITC). The thermodynamic parameters suggested that the binding process was entropy driven and energetically favourable, thereby leading to the further stabilization of vesicles suspension. Based on the data from ζ-potential and dynamic light scattering, the concentration of polyelectrolyte required to afford stable secondary niosomes was estimated by applying an empirical model and was found to be in excellent agreement with our experimental results. Vesicles were unstable when polyelectrolyte concentration below or above the optimum range owing to bridging flocculation or depletion flocculation, respectively. The prepared secondary vesicles exhibited significantly improved resistance to pH variation, thermal and osmotic stress compared with bare ones. This study would facilitate application of polyelectrolyte deposition to produce stable secondary niosomal vesicles with better performance, which holds a great promise as nano-carriers for bioactive compounds .
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JOURNAL OF NANOPARTICLE RESEARCH
·
2017
·Vol. 19
·期 6
·1-15
·
IF 2.02
Qin Xin,Shi Penghui,Liu Haolin,Fan Jinchen,Min Yulin,Xu Qunjie,Yao Weifeng
Metal nanoparticles have been combined with magnet metal–organic frameworks (MOFs) to afford new materials that demonstrate an efficient catalytic degradation, high stability, and excellent reusability in areas of catalysis because of their exceptionally high surface areas and structural diversity. Magnetic M
x
O
y
@N-C (M = Fe, Co, Mn) nanocrystals were formed on nitrogen-doped carbon surface by using 8-hydroxyquinoline as a C/N precursor. The Co@N-C, MnO@N-C, and Fe/Fe 2 O 3 @N-C catalysts were characterized by X-ray diffraction (XRD), Raman, scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), N 2 adsorption/desorption, and X-ray photoelectron spectroscopy (XPS). The catalytic performances of catalysts were thoroughly investigated in the oxidation of aniline solution based on sulfate radicals (SO 4
−. ) toward Fenton-like reaction. Magnetic M
x
O
y
@N-C exhibits an unexpectedly high catalytic activity in the degradation of aniline in water. A high magnetic M
x
O
y
@N-C catalytic activity was observed after the evaluation by aniline degradation in water. Aniline degradation was found to follow the first-order kinetics, and as a result, various metals significantly affected the structures and performances of the catalysts, and their catalytic activity followed the order of Co > Mn > Fe. The nanoparticles displayed good magnetic separation under the magnetic field.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiajun Yang,Siyu Hou,Yuhui Zhao,Zhaoyang Sun,Lilin Zhang,Yan Deng,Xiaoli Shang,Hanjie Yu,Zheng Li,Hongmei Li
The antidiabetic activity of the novel Buckwheat protein-derived peptide (Ala-Phe-Tyr-Arg-Trp, AFYRW) and its associated protein glycosylation have been verified. Our preliminary study demonstrates the potential of AFYRW as a therapeutic agent for diabetes, but the mechanism needs further investigation. Given the vital role of O-linked N -acetylglucosamine transferase (OGT) in diabetes mellitus and insulin resistance (IR), we focused on the underlying molecular mechanisms of them in ameliorating IR. We found AFYRW protects against hyperglycemia in diabetic mice and improves glucose metabolism in an IR cell model. Mechanistically, we demonstrated that AFYRW decreases glutamine-fructose-6-phosphate amidotransferase (GFAT) expression via X-box binding protein 1 (XBP1) in the hexosamine biosynthesis pathway (HBP), consequently decreasing OGT and stimulating the SIRT1/PGC1α pathway. Of note, the overlapping roles of increased SIRT1 and decreased OGT caused by AFYRW ameliorated IR. The data presented here show that AFYRW contributes to metabolism by directly controlling glucose homeostasis. Taken together, our study unveils that AFYRW protects against both insulin resistance and diabetes mellitus-induced hyperglycemia through OGT to regulate the SIRT1/PGC1α pathway, which provides a mechanistic basis for novel AFYRW to be a potential therapeutic agent.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Feng Chen,Xuebin Lin,Wei Chen,Na Wen,Yanqiao Jin
The design of a highly active Cu-Co catalyst for catalytic transfer hydrogenolysis of lignin without the use of external hydrogen remains highly challenging. In this work, Cu 2 O was initially encapsulated in ZIF-67, and subsequently Cu 2 O@ZIF-67 was utilized as a precursor and sacrificial template to prepare the unique double core–shell hollow nanocage CuO@Co 3 O 4 . Co and Cu, serving as Lewis acid sites and dehydrogenation sites for the hydrogen-donor solvent isopropanol, respectively, exhibited synergistic enhancement, further increasing the catalytic activity. Under the optimal conditions of 220 °C, 1 MPa N 2 , and 4 h, the catalyst achieved 100 % conversion of 2-phenoxy-1-phenylethanol and 100 % yield towards cyclohexanol and ethylbenzene. Furthermore, the catalyst remained stable and reusable after 5 cycles, providing a practicable guidance for the value-added conversion of lignin.
