SCIENCE OF THE TOTAL ENVIRONMENT
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2018
·
IF 4.61
Jinfeng Zhao,Shixiang Liu,Na Liu,Han Zhang,Qiongzhi Zhou,Fei Ge
Extracellular polymeric substances (EPS) play significant roles in protecting cells against environmental stresses. However, little information is known about the roles of different EPS in these processes. In this study, the productions and physicochemical characterizations of soluble-EPS (S-EPS) and bound-EPS (B-EPS), the two different fractions of EPS from a green alga Chlorella vulgaris under the stress of ZnO nanoparticle (nano-ZnO) were investigated. The contents of S-EPS and B-EPS which described as dissolved organic carbon , polysaccharides and proteins, both increased with the addition of tested nano-ZnO (0.01 and 0.04 mM) in a 72 h cultivation. EPS-Free (EPS-F) cells produced more S-EPS and B-EPS than the EPS-Cover (EPS-C) cells did with the tested nano-ZnO, especially the contents of protein in the S-EPS of EPS-F cells increased by 45.5% with 0.04 mM nano-ZnO compared to the control at 72 h. Tryptophan-like substances of the protein in S-EPS exhibited a stronger chemical static quenching than tyrosine-like substances with nano-ZnO. In addition, the hydroxyl ( OH) as well as carboxyl (C O) group, and C O of amide I, N H/C N of amide II groups in proteins were confirmed that involved in the reaction of S-EPS and B-EPS with nano-ZnO, meanwhile hemiacetal groups in saccharides were oxidized to carboxyl groups. This study could provide a better understanding of EPS in protecting against cells damage with nanoparticles.
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高影响因子
IET Nanobiotechnology
·
2019
·Vol. 13
·期 6
·640-649
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IF 1.925
Wanxia Wang,Youyun Wang,Yu Wang,Huameng Gong,Hongda Zhu,Mingxing Liu
New drug delivery system (ZnO@CMS) of the redox and pH dual-stimuli responsive based on colloidal mesoporous silica nanoparticles (CMS) has been designed, in which zinc oxide quantum dots (ZnO QDs) as a capping agent was conjugated on the surface of nanoparticles by amide bonds. The release behaviour of doxorubicin (DOX) as the model drug from ZnO@CMS (ZnO@CMS-DOX) indicated the redox and pH dual-stimuli responsive properties due to the acidic dissolution of ZnO QDs and cleavage of the disulphide bonds. The haemolysis and bovine serum albumin adsorption assays showed that the modification of ZnO QDs on the mesoporous silica nanoparticles modified by mercapto groups (CMS-SH)(ZnO@CMS) had better biocompatibility compared to CMS-SH. The cell viability and cellular uptake tests revealed that the ZnO@CMS might achieve the antitumour effect on cancer cells due to the cytotoxicity of ZnO QDs. Therefore, ZnO@CMS might be potential nanocarriers of the drug delivery system in cancer therapy. The in vivo evaluation of ZnO@CMS would be carried out in future work.
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SOLID STATE SCIENCES
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2019
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IF 2.155
Zhenghao Sun,Yaping Guo,Baoe Li,Taizhe Tan,Yan Zhao
The application of lithium/sulfur (Li/S) batteries is negatively affected by the insulation of sulfur and large volumetric change during the cycles as well as the polysulfides dissolution. To solve the above problems, we fabricated a composite interlayer for Li/S batteries using ZnO nanocrystals anchored on connected carbon nanotube and graphene. The preparation of ZnO/carbon nanotube/reduced graphene oxide (ZnO/CNT/RGO) composite film was inspired from the combination of a one-step sol-gel synthetic technique and vacuum-assisted filtration. The ZnO/CNT/RGO interlayer showed effective adsorption of polysulfides during diffusion experiments. This ZnO/CNT/RGO interlayer can efficiently increase sulfur utilization by immobilizing soluble intermediate polysulfides. When used as a composite interlayer in Li/S batteries, an impressive high capacity of 768 mAh g −1 at 0.2C was achieved after 150 cycles and improved rate performance of 597 mAh g −1 at 2C was obtained. This study offers a facile method to improve the electrochemical performance of the Li/S batteries.
