Materials Today Bio
·
2023
·
IF 8.2
Qing Shi,Xingxing Zhang,Minmin Wu,Yuhan Xia,Yating Pan,Jialu Weng,Na Li,Xingjie Zan,Jinglin Xia
Lipiodol-based transcatheter arterial chemoembolization (TACE) is currently the predominant and first-line treatment option recommended by the global standard for unresectable hepatocellular carcinoma (HCC). However, the unstable emulsion of Lipiodol causes a substantial proportion of chemotherapy drugs to enter the circulation system, leading to poor accumulation in cancer tissues and unexpected side effects of chemotherapy drugs. Herein, we emulsified Lipiodol with a pH-sensitive drug delivery system assembled from hexahistidine and zinc ions (HmA) with a super-high loading capacity of doxorubicin (DOX) and a promising ability to penetrate bio-barriers for the effective treatment of HCC by TACE. In vitro tests showed that DOX@HmA was comparable to free DOX in killing HCC cells. Impressively, during the in vivo TACE treatment, the anti-tumor efficacy of DOX@HmA was significantly greater than that of free DOX, indicating that DOX@HmA increased the accumulation of DOX in tumor. Emulsifying Lipiodol with pH-sensitive DOX@HmA significantly inhibited cell regeneration and tumor angiogenesis and decreased the systemic side effects of chemotherapy, especially by suppressing pulmonary metastasis in liver VX2 tumors in rabbits by inhibiting epithelial–mesenchymal transition (EMT). Emulsifying tumor microenvironment-responsive drug delivery systems (DDSs) with Lipiodol could be a new strategy for clinical TACE chemotherapy with potentially enhanced HCC treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Zenghong Chen,Jie Shan,Qiang Niu,Hongrang Chen,Wei Zhang,Dongsheng Cao,Xianwen Wang
The abuse of antibiotics accelerates the spread and evolution of drug-resistant bacteria, which seriously threatens human health. Hydroxyl radicals (•OH) are generated by peroxidase in the presence of H 2 O 2 , which is strongly oxidizing and can effectively kill bacteria. However, high production costs and poor stability limit the clinical use of natural enzymes. “Nanozyme” is a general term for nanomaterials with catalytic activity similar to that of biological enzymes. Compared to biological enzymes, nanozymes have the advantages of low cost, facile preparation, and easy storage, making them a good choice for the development of antibacterial agents . Here, a nickel-based metal–organic framework (Ni-MOF) with dual enzymatic activity that switches depending on the pH environment was studied. In a slightly acidic environment, Ni-MOF can react with hydrogen peroxide to produce hydroxyl radicals that kill bacteria; in a neutral environment, Ni-MOF instead removes excessive reactive oxygen species (ROS) and promotes the transformation of macrophages into M2 macrophages. Compared to most nanozymes, Ni-MOF has unique electrical conductivity and better biosafety. The results of animal experiments show that Ni-MOF can not only treat infected wounds but also promote the healing of acute wounds and exhibits great clinical application potential.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Jianhao Liang,Junhong Ling,Xu Zhang,Xiao–kun Ouyang,A.M. Omer,Guocai Yang
Nanodrug delivery systems (NDSs), such as mesoporous silica , have been widely studied because of their high specific surface area , high loading rate, and easy modification; however, they are not easily metabolized and excreted by the human body and may be potentially harmful. Hence, we aimed to examine the synergistic anti-tumor effects of ex vivo chemo-photothermal therapy to develop a rational and highly biocompatible treatment protocol for tumors. We constructed a biodegradable NDS using organic mesoporous silica with a tetrasulfide bond structure, copper sulfide core, and folic acid-modified surface (CuS@DMONs-FA-DOX-PEG) to target a tumor site, dissociate, and release the drug. The degradation ability, photothermal conversion ability, hemocompatibility, and in vitro and in vivo anti-tumor effects of the CuS@DMONs-FA-DOX-PEG nanoparticles were evaluated. Our findings revealed that the nanoparticles encapsulated in copper sulfide exhibited significant photothermal activity and optimal photothermal conversion rate. Further, the drug was accurately delivered and released into the target tumor cells, annihilating them. This study demonstrated the successful preparation, safety, and synergistic anti-tumor effects of chemo-photothermal therapeutic nanomaterials .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AQUATIC TOXICOLOGY
·
2023
·
IF 4.5
Mengnan Shen,Yi Hu,Ke Zhao,Zhi Qu,Chen Lyu,Binshuo Liu,Ming Li,Xiaodan Bu,Chenyang Li,Shuang Zhong,Jie Cheng
