查找使用阿拉丁产品的科研文献

Highly Efficient Non-Nucleophilic Mg(CF3SO3)2-Based Electrolyte for High-Power Mg/S Battery

Dan Huang,Shuangshuang Tan,Maosheng Li,Dandan Wang,Chunhua Han,Qinyou An,Liqiang Mai

The application of high-energy Mg/S batteries was obstructed by the insufficiency of low-cost and non-nucleophilic electrolyte. In this work, a non-nucleophilic electrolyte was prepared by facilely dissolving Mg(CF3SO3)2, MgCl2, and AlCl3 in 1,2-dimethoxyethane (DME). The equilibrium species of the MTB electrolyte mainly comprise [Mg2(μ-Cl)2(DME)4]2+ and [(CF3SO3)AlCl3]−, which are generated by dehalodimerization reaction and Lewis acid–base reaction, respectively. The electrolyte exhibits a highly efficient reversible Mg deposition/dissolution, low overpotential of around 250 mV, and good oxidative stability up to 3.5 V after conditioning. The conditioning process that the active [Mg2(μ-Cl)2(DME)4]2+ species transforms into [Mg3(μ3-Cl)(μ2-Cl)2(DME)7]3+ was demonstrated, owing to the irreversible deposition of Al3+ on Mg foil. More importantly, this electrolyte exhibited good compatibility and kinetics for reversible Mg/MgSx redox, resulting in a high specific capacity of 866 mAh g–1 at 200 mA g–1 and high power density of 550 W kg–1. This work offers a new direction for low-cost, non-nucleophilic electrolyte and paves the way to explore high-power Mg/S batteries.

Highly efficient photocatalytic hydrogen evolution driven by adjustable bimetal CuNi derived hexagonal Ni(OH)2

Lingjiao Li,Jing Xu,Binyi Su

In the field of photocatalysis, most of the photocatalysts are semiconductors. Recent years, there have been many photocatalytic systems related to non-semiconductor catalysts. In this paper, a photocatalytic hydrogen evolution system of hexagonal Ni(OH) 2 derived from CuNi bimetal is obtained by classical hydrothermal method. The derived hexagonal Ni(OH) 2 can promote the separation of photogenerated electron-hole pairs and greatly improve the effect of photocatalytic hydrogen evolution. The electron-hole pair comes from the surface plasmon resonance (SPR) effect of Cu from CuNi composite. It is worth noting that photoluminescence spectra and photoelectrochemical experiments have confirmed that the CuNi-5 complex can effectively improve space charge separation. The results of linear scanning voltammetry show that the material has high current response characteristics. This system gives a practical solution for planning and synthesizing non-semiconductor catalysts with high photocatalytic activity.

5-Aza-2-deoxycytidine inhibits osteolysis induced by titanium particles by regulating RANKL/OPG ratio

Yafei Wang,Huimin Liu,Jianmin Wu,Yunjian Liao,Daifeng Lu,Feng Dong,Hongxi Li,Zhitao Zhang,Yongyun Lian

Periprosthetic osteolysis (PIO) caused by wear particles is the main cause of implant failure, which is regulated by nuclear factor κ B receptor activator ligand (RANKL)/osteoprotegerin (OPG) system. At present, there is a lack of effective drugs to prevent or treat PIO. Previous studies have confirmed that DNA methylation is closely related to postmenopausal osteoporosis and can affect the expression of OPG and RANKL . However, the relationship between DNA methylation and PIO is not clear. In this study, we investigated the inhibitory effect of 5-Aza-2-deoxycytidine (AzadC) on osteolysis induced by titanium particles in a mouse model. This inhibition mechanism is achieved by changing the ratio of RANKL/OPG in the osteolysis model. In conclusion, there is a relationship between DNA methylation and PIO. AzadC has a certain inhibitory effect on osteolysis induced by titanium particles. Regulating DNA methylation may be a new way to treat PIO. Our findings lay a foundation for epigenetic understanding and intervention of osteolysis.

