RSC Advances
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2024
·Vol. 14
·期 24
·16649-16660
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IF 3.9
Juan Wei,Chaoqun Yan,Yi Chen,Zhiliang Cheng,Facheng Qiu,Congming Tang,Cheng Yang,Zejun Wei,Anke Du
Currently, the surface structure modification of photocatalysts is one of the effective means of enhancing their photocatalytic efficiency. Therefore, it is critically important to gain a deeper understanding of how the surface of α-Fe2O3 photocatalysts influences catalytic activity at the nanoscale. In this work, α-Fe2O3 catalysts were prepared using the solvothermal method, and four distinct morphologies were investigated: hexagonal bipyramid (THB), cube (CB), hexagonal plate (HS), and spherical (RC). The results indicate that the hexagonal bipyramid (THB) exhibits the highest degradation activity towards tetracycline (TC), with a reaction rate constant of k = 0.0969 min−1. The apparent reaction rate constants for the cube (CB), hexagonal plate (HS), and spherical (RC) morphologies are 0.0824, 0.0726, and 0.0585 min−1, respectively. In addition, it has been observed that the enhancement of photocatalytic activity is closely related to the increase in surface area, which provides more opportunities for interactions between Fe2+ and holes. The quenching experiments and electron paramagnetic resonance (EPR) results indicate that the ˙O2, ˙OH and h+ contribute mainly to the degradation of TC in the system. This research contributes to a more comprehensive understanding of catalyst surface alterations and their impact on catalytic performance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Linwei Yu,Xi Li,Tianyi Shi,Ning Li,Donge Zhang,Xikai Liu,Yushuo Xiao,Xinran Liu,Robert B. Petersen,Weikang Xue,Yanxun V. Yu,De-sheng Hu,Li Xu,Hong Chen,Ling Zheng,Kun Huang,Anlin Peng
Parkinson's disease (PD), a neurodegenerative disorder without cure, is characterized by the pathological aggregation of α-synuclein (α-Syn) in Lewy bodies. Classic deposition pathway and condensation pathway contribute to α-Syn aggregation, and liquid-liquid phase separation is the driving force for condensate formation, which subsequently undergo liquid-solid phase separation to form toxic fibrils. Traditional Chinese Medicine (TCM) has a long history in treating neurodegenerative disease; herein, we identified chemicals from herbs that inhibit α-Syn aggregation. We screened commonly prescribed TCMs for PD from the CNKI database and registered patents, 13 chemicals were identified in the TCMSP databases as candidate inhibitors, among which three phenols, forsythoside B (FTSB), echinacoside (ECH), and 4-hydroxyindole (C4-OH) efficiently inhibit α-Syn aggregation. Moreover, FTSB and ECH increase α-Syn fluidity within condensates, inhibit α-Syn transition into amyloid fibrils and reduce fibril-induced toxicity in SH-SY5Y cells. Importantly, they disaggregated preformed α-Syn amyloid fibrils. Notably, in an α-Syn overexpressing NL5901 C. elegans PD model, either FTSB or ECH treatment significantly extended the lifespan and improved the PD-like movement disorders, both in the preventive and therapeutic treatment approaches, by reducing toxic α-Syn inclusion formation and improving the fluidity of α-Syn. Together, we offer new therapeutic candidates targeting phase separation-associated aggregation for PD.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qingxiang Wang,Min Liu,Jihong Zhao,Jiahao Yuan,Shasha Li,Ruijiang Liu
The prevention, diagnosis and treatment of cancer have always been the focus of medical research. In this study, a label-free, rapid, simple, sensitive, and specific method for the detection of HPV16 E7 oncoprotein was developed. The electrochemical biosensor platform was constructed by magnetic self-assembly of α-Fe 2 O 3 /Fe 3 O 4 @Au nanocomposites onto the surface of magnetic glass carbon electrode (MGCE), and the nanocomposite was connected to aptamer through Au S bond to construct a probe to capture HPV16 E7. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were applied to verify the performance of the constructed biosensor. The condition optimization and performance analysis were carried out by differential pulse voltammetry (DPV). Under optimal conditions, the biosensor exhibited a strong linearity between current value and the logarithm of HPV16 E7 oncoprotein concentration in the range of 10 pg/mL – 0.1 μg/mL, with a limit of detection (LOD) of 159 fg/mL and a limit of quantification (LOQ) of 530 fg/mL, and it also revealed excellent reproducibility, long-term stability, and anti-interference ability. In a word, the biosensor would contribute to the early diagnosis of oncoprotein HPV16 E7 and had promising application prospects.
