Nature Chemistry
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2026
·
IF 24.5
Fan Yunlong,Guo Jinkun,Yao Ze-Fan,Zhang Zhenghan,Zhang Haoyang,Huang Xing,Pan Zhichao,Yang Luming,Ma Chao,Wu Xinyan,Le Khoa N.,Chen Tianyang,Xu Zhichen,Zhang Ling,Chen Hao,Zhao Tongyang,Qiao Shuo,Zhang Tingsong,Ji Qingqing,Zheng Yu-Qing,Sun Lei,Skorupskii Grigorii,Arguilla Maxx Q.,Yi Yuanping,Hendon Christopher H.,Dincă Mircea,Li Jian,Dou Jin-Hu
The physical properties of van der Waals materials are highly dependent on their stacking sequences. However, constructing layered materials with specific compositions and desired stackings is challenging. Here we show that a solvent-directed strategy enables targeted stacking in van der Waals metal–organic frameworks, an emerging class of van der Waals materials. By leveraging the tunable metastable states of conjugated ligands through various solvents, and stabilizing these states via metal–ligand coordination, we enable the inheritance of stacking patterns from ligands to van der Waals metal–organic frameworks. Notably, this strategy enables the controlled manipulation of stacking sequences and divergent charge transport regimes in two-dimensional and three-dimensional van der Waals metal–organic framework single crystals, yielding an electrical conductivity of 1,792 S cm −1 . These results provide a versatile approach for designing layered materials with programmable stackings and tailored electronic properties. The alternative text for this image may have been generated using AI.
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Nature Communications
·
2026
·
IF 18.1
Xiong Ming,Zou Chen-Yu,Zhao Lei,Jiang Yan-Lin,Li Qian-Jin,Fan Ming-Hui,Song Yu-Ting,Shen Zhi-Xue,Gao Ya-Ya,Dong Yi-Jun,Tang Lin-Qiao,Liu Jun,Hu Juan-Juan,Yang Hui,Xie Hui-Qi
Vocal fold (VF) injury, frequently caused by laryngeal microsurgery, leads to fibrosis and phonation impairment. Effective therapies remain limited, partly due to limited understanding of VF injury mechanisms. Using single-cell RNA sequencing of injured human VFs, we identified marked oxidative stress upregulation in epithelial cells, highlighting the need for epithelial protection and redox modulation. Informed by this insight, we developed an in situ-forming redox-regulated hydrogel, compatible with endoscopic spray delivery. It forms a conformal gel on the VF surface within 2 seconds, providing physical shielding and oxidative microenvironment regulation. The hydrogel reduced intracellular and mitochondrial reactive oxygen species, activated endogenous protective mechanisms, preserved mitochondrial function, and consequently rescued epithelial cells from oxidative stress-induced apoptosis and proliferation loss. In vivo, the hydrogel accelerated epithelialization and restored functions (vibratory and phonatory). Overall, this study introduces a unique approach for functional VF repair and offers a promising paradigm for biomaterial development guided by pathological microenvironment.
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COLLOID AND POLYMER SCIENCE
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2026
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IF 2.9
Wang Gonghao,Zhang Yuchen,Deng Rong,Yang Die,Yang Shuyi,Ding Yongbo,Shen Liang
In this study, a series of acrylate-modified epoxy ester dispersions were designed and prepared via a two-step polymerization strategy. The influence of carboxyl group distribution on dispersion stability, particle characteristics, and coating properties was systematically investigated. Results show that delaying the addition of hydrophilic monomers progressively increases particle size from 47.4 nm (EA-0) to 100.6 nm (EA-4), reduces viscosity from 15,800 mPa·s to 164 mPa·s, and improves thermal storage stability initially followed by a gradual decline. The optimal balance between colloidal stability and coating performance is achieved in sample EA-2, which exhibits the smallest changes in pH, particle size, and viscosity after thermal aging. With increased surface carboxyl enrichment, the coatings show prolonged hard-drying time from 7 h to 12 h, decreased König hardness from 90 s to 58 s, reduced water contact angle from 83.1° to 62.0°, and gradually deteriorated water resistance. The underlying mechanism reveals that appropriate carboxyl distribution enhances electrostatic stabilization by extending the Debye length and thickening the electric double layer, while excessive surface carboxyl groups promote water adsorption and accelerate hydrolytic degradation. This study provides mechanistic insights and practical guidance for designing low-VOC, high-stability waterborne epoxy ester coatings with tunable colloidal and film properties.
