RSC Advances
·
2017
·Vol. 7
·期 89
·56519-56527
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IF 3.108
Aihua Yao,Qingge Fu,Ling Xu,Yan Xu,Wenqi Jiang,Deping Wang
Poly(4-vinylpyridine) (P4VP), a pH-sensitive polymer, was employed to non-covalently functionalize graphene oxides (GOs) through π–π stacking interactions. Citrate-capped Au nanoparticles (Au NPs) were then immobilized onto the P4VP-grafted GO, yielding pH-responsive Au NPs–GO nanocomposites. Such Au NPs–GO nanocomposites displayed pH-responsive localized surface plasmon resonance (LSPR) changes and assembly behavior due to protonation and deprotonation of the pyridine units of P4VP molecules. The catalytic activity of the Au NPs–GO nanocomposites was evaluated using the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) as a model reaction, and demonstrated significantly high catalytic activity and stability at low pH (2.0), which was 4-fold higher than that at high pH (5.0). Furthermore, our results indicated that the Au NPs–GO nanocomposites induced active adsorption and selective SERS detection of negatively charged analytes under low pH conditions, and are therefore highly attractive for real-world chemical detection.
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Materials
·
2018
·Vol. 11
·期 2
·239
·
IF 2.467
Dandan Men,Yingyi Wu,Chu Wang,Junhuai Xiang,Ganlan Yang,Changjun Wan,Honghua Zhang
Two-dimensional (2D) periodic micro/nanostructured arrays as SERS substrates have attracted intense attention due to their excellent uniformity and good stability. In this work, periodic hierarchical SiO2nanopillar arrays decorated with Ag nanoparticles (NPs) with clean surface were prepared on a wafer-scale using monolayer Au NP arrays as masks, followed by reactive ion etching (RIE), depositing Ag layer and annealing. For the prepared SiO2nanopillar arrays decorated with Ag NPs, the size of Ag NPs was tuned from ca. 24 to 126 nanometers by controlling the deposition thickness of Ag film. Importantly, the SiO2nanopillar arrays decorated with Ag NPs could be used as highly sensitive SERS substrate for the detection of 4-aminothiophenol (4-ATP) and rhodamine 6G (R6G) due to the high loading of Ag NPs and a very uniform morphology. With a deposition thickness of Ag layer of 30 nm, the SiO2nanopillar arrays decorated with Ag NPs exhibited the best sensitive SERS activity. The excellent SERS performance of this substrate is mainly attributed to high-density “hotspots” derived from nanogaps between Ag NPs. Furthermore, this strategy might be extended to synthesize other nanostructured arrays with a large area, which are difficult to be prepared only via conventional wet-chemical or physical methods.Keywords:wafer-scale;hierarchical arrays;RIE;Ag NPs;SERS substrate
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Huan Cheng,Kuang Luo,Xiaojun Wen,Lijun You,Ning Cai,Jumei Li
In this work, we proposed a straightforward self-assembly and in-situ deposition protocol to construct Cu 2 O/g-C 3 N 4 /Ag composites, which demonstrated peroxidase-like attribute and exceptional SERS activity. These composites proved to be an effective SERS analysis tool for detecting organic fungicides like malachite green (MG) and crystal violet (CV). Remarkably, they achieved detection limits as low as 10 −9 M in DI water as well as fish pond water, and exhibited a strong linear correlation between logarithmic concentrations and SERS intensities (R 2 ≥ 0.97). Beyond that, with the aid of hydrogen peroxide (H 2 O 2 ), the peroxidase-like Cu 2 O/g-C 3 N 4 /Ag composites rapidly degraded MG and CV molecules within just 5 min. Furthermore, their practical reusability based on the peroxidase-like reaction was proved by high SERS performance across 5 detection cycles. These results emphasize the immense potential of Cu 2 O/g-C 3 N 4 /Ag in SERS-based trace fungicide detection and suggest future applications in ecological restoration through peroxidase-like reactions.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yang Feng,Mengyi Yuan,Lan Zhang,Tingting Zhang,Shiying Wu,Lujie Li,Lingling Wang,Weihua Li,Rui Lu
This study reports the development of an electrostatic self-assembly surface-enhanced Raman scattering (SERS) substrate based on zeolitic imidazolate framework-8 (ZIF-8) decorated with silver nanoparticles (AgNPs). A seed-mediated growth method was employed to synthesize AgNPs with an average diameter of 30 nm, and a mild synthesis process was used to prepare ZIF-8 nanoparticles with an average diameter of 350 nm. The ZIF-8/Ag nanocomposites have been optimized and characterized using a variety of techniques. As a probe molecule, 4-aminothiophenol was used to evaluate the SERS performance of the ZIF-8/Ag nanocomposites, demonstrating low limit of detection to 8.32 × 10 −8 M, respectively. ZIF-8/Ag nanocomposites also demonstrated good signal reproducibility with a relative standard deviation of 12.5 % for 10 −6 M 4-aminothiophenol. Furthermore, the ZIF-8/Ag nanocomposites have successfully been used to detect 4-mercaptopyridine and the pesticide thiram in laboratory tap water with recoveries ranging from 87 % to 113 %. The ZIF-8/Ag nanocomposites were further investigated for their potential use as SERS substrates for the detection of thiram residues on the surface of apples. A finite difference time-domain simulation was also conducted to investigate the SERS enhancement mechanism of the ZIF-8/Ag nanocomposites.
