Frontiers in Chemistry
·
2021
·
IF 5.221
Li Yu,Wang Dan,Xu Guanchen,Qiao Li,Li Yong,Gong Hongyu,Shi Lei,Li Dongwei,Gao Meng,Liu Guoran,Zhang Jingjing,Wei Wenhui,Zhang Xingshuang,Liang Xiu
Air and water pollution poses a serious threat to public health and the ecological environment worldwide. Particulate matter (PM) is the major air pollutant, and its primary sources are processes that require high temperatures, such as fossil fuel combustion and vehicle exhaust. PM0.3 can penetrate and seriously harm the bronchi of the lungs, but it is difficult to remove PM0.3 due to its small size. Therefore, PM0.3 air filters that are highly efficient and resistant to high temperatures must be developed. Polyimide (PI) is an excellent polymer with a high temperature resistance and a good mechanical property. Air filters made from PI nanofibers have a high PM removal efficiency and a low air flow resistance. Herein, zeolitic imidazolate framework-8 (ZIF-8) was used to modify PI nanofibers to fabricate air filters with a high specific surface area and filtration efficiency. Compared with traditional PI membranes, the ZIF-8/PI multifunction nanofiber membranes achieved super-high filtration efficiency for ultrafine particles (PM0.3, 100%), and the pressure drop was only 63 Pa. The filtration mechanism of performance improvement caused by the introduction of ZIF-8/PI nanofiber membrane is explored. Moreover, the ZIF-8/PI nanofiber membranes exhibited excellent thermal stability (300 C) and efficient water–oil separation ability (99.85%).
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DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Fugang Xu,Wenjuan Shang,Mengren Xuan,Guangran Ma,Zixiang Ben
A SERS substrate FP/Ag/ZIF-8 composed of filter paper (FP), silver nanoparticles (AgNPs) and zeolitic imidazolate framework (ZIF-8) film arranged in a layered structure was developed for sensitive detection of pesticide thiram in various samples. Roles of these components in analyte adsorption and Raman signal enhancement were studied using a pesticide intermediate 4-Aminothiophenol (4-ATP) as the probe. The substrate showed high adsorption and optimized SERS response with thick metal organic framework (MOF) coating (125 nm), which is different from previous reported plasmonic particle-MOF composite substrate, where thinnest MOF coating produced the strongest SERS signal. Detection limit for 4-ATP improved 1000-fold on FP/Ag/ZIF-8 (3 pM) compared with that on FP/Ag (3 nM). Importantly, the FP/Ag/ZIF-8 with porous and flexible property can efficiently capture pesticide thiram in different real samples using soaking, filtration or swabbing operation. The subsequent SERS detection of thiram showed advantages of low detection limit (soaking, LOD: 0.04 nM in lake water), fast detection (filtration, within 1 min in peach juice) and suitable for curve surface analysis (swabbing, LOD: 0.1 ng/cm 2 on apple peel), respectively. The substrate also displayed good reproducibility, high stability and size-selective response for thiram detection. Such a layered plasmonic particle/MOF hybrid may hold great promise for toxicant analysis in environment and food.
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高影响因子
INTERNATIONAL JOURNAL OF HYPERTHERMIA
·
2024
·
IF 3
Guanghui Zi,Jin Chen,Yatu Peng,Yue Wang,Baowei Peng
Background Hyperthermia can play a synergistic role with chemotherapy in combination therapy. Although the association between caspase activation, apoptosis, and pyroptosis have been published for both cisplatin (CDDP) and hyperthermia therapies independently, the interactions between these molecular pathways in combination therapy are unknown. The present study aimed to investigate the possible interactions between caspase 8 activation, apoptosis, and pyroptosis in combination therapy.Methods Cells were treated with CDDP (15 µg/ml), followed by hyperthermia at optimized temperature (42.5 °C) in water-bath. After combination therapy, cell viability was analyzed by CCK-8, and cell death was analyzed by Annexin-V-FITC/PI and caspases activation. Immuno-staining and co-immuno-precipitation were used to examine the interaction between p62 and caspase-8. Pyroptosis was investigated by western blotting and transmission electron microscopy. E3 ligase Cullin 3 was knockdown by siRNA. In addition, caspase-8 activation was modulated by CRISPR-Cas9 gene-editing or pharmacological inhibition.Results Combination therapy promoted K63-linked polyubiquitination of caspase-8 and cellular accumulation of caspase-8. In turn, polyubiquitinated caspase-8 interacted with p62 and led to the activation of caspase-3. Knockdown of the E3 ligase Cullin 3 by siRNA reduced caspase-8 polyubiquitination and activation. In addition, combination therapy induced release of the pore-forming N-terminus from gasdermins and promoted pyroptosis along with caspase-8 accumulation and activation. Knockdown of caspase-8 by CRISPR/Cas9 based gene editing reduced the sensitivity of tumor cells to apoptosis and pyroptosis.Conclusions Our study presented a novel mechanism in which hyperthermia synergized with chemotherapy in promoting apoptosis and pyroptosis in a caspase-8 dependent manner.