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BIORESOURCE TECHNOLOGY
·
2025
·
IF 9
Yapeng Zhang,Zhidong Ma,Wenqiang Li,Chenwen Liu,Huipeng Gao,Meng Wang,Lanpeng Li,Quan Zhang,Bo Lv,Lei Qin,Chun Li
Pinene is a plant volatile monoterpenoid which is used in the fragrance, pesticide, and biofuel industries. Although α-pinene has been synthesized in microbial cell factories, the low synthesis efficiency has thus far limited its production. In this study, the cell growth and α-pinene production of the engineered yeast were decoupled by a dynamic regulation strategy, resulting in a 101.1-fold increase in α-pinene production compared to the control. By enhancing the mevalonate pathway and expanding the cytosolic acetyl-CoA pool, α-pinene production was further increased. Overexpression of the transporter Sge1 resulted in a redistribution of global gene transcription, leading to an increased flux of α-pinene synthesis. By optimizing the aeration flow rate in 3-L bioreactors, the α-pinene production reached 1.8 g/L, which is the highest reported α-pinene production in cell factories. Our research provides insights and fundamentals for the efficient synthesis of monoterpenoids in microbial cell factories.
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Materials
·
2024
·Vol. 17
·期 11
·2706
·
IF 3.1
Yingzhe Du,Lili Li,Yukun Yuan,Yufaning Yin,Genggeng Dai,Yaqing Ren,Shiying Li,Peng Lin
Throughout the nuclear power production process, the disposal of radioactive waste has consistently raised concerns about environmental safety. When the metal tanks used for waste disposal are corroded, radionuclides seep into the groundwater environment and eventually into the biosphere, causing significant damage to the environment. Hence, investigating the adsorption behavior of radionuclides on the corrosion products of metal tanks used for waste disposal is an essential component of safety and evaluation protocols at disposal sites. In order to understand the adsorption behavior of important radionuclides60Co,59Ni,90Sr,135Cs and129I on α-FeOOH, the influences of different pH values, contact time, temperature and ion concentration on the adsorption rate were studied. The adsorption mechanism was also discussed. It was revealed that the adsorption of key nuclides onto α-FeOOH is significantly influenced by both pH and temperature. This change in surface charge corresponds to alterations in the morphology of nuclide ions within the system, subsequently impacting the adsorption efficiency. Sodium ions (Na+) and chlorate ions (ClO3−) compete for coordination with nuclide ions, thereby exerting an additional influence on the adsorption process. The XPS analysis results demonstrate the formation of an internal coordination bond (Ni–O bond) between Ni2+and iron oxide, which is adsorbed onto α-FeOOH.
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ACS Omega
·
2025
·
IF 4.3
Xueni Sun,Qiang Fu,Lidong Li,Chunxiang Huang,Jun Wang,Hui Shao
Experiments and molecular simulations were combined to investigate the adsorption mechanism of dimethyl carbonate (DMC) and methanol (MeOH) azeotrope onto α-Al2O3 while the differences and similarities between pure and azeotropic components were discussed. Static experimental results have shown that α-Al2O3 exhibited capacities in an unexpected order as azeotropic MeOH > pure DMC > pure MeOH > azeotropic DMC. MeOH-DMC and pure MeOH both fitted the PFO model with proximal kinetic constants, while the pure DMC exhibited a different behavior with a diffusion-controlled stage followed by chemisorption. The interfacial configuration as well as the mechanism at the molecular level was studied by molecular dynamics and density functional theory. Molecular simulation results indicate that a multilayer adsorption conformation is formed on the α-Al2O3 (0 0 1) surface for MeOH-DMC with most Al sites being occupied by MeOH followed by DMC constructing a bilayerlike structure with the preadsorbed MeOH molecules. Moreover, the adsorption of DMC can further reduce the dissociation of preadsorbed MeOH. This factor seems to promote the adsorption of more MeOH molecules on the α-Al2O3 (0 0 1) surface, leading to DMC aggregation outside the MeOH layer.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2009
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IF 2.562
Zhao-Feng Li,Bin Li,Zhi-Guo Liu,Miao Wang,Zheng-Biao Gu,Guo-Cheng Du,Jing Wu,Jian Chen