HYR-2 plays an anti-lung cancer role by regulating PD-L1 and Akkermansia muciniphila

Linxin Teng,Kaiyuan Wang,Weiping Chen,Yun-shan Wang,Lei Bi

Traditional Chinese medicine (TCM) plays a vital part in cancer treatment due to its unique superiority. Huoxue Yiqi Recipe-2 (HYR-2) was supposed to have therapeutic effect on lung cancer, which came from Ze Qi Decoction in one of the four great classics of TCM called "Synopsis of Prescriptions of the Golden Chamber". Network pharmacology demonstrated that the targets of active components from HYR-2 were significantly enriched in the signaling pathways, which were closely associated with non-small cell lung cancer (NSCLC) and programmed death ligand 1 (PD-L1). Then, data about NSCLC was downloaded from Gene Expression Omnibus database (GEO). The Cancer Genome Atlas (TCGA) and DisGeNET was analyzed by bioinformatics, and 214 biomarkers for NSCLC were obtained, containing 14 targets of active components from HYR-2 (which were significantly enriched in the PD-L1 related signaling pathway). In vivo and in vitro experiments showed that HYR and HYR-2 could inhibit the growth of lung cancer and down-regulate the expression of PD-L1, which might be related to the blocking effect of HYR-2 on the PI3K/Akt signaling pathway. Furthermore, HYR-2 promoted the transformation of M2 macrophages into M1 macrophages as well. It is deserved to be mentioned that the level of Akkermansia muciniphila was also significantly elevated by HYR-2, which was believed to enhance the therapeutic effect of PD-L1 antibodies. To sum up, HYR-2 might play an anti-lung cancer effect by down-regulating PD-L1 together with up-regulating Akkermansia muciniphila.

Biocompatible Ionic Liquid Promote One-Pot Synthesis of 2-Amino-4H-Chromenes Under Ambient Conditions

Zhu Anlian,Li Qixing,Feng Wanlu,Fan Dongshuang,Li Lingjun

Abstract The synthesis of 2-amino-4H-chromenes through one-pot multicomponent reactions has received great attention due to the high atom efficiency and the broad bioactivities of the products. Here, the catalytic performances of a series of functional ionic liquids towards this type of reaction were investigated and the results showed that the ionic liquid, choline acetate ([Choline][Ac]), could efficiently promote this reactions under room temperature without the necessary of organic solvents. The reaction is easy to be conducted and the following work-up procedures are very simple. The pure products can be obtained through extraction and washing procedures, no column separation procedures are needed. Intriguingly, this reaction system can be easily scaled up to multi-gram, suggesting its perspective in industrial applications. In addition, the ionic liquid [Choline][Ac] can be easily prepared from cheap and biocompatible materials, and it can be feasibly recycled and reutilized for at least five cycles. Graphic Abstract Various aldehydes, malononitrile and activated phenols could be converted to the corresponding 2-amino-4H-chromenes with good to excellent isolated yields under the catalysis of choline acetate at room temperature.

Preparation and fluorescence properties of novel 2-quinolone derivatives and their corresponding Eu(III) complexes

Zhongqian Hu,Qingyou Deng,Shuaishuai Yang,Dongcai Guo

A series of novel 2-quinolone ligands and their corresponding Eu(III) complexes were prepared. The effect of different solvents, different ligand concentrations and different substituents on the fluorescence intensity of ligands were investigated in detail. The fluorescence intensity of Eu(III) complexes were studied by comparing different substituents on the ligand. The results indicate that all ligands show the strongest fluorescence intensity in ethanol with the ligand concentration of 50 μM. Among these ligands, the ligand (K 6 ) containing -COOCH 3 group owns the strongest fluorescence intensity and the corresponding fluorescence quantum yield reaches 0.317. All complexes exhibit characteristic red light of Eu(III) ions with good thermal stability. The effect of diverse substituents on the fluorescence intensity is ordered: -COOCH 3 >-Cl> -Br> -OCH 3 >-CH 3 >-H, which indicates the complex [EuK 6 (NO 3 ) 3 ]·2H 2 O with the strongest electron-donating group (-COOCH 3 ) possesses the strongest fluorescence intensity. The above analysis shows that the ligand (K 6 ) and corresponding Eu(III) complex [EuK 6 (NO 3 ) 3 ]·2H 2 O own the best fluorescence property, which has an outstanding application prospect in the field of optical materials and biomedicine materials.