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Journal of Physical Chemistry C
·
2011
·
IF 4.524
Deping Huang,Xiangtao Bai,Liqiang Zheng
Three-dimensional dendritic gold nanostructures were prepared via an ultrafast one-step homogeneous solution method. Cationic surfactants, decane-1,10-bis(methylpyrrolidinium bromide) ([mpy-C10-mpy]Br2), were used as the capping agent and l-ascorbic acid (AA) was used as the reducing agent. The as-prepared gold dendrites present a [111] plane and grow along the ⟨211⟩ direction. The AA plays an important role in the formation of the dendritic nanostructures. The methylpyrrolidinium quaternary ammonium headgroups and bolaform nanostructures of the surfactants are the key factors for the formation of dendritic structures. Further investigation revealed that the reaction time and concentration of HAuCl4 weakly affect the formation of the dendrites. Moreover, the obtained gold dendrites exhibit excellent activity toward the catalytic reduction of p-nitraniline and higher enhancement of surface-enhanced Raman scattering when using Rhodamine 6G as the model molecules.
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ANALYST
·
2024
·
IF 3.6
Binbin Chen,Lizhu Fan,Chunyu Li,Lu Xia,Kaiwen Wang,Jinshu Wang,Dawei Pang,Zhouhao Zhu,Peijie Ma
In this work, Au/Bi2O3 was synthesized by loading Au nanoparticles (NPs) onto β-Bi2O3 by a simple solution reduction method. β-Bi2O3 was synthesized by a precipitation-thermal decomposition procedure, which results in significantly improved SERS detection limits down to 10−9 M for methylene blue (MB) and 10−7 M for methyl orange (MO) as probe molecules, comparable to those reported for the best semiconductor SERS substrates. In particular, further deposition of Au NPs (5.20% wt%) onto β-Bi2O3 results in a two-order-of-magnitude enhancement in detection sensitivity, achieving a detection limit of 10−11 M for MB and 10−9 M for MO. Under ultraviolet/visible irradiation, the Au/Bi2O3 hybrids substrate exhibits superior self-cleaning ability due to its photocatalytic degradation ability which can be applied repeatedly to the detection of pollutants. The advanced composite substrate simultaneously achieved ultra-low mass loading of Au NPs, outstanding detection performance, good reproducibility, high stability and self-cleaning ability. The development strategy of low load noble metal coupled high performance semiconductor β-Bi2O3 to obtain nano-hybrid materials provides a method to balance SERS sensitivity, cost effectiveness and operational stability, and can be synthesized in large quantities, which is a key step towards commercialization and has good reliability prospects.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Haoyu Cai,Guojun Weng,Jianjun Li,Gaofeng Wu,Jian Zhu,Junwu Zhao
Surface deposition of metal on plasmonic nanoparticles is a powerful technique to enhance their Raman activity. In this paper, we demonstrated a sensitive surface-enhanced Raman scattering (SERS) substrate based on asymmetric deposition of Ag on gold nanobipyramids (Au NBP@BDT@Ag), which was applied to detect the drug residues of malachite green (MG), methylene blue (MB), and crystal violet (CV) in aquaculture water. By tuning the concentrations of 1,4-benzenedithiol (BDT) and AgNO 3 , the deposited Ag component showed an asymmetric growth on the two ends of Au NBPs, forming Au@Ag nanodarts. The Au@Ag nanodarts exhibited the most outstanding SERS performance and was thus used to detect the drug residues. Comparing with the original Au NBP, the SERS enhancement of Au@Ag nanodart has been dramatically improved with the maximum enhancement factor (EF) of 8 × 10 6 . The limit of detection (LOD) of the three drugs are respectively 8.4 × 10 −11 M for MG, 8.5 × 10 −9 M for MB, and 6.7 × 10 −9 M for CV, while the broad linear detection range is 1.0 × 10 −10 M ∼ 1.0 × 10 −6 M for MG, 1.0 × 10 −8 M ∼ 1.0 × 10 −5 M for MB, and 1.0 × 10 −8 M ∼ 1.0 × 10 −5 M for CV, respectively. And the detection of real clam feeding water samples also showed the potential of this detection strategy. We believed the detection strategy could have an application in the field of the detection of drug residues in aquaculture water and the asymmetric deposition will be meaningful in the field of dimer synthesis using Au NBP as core.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Honglian Wu,Ruolin Zhang,Huang Lai,Luogen Lai,Yi Liu,Yadi Fan,Yu Zhang,Jingyu Shi,Mo Yang
