JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Yajie Deng,Zhihao Jiang,Zihao Han,Tiqun Wei,Jianwei Dao,Liang Yang
Driven by the escalating demand for efficient and stable full-spectrum red-emitting phosphors, a series of Eu-doped Sr 3 Y(BO 3 ) 3 red phosphors were synthesized via high-temperature solid-state reaction method. The crystal structure, morphology, and photoluminescence properties were systematically characterized. Under near-ultraviolet (near-UV) excitation, the Sr 3 Y(BO 3 ) 3 :Eu 3+ phosphor exhibits intense red emission corresponding to the 5 D 0 → 7 F 2 transition of Eu 3+ , with high color purity. Particularly noteworthy is its combination of excellent thermal stability and humidity resistance—it retains 75% of its room-temperature luminescence intensity at 473 K, and maintains as high as 86.2% of its luminescence intensity under high-humidity conditions. To evaluate its practical applicability, white light-emitting diodes (WLEDs) were fabricated by incorporating commercial BMA:Eu 2+ blue phosphor, BSS:Eu 2+ green phosphor and Sr 3 Y(BO 3 ) 3 :0.36Eu 3+ phosphor into near-UV chips. Driven at 150 mA, the fabricated device emits white light with CIE coordinates of (0.3186, 0.3130), lying close to Planckian locus, correlated color temperature (CCT) of 6284 K and a well-balanced RGB spectrum. Notably, a high CRI value (R a = 81.5) is achieved by the device with an especially impressive R 9 (special color rendering index for deep red) value of 93.3, indicating excellent red rendering performance. Collectively, these results identify Sr 3 Y(BO 3 ) 3 :Eu 3+ as a highly competitive red-emitting phosphor for near-UV-excited full spectrum white LEDs, owing to its superior thermal stability, humidity resistance, and device performance.
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DYES AND PIGMENTS
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2026
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IF 3.9
Yuantong Yang,Zhao Jiang,Yang Ren,Senqiang Zhu,Rui Liu,Hongjun Zhu
Designed two water-soluble D–π–A fluorescent probes for LFP visualization. • Inert ammonium groups grant high water solubility and LFP enrichment ability. • Probes show weak aqueous emission (TICT) and strong solid-state RIR fluorescence. • Achieved high-contrast imaging of level-3 LFP features on diverse substrates. • Electrostatic adsorption to LFP lipids drives the high-contrast development. High-sensitivity, high-contrast and eco-friendly visualization of latent fingerprints (LFPs) remains a key demand in forensic analysis. Most organic fluorescent developers suffer from poor water solubility and rely on organic solvents, while hydrophilic modifications often lead to fluorescence quenching. Herein, we designed and synthesized two D-π-A fluorescent molecules ( TPA-Q and DMPA-Q ) functionalized with spectroscopically inert alkyl quaternary ammonium groups for LFP development. The alkyl quaternary ammonium groups confer mg/mL-level water solubility and electrostatic enrichment for fingerprint residues without perturbing the intrinsic luminescence. Both compounds exhibit weak fluorescence in aqueous solution due to twisted intramolecular charge transfer (TICT), but intense emission in solid (Φ> 62%) and film states. Using an aqueous atomization method, clear LFPs were successfully developed on various substrates with well-resolved level-3 details (e.g., pores and ridge contours). Notably, TPA-Q excelled on green backgrounds (e.g., Snow beer cans), while DMPA-Q performed better on blue ones (e.g., Pepsi cans, G/G 0 = 3.0), respectively avoiding blue/green substrate interference. These water-soluble fluorescent developers exhibit low background interference, high contrast, and broad applicability when combined with aqueous nebulization and powder-dusting protocols, offering a promising strategy for efficient and nondestructive LFP visualization in practical forensic applications. Download: Download high-res image (298KB) Download: Download full-size image
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ADVANCED MATERIALS
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2026
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IF 29.1
Lingjie Liu,Juncai Zhang,Hu Li,Jinrui Cai,Limei Lin,Shuiyuan Chen,Guilin Chen