Water pollution induced by antibiotics has garnered considerable concern, necessitating urgent and effective removal methods. This study focused on exploring ciprofloxacin (CIP) removal by duckweed and assessing CIP bioaccumulation and toxic effects within duckweed under varying dissolved organic matter categories, pH levels, and nutrient (nitrogen (N) and phosphorus (P)) levels. The results revealed the proficient and rapid elimination of CIP from water by duckweed, resulting in 86.17 % to 92.82 % removal efficiency at the end of the 7-day experiment. Across all exposure groups, varying degrees of CIP bioaccumulation in duckweed were evident, with uptake established as a primary pathway for CIP elimination within this plant. Additionally, five CIP metabolites were identified in duckweed tissues. Interestingly, the presence of humic acid (HA) and fulvic acid (FA) reduced CIP absorption by duckweed, with FA yielding a more pronounced impact. Optimal CIP removal was recorded at a pH of 7.5, while duckweed displayed heightened physiological stress induced by CIP at pH 8.5. Although the influence of N and P concentrations on CIP removal by duckweed was modest, excessive N and P levels intensified the physiological strain of CIP on duckweed.
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Jianpeng Cui,Shuangqing Sun,Zhenkun Chen,Junjie Fan,Jianwen Hu,Songqing Hu,Zhikun Wang
Responsive Pickering emulsions capable of responding to external stimuli have been extensively studied, however, there are few studies on double-responsive Pickering emulsions. Here in, a novel ferrocene surfactant (FcACUa) was synthesized and combined with aminated silica nanoparticles (0.5 wt%) to stabilize pH and redox sensitive smart Pickering emulsions. The carboxyl groups act as pH-sensitive parts, while ferrocene serves as the redox-responsive center. Stability and pH/redox response performance of the emulsions were investigated through various methods, such as the contact angle, macroscopic states, creaming index, microscopic images, droplet size distributions, etc. All atom molecular dynamics and dissipative particle dynamics simulations were used to probe the distribution of nanoparticles and surfactant at the water-oil interface, as well as to reveal the stabilization and pH/redox response mechanisms of the Pickering emulsions. Pickering emulsions can be reversibly switched between stable and unstable by adding HCl and NaOH or adding H 2 O 2 and N 2 H 4 ·H 2 O. After five pH-induced cycles, the emulsion shows no significant degradation or morphological changes. However, for the redox induced emulsification demulsification process, the size of the emulsion drops increases with the increase of the number of cycles. This work provides insights into the Pickering emulsion stabilization mechanism and the regulation mechanisms of pH and redox stimulation, which may have potential value in emulsion polymerization , biphasic catalysis, and oil and gas transportation.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Ke Wang,Jialu Zhang,Meiyu Si,Zilong Wang,Liru An,Guiyan Liu,Yongfei Zeng
A series of temperature/pH/CO2/redox-quadruple-responsive ferrocene-containing homopolymers were prepared for the first time. These homopolymers contain hydrophilic ethoxy group, amino group, and hydrophobic ferrocene (Fc) and were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization. They showed four different stimuli responses. (1) They exhibit an upper critical solution temperature (UCST) in n-propyl alcohol and n-butanol, which can be adjusted by the molecular structure, molecular weight, and concentration. (2) They have a critical pH in aqueous solution and are affected by molecular structure, molecular weight, and concentration. (3) The CO2 response of the homopolymers was confirmed by cyclic bubbling CO2/N2 to the solution. (4) The redox response of homopolymers was demonstrated by adding a chemical oxidant (FeCl3)/reductant (VC) or electrical stimulation to the solution of homopolymers. In addition, these homopolymers are amphiphilic, and their self-assembly behavior in solution was investigated. It was found that they have different critical micelle concentrations (cmc) and can form lamella, sphere, and agglomerated sphere in solution, and the morphology can be reversibly changed by applying stimulation. Finally, the release behavior of micelles of the homopolymer was explored by wrapping Nile Red (NR), which proved that they had good release efficiency. These temperature/pH/CO2/redox-quadruple-responsive ferrocene-containing homopolymers expand the types of multistimuli-responsive homopolymers and have excellent application prospects in the fields of self-assembly, drug delivery, and electrode materials.