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FOOD AND CHEMICAL TOXICOLOGY
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2019
·
IF 3.775
Leying Jiang,Zhen Li,Yixi Xie,Liangliang Liu,Yi Cao
Recent studies suggest that phytochemicals , as part of the food matrix, might alter the toxicity of nanoparticles (NPs); however, relatively few studies have investigated the impact of anthocyanidins on the toxicity of NPs to cells lining the gastrointestinal tract. Therefore, this study used cyanidin chloride (CC) as the model for anthocyanidins and investigated the effects of CC on the toxicity of ZnO or Ag NPs to Caco-2 cells. Exposure to ZnO but not Ag NPs significantly induced cytotoxicity. The presence of CC, but not its analog quercetin (Qu), modestly protected Caco-2 cells from ZnO NP exposure. However, the intracellular superoxide, Zn ions , or release of interleukin-8 after ZnO NP exposure were not significantly affected by the presence of CC. Rather, CC promoted the expression of autophagic genes ATG5 , ATG7 , and BECN1 as well as the ratio of LC3-II/I after exposure to ZnO NPs. Meanwhile, the presence of autophagic inhibitors (chloroquine, NH 4 Cl, bafilomycin A1) significantly promoted the cytotoxicity of ZnO NPs and inhibited the cytoprotective effects of CC. In conclusion, these data suggest that CC could modestly protect Caco-2 cells from ZnO NP exposure, probably through the induction of autophagy.
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Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 10
·5712-5718
·
IF 10.733
Ying Zhou,Kai Zhao,Yu Han,Zhenhe Sun,Hongtao Zhang,Lingqun Xu,Yanfeng Ma,Yongsheng Chen
The two most challenging issues for Li metal anodes are large volume change during the plating/stripping process and the growth of Li dendrites induced by uneven Li deposition. They lead to low coulombic efficiency, short cycling lifespan and serious safety issues of Li metal batteries. Here we developed a facile strategy to prepare a nitrogen-doped-carbon/ZnO (NDC/ZnO) modified Cu foam (MCuF) current collector for Li metal anodes. The MCuF shows stable Li plating/stripping behavior with the Li dendrite-mitigation feature. The resultant half cells achieve a super long lifespan of over 600 cycles at 1 mA cm−2 and over 200 cycles at a high current density 10 mA cm−2. Moreover, the full cell paired with LiFePO4 also exhibits a long lifespan of over 150 cycles at a high rate of 5C. Such high performance can be attributed to the characteristics of MCuF, including its 3D porous structure with high conductivity, enlarged surface area and uniform lithophilic NDC/ZnO sites. We believed that our work can provide a facile strategy for fabricating high-performance 3D current collectors for Li metal storage and stable Li metal batteries.
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MOLECULES
·
2019
·Vol. 24
·期 3
·503
·
IF 3.06
Lisha Ai,Yejing Wang,Gang Tao,Ping Zhao,Ahmad Umar,Peng Wang,Huawei He
Silk sericin (SS) is a type of natural macromolecular protein with excellent hydrophilicity, biocompatibility and biodegradability, but also has very poor mechanical properties. To develop sericin-based wound dressings, we utilized polyvinyl alcohol (PVA) to reinforce the mechanical property of sericin by blending PVA and sericin, then modified zinc oxide nanoparticles (ZnO NPs) on SS/PVA film with the assistance of polydopamine (PDA) to endow SS/PVA film with antibacterial activity. Scanning electron microscopy, energy dispersive spectroscopy and X-ray powder diffraction demonstrated ZnO NPs were well grafted on PDA-SS/PVA film. Fourier transform infrared spectra suggested PDA coating and ZnONPs modification did not alter the structure of sericin and PVA. Water contact angle and swelling tests indicated the excellent hydrophilicity and swellability of ZnO NPs-PDA-SS/PVA composite film. Mass loss analysis showed ZnO NPs-PDA-SS/PVA film had excellent stability. The mechanical performance test suggested the improved tensile strength and elongation at break could meet the requirement of ZnO NPs-PDA-SS/PVA film in biomaterial applications. The antibacterial assay suggested the prepared ZnO NPs-PDA-SS/PVA composite film had a degree of antimicrobial activity againstEscherichia coliandStaphylococcus aureus. The excellent hydrophilicity, swellability, stability, mechanical property and antibacterial activity greatly promote the possibility of ZnO NPs-PDA-SS/PVA composite film in antibacterial biomaterials application.Keywords:ZnO nanoparticles;polydopamine;sericin;mechanical performance;antibacterial activity