Severe carrier recombination at the back interface, exacerbated by valence-band misalignment arising from the tunable S/Se composition in Sb 2 (S x ,Se 1−x ) 3 (0 ≤ x < 1) absorbers, remains a critical bottleneck in these solar cells. Here, we address this issue by inserting an Sb 2 S 3 interlayer between the narrow-bandgap Sb 2 (S x ,Se 1−x ) 3 absorber and the PbS hole transport layer (HTL). KPFM and GIWAXS measurements reveal that this Sb 2 S 3 interlayer reduces surface defect density and improves the crystalline quality of the film surface. Moreover, leveraging the complete mutual solubility between Sb 2 S 3 and Sb 2 (S,Se) 3 , TOF-SIMS confirms the formation of a compositionally graded heterojunction from the Se-rich bulk to the S-rich back surface during annealing, creating a continuous energy staircase. Consequently, the hole-extraction barrier is eliminated, the built-in electric field is enhanced, and the depletion region is broadened, accelerating hole collection. This strategy delivers the following performance: for Sb 2 (S,Se) 3 -derived devices, efficiency increases from 6.88% to 9.76%; when extended to the Sb 2 Se 3 -derived case, efficiency rises from 7.77% to 10.03%. These results set new benchmarks for all-inorganic Sb 2 (S x ,Se 1−x ) 3 thin-film solar cells, especially for carbon-electrode devices, and establish a back-interface engineering strategy for Sb 2 (S x ,Se 1−x ) 3 solar cells.
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高影响因子
BIORESOURCE TECHNOLOGY
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2026
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IF 8.2
Jinming Gu,Lang Xie,Dandan Zhou,Yue Yu,Hongliang Huo,Kejian Tian
3-oxo-C12-HSL accumulates markedly under low-temperature stress. • Multiple AHL receptors participate in signal perception and transcriptional control. • Exogenous 3-oxo-C12-HSL enhances key gene expression at 15 and 8°C. • Exogenous 3-oxo-C12-HSL affects energy, antioxidant and fatty acid pathways in cold. Low-temperature stress markedly suppresses the metabolic activity of activated sludge microorganisms, thereby compromising the operational stability of biological wastewater treatment systems. This study investigated associations between 3-oxo-C12-HSL-related quorum-sensing (QS) responses and physiological, transcriptional, and metabolic changes in activated sludge following rapid temperature decline. At 15°C and 8°C, lasI g was upregulated with log 2 FC values of 1.02 and 3.01, respectively, accompanied by 27.79- and 32.87-fold increases in endogenous N-(3-oxo-dodecanoyl)- l -homoserine lactone (3-oxo-C12-HSL) levels, reaching maximum concentrations of 25.05 and 32.90 μg g⁻1 VSS. With 3-oxo-C12-HSL accumulation, QS-related genes, including lasR g , luxR g and sdiA g , were significantly upregulated, with log 2 FC values ranging from 1.13 to 4.84. These changes coincided with the upregulation of genes involved in extracellular polysaccharide biosynthesis, energy metabolism, oxidative phosphorylation, fatty acid metabolism, and antioxidant defense. Meanwhile, differential metabolites associated with the pentose phosphate pathway (PPP), glycolysis (EMP), and the tricarboxylic acid cycle (TCA) increased by 1–104%. These molecular changes were accompanied by pronounced physiological responses, including a 73.37–508.91% increase in extracellular polysaccharides (PS), an increase in ATP from 3278.82 to 7016.70 nmol L⁻ 1 , a 24% decrease in reactive oxygen species (ROS), and a 16% increase in total antioxidant capacity ( T -AOC). Exogenous 3-oxo-C12-HSL supplementation further enhanced these responses, supporting a potential functional role potential functional association in the low-temperature response of activated sludge. Overall, 3-oxo-C12-HSL was associated with coordinated changes in polysaccharide formation, energy metabolism, antioxidant defense, and fatty acid-related responses, suggesting its potential as a candidate QS signal for low-temperature biological wastewater treatment. Download: Download high-res image (286KB) Download: Download full-size image
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BIOPHYSICAL CHEMISTRY
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2026
·
IF 2.3
Pingzhang Gao,Yinhua Sui,Xiao-Lan Xie,Rong Tian,Naihao Lu
The health-promoting function of bioactive polyphenols in vitro and in vivo is usually restrained by their low stabilities, which might be counteracted by the use of protein as carriers for these compounds. Demonstration of the binding mechanism of protein-ligand complex is important for the encapsulation and protection of bioactive compounds. In this study, human serum albumin (HSA) was used to investigate its binding characteristic to (−)-epigallocatechin-3-gallate (EGCG, the main component of catechins in green tea), in the presence of free heme (an inducer for cytotoxicity) by multi-spectroscopic analysis and molecular docking. The free radical scavenging capability of bioactive EGCG was retained in the albumin-ligand complex relative to free flavonoid. Albumin-diligand complex (HSA-EGCG-heme) was successfully formed when EGCG and heme was added to protein solution. The toxicity of heme in vascular endothelial cells was declined in the HSA-diligand complex comparison with those of free heme or HSA-heme complex, where the stability of EGCG during storage was improved in the HSA-diligand complex comparison with that in the free EGCG. Our results demonstrate the possibility and advantage of designing albumin protein-based carriers for the protection of active flavonoid and suppression of heme toxicity during their biomedical applications.
