ACS Applied Polymer Materials
·
2025
·
IF 4.7
Qiao Fan,Kai Zhang,Yufei Liu,Chong Chen,Lanlan Wei,Yucheng Yin,Tingting Luo,Shigui Peng,Min He,Jie Yu
This work demonstrates a molecular engineering strategy to optimize the capacitive performance of PEDOT:PSS by precisely controlling the structure of the amphiphilic block copolymer PSS-b-PAPEG (poly(styrenesulfonate)-block-poly(allyloxy polyethylene glycol)). Five copolymers with PSS:PAPEG ratios of 2:1, 1.5:1, 1:1, 1:1.5, and 1:2 were synthesized via controlled polymerization and integrated into a PEDOT (poly(3,4-ethylenedioxythiophene)) matrix. Electrochemical testing revealed that the 1:1 ratio composite exhibited a maximum specific capacitance of 32.1 F/g at 1 A/g, attributed to the synergistic effects of microphase-separated dual continuous networks and porous structures. Multiscale characterization (XPS, SEM, TEM, AFM, BET, and contact angle measurements) revealed that the 1:1 ratio forms optimal conductive pathways, interfacial doping, and ionic diffusion channels. This study establishes that block ratio engineering is an effective method for balancing conductivity and ionic pathways in conductive polymer-based supercapacitor electrode materials, providing a theoretical basis for high-performance energy storage materials.
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LANGMUIR
·
2022
·
IF 4.331
Chao Lin,Pengju Pan,Guorong Shan,Miao Du
Water-in-oil-in-water (W/O/W) Pickering double emulsions are promising materials for the construction of carriers for water-soluble and oil-soluble molecules or drug delivery systems if the contradictive trade-off between their extreme stability and controlled release properties can be resolved. In this study, biodegradable and biocompatible poly(ethylene glycol)-b-poly(ε-caprolactone-co-δ-valerolactone) (PEG-b-PCVL) diblock copolymers with predesigned hydrophilic to hydrophobic block length ratios and nearly identical ε-caprolactone/δ-valerolactone molar ratio (8/2), were synthesized by ring-opening copolymerization. Then, they self-assembled to create semicrystalline micelles. The melting points of PEG-b-PCVL copolymers and their lyophilized micelles were within a physiological range of temperatures, as determined by differential scanning calorimetry. Water contact angle measurements provided evidence that the surface wettability of PEG-b-PCVL micelles could be tuned by the PCVL block mass fractions or temperature stimulus. Such PEG-b-PCVL micelles were employed as a single particulate stabilizer to develop Pickering double emulsions through a one-step emulsification technique. W/O/W Pickering double emulsions could be generated using relatively hydrophobic PEG-b-PCVL micelles with high mass fractions (exceeding about 89%) of PCVL blocks, and they displayed excellent long-term physical stabilities at room temperature. However, the Pickering double emulsions underwent a rapid microstructural transition into simple oil-in-water Pickering emulsions instead of complete demulsification at elevated temperature (37 °C), which was attributed to the hydrophilicity of micelles enhanced when the core-forming PCVL melted realized by temperature stimulus. Consequently, such W/O/W Pickering double emulsions stabilized solely with semicrystalline PEG-b-PCVL micelles exhibit thermal responsiveness, enabling them to release vitamin B12 encapsulated within the internal aqueous phase rapidly.
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2019
·
IF 2.121
Zhen Yue,YuJu Che,Zhiwen Jin,Sisi Wang,Qinglin Ma,Qian Zhang,Yebang Tan,Fanjun Meng
A thermo- and pH-sensitive hydrogel was prepared by a facile free aqueous radical copolymerization of PEGMA and AAc without any crosslinkers for controlled drug delivery. The successful fabrication of hydrogels was confirmed by Fourier transform infrared spectroscopy (FT-IR) and thermo gravimetric analysis (TGA) measurements. The morphological, mechanical and swelling properties of the obtained hydrogels were studied systematically. The results showed that the morphological and mechanical behaviors of the resultant hydrogels were strongly affected by the content of AAc. Moreover, the obtained hydrogels showed an excellent thermo-, pH- and salinity sensitivities. Release profiles of 5-Fu were studied at different pH (gastric pH 1.2 and intestinal pH 7.4) and temperatures (25 °C and 37 °C). The results showed that the release is very low at pH 1.2/37 °C and high at pH 7.4/25 °C. The cytotoxicity of hydrogels to cells was determined by an MTT assay. The result demonstrated that the blank hydrogels had negligible toxicity to cells, whereas the 5-Fu-loaded hydrogels remained high in cytotoxicity for LO2 and HepG-2 cells. Results of the present investigation exemplify the potential of this novel thermo- and pH-sensitive hydrogel for the controlled and targeted delivery of the anti cancer drug 5-Fu.