Endotoxins or lipopolysaccharides (LPS) are potent inflammatory agents that pose serious health risks even at low concentrations, thus requiring sensitive and reliable detection methods. Current methods for endotoxin detection, primarily the Limulus Amebocyte Lysate (LAL) assay and Enzyme-linked Immunosorbent Assays (ELISA) are limited by complex procedures, prolonged assay time, and susceptibility to interference. To address these challenges, we developed a single-reporter probe-based dual-mode biosensor integrating MXene-Au nanosheets with the CRISPR/Cas12a system for endotoxin detection. The sensing platform was constructed by conjugating ssDNA-Cy5 reporters onto MXene-Au nanosheets. MXene-Au nanosheets served dual functions, including efficient quenching of fluorescence and strong enhancement of SERS signals. In the presence of target endotoxins, CRISPR/Cas12a remains inactive, leaving the ssDNA-Cy5 reporters intact on the MXene-Au surface. The close proximity of Cy5 to the MXene-Au surface results in quenched fluorescence (“FL off”) but enhanced SERS signals (“SERS on”). Conversely, in the absence of endotoxins, activated CRISPR/Cas12a cleaves the ssDNA-Cy5, releasing Cy5 from the surface, thus leading to fluorescence recovery (“FL on”) but diminished SERS signals (“SERS off”). By measuring the changes in SERS and FL signals and analysing the ratiometric I SERS /I FL signals, the biosensor achieved a lower limit of detection (LOD) of 15.9 pg/mL within 30 minutes compared to single detection modes. Validation studies in complex matrices, including spiked water and milk samples, showed performance comparable to commercial endotoxin detection kits. Overall, our CRISPR-Cas12a-mediated fluorescent-SERS dual-mode biosensor not only improves detection sensitivity but also provides built-in quality control, improving the reliability of results through cross-validation.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Weida Zhang,Yusi Peng,Chenglong Lin,Meimei Xu,Shuai Zhao,Dan Li,Yingchun Yang,Yong Yang
Misuse and residues of antibiotics in food seriously threaten human health, which urges us to develop ultra-sensitive semiconductor surface-enhanced Raman scattering (SERS) substrates to achieve the direct and ultra-sensitive detection of specific various antibiotics. Here, we innovatively propose polyvinylpyrrolidone K30 as surfactants to regulate the liquid–liquid interface growth and successfully synthesize a novel SERS substrate V 5 S 4 nanopompons (NPPs) formed by the cross-growth nanosheets, which exhibits a limit of detection (LOD) of 10 −11 M for Rhodamine 6G (R6G) molecules with a high enhancement factor of 1.9 × 10 8 . To the best of our knowledge, this ultra-high SERS sensitivity of V 5 S 4 NPPs is superior to most of reported pure semiconductor SERS substrates, mainly due to the synergistic effect of photo-induced charge transfer resonance from the valence band of V 5 S 4 to the LUMO energy level of R6G and the molecule resonance originating from the aromatic C–C stretching in R6G. Benefitting from the excellent SERS sensitivity of V 5 S 4 NPPs, the sensitive and specific detection with LODs of 10 −7 M, 10 −8 M, and 10 −7 M and accurate identification with the accuracy of 97.5% for common antibiotics of ciprofloxacin, tetracycline, and chloramphenicol, respectively, are achieved using a newly developed convolutional-residual neural networks models of AI processing method. This research not only enriches the material reservoir of the conventional semiconductor SERS substrates but also provides an efficient detection and identification method for monitoring antibiotic residues in milk to ensure the food safety.