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2023
·Vol. 12
·期 19
·3598
·
IF 5.2
Jia-Nan Yan,Bin Nie,Zhu-Jun Zhang,Ling-Yi Gao,Bin Lai,Ce Wang,Li-Chao Zhang,Hai-Tao Wu
The gelation of scallopPatinopecten yessoensismale gonad hydrolysates (SMGHs) andκ-carrageenan (KC) subjected to pH (2–8, 3–9) and NaCl/KCl stimuli-response was investigated. SMGHs/KC gels subjected to a NaCl response exhibited an increasing storage modulusG′from 2028.6 to 3418.4 Pa as the pH decreased from pH 8 to 2, with correspondingT23fluctuating from 966.40 to 365.64ms. For the KCl-treated group, SMGHs/KC gels showed an even greaterG′ from 4646.7 to 10996.5 Pa, withT23fluctuating from 622.2 to 276.98msas the pH decreased from 9 to 3. The improved gel strength could be ascribed to the blueshift and redshift of hydroxyl groups and amide I peaks, enhanced enthalpy and peak temperature, and gathered characteristic diffraction peaks from SMGHs, KC, NaCl, and KCl. The CLSM and cryo-SEM images further reflected that SMGHs/KC gels showed more flocculation formation and denser and more homogeneous networks with smaller pore sizes in more acidic domains, especially when subjected to the KCl response. This research gives a theoretical and methodological understanding of the construction of salt- and pH-responsive SMGHs/KC hydrogels as novel functional soft biomaterials applied in food and biological fields.Keywords:scallop;κ-carrageenan;NaCl;KCl;responsive hydrogels
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xiaohui Wang,Yuanxiangyi Feng,Zhe Li,Jinhua Liu,Dandan Sun,Wei Yang,Xiaowei Xing,Wenjun Liu,Hongxin Zhang
A fluorescent capillary sensor for detecting the bioanalytically and biologically relevant analytes pH, O 2 , and CO 2 has been designed. The sensor is based on single capillary tube with 2 mm inner diameter, which is simultaneous doped with emissive O 2 -sensitive indicator Ru(dpp) 3 (PF6) 2 (RuDP), pH-sensitive and CO 2 -sensitive indicator 8-hydroxypyrene-1, 3,6-trisulfonic acid trisodium salt (HPTS). The multifunctional sensor can be excited at the same wavelength and realize multi-parameter optical monitoring at the different sensing position. Studies in phosphate-buffered solutions display the excellent feasibility of the capillary sensor for fluorescence detection of pH, O 2 , and CO 2 . Overall, the multifunctional capillary sensor exhibits great potential in real-time blood gas analysis, and clinical application of multi-parameter biological detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Xiangyu Zhang,Zelai He
Aim To produce pH-responsive bionic high photothermal conversion nanoparticles actively targeting tumors for sensitizing photothermal therapy (PTT).Materials and Methods The bionic nanoparticles (ICG-PEI@HM NPs) were prepared by electrostatic adsorption of indocyanine green (ICG) coupled to polyethyleneimine (PEI) and modified with tumor cell membranes. In vitro and in vivo experiments were conducted to investigate the efficacy of ICG-PEI@HM-mediated PTT.Results The intelligent responsiveness of ICG-PEI@HM to pH promoted the accumulation of ICG and enhanced the PTT performance of ICG-PEI@HM NPs. Compared with free ICG, NPs exhibited great photothermal stability, cellular uptake, and active tumor targeting for PTT.Conclusion ICG-PEI@HM NPs can enhance the efficacy of PTT and can be used as a new strategy for the construction of photothermal agents.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 45
·e54657
·
IF 3
Xuefei Chen,Yi Wang,Qianqian Zhang,Jie Meng,Tiandi Pan,Huaizhong Xu,Lei Du,Xiaohua Yang