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DRUG DELIVERY
·
2017
·
IF 6.402
Hongmei Yan,Jie Song,Xiaobin Jia,Zhenhai Zhang
Baohuoside I is an effective but a poorly soluble antitumor drug. In this study, we prepared baohuoside I-loaded mixed micelles with didecyldimethylammonium bromide (DDAB) and d-a-tocopheryl polyethylene glycol succinate (TPGS) (DTBM) and active targeting mixed micelles (HDTBM) with hyaluronic acid (HA) as the targeting ligand on the surface of the mixed micelles. We performed a systematic comparative evaluation of the antiproliferative effect, cellular uptake, antitumor efficacy, and in vivo tumor targeting of these micelles using A549 cells. HDTBM showed improved cellular uptake and had a greater hypersensitizing effect on A549 cell lines than baohuoside I; half-maximal inhibitory concentration (IC50) was 8.86 versus 20.42 μg/mL, respectively. Results of the antitumor efficacy study and the imaging study for in vivo targeting showed that the mixed-micelle formulation had higher antitumor efficacy and achieved effective and targeted drug delivery. Therefore, our results indicate that HA/baohuoside I-M may be used as a potential antitumor formulation.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Yongli Shi,Weiwei Ma,Min Gao,Yaxing Yang
The purpose of this paper was to fabricate a novel methoxy poly(ethylene glycol)-block-poly(caprolactone)-block-poly(1, 4, 8-Trioxa [4.6] spiro-9-undecanone) (mPEG- b -PCL- b -PTOSUO, mPECT) triblock copolymer and study on the in vitro anti-tumor activity of curcumin-loaded mPECT nanoparticles (NPs). The mPEG- b -PCL- b -PTOSUO NPs were fabricated with solvent evaporation. Transmission electron microscope (TEM) and laser particle analyzer were applied to investigate the morphology and size distribution of the obtained mPECT NPs. The cytotoxicity of the copolymer (mPECT) was reflected by cell viability. Curcumin (CUR), as a model drug, was encapsulated into mPECT NPs. The in vitro anti-tumor activity of CUR-loaded mPECT NPs were also studied. 1 H nuclear magnetic resonance ( 1 H NMR), Raman, and Fourier transform infrared spectroscopy (FTIR) spectra confirmed the obtaining of mPECT. TEM photograph showed that most of mPECT NPs were in spherical shapes with a uniform size distribution. High cell viability suggested that the cargo-free mPECT NPs had no obvious cytotoxicity. Fluorescent photographs illustrated that CUR-loaded mPECT NPs could be up-taken by SW1990 cells. The medicated NPs could inhibit the proliferation of SW1990 cells. Therefore, the mPECT NPs could be used as a vehicle to improve the bioavailability and anti-tumor effects of CUR.
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Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 46
·18116-18127
·
IF 8.262
Ruiqi Na,Guanze Huo,Shuling Zhang,Pengfei Huo,Yinlong Du,Jiashuang Luan,Kai Zhu,Guibin Wang
A novel strategy was used to prepare a high performance micro-porous polymer electrolyte (MPE) from a poly(arylene ether ketone) (PAEK)/poly(ethylene glycol) grafted poly(arylene ether ketone) (PAEK-g-PEG) polymer composite membrane matrix incorporating a chitosan based LiClO4 gel electrolyte. The morphology, porosity, and thermal and mechanical properties of the PAEK/PAEK-g-PEG polymer blend membrane matrix were investigated. To improve the liquid retention capacity of the MPE, a simple but effective method involving the addition of chitosan was implemented. The effects of chitosan concentration on the liquid uptake and leakage behaviors as well as the ionic conductivity of the electrolyte were also evaluated. The synthesized MPE exhibited an ionic conductivity as high as 8 × 10−3 S cm−1 at room temperature. More importantly, a novel solid-state electric double layer capacitor (S-EDLC) could be fabricated using the synthesized MPE and activated carbon electrodes. For comparison, an EDLC was also assembled using the corresponding aqueous electrolyte and a commercial separator (NKK-MPF30AC-100). Alternating current (AC) impedance measurement results showed that the interfacial compatibility of the MPE and the activated carbon electrodes was high. Meanwhile, the as-prepared S-EDLC showed a specific capacitance of 118.63 F g−1, with an energy density of 7.87 W h kg−1 and power density being 95.97 W kg−1 at a current density of 1 A g−1. Furthermore, the S-EDLC exhibited greater cell-cycling stability after 5000 charge/discharge cycles than did the EDLC, indicating that this novel MPE should be suitable for use in EDLCs and other energy storage systems.