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Xiaoxiao Sun,Chao Liu,A.M. Omer,Wuhuan Lu,Shuxing Zhang,Xun Jiang,Hongjie Wu,Di Yu,Xiao-kun Ouyang
To develop relatively green and ecofriendly smart vehicles for colon-specific drug delivery, carboxymethyl cellulose (CMC) and chitosan (CS) pH-sensitive biopolymers were used in this study. To overcome the weaknesses of CMC carriers, such as poor mechanical performance and an explosive drug release, zinc oxide (ZnO) nanoparticles were incorporated into CMC beads and then coated with a CS layer via a self-assembly technique to form core–shell polyelectrolyte complexes. An anticancer drug, 5-fluorouracil (5-FU), used as a model drug, was loaded into ZnO/CMC/CS bio-nanocomposite beads. Fourier transform infrared spectroscopy , scanning and transmission electron microscopy , and thermogravimetric analysis were used to characterize the chemical structure, morphological changes, and thermal properties of the developed drug carrier, respectively. By studying their swelling and in vitro 5-FU release profiles under simulated gastrointestinal conditions, the pH sensitivity of the developed bio-nanocomposite hydrogel beads could be investigated. The obtained beads with reduced porosity could effectively encapsulate 5-FU and showed self-sustained release behavior depending on the concentrations of CMC, CS, and ZnO nanoparticles. The developed beads also demonstrated a capacity for biodegradation. The results indicated that the ZnO/CMC/CS bio-nanocomposite beads exhibited pH-sensitivity and could be applied efficiently as biodegradable carriers for colon-specific 5-FU delivery.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 47
·7898-7907
·
IF 4.776
Qiu-ge Zhao,Jing Wang,Yu-peng Zhang,Jing Zhang,An-na Tang,De-ming Kong
To overcome the side effects caused by premature drug leakage from carriers and to achieve more efficient cancer treatment via the synergy of photodynamic therapy (PDT) and chemotherapy, a porphyrinic metal–organic framework (porMOF)-based drug delivery system (ZnO-gated porMOF-AS1411) was prepared and its ability to efficiently deliver small molecule drugs was tested. In this system, the porous porMOF plays the dual roles of a PDT photosensitizer and a drug carrier. To overcome premature drug leakage and thus reduce side effects and improve drug delivery efficiency, pH-sensitive ZnO nanoparticles were used to cover the porMOF nanopores. Neutral and alkaline pH-stable ZnO ensured that the loaded drugs were encapsulated in the porMOF pores during delivery. However, ZnO disintegration in the acidic lysosomal environment opened the pores, permitting drug release. Further assembly of nucleolin-specific AS1411 aptamers conferred the nanosystem with target-specific recognition and accumulation abilities. In this work, we demonstrated that the proposed nanosystem could be successfully used to efficiently deliver, with controllable release, the chemotherapeutic drug doxorubicin (DOX), thus achieving bimodal cancer treatment by PDT and chemotherapy. In vitro and in vivo experiments demonstrated that this synergistic therapeutic modality achieved highly efficient cancer cell-killing and tumor ablation without undesirable side effects.
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CHEMICAL ENGINEERING JOURNAL
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2019
·
IF 8.355
Ying Liang,Mingqian Wang,Zhicheng Zhang,Guohong Ren,Yajun Liu,Shishan Wu,Jian Shen
We have constructed biocompatible antibacterial nanoplatforms on the basis of a hybrid hydrogel via simple electrostatic interaction embedded with thin layer graphene oxide (GO) sheets modified with zinc oxide quantum dots (ZnO QDs). The materials possess favorable antibacterial efficacy, thereby providing excellent killing effect for Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) compared with materials that have single diagnosis and treatment mode. The excellent performance stems from the combined effects of hyperthermia produced under the near-infrared irradiation of GO sheets, reactive oxygen species, the release of Zn 2+ from ZnO QDs under acidic environment, and the antibacterial activity of hydrogel. The synergy of antibacterial nanoplatforms can be used for wound anti-inflammatory in vivo indicated by the wound healing results. The hybrid hydrogel causes no evident side effects to major organs in mice during wound healing. Therefore, the biocompatible multimodal therapeutic nanoplatforms have great potential for antibacterial activity and wound healing.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yonghai Song,Jiajia Han,Lijuan Xu,Longfei Miao,Canwei Peng,Li Wang