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JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 7
·273
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IF 3.5
Yan Xilai,Tang Yuqing,Huang Guangying,Han Han,Mondal Ajoy Kanti,Lin Weijie,Huang Fang
The use of renewable Kraft lignin (KL) as a partial substitute for petroleum-based polyols has attracted significant interest in polyurethane foam (PUF) development. However, the effect of unmodified KL content on the balance among cellular structure, mechanical stability, cyclic compression behavior, and thermal properties of flexible polyurethane foam (FPUF) still requires further clarification. In this study, a series of lignin-based flexible polyurethane foams (LFPUF) with different KL contents were prepared via a one-shot method using polyethylene glycol 400 (PEG400) and hexamethylene diisocyanate (HDI). The proposed interactions between KL and PEG400, together with the reaction between hydroxyl groups and –NCO groups, contributed to the formation of lignin-containing polyurethane networks. With 15 wt% KL addition, L 15% FPUF exhibited the most favorable cellular structure, with the smallest average cell size (843.5 μm) and pore diameter (249.3 μm). Its rebound resilience and elastic recovery rate reached 20.36% and 98.24%, respectively, which were higher than those of KL-free FPUF (13.45% and 96.97%). After 300 compression cycles at 75% strain, L 15% FPUF maintained a high elastic recovery rate of 93.53% and a stable hysteresis loss of 32.71%, demonstrating good cyclic compression stability. Thermal analysis further showed that KL incorporation improved high-temperature residue retention while affecting the initial degradation behavior. This study identifies 15 wt% KL as a balanced substitution ratio for preparing LFPUF with improved cellular structure, mechanical stability, cyclic compression stability, and thermal performance, supporting its potential application in flexible cushioning materials.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2026
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IF 3.1
Pan Jianzhen,Liu Xinting,Yang Minghui
By in situ reduction of Pt nanoparticles (Pt NPs) onto the surface of multi-walled carbon nanotubes (MWCNTs), Pt NPs@MWCNTs nanocomposite was successfully synthesized. Experimental results indicate the nanocomposite exhibits good NADH oxidase activity, which can generate •O 2− through O 2 and efficiently catalyze the oxidation of nicotinamide adenine dinucleotide (NADH) to generate biologically active NAD + . Based on this characteristic, we developed an NAD + /NADH dependent dehydrogenase electrochemical cascade biosensor for the detection of β-hydroxybutyric acid (HB) via β-hydroxybutyrate dehydrogenase that does not require additional redox mediators. This biosensor exhibited good performance for HB with high sensitivity and good specificity, and a wide linear range of 10 µM to 10 mM. To verify its practical application, the biosensor was applied to the detection of HB in human serum samples, which indicate the biosensor has potential for clinical diagnosis of diabetes ketoacidosis.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Zhang Wen,Shi Manman,Wang Guibin,Cao Fuliang,Su Erzheng
The primary poisonous components in Ginkgo biloba seeds are ginkgotoxin (4’-O-methylpyridoxine, MPN) and its 5’-glucoside (MPN-5’-glucoside, MPNG). When Ginkgo biloba kernels are consumed in excess at one time, the total amount of MPN and MPNG (TMPN) can reach toxic levels. We investigated the effects of four storage methods (room temperature storage, sand storage, 4 °C storage, -20 °C storage) on MPN and MPNG levels and their distribution in embryos and endosperms of different Ginkgo biloba cultivars. Results showed that room temperature and sand storage promoted embryonic post-maturation of Ginkgo biloba seeds, whereas 4 °C and − 20 °C storage inhibited embryo development. During all storage treatments, the total TMPN mass in the whole kernel and its proportional distribution between embryo and endosperm remained stable, while the content concentrations (µg/g) of MPN, MPNG, and TMPN in the two tissues exhibited dynamic fluctuations driven by the interconversion of MPN and MPNG. Notably, over 93% of TMPN was concentrated in the endosperm across all storage conditions, with only 1.49 ± 0.00 ~ 5.04 ± 0.05%, 0.52 ± 0.02 ~ 6.13 ± 0.08%, 0.2 ± 0.00 ~ 2.01 ± 0.12% and 0.19 ± 0.00 ~ 2.36 ± 0.04% of TMPN detected in the embryo under room temperature storage, sand storage, 4 °C storage, and − 20 °C storage, respectively. This study refutes the long-standing misconception that the embryo is the most toxic part of Ginkgo biloba seeds and that mechanical embryo removal achieves effective detoxification, providing a scientific basis for the precise detoxification of Ginkgo biloba seeds.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 7
·469
·
IF 5.4
Lin Luyao,Wang Haonan,Lei Xinlin,Zhuang Xin,Chen Yiqing,Lai Qiyue,Li Bo,Fang Yulin,Xu Yunli,You Ruiyun,Lu Yudong
Efficient localization of analytes near plasmonic hotspots remains a major challenge for surface-enhanced Raman scattering (SERS) detection in complex liquid-phase systems. Herein, an interlaced cellulose-based porous membrane composed of dissolving pulp fibers (DPFs), mechanically ground nanofibers (MGNFs), sodium alginate (SA), and Ag nanoparticles was developed as a molecular enrichment-assisted SERS platform for sweat biomarker determination. The hierarchical porous architecture provided interconnected transport channels and abundant interfacial adsorption sites, facilitating analyte retention and localized enrichment within the plasmonic region. Benefiting from the synergistic effects of porous confinement and uniformly distributed Ag nanoparticles, the optimized substrate exhibited sensitive and reproducible SERS performance with an enhancement factor of 4.36 × 10⁷, a relative standard deviation of 8.04%, and a detection limit down to 1.0 × 10⁻⁸ mol/L for Rhodamine 6G (R6G). Systematic adsorption experiments using molecules with different charge properties further demonstrated the broad molecular enrichment capability of the structured cellulose network. The developed platform enabled quantitative detection of lactate and urea within physiologically relevant sweat concentration ranges and showed satisfactory analytical performance in spiked sweat samples. More importantly, this work demonstrates a structure-engineered porous membrane strategy for integrating molecular enrichment with plasmonic sensing, providing new insight into cellulose-based SERS platforms for complex bioanalytical applications. Graphical abstract The alternative text for this image may have been generated using AI.