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JOURNAL OF CATALYSIS
·
2017
·
IF 6.844
Chenglong Wen,Shanlei Han,Jundong Xu,Yu Fan
The article proposes a novel and eco-friendly method for synthesizing SAPO-11 in ethylene glycol (EG) and supercritical carbon dioxide (ScCO 2 ). The method incorporates ScCO 2 into EG to decrease the solubility of SAPO-11 precursors in EG and thereby forms a highly supersaturated solution of SAPO-11 precursors. The as-synthesized SAPO-11 possesses smaller particles, a larger external surface area, and a larger number of acid sites than the SAPO-11 synthesized in EG and the SAPO-11 synthesized in water and ScCO 2 , respectively. These advantages of the as-synthesized SAPO-11 endow the corresponding catalyst with superior dibranched isomer selectivity and low cracking selectivity during 1-octene hydro isomerization.
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高影响因子
Journal of Biomaterials and Tissue Engineering
·
2019
·Vol. 9
·期 12
·1635-1643
·
IF 0.824
Feng Song,Liu Jingming,Ramalingam Murugan
The main aim of this study was to develop a 3D printed stem cell-responsive polyethylene glycol diacrylate (PEGDA) and sodium alginate (SA) composite hydrogel system (PEGDA/SA) loaded with basic fibroblast growth factor (bFGF) suitable for dental pulp tissue engineering. The PEGDA/SA
loaded with bFGF (PEGDA/SA-bFGF) at different concentration ratios were 3D printed via stereolithography (SLA) under optimal processing conditions, followed by ionic crosslinking. The morphological and porous structure of the 3D printed PEGDA/SA-bFGF constructs and release profile of the bFGF
were analyzed. The cellular compatibility of the hydrogel constructs was evaluated using human dental pulp stem cells (hDPSCs)in vitro. Subsequently, biocompatibility and tissue regenerative potential of the hydrogel constructs were evaluated in immunodeficient mice model. The in
vitro cell culture results of PEGDA/SA-bFGF constructs exhibited high cell compatibility and supported cell proliferation, irrespective of their concentration ratios. Thein vivo animal experiment results showed that the hDPSCs-laden PEGDA/SA (PEGDA/SA-hDPSCs) group failed to form
a good pulp structure even at various concentration ratios. When the mass ratio of PEGDA/SA was 25:1, hDPSCs-laden PEGDA/SA-bFGF (PEGDA/SA-bFGF-hDPSCs) group also failed to form dental pulp-like tissue but a partial loose connective tissue formation was observed. However, when the mass ratio
of PEGDA/SA reduces to 20:1 ~ 15:1, the PEGDA/SA-bFGF-hDPSCs group tends to form a well-organized pulp structure post 4 weeks implantation, thus highlighting the potential of this particular hydrogel scaffolding system for dental pulp tissue regenerative applications.
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International Journal of Nanomedicine
·
2016
·
IF 4.32
Lingling Ding,Jiawei Li,Rui Huang,Zhidong Liu,Chunhua Li,Shaozi Yao,Jinyan Wang,Dongli Qi,Nan Li,Jiaxin Pi
Targeted delivery by the folate ligand is an effective way to enhance an anti-breast carcinoma effect, due to its high affinity for the folate receptor, which is overexpressed in many tumor cells. In this study, we firstly synthesized a folic acid (FA)-targeted and polyethylene glycol (PEG)-modified TiO 2 nanocarrier. Then, an FA-PEG-TiO 2 nanoparticle (NP) codelivery system loaded with curcumin and salvianolic acid B were prepared by emulsion evaporation–solidification at low temperature. The obtained folate-targeted NPs (FA-NPs) showed more cytotoxicity on MCF7 cells and MDA-MB-231 cells than a nontargeted NP group. Apart from a synergistic anti-breast cancer effect with curcumin, salvianolic acid B protects the cardiovascular system from oxidative injury by the TiO 2 nanocarrier. With coumarin 6 as a fluorescent probe to observe cellular uptake of NPs, the results of in vitro cellular uptake demonstrated FA-NPs exhibited higher cellular uptake and accumulation in MCF7 cells and MDA-MB-231 cells than nontargeted NPs. Then, in vivo biodistribution of NPs was further qualitatively and quantitatively confirmed by in vivo imaging. More importantly, the animal study further suggested that FA-NPs had significantly stronger antitumor effects via receptor-mediated targeted delivery. Consequently, FA-PEG-TiO 2 NPs loaded with curcumin and salvianolic acid B could be a promising drug-delivery system to treat breast cancer.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2013
·
IF 4.612
Wenjing Niu,Lijuan Wang,Ligai Bai,Gengliang Yang
A new polymeric monolith was synthesized in fused-silica capillary by in situ polymerization technique. In the polymerization, bisphenol A epoxy vinyl ester resin (VER) was used as the functional monomer, ethylene glycol dimethacrylate (EDMA) as the crosslinking monomer, 1,4-butanediol, 1-propanol and water as the co-porogens, and azobisisobutyronitrile (AIBN) as the initiator. The conditions of polymerization have been optimized. Morphology of the prepared poly (VER-co-EDMA) monolith was investigated by the scanning electron microscopy (SEM); pore properties were assayed by mercury porosimetry and nitrogen adsorption. The optimized poly (VER-co-EDMA) monolith showed a uniform structure, good permeability and mechanical stability. Then, the column was used as the stationary phase of high performance liquid chromatography (HPLC) to separate the mixture of benzene derivatives. The best column efficiency achieved for phenol was 235 790 theoretical plates per meter. Baseline separations of benzene derivatives and halogenated benzene compounds under optimized isocratic mode conditions were achieved with high column efficiency. The column showed good reproducibility: the relative standard deviation (RSD) values based on the retention times ( n = 3) for run-to-run, column-to-column and batch-to-batch were less than 0.98, 1.68, 5.48%, respectively. Compared with poly (BMA-co-EDMA) monolithic column, the proposed monolith exhibited more efficiency in the separation of small molecules.