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高影响因子
BIOMACROMOLECULES
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2026
·
IF 5.9
Zehui Wei,Shuxian Ge,Yukai He,Lina Mu,Shuangxian Yan,Yu Cheng,Tiantian Gao,Kefan Xie,Miaomiao Zhang,Suhong Wang,Mei Tian
Carbohydrate antigen 15-3 (CA15-3) is an important biomarker for early breast cancer diagnosis and therapeutic monitoring. This work presents an ultrasensitive fluorescent probe based on a dual-ligand peptides/UiO-66-NH2@AYG composite for CA15-3 detection. Dual-ligand peptides (GTTFSNYW and MHYLEYPF) target distinct CA15-3 epitopes, enhancing the binding affinity and specificity. The peptides are immobilized on UiO-66-NH2, whose high surface area supports efficient loading of the fluorescent reporter Acridine Yellow G (AYG). This probe demonstrates exceptional performance with a linear detection range of 0.05–1.5 pg/mL (R2 = 0.9981) and an ultralow detection limit of 0.004147 pg/mL. Practical validation in spiked mouse serum shows recovery rates of 91.57–103.7%, while clinical testing with serum samples from 10 cancer patients reveals a strong correlation with ELISA results (r = 0.9944, P < 0.001). This robust platform offers significant potential for cost-effective, early cancer screening in primary healthcare settings.
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高影响因子
CERAMICS INTERNATIONAL
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2026
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IF 6
Kunqi Liu,Junxia Wang,Jin Wang,Long Kang,Jun Li,Die Liu,Yuan Liu,Qing Tao
To explore the application potential of ceramic waste forms for immobilizing multiple nuclides in high-level waste, a systematic study was conducted on (1- x )Sr 0.5 Zr 2 (PO 4 ) 3 - x Ce 0.5 Sm 0.5 PO 4 ( x = 0, 0.5, and 1) ceramics, focusing on their chemical and irradiation stability. The composite ceramics can simultaneously immobilize multiple nuclides (Sr, Ce, and Sm), while retaining a homogeneous microstructure and high relative density (>97%). Static leaching experiment indicated low normalized leaching rates: LR Sr ∼ 10 -4 -10 -3 g·m -2 ·d -1 , LR Ce ∼ 10 -8 -10 -7 g·m -2 ·d -1 , and LR Sm ∼ 10 -7 -10 -6 g·m -2 ·d -1 . Different leaching behaviors of nuclides (Sr, Ce, Sm) were further identified using the de Groot and van der Sloot model. With 5 MeV Xe 20+ irradiation at a fluence of 2.5×10 15 ions/cm 2 , Sr 0.5 Zr 2 (PO 4 ) 3 phase in the composite ceramics can still maintain part of its crystal structure, while Ce 0.5 Sm 0.5 PO 4 phase tends to amorphize. Interestingly, subsequent TEM observation further vitrificated the Xe 20+ -induced amorphous Ce 0.5 Sm 0.5 PO 4 phase recrystallizes under electron-beam (e-beam) irradiation.