Construction of AgI/Bi2MoO6/AgBi(MoO4)2 multi-heterostructure composite nanosheets for visible-light photocatalysis

Tiantian Zhou,Haonan Zhang,Xiaoming Ma,Xin Zhang,Yuanna Zhu,Aiyu Zhang,Yongqiang Cao,Ping Yang

The AgI/Bi 2 MoO 6 /AgBi(MoO 4 ) 2 (ABM) multi-heterostructure nanosheet composite system for visible-light photocatalysis have been successfully constructed by a simple one-step calcination method. The ABM multi-heterostructure composite photocatalysts exhibited the obviously improved photocatalytic performance than the pristine Bi 2 MoO 6 , AgBi(MoO 4 ) 2 , and AgI for the degradation of both Tetracycline hydrochloride (TC) and Rhodamine B (RhB). The apparent degradation rate for the ABM sample with the highest photocatalytic activity is 5.4 (TC) and 23.4 times (RhB) that of Bi 2 MoO 6 , 4.0 (TC) and 4.9 times (RhB) that of AgBi(MoO 4 ) 2 , and 1.9 (TC) and 2.4 times (RhB) that of AgI, respectively. This ABM sample with the highest activity showed a Bi 2 MoO 6 /AgBi(MoO 4 ) 2 composite nanosheet morphology (lateral size: 1–5 u m, thickness: 90−130 nm) with a large amounts of small AgI nanocrystals (diameter: 2−25 nm) uniformly distributed on the surface of composite sheet. The outstanding performance of the ABM composite photocatalysts should be ascribed to the effective separation of photoinduced electron-hole pairs via the multi-heterostructure in ABM, the enhanced visible-light absorption, as well as the two-dimensional (2D) morphology benefitting to the exposure of plenty of surface reactive sites and significant reduction of migration distances of photogenerated carriers. It is hoped that this facile method for the fabrication of multi-heterostructure in our work could promote and inspire the other multicomponent functional nanomaterials used in the fields of not only photocatalysis, but also solar cells, sensors, catalysis, and so on, in the future.

Novel synthesis of poly(2-acryloyloxyethyl ferrocenecarboxylate) as quasi-reversible redox-active gel polymer electrolytes

Gao Zhenguo,Zhang Jiaoqiang,Li Ke,Lan Di,Zhao Zehao,Kou Kaichang

In this research, the electrochemical behavior of poly(2-acryloyloxyethyl ferrocenecarboxylate) (PAEFc) synthesized via an atom transfer radical polymerization (ATRP) strategy was investigated in a series of tetrabutylammonium perchlorate (TBAP)/acetonitrile vs. Ag/AgNO 3 system. In comparison, series of PAEFc electrolyte with specific molecular weight and depositing concentration were analyzed via cyclic voltammetry (CV) method. Furthermore, chronocoulometry (CC) technology has been employed on the dynamic electron/mass transfer mechanism and the determination of kinetic parameters (diffusion coefficients, reaction rate constant, etc.). Finally, it is demonstrated that anodic and cathodic process of PAEFc was controlled by diffusion and adsorption–diffusion, respectively. Meanwhile, the kinetic parameters of the typical quasi-reversible redox process were obtained, of which the apparent activation energy ( E a ) and pre-exponential factor ( A ) were 121.38 kJ mol −1 4.28 × 10 18 s −1 , respectively.

Near-infrared emission tracks inter-individual variability of carboxylesterase-2 via a novel molecular substrate