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高影响因子
ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
JinFeng Liao,YanPeng Jia,BeiYu Wang,Kun Shi,ZhiYong Qian
In our study, a hybrid alginate hydrogel cross-linked by calcium gluconate crystals deposited in poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) (PCL-PEG-PCL, abbreviated as PCEC) porous microspheres was developed for skin engineering. The diameter of microspheres was ∼212 μm, and the pore size was ∼8 μm. The PCEC porous microspheres supplied different functions in the hydrogel: (1) Calcium gluconate crystals were loaded in the inner pores of the microspheres, which can induce alginate hydrogel to cross-link in a few minutes once they were mixed. (2) The porous structure of the microspheres provided more anchor points for fibroblast attachment and growth, resulting in the enhancement of cell growth in the hybrid hydrogel. The PCEC microspheres/Alg hydrogel (MPs/Alg hydrogel) possessed excellent compatibility, because cell viability remained around 100% even at a concentration of 500 μg/mL. Meanwhile, the morphology of 3T3 and L929 cells attached on both PCEC porous microspheres and MPs/Alg hydrogel were confirmed by confocal laser spectrometry (CLSM). What’s more, MPs/Alg hydrogel promoted wound regeneration in a full-thickness skin defect model of rats. The mild inflammation reaction existed at the early stage of wound repair and gradually disappeared. These findings suggested that MPs/Alg hydrogel may possess great potential in the application of skin tissue engineering.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yiwei Zhao,Qiao Li,Lei Huang,Xilei Ye,Huaixia Chen,Xueping Dang
In this study, a diethoxy-pillar[5] arene (EtP5) doped deep eutectic solvent (DES) monolithic column was prepared using diethylene glycol dimethacrylate (EGDMA) as the crosslinker for pipette tip micro-solid phase extraction (PT-μSPE) of phthalate esters (PAEs). The column was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, nitrogen adsorption-desorption measurement, thermogravimetric analysis, and contact angle goniometry. The saturated adsorption capacities of the EtP5 doped poly(DES- co -EGDMA) monolithic column for dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBP), dicyclohexyl phthalate (DCHP), diethylhexyl phthalate (DEHP), dioctyl phthalate (DOP), and dinonyl phthalate (DNP) were 15.3, 22.7, 41.2, 43.0, 37.6, 36.1, 35.6, and 32.8 mg·g −1 , respectively. The EtP5 doped poly(DES- co -EGDMA) monolithic column has a service life of at least 80 cycles and exhibits superior adsorption selectivity for PAEs. Electrostatic potential analysis, Fourier transform infrared analysis and the relationship between the adsorption capacity and hydrophobic coefficients (log K ow ) of PAEs indicated the existence of C − H⋯π interaction, π-π stacking and hydrophobic interaction between PAEs and EtP5, as well as O − H⋯O hydrogen bond interaction between PAEs and ChCl-IA. After optimizing the extraction conditions, a PT-μSPE-HPLC-UV method was established for the detection of 8 PAEs in baijiu. The method exhibited linear ranges of 0.5–1000 μg·L −1 for DMP and DEP; 1.0–1000 μg·L −1 for DBP, BBP, and DCHP; 1.5–1000 μg·L −1 for DEHP and DOP; and 2.0–1000 μg·L −1 for DNP (R 2 ≥ 0.998). The limits of detection (LODs, S/N = 3) and limits of quantitation (LOQs, S/ N = 10) ranged from 0.2 to 0.7 μg·L −1 and 0.5 to 2.0 μg·L −1 , respectively. Recoveries of the 8 PAEs in spiked baijiu samples ranged from 83.7 % to 105.5 %. Intra-day and inter-day precisions (RSDs) were no more than 6.0 %. These results demonstrate that the EtP5 doped poly(DES- co -EGDMA) monolithic column is an ideal medium for the separation and detection of PAEs in baijiu.
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