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高影响因子
FOOD CHEMISTRY
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2026
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IF 10.4
Sheng Wang,Xianhui Du,Li Wang
Myofibrillar protein (MP) suspension was nitrated by exposing to nitrite. • 3-Nitrotyrosine (3-NT) is a biomarker of MP nitration. • A Sensor was made by CeVO 4 -CNT-Nafion nanocomposite modifying on GCE. • 3-NT in nitrosative MP was detected by the sensor coupled with CV. • The proposed method was compared with HPLC method. 3-Nitrotyrosine (3-NT) is a recognized biomarker of protein nitration. In this study, an electrochemical nonenzymatic sensor was developed for 3-NT detection by modifying a glassy carbon electrode with a nanocomposite of CeVO 4 , carboxylated carbon nanotubes (CNT), and Nafion. Scanning electron microscopy revealed that flower-like CeVO 4 nanoparticles were uniformly embedded within the interconnected tubular network of CNT and Nafion. Under optimal conditions, the sensor exhibited a wide linear response to 3-NT in the range of 10 to 900 μM, with a detection limit of 1.20 μM. To validate its practical application, myofibrillar protein (MP) was extracted from pork and exposed to varying concentrations of nitrite at pH 6.0, leading to the formation of 3-NT. These nitrosative MP samples were then analyzed using the developed sensor, and the results were compared with those obtained by HPLC using split samples. The findings demonstrated no significant differences between the two methods. Download: Download high-res image (105KB) Download: Download full-size image
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高影响因子
BIOLOGICAL CONTROL
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2026
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IF 4
Lingling Cao,Junjie Lu,Yinglu Chen,Yajie Du,Shuqiong Yang,Zhiqiang Yan,Qingling Zheng,Pengfei Duan
White mold disease caused by Pseudodiploöspora longispora is destructive to the production and quality of Morchella . In this study, an endophytic bacterial strain YX-3 was isolated from the ascocarp of Morchella and exhibited significantly antagonistic effects against P. longispora with the inhibition rate of 91.5%. The strain YX-3 was identified to be Pseudomonas chlororaphis subsp. piscium through multi-locus sequence analysis and morphological characteristics. The gene features and functional annotation were analyzed according to the whole genome sequencing. The VOCs produced by strain YX-3 demonstrated significant inhibitory effects on mycelial growth, spore germination of P. longispora and reduced the severity of white mold disease through fumigation during storage. In field experiments, the biological control effect of YX-3 reached to 57.3%. The scanning and transmission electron microscope (SEM and TEM) and fluorescence microscopy revealed that VOCs from YX-3 caused abnormal changes and damaged the cell membrane integrity. Ten VOCs produced by YX-3 were detected through gas chromatography-mass spectrometry, of which seven were evaluated for their antifungal activity against P. longispora. The volatiles, namely 2-undecanone and 2-undecanol exhibited notable inhibitory effects on P. longispora with inhibition rate of 100%, 77.06% at 80 μL/plate and the minimum inhibition concentration of 2-nonanol was 0.75 μL/plate and reduced the severity of white mold disease. Overall, these findings elucidate the biocontrol mechanisms of P. chlororaphis subsp. piscium strain YX-3 and support its potential application as a biocontrol agent against white mold disease in Morchella .
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高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
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2026
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IF 3.6
Chengshuang Pan,Jingjing Li,Fuhong Tian,Chentao Ding,Shaowei Wang,Ren-shan Ge,Qianjin Fei,Yang Zhu
Per - and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals as carboxylic acid (PFCA) and sulfonic acid (PFSA) found in everyday products, from non-stick cookware to waterproof clothing, and are potential endocrine disruptors. However, whether they inhibit 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) and structure-activity relationship (SAR) and mode of action remains unclear. In this study, we screened 18 PFAS (11 PFCAs and 7 PFSAs) with different carbon-chain lengths from C4 to C14 to inhibit human and rat 17β-HSD3 from HSD17B3 -overexpressed LNCaP cells and rat testicular microsomes. Of the 11 PFCAs, 6 compounds significantly inhibited human 17β-HSD3, with IC 50 values ranging from 5.36 (C10) to 145.15 μM (C8) and a V-shaped turn at C10, and of the 7 PFSAs, only perfluorooctanesulfonic acid markedly inhibited this enzyme (IC 50 , 5.87 μM). Of the 18 PFAS, only 6 PFCAs inhibited rat 17β-HSD3, with IC 50 values ranging from 14.2 (C10) to no inhibition at 100 μM (C8). These PFAS are mixed/noncompetitive inhibitors of human and rat 17β-HSD3 enzymes. Molecular docking studies suggest that the degree of inhibition is linked to the carbon-chain length of the PFAS molecule. 3D-QSAR indicates that structural hydrophobic regions determine the inhibitory potency up to C10 (PFDA). Our in vitro observation of 17β-HSD3 inhibition represents a putative upstream mechanistic factor that may contribute to elevated reproductive dysfunction and hypogonadism risk reported in existing human epidemiological PFAS exposure cohorts. In conclusion, PFAS inhibit human and rat 17β-HSD3 with clear SAR and carbon-chain length determines their inhibitory potency, and C10 PFCA is the most potent inhibitor of human and rat 17β-HSD3.