Overexpression of recombinant genes in Escherichia coli and targeting recombinant proteins to the culture medium are highly desirable for the production of industrial enzymes. However, a major barrier is inadequate secretion of recombinant protein across the two membranes of E. coli cells. In the present study, we have attempted to circumvent this secretion problem of the recombinant α-cyclodextrin glycosyltransferase (α-CGTase) from Paenibacillus macerans strain JFB05-01. It was found that glycine, as a medium supplement, could enhance the extracellular secretion of recombinant α-CGTase in E. coli. In the culture with glycine at the optimal concentration of 150 mM, the α-CGTase activity in the culture medium reached 23.5 U/mL at 40 h of culture, which was 11-fold higher than that of the culture in regular TB medium. A 2.3-fold increase in the maximum extracellular productivity of recombinant α-CGTase was also observed. However, further analysis indicated that glycine supplementation exerted impaired cell growth as demonstrated by reduced cell number and viability, increased cell lysis, and damaged cell morphology, which prevented further improvement in overall enzyme productivity. Significantly, Ca2+ could remedy cell growth inhibition induced by glycine, thereby leading to further increase in the glycine-enhanced extracellular secretion of recombinant α-CGTase. In the culture with 150 mM glycine and 20 mM Ca2+, both extracellular activity and maximum productivity of recombinant enzyme were 1.5-fold higher than those in the culture with glycine alone. To the best of our knowledge, this is the first article about the synergistic promoting effects of glycine and Ca2+ on the extracellular secretion of a recombinant protein in E. coli.
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JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Yuxuan Ke,Shuzhen Chen,Suisui Su,Jiao Zhang,Shenghua Hu,Cuiqing Zhang,Changyuan Hu,Shizheng Zheng
Bi 2 O 3 has been recognized as a promising anode of aqueous secondary battery because of the high capacity, but the application is greatly hindered by the poor conductivity and limited actual capacity. Herein, for the first time, one dimensional (1D) α-Bi 2 O 3 nanobelt is fabricated via alkali etching strategy using rod-shaped Bi-MOF (CAU-17) as the self-sacrificial template. Specifically, high-crystalline and oxygen-deficient α-Bi 2 O 3 nanobelt with length and width of 6 μm and 300 nm are identified. The electrochemical results demonstrate the high specific capacity (247 mAh g −1 @1 A g −1 ) and acceptable stability of α-Bi 2 O 3 nanobelt. Such superior capacity is derived from the exposed electrochemical active sites, fast charge transfer and efficient ion diffusion in 1D high-crystalline and oxygen-vacancies enriched structure. The assembled Ni-Bi battery displays high capacity (78.3 mAh g −1 ) and high energy density of 100.2 Wh kg −1 (at power density of 2829.8 W kg −1 ). Our work provides rational guidance for architecting 1D high-capacitive electrodes for aqueous rechargeable alkaline battery.
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FUEL
·
2024
·
IF 6.7
Hui Ding,Qingwen Dong,Qishan Chen,Xu Li,Jinxiang Dong
The effective and stable use of α-olefins is a topic of great research interest due to their abundant reserves, and the fact that the hydrolysis and epoxidation reaction of these substances produces hydroxyl group as a key linking group plays an important role in the synthesis of surfactants. Consequently, a series of alkyl polyglycosides (DC 08 PG, DC 10 PG, and DC 12 PG) were synthesized as non-ionic surfactants via the glycosidation reaction of long-chain 1, 2-vicinal diol with different carbon numbers and glucose. The results showed that 1, 2-vicinal diol exhibited increased reactivity in glycosidation due to their unique molecular structure. Furthermore, it was observed that the degree of polymerization (DP) achieved was notably elevated, registering at 1.63, surpassing the DP of 1.37 typically prepared using conventional methods. This enhancement was paralleled by a demonstrable increase in hydrophilicity, as evidenced by the hydrophile-lipophile balance number (HLB), resulting in a substantial improvement in the water solubility of the product, the transmission rate > 90 %. For adsorption and aggregation behavior, DC 12 PG showed a smaller cross-sectional area ( A min ), larger saturation adsorption ( Γ max ), and could aggregate to form micelles at low concentrations, and short-term dynamic adsorption properties (DST) was prominent. At the same concentration, for foam properties, DC 12 PG with longer alkyl chains produced higher and more stable foam; for emulsification properties, the emulsification time was 298 s; for wetting properties, the contact angle was 61.59° in 30 s. This analysis will help to reveal the intrinsic connection between the molecular structure and properties of surfactants.