Dopamine (DA) is a nerve-transducing chemical that helps cells transmit pulses. Too high or too low concentration of DA is detrimental to human health. Therefore, finding a fast, efficient and sensitive method for detecting DA is of great significance. Here, a DA-imprinted chitosan (CS) film/ZnO nanoparticles (NPs)@carbon (C)/three-dimensional kenaf stem-derived macroporous carbon (3D-KSC) was prepared for electrochemical detection of DA. The DA-imprinted CS film/ZnO NPs @C/3D-KSC was prepared by growing zeolite imidazole framework-8 (ZIF-8) on 3D-KSC, carbonizing under N 2 atmosphere, electrodepositing AA-CS on ZnO NPs@C/3D-KSC and eluting template AA molecules. The results showed that ZIF-8 derived porous ZnO NPs@C nanospheres were arranged evenly on 3D-KSC surface to form a monolayer. The diameter of nanospheres was approximately 500–600 nm, and the nanospheres were composed of ZnO NPs embedded in porous carbon. A layer of CS with DA-imprinted pores was covered on the ZnO NPs@C nanospheres, so the DA-imprinted CS film/ZnO NPs@C/3D-KSC integrated electrode exhibited better selectivity for DA detection. The linear range was 0.12 nM-152 μM, the detection limit was 0.039 nM, and the sensitivity was 757 μA mM −1 cm -2 . The DA-imprinted CS film/ZnO NPs@C/3D-KSC integrated electrode also showed higher stability.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Bei Xue,Kezhi Li,Shengyue Gu,Leilei Zhang,Jinhua Lu
Nanocrystalline transition metal oxides have attracted a great deal of attention due to their good electrochemical activity. To pursue novel active electrode materials with low detection, high sensitivity and good selectivity for the detection of H 2 O 2 , Ni foam-supported ZnO nanowires and Co 3 O 4 /NiCo 2 O 4 double-shelled nanocages (ZnO/Co 3 O 4 /NiCo 2 O 4 /Ni foam) have been successful fabricated by facile and effective methods When tested as an enzymatic-free H 2 O 2 electrochemical sensor, the obtained ZnO/Co 3 O 4 /NiCo 2 O 4 /Ni foam exhibits fast response time within 5 s, low detection limit of 0.163 μM (S/N = 3), high sensitivity of 0.388 mA mM −1 cm −2 , wide linear range from 0.2 μM to 2.4 mM (R 2 = 0.996), exhibiting good selectivity and long-term stability. The reason is that special structure of the ZnO nanowires could provide direct electrical pathways for the fast electron transport and Co 3 O 4 /NiCo 2 O 4 double-shell nanocages provide abundant mesopores and large specific surface area to enhance the catalytic activity of H 2 O 2 detection. These results suggest that the ZnO/Co 3 O 4 /NiCo 2 O 4 /Ni foam could be considered as a promising electrode material to build electrochemical biosensor.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Peng Nian,Lu Peng,Jingwei Feng,Xiangxiang Han,Binhua Cui,Songsheng Lu,Jie Zhang,Qiong Liu,Aiyong Zhang
The feasibility of methylparaben (MeP) degradation in aqueous solution by dielectric barrier discharge induced non-thermal plasma combined with zinc oxide-reduced graphene oxide (ZnO-rGO) nanosheets was investigated. The ZnO-rGO nanosheets were synthesized by hydrothermal method and characterized by X-ray diffraction, nitrogen adsorption-desorption isotherm, scanning electron microscope, transmission electron microscope, UV–vis absorption spectroscopy, photocurrent, photoluminescence spectroscopy and X-ray photoelectron spectroscopy. The effects of various factors (discharge power, initial concentration of MeP, initial pH value and air flow rate) on the degradation of MeP were evaluated and the changes of solution pH, conductivity and TOC during the degradation process were discussed. The results showed that when the discharge power was 20 W, the airflow rate was 20 L/h, the ZnO-rGO nanosheets dosage was 0.015 g/L, the initial concentration of MeP was 20 mg/L, and the initial pH value was 7.0, the degradation efficiency of MeP achieved 99% at 15 min. The adding of ZnO-rGO nanosheets to the non-thermal plasma system greatly enhanced the degradation efficiency of MeP. In addition, the role of some reactive species during the degradation process of MeP was also investigated. The degradation process of MeP was well fitted by the pseudo-first-order kinetics. Good stability of the synthetic ZnO-rGO was observed. The degradation intermediates of MeP were determined by gas chromatography-mass spectrometer and the degradation pathways were proposed. Under the attack of reactive species, conjugated structure destruction, hydroxylation, carboxylation and ring-opening reaction occurred during MeP degradation, resulting in the formation of organic acids and alcohols; furthermore, some of the degradation intermediates were mineralized to H 2 O and CO 2 .
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