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高影响因子
BIOTECHNOLOGY AND BIOENGINEERING
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2026
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IF 3.9
Teng-Kun Huang,Cen Huang,Du Wu,Shuang Li,Ren-Chao Zheng,Xiao-Ling Tang,Yu-Guo Zheng
( R )-3-Aminobutanol is a valuable chiral amino alcohol widely used in the pharmaceutical industry. The amine dehydrogenase (AmDH)-catalyzed synthesis with inorganic ammonia as the amine donor represents one of the most promising routes for its production. However, this approach is limited by the low catalytic efficiency of AmDHs toward the unnatural substrate 4-hydroxy-2-butanone, as well as the high cost associated with coenzyme requirements. To address these issues, a structure-guided engineering strategy integrating loop remodeling with dynamically coupled network analysis was employed to modify an AmDH derived from leucine dehydrogenase ( GKGB -AmDH). A pentamutant was obtained with a 7.8-fold increase in catalytic efficiency ( k cat / K m ) and a 6.8-fold increase in specific activity. Molecular dynamics simulations were performed to elucidate the molecular mechanism underlying the improved catalytic performance. A dual − enzyme co-expression system for GKGB -AmDH-M5 and formate dehydrogenase (FDH) was established for in situ NADH regeneration. As a result, the catalytic efficiency toward 4-hydroxy-2-butanone was enhanced, and the conversion reached 83.8% at a substrate concentration of 300 mM, with an enantiomeric excess ( e.e .) of > 99.99%. These results demonstrate the feasibility of this engineering strategy and provide a theoretical basis for the efficient and green biomanufacturing of chiral amino alcohols.
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高影响因子
CNS Neuroscience & Therapeutics
·
2026
·Vol. 32
·期 7
·e71058
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IF 6.6
Chenglong Li,Xi Gou,Yingying Zhao,Lina Zhang,Shuai Liu,Shenhui Deng,Qi Li,Sihua Qi
Aims This study investigates whether histone H3K18 lactylation (H3K18la) contributes to perioperative neurocognitive disorders (PND) by upregulating immune checkpoint Lymphocyte activation gene 3 (Lag3) and microglial pyroptosis, thereby aggravating neuroinflammation in the hippocampus. Methods Lactate levels and H3K18la expression were measured in mouse hippocampus after surgery. H3K18la downstream targets were identified by CUT&Tag and RNA-seq. After Lag3 silencing in BV2 cells, downstream pathways were screened and validated by RNA-seq and in vitro assays. Glycolysis inhibitors and Lag3 antibody were used to assess cognitive function and pyroptosis-related protein expression in postoperative mice. Results Surgery significantly elevated hippocampal lactate and H3K18la levels in mice. Inhibiting glycolysis led to a reduction in H3K18la and mitigated cognitive impairments in the PND model mice. CUT&Tag and RNA-seq revealed that H3K18la transcriptionally activates Lag3 by enriching at its promoter, and Lag3 blockade improved postoperative cognition. Furthermore, Lag3 upregulation triggered microglial pyroptosis via NOD-like receptor protein 3 (NLRP3) signaling, thereby aggravating neuroinflammation and promoting PND. Conclusions Surgical trauma-induced increase of H3K18la in microglia promotes PND by upregulating Lag3 and triggering NLRP3-dependent microglial pyroptosis, highlighting the H3K18la–Lag3–NLRP3 axis as a therapeutic target for PND.
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高影响因子
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