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Food Analytical Methods
·
2026
·Vol. 19
·期 9
·259
·
IF 3
Yang Yue,Liu Jianghua,Liu Fulu,Chen Jianing,Li Qianyu,Xu Bufan,Xu Qinfeng,Li Guoliang
The development of a detection technique with superior accuracy, high sensitivity, and visual applicability simultaneously for economically motivated adulteration (EMA) of fruit juice remains a formidable challenge. Herein, we developed a CRISPR/Cas12a-regulated fluorescence detection platform capable of converting trace level of target into detectable fluorescence signals. This strategy was inspired by the extraordinary trans- cleavage capacity of CRISPR/Cas12a and significant fluorescence response of the fluorescence probe [Ru(phen) 2 (dppz)] 2+ . After the target DNA had been identified, activated CRISPR/Cas12a cleaved the block ssDNA (bDNA), preventing the formation of short dsDNA and initiating a hybridization chain reaction (HCR). Consequently, large amounts of [Ru(phen) 2 (dppz)] 2+ intercalated into the resulting long dsDNA nanowires, enabling cascade signal amplification and a highly sensitive signal output. The output could be observed as a strong orange fluorescence only using a blue transilluminator. Then, we used the strategy to detect adulteration in blueberry juice, which displayed excellent specificity and satisfactory sensitivity with the limit of detection (LOD) as low as 19.5 fM. Our study demonstrated a novel method utilizing the fluorescence switch regulated by CRISPR/Cas12a, showing extremely high specificity, excellent sensitivity, and capability for visual detection of trace target substances in complex food matrices. Graphical
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Advanced Composites and Hybrid Materials
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2026
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IF 15.5
Xu Chang,Dong Xufeng,Wang Guixue,Zhuang Xijing
High-strength and high-toughness hydrogels have demonstrated exciting application prospects in soft robotics, artificial skin, and tissue engineering, but the development of such high-performance soft materials remains a challenging task. Here, inspired by the multiscale oriented hierarchical assembly structure of wood, this study innovatively reproduces the multilevel oriented compositional units of wood by incorporating millimeter-scale pulp fibers, nano-scale bacterial cellulose, and molecular-scale sodium lignosulfonate into pre-stretched polyvinyl alcohol hydrogels. The strong interfacial electrostatic interactions and hydrogen bonds formed between the functional groups of these components effectively stabilize and firmly bundle the hierarchical anisotropic structure. The resulting hierarchically oriented hydrogel exhibits remarkable mechanical properties, including an exceptional fracture strength exceeding 15.5 MPa, an ultimate strain of ~ 130%, and a toughness of ~ 14 MJ/m³, along with enhanced tear resistance. Notably, the hydrogel maintains satisfactory strength and toughness even in non-oriented directions, reinforcing its resistance to complex stress conditions. Furthermore, the composite hydrogel demonstrates extremely low biotoxicity, acceptable blood compatibility, and highly linear strain-sensing behavior. This study presents a natural structure-inspired hierarchical strategy, exploring a promising pathway for fabricating advanced hydrogel materials with outstanding mechanical properties. Graphical abstract The alternative text for this image may have been generated using AI.