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Foods
·
2024
·Vol. 13
·期 14
·2163
·
IF 4.7
Xian He,Yunyun Qin,Haoyue Liu,Kang Cheng,Wanshui Yang,Xinsheng Qin
In this study, for enhancing the resistance of probiotics to environmental factors, we designed a microgel beads delivery system loaded with synbiotics. Multiple droplets of W1/O/W2emulsions stabilized with zein–apple pectin hybrid nanoparticles (ZAHPs) acted as the inner “egg,” whereas a three-dimensional network of poly-L-lysine (PLL)-alginate-CaCl2(Ca) crosslinked gel layers served as the outermost “box.” ZAHPs with a mass ratio of 2:1 zein-to-apple pectin showed excellent wettability (three-phase contact angle = 89.88°). The results of the ζ-potentials and Fourier transform infrared spectroscopy demonstrate that electrostatic interaction forces and hydrogen bonding were the main forces involved in the formation of ZAHPs. On this basis, we prepared W1/O/W2emulsions with other preparation parameters and observed their microstructures by optical microscopy and confocal laser scanning microscope. The multi-chambered structures of W1/O/W2emulsions were successfully visualized. Finally, the W1/O/W2emulsions were coated with PLL-alginate-Ca using the solution extrusion method. The results of the in vitro colonic digestion stage reveal that the survival rate of probiotics in the microgel beads was about 75.11%, which was significantly higher than that of the free. Moreover, probiotics encapsulated in microgel beads also showed positive storage stability. Apple pectin would serve as both an emulsifier and a prebiotic. Thus, the results indicate that the “egg-box” shaped microgel beads, designed on the basis of pH-sensitive and enzyme-triggered mechanisms, can enhance the efficiency of probiotics translocation in the digestive tract and mediate spatiotemporal controlled release.
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Small
·
2024
·
IF 13
Guilin Wei,Linsen Zhou,Xianglin Wang,Ru Tang,Kelin Chen,Junhong Luo,Jiangfeng Song,Yan Shi,Ning Liu,Xingwen Feng
The construction, use, and maintenance of tritium-related equipment will inevitably produce tritium-containing radioactive waste gas, and the production of efficient catalysts for tritium removal remains a difficult problem. Herein, silicalite-1 zeolite with entrapped Pt nanoclusters is skillfully post-oxidized at an appropriate temperature, building highly active Pt─O sites on the nanoclusters to achieve efficient oxidation of hydrogen isotopes at low temperatures. The designed Pt─O sites can directly participate in the oxidation reaction of hydrogen isotopes. Compared to the case without Pt─O sites, the presence of these sites significantly reduces the reaction energy barrier to 0.55 eV, enabling the catalyst to achieve a hydrogen conversion rate of 99% at a low temperature of 40 °C. Specifically, the O atoms consumed by the Pt─O sites in the reaction are replaced by O 2 gas and this cycle repeats, which is consistent with the Mars-van Krevelen (M–K) theory. This ensures efficient catalytic oxidation of hydrogen isotopes, and provides an astonishingly high conversion rate of 99% in the nearly 34 days restart performance test. The results of this study provide insights into the strategic design of efficient catalysts for hydrogen isotope oxidation.
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