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NANOTECHNOLOGY
·
2024
·Vol. 35
·期 19
·195710
·
IF 2.9
Hang Chen,Caiqin Han,Le Zhang,Ying Wu
A surface enhanced Raman scattering (SERS) substrate of porous rod-shaped ferric oxide (Fe2O3) combined with silver nanoparticles (Ag NPs) and black phosphorus (Fe2O3/Ag/BP) was fabricated to detect the persistent organic pollutants (POPs) at low concentration. The organic pollutant Rhodamine 6G (R6G) was used as the probe molecule to study the performances of Fe2O3/Ag/BP, and 4-chlorobiphenyl (PCB-3) was the target of detection. The limit of detection (LOD) of R6G based on this novel SERS substrate Fe2O3/Ag/BP was as low as 1.0 × 10−15 M, which was five orders of magnitude lower than that of Fe2O3/Ag (10−10 M). The enhancement factor (EF) of Fe2O3/Ag/BP was 6.44 × 108, which was 3.1 times higher than that of porous rod-shaped Fe2O3/Ag (2.08 × 108). The Raman signal of R6G based on Fe2O3/Ag/BP had a good homogeneity, and the relative standard deviation (RSD) of Raman signal intensities of R6G at 1643 cm−1 was only 5.97%. Furthermore, the Fe2O3/Ag/BP substrate exhibited a recyclability through the photocatalytic degradation of R6G. The LOD of PCB-3 based on Fe2O3/Ag/BP was 10−9 M. Besides, Fe2O3/Ag/BP had a high SERS activity even it was kept in a centrifuge tube without requiring complicated treatment. These results highlight the potential application of Fe2O3/Ag/BP for ultra-trace detection of POPs in the environment.
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VIBRATIONAL SPECTROSCOPY
·
2024
·
IF 2.7
Fan Yang,Jing Zhao,Zhengang Wu,Yingna Wei,Hengyong Wei,Jingwu Li,Bo Li
Cocrystal is a new class of pharmaceutical crystal form, which could improve the physical and chemical properties of drug substance without affecting the internal structure of drug substance. Therefore, the cocrystals show a great deal of potential in the development and research of drugs. 5-Fluorouracil (5-FU) is one of the most widely used anti-pyrimidine drugs. However, its solubility is poor and its oral bioavailability is low. In this work, the cocrystal of 5-FU with nicotinamide was prepared by the solvent evaporation method. The cocrystal structure was confirmed by infrared spectroscopy (IR), X-ray diffraction (XRD) and Raman spectroscopy. The X-ray diffraction and infrared spectroscopy presented that there were significantly different peaks between the raw drug and the cocrystal. Raman spectral results also indicated the differences of such cocrystal compared with the raw drug. In addition, TiN-Ag composite SERS substrate was used to study the formation of 5-FU cocrystal drugs and the formation process was dynamically monitored, and the interaction between molecules during the cocrystal reaction was deeply understood. The cocrystal reaction process was tracked, it can be found that the peak intensity of the raw drug and cocrystal changes with the reaction, indicating that the TiN-Ag composite substrate can monitor the cocrystal transformation process.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Yuzhu Li,Zhongxiang Ding,Hongyan Wang,Cheng Qu,Guangping Li,Honglin Liu
In clinical diagnostics, human breath presents an alternative and more convenient sample than biofluids for detecting the ingestion of nonvolatile drugs. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy technique with high sensitivity based on molecular fingerprinting. However, the low affinity of traditional SERS substrates for aerosols and the stochastic fluctuation of the SERS signal at low concentrations limit their application in breath aerosol analysis. In this study, we synthesized hydrogel microsphere SERS substrates with highly reversible swelling/shrinking properties that enhance target analyte accumulation in breath aerosols and promote plasmonic nanoparticle aggregation for intense Raman hotspot formation. Furthermore, these hydrogel microsphere SERS substrates function as a three-in-one system, enabling multilevel selectivity based on size, charge, and hydrophilicity for target molecules simultaneously without pretreatment. Notably, by “digitizing” the SERS signal of each individual hydrogel microsphere and calculating the proportion of positive microspheres, the hydrogel microspheres can serve as a digital SERS platform that circumvents the low stability issues resulting from fluctuations in SERS signal intensity. Consequently, the digital SERS platform achieved a detection limit of 0.5 ppm for fentanyl in simulated breath aerosols. This innovative sensing strategy not only demonstrates a promising approach for screening nonvolatile drugs but also simplifies the sampling process, holding great potential for clinical diagnosis of breath aerosols.
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