Liu Xingyu,Li Xiangqian,Dong Pei,Wu Zhiming,Gao Jinwei,Wang Qianming

A low-molecular-weight molecule (4-(2-(3-(dicyanomethyl)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)phenyl-benzoate, DDPB) has been developed. The organic framework possesses very weak fluorescence . The feasibility of the signal transduction has been performed via fluorometric titrations in solution. DDPB gives rise to responses to carboxylesterase 2 (CES2) based on “off-on” responses. The red emission at 670 nm has been derived from the enzyme-induced hydrolysis of ester linkages, thus suppressing the intramolecular charge transfer (ICT) effect and thereby generating the fluorescent segment. The optical excitation window for this probe is extended to the visible light range ( λ ex  = 516 nm), and it will induce less harmful influence on biological substances. The detection limit for the measurement of CES2 concentration is as low as 2.33 mU/mL. The conventional studies concerning the activation process are generally performed within only a single liveing cell system. In this study, it is the first time that expression of carboxylesterase 2 in five kinds of cell lines (HeLa > C1498 > active T cell > Jurkat > unactive T cell) has been clarified by flow cytometry, Western blotting, and confocal microscopy analysis. The elucidation of CES2 and its variability in a variety of cells will open new ways for drug metabolism and disease prevention. We reported a new “substrate-mediated light-on” strategy based on an ester bond cleavage reaction. Most of prepared nanomaterials and organic fluorophores possessed short wavelength emissions in the blue or green region which will not be difficult for cellular imaging. In this study, a novel functional molecule (DDPB) was considered as the substrate for CES2 and the optical “off-on” response was realized. DDPB was cell permeable and possessed very low cytotoxicity. Moreover, the identification of CES2 and their subtle changes in five different cells afforded the sequence for carboxylesterase-2 as Hela > C1498 > Active T cell > Jurkat > Unactive T cell. Inhibition studies showed that the hydrolysis of DDPB was effectively suppressed by bis-p-nitrophenyl phosphate and the cellular tracking results firmly supported this point. To our knowledge, the inter-individual variability for the CES2 expressions in five different cell lines has never been reported via the substrate induced optical changes.

Directing cell catalysis of glucose to 2-keto-d-gluconic acid using Gluconobacter oxydans NL71

Xuelian Zhou,Yi Shen,Yong Xu,Venkatesh Balan

2-Keto- d -gluconic acid (2-KGA) is a high-value-added product from lignocellulosic straw-based biorefining process obtained via cell catalysis using Gluconobacter oxydans ( G. oxydans ); nonetheless, the economical production has some limitations because of the formation of undesirable mixture products of keto-gluconic acid from glucose. In this study, it was demonstrated that pulse addition of hydrogen peroxide (H 2 O 2 ) to synthetic media was beneficial to improve the conversion rate of glucose to 2-KGA by 1.47-fold in G. oxydans . Moreover, some lignocellulosic degradation compounds served as substitute and played the role of H 2 O 2 on corn stover hydrolysate for the production of 2-KGA. By conducting qRT-PCR analysis, eight dehydrogenase genes were identified in G. oxydans , which were responsible for regulating 2-KGA production. Moreover, most of the identified genes were found to produce membrane-bound glucose dehydrogenase and gluconate 2-dehydrogenase, and were up-regulated by adding H 2 O 2 or degradation compounds. These up-regulated genes could be responsible for directing cell catalysis of glucose to 2-KGA in G. oxydans .

Activation of peroxydisulfate by a novel Cu0-Cu2O@CNTs composite for 2, 4-dichlorophenol degradation

Yong Liu,Yang Zhao,Jianlong Wang

In this study, a novel Cu 0 -Cu 2 O@CNTs composite was synthesized, characterized and applied to activate peroxydisulfate (PDS) for the degradation of 2, 4-dichlorophenol (2,4-DCP) in contaminated lake water. The results indicated that Cu 0 -Cu 2 O@CNTs can effectively activate PDS to produce O 2 • − radical, which has high selectivity to degrade organic pollutants in actual contaminated water. The efficiency of 2,4-DCP degradation and mineralization was 99.27% and 66.90%, respectively under the optimal condition. In the presence of Cl − , HCO 3 − and natural organic matters (NOMs) or in real wastewater containing 2,4-DCP, Cu 0 -Cu 2 O@CNTs/PDS system had a good selectivity for 2,4-DCP degradation. O 2 • − was the dominant reactive species in Cu 0 -Cu 2 O@CNTs/PDS system for 2,4-DCP degradation. The possible degradation pathway of 2,4-DCP was proposed. It was concluded that Cu 0 -Cu 2 O@CNTs composite could overcome the shortcomings of PDS activation by Cu 0 and Cu 2 O alone, such as low activating capability of Cu 0 and instability of Cu 2 O, which was high efficient for activating PDS. Cu 0 -Cu 2 O@CNTs composite can be used as an efficient catalyst to activate PDS for the degradation of toxic organic pollutants in water and wastewater.

Predicting Di-2-Ethylhexyl Phthalate Toxicity: Hybrid Integrated Harris Hawks Optimization With Support Vector Machines

Beibei Shi,Ali Asghar Heidari,Cheng Chen,Mingjing Wang,Changcheng Huang,Huiling Chen,Jiayin Zhu