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BIOORGANIC CHEMISTRY
·
2024
·
IF 4.5
Honghui Liu,Yanxu Wei,Yan Wang,Qiu Zhao,Lan Liu,Hong Ding,Yuntian Hong
Due to the high incidence of diabetes and its associated complications, diabetes is widely recognized as a serious global health problem. In diabetes treatment strategies, targeting α-glucosidase, a key carbohydratehydrolyzing enzyme, has emerged as a highly regarded approach. To develop novel α-glucosidase inhibitors, we successfully synthesized a series of apigenin analogs, collectively referred to as H1 – H27 compounds and examined their inhibitory effects on α-glucosidase activity. H7 showed a remarkable inhibitory effect, surpassing that of the standard drug acarbose. Further analysis revealed that H7 , H10 , and H24 act as non-competitive inhibitors of α- glucosidase. In vivo experiments using a type 2 diabetes mouse model demonstrated the diverse therapeutic potential of H7 ; it effectively lowered blood sugar levels, improved glucose tolerance, and corrected lipid metabolism. In addition, H7 showed hepatoprotective effects, highlighting its ability to improve liver function. H7 also positively influenced the gut microbiota composition in diabetic mice, increasing diversity and richness. These results highlight the promising therapeutic effects of apigenin analogs, such as H7 , for treating type 2 diabetes and show how they could provide numerous benefits, including effective inhibition of α-glucosidase, improved glucose control, correction of lipid metabolism, hepatoprotection, and modulation of the intestinal microbiota.
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ACS Catalysis
·
2025
·
IF 13.1
Yuyang Wang,Chun Cai
It is a promising endeavor to explore the photocatalytic oxidation for 5-hydroxymethylfurfural (HMF) to produce high-value-added derivatives. The absence of efficient photocatalytic systems has hindered the transformation of HMF to 2,5-diformylfuran (DFF), while DFF is susceptible to subsequent oxidation into 2,5-furandicarboxylic acid (FDCA). Herein, we design a Z-scheme heterojunction photocatalyst α-Fe2O3/Zn0.5Cd0.5S via hydrothermal methods, which exhibits superior activity toward the selective oxidation of HMF to DFF or FDCA in aqueous solution. Photocatalytic investigations demonstrated the highest activity for 15% Fe2O3/Zn0.5Cd0.5S, resulting in a DFF selectivity of 99% and conversion of 75%, affording FDCA selectivity of 85% and conversion of 99%. The high catalytic activity has been ascribed to the effective separation of photogenerated charge carriers and generation of reactive oxygen species (ROS) in different atmospheres with the Z-scheme mechanism. Research revealed that the oxidation to DFF is associated with •OH in an Ar environment, while the generation of FDCA is related to •O2– in the air. Moreover, selective oxidation may also exhibit significant potential for the utilization of sunlight and other benzene substrates. Overall, this study offers a unique demonstration of designing a noble metal-free Z-scheme heterojunction photocatalyst for the oxidation of HMF to selective products in water.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2024
·
IF 2
Yanfei Sun,Yuan Gao,Ziping Yin,Zuoxin Liu,Xianxiong Chen,Yu Zhang,Jun Luo
For solid-state energetic materials, it might be able to exist in different crystal structures, which is well-known as polymorphism. Different polymorphs of the crystals exhibit different physiochemical properties, such as solubility, dissolution rate, morphology, etc. In this work, the solid–liquid phase equilibrium of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane form α (α-HMX) over various temperature ranges (298.15 to 358.15 K) was experimentally determined using the dynamic method in 12 pure solvents, including acetone, pyridine, acetic acid, 2-butanone, cyclopentanone, acetonitrile, methyl acetate, ethyl acetate, isopropyl acetate, ethyl acetoacetate, methyl propyl ketone, and dimethyl sulfoxide (DMSO), at atmospheric pressure. The experimental results indicate that the solubility of α-HMX increases with increasing temperature in all test solvents. The experimental solubility data were correlated with four thermodynamic models, which are the modified Apelblat equation, the λh equation, the Wilson model, and the NRTL model. In addition, the dissolution thermodynamic properties, such as the enthalpy, entropy, and Gibbs free energy change, were also calculated with the experimental data and NRTL model. All of these results lay the foundation for the study of preparation and phase transformation of different crystal forms of HMX and provide guidance for designing suitable crystallization methods in different solvents.
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