The synergistic antibacterial effect of photothermal and drug treatments is a promising therapeutic method for treating the persistent bacterial infection of chronic wounds. In this study, we used electrospinning to fabricate functionalized poly(ε-caprolactone) (PCL) nanofiber membranes as antibacterial wound dressings after incorporating tannic acid (TA) and ferric ion (Fe 3+ ). The abilities of pH-responsive controlled release TA and the photothermal effect of the membrane were obtained by introducing the TA/Fe 3+ complexes. Additionally, the membrane had a defined nanofibrous network structure, excellent mechanical properties, hydrophilicity, and water uptake ability. While the controlled release of TA endowed the membrane with high antibacterial properties at different pH values, the antibacterial ratio was further enhanced by approximately 10% under the photothermal synergistic effect. These results indicate that the PCL/TA/Fe 3+ nanofiber membranes could be regarded as an ideal candidate for treating bacterial infection of chronic wounds.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2023
·
IF 6.1
Chenyu Zhu,Xue Zhang,Fuzhi Li,Ruochen Yang,Xuan Zhao
The thin film composite nanofiltration (TFC-NF) membranes with various properties were prepared by changing type and concentration of acid acceptors in the piperazine (PIP) solution. The influences of acid acceptors on interfacial polymerization (IP) process depend on the pH of PIP solution and the properties of acid acceptors. Na 2 CO 3 and TEA provide positive effects at a pH range of 11.2–12.0. Especially for Na 2 CO 3 , water permeability and ion selectivity of the membrane simultaneously enhanced. The pH values reached above 12.8 with NaOH, and negative effects on permeance and selectivity were detected. The pH values ranged 10–11 after adding Na 3 PO 4 and NaHCO 3 . The rejections of both Cl − and SO 4 2− were high, especially for Cl − rejection increasing to above 73%. The pH values got to around 7 with NaH 2 PO 4 . The IP reaction was retarded and defects were detected on the membrane with quite low SO 4 2− rejection. Protonation of PIP happens at low pH, while hydrolysis of acyl chloride of trimesoyl chloride happens at high pH. These changes will slow down the deprotonated PIP diffusion and the IP reaction. It is a feasible way to fabricate tailored NF membranes by changing acid acceptors and adjusting pH value of the PIP solution.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Danmin Yang,Qun Liu,Xu Zeng,Xiaoting Chen,Meng Li,Xialing Wu,Yue Liu,Yanzhen Zheng,Jionghua Xiang,Chunchun Wang,Wuyin Weng,Yucang Zhang
The cellulose nanofibers (CNFs) based pH-sensitive indicator films were developed by mixing guar gum (GG) with bromothymol blue-anchored chitin (BTB-Chitin) as an indicator to monitor shrimp freshness. The BTB-Chitin was prepared by grafting hydroxypropyltriethylamine groups (HPTA) to chitin first, then anchoring bromothymol blue (BTB) to prepare intelligent pH response BTB-Chitin. The 0.08 BTB-Chitin films had a good tensile strength of 11.76 MPa and the water contact angle values were 125°, which displayed obvious color response to pH buffers and acid base volatile gas. Besides, the homogeneous and flexible composite films showed good color stability and reversibility. The released amount of BTB was very low from the BTB-Chitin films in heptane and corn oil. The composite films had been degraded completely in 15 days in soil. The pH and volatile base nitrogen were measured to determine the degree decay of shrimp ( Litopenaeus vannamei ), and the prepared pH-sensitive films changed from yellow (fresh) to cyan (spoiled) with the freshness of shrimp decreased, indicating the BTB-Chitin films could detect the shrimp freshness in real-time and high visibility.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）