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Nature Communications
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2026
·
IF 18.1
Wu Zucheng,Wei Hao,Shao Zhipeng,Kou Dongxing,Wang Lijing,Jia Jia,Li Yimeng,Cui Changcheng,Feng Xiaopeng,Xia Shengren,Lv Luyao,Liu Ziye,Wang Yuehui,Wu Sixin,Cui Guanglei
Cu 2 ZnSn(S,Se) 4 kesterite solar cells, while promising for sustainable photovoltaics, are constrained by undefined crystallization kinetics during selenization, which introduces bilayer crystallization with detrimental horizontal grain boundaries, voids, and secondary phases. This work traces this issue to early-stage Se-driven reaction at the back interface, which forms a low-melting-point Cu(S,Se) phase and triggers uncontrolled reverse crystallization. To address this, we propose a thermal-decoupled selenization strategy that creates a vertical Se concentration gradient in the initial stage. This approach decouples Se supply from the Cu(S,Se) formation temperature range, thereby suppressing bilayer crystallization. Consequently, it enables the growth of top-down columnar grains, which enhance carrier transport and suppress recombination, achieving a champion power conversion efficiency of 15.7% (certified 15.3%) in the resultant devices. This approach offers critical insights into crystallization kinetics and is also applicable to solution-processed Cu(In,Ga)Se 2 solar cells, highlighting its great significance for diverse copper-based chalcogenides.
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Cell Death Discovery
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2026
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IF 10.4
Chen Yu,Wen Yuetao,Xu Diru,Hao Lei,Liu Qinglin,Kuang Jia,Zhao Wang,Yang Zhao
Depression is associated with complex hippocampal pathology, including disrupted signaling and neuronal damage. In this study, we developed a novel targeted nanoplatform using nucleic acid aptamer-modified astrocyte-derived extracellular vesicles loaded with geniposide (Apt-EVs@GP) to investigate its therapeutic mechanism, with a focus on the GATA binding protein 1 (GATA1)/adrenergic receptor beta 2 (ADRB2) axis in a chronic unpredictable mild stress (CUMS) mouse model. Apt-EVs@GP exhibited excellent biocompatibility and targeted accumulation in the hippocampus. Apt-EVs@GP treatment significantly ameliorated depression-like behaviors, as evidenced by enhanced locomotor activity and reduced immobility in standard behavioral assays. Transcriptomic analysis combined with molecular validation identified a key regulatory mechanism: Apt-EVs@GP suppressed stress-induced upregulation of GATA1, thereby relieving its transcriptional repression of ADRB2. This regulatory interaction was confirmed by chromatin immunoprecipitation and dual-luciferase reporter assays. Restoration of ADRB2 expression led to robust activation of the downstream cAMP/PKA/CREB signaling pathway. Functionally, reprogramming of the GATA1/ADRB2/cAMP axis conferred comprehensive hippocampal protection, including attenuation of neuroinflammation, suppression of neuronal apoptosis, and restoration of synaptic integrity. Our findings demonstrate that Apt-EVs@GP alleviates depression by targeting a novel GATA1/ADRB2 mechanism, highlighting its potential as a promising therapeutic strategy against depression-related hippocampal pathology. The alternative text for this image may have been generated using AI.
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Food Analytical Methods
·
2026
·Vol. 19
·期 9
·248
·
IF 3
Qin Shili,Zhao Dongsheng,Jin Fenglong,Qin Yuting,Liang Xinyu,Liu Jingwen,Chu Hongtao,Gao Lidi,Zhao Ming
In this study, the octahedral core–shell ZIF-8@UiO-66-NH 2 composite, exhibiting high crystallinity, microporous structural properties and multifunctional groups, was synthesized, characterized, and applied for the first time as stationary phase in capillary electrochromatography. The baseline separation of four groups containing 14 analytes was achieved within 11.6 min, with resolution of at least 1.51. Compared to the individual components of ZIF-8 and UiO-66-NH 2 used as chromatographic stationary phase, the bonded capillary column based on ZIF-8@UiO-66-NH 2 exhibited the improvement in resolution and column efficiency (theoretical plate numbers) ranging from 68.14 to 918.75% and from 3.92 to 398.31%, respectively, and sample loading capacity increased by ≥ 26.8%. Furthermore, an accurate, rapid, and reliable electrochromatography method was developed for the qualitative and quantitative analysis of thiamphenicol and florfenicol in pork meat. The limits of detection and quantification for thiamphenicol were 0.34 μg/mL and 1.75 μg/mL, and for florfenicol, 1.00 μg/mL and 5.82 μg/mL, with sample recoveries in the range of 96.00 to 108.00% and the standard deviations less than 4.59%. This work not only confirmed the potential of MOF@MOF composite as high-performance stationary phases but also broadened the electrochromatography application in food inspection. Graphical
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危险品化学品经营许可证（带存储）