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DOI
PubMed
高影响因子
JOURNAL OF CLUSTER SCIENCE
·
2024
·
IF 2.7
Luo Honghuan,Chen Menglan,Song Fangxiang,Cai Xiaoqin,Yan Yibing,Li Tingxian,Songye Li,Li Yan
Zeolitic imidazolate framework-8 (ZIF-8) is a promising material for drug delivery, but its poor stability limits its wide application. In this work, homogeneous dodecahedral ZIF-8 was prepared by the room-temperature solution stirring method, and to improve the stability of ZIF-8, ZIF-8@mSiO 2 and DZIF-8 (ZIF-8 after calcination) @PMO composites with the core-shell structure were obtained using mesoporous silica (mSiO 2 ) and periodic mesoporous organic silica (PMO) coatings. Folic acid-coupled chitosan (CS-FA) was modified on nanoparticles, and curcumin (CUR) was used as a model anti-tumor drug to obtain the drug delivery systems with targeting and pH stimulation response: ZIF-8@mSiO 2 @CUR@CS-FA and DZIF-8@PMO@CUR@CS-FA, which exhibited good dispersion and high drug loading capability. In addition, we used the MTT assay to assess the cytotoxicity of the drug-carrying systems and selected human cervical cancer cells (Hela) as model cells. The results of the in vitro experiments suggested that the final CUR-loaded drug delivery systems had significantly increased anticancer efficiency compared with the free drug CUR, which improved the therapeutic effect of the hydrophobic CUR on tumors. In conclusion, the pH-responsive nanocarriers provided potential for the targeted delivery of anticancer medication, resulting in a platform for drug-controlled release and cancer therapy.
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 12
·847
·
IF 5.3
Ma Haibo,Ru Changhai,Zhang Fanghao,Hoettges Kai,Zhu Junhui,Song Pengfei
ZIF-8-core/Au-shell (ZIF-8@Au) nanoparticles were fabricated through a two-step strategy involving thiol-modification of ZIF-8 substrates and subsequent Au shell growth via seed-mediated approach, and the ZIF-8@Au nanoparticles were applied to the screening of clostridium difficile infection (CDI). Through regulating dosage of thiol-modifier, we established a surface functionalization protocol that introduced tunable thiol groups onto ZIF-8 particles while preserving their pristine morphology and crystallinity. Subsequent refinement of Au coating parameters enabled the construction of ZIF-8@Au core–shell nanostructures via seed-mediated growth. The resulting ZIF-8@Au nanoparticles were successfully applied to detect biomarkers of CDI, including toxin A, toxin B, and glutamate dehydrogenase (GDH), with sensitivities of 7 pg/mL, 115 pg/mL, and 27 pg/mL, respectively. These results demonstrate the promising potential of this nanoparticle-based platform for lateral flow assays. Graphical
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jianzhong Ma,Chongxin An,Lei Zhang
In this work, we synthesized an acid-responsive zinc metal–organic framework (ZIF-8) at room temperature by a solvent method, which can not only be used as an antibacterial by releasing zinc ions but also as a carrier for antibacterial material encapsulation. Subsequently, the broad-spectrum antibacterial triclosan (TCS) was encapsulated in ZIF-8 by the impregnation method, and a long-term antibacterial and antimildew material with slow-release effect TCS@ZIF-8 was synthesized successfully. The encapsulation rate and drug loading rate of TCS@ZIF-8 prepared by adjusting the mass ratio of ZIF-8 and TCS were 71.9 and 25.1%, respectively. Further, TCS@ZIF-8 was introduced into polyacrylate (PA) emulsion, and PA/TCS@ZIF-8 nanocomposite emulsion was prepared successfully by the physical blending method. When the pH of the coating surface became slightly acidic due to the metabolic byproducts of microbial growth, ZIF-8 in PA/TCS@ZIF-8 disintegrated to release Zn2+ and TCS, which can effectively kill bacteria and mold. When the dosage of TCS was 4.0 wt %, the antibacterial rate of the PA/TCS@ZIF-8 nanocomposite film against Escherichia coli and S. aureus was 100 and 97.3%, respectively. Finally, PA/TCS@ZIF-8 nanocomposite emulsion-coated leather was prepared by the spraying method. Compared with the control group that did not use ZIF-8-encapsulated TCS, PA/TCS@ZIF-8 nanocomposite emulsion-coated leather not only showed better antibacterial and antimildew effects but also showed long-term antibacterial and antimildew performance even after being treated under hot and humid environments of 90% humidity and 40 °C for 30 days. Overall, this study not only provides theoretical guidance into the preparation of long-term antibacterial and antimildew coatings for leather but also has great application prospects in paper, clothing, furniture, and other fields, which has great significance in protecting consumers from the invasion of bacteria and mildew.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Yang Chen,Chengyin Yang,Xiaoqing Wang,Jiangfeng Yang,Jinping Li
Solvent-evaporated conversion (SEC) and steam-assisted conversion (SAC) have been developed to prepare the typical metal-organic frameworks (MOFs) Cu-BTC (HKUST-1) and ZIF-8 using a unique solvent recovery strategy using zeolite. As a green circulation medium, zeolite Na-4A loading and removal of solvent (H 2 O and EtOH) can transport solvent in the vapor phase and avoid solvent condensation, which was the defect in previous SAC syntheses of MOFs, and achieves efficient solvent recovery as well as being an economical and green synthetic process. Moreover, SEC and SAC processes exhibited different mechanisms during the multi-stage reaction and solid diffusion reaction, respectively and both can synthesize the desired products in 12 h. These two methods for MOFs preparation were characterized in detail using XRD, SEM and N 2 adsorption during the different growing stages. According to polar molecules (H 2 O and EtOH) steam-assisted in those synthesis, polar destruction molecules (H 2 O, NH 3 ) adsorption and stability of Cu-BTC and ZIF-8 was investigated.
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DOI
高影响因子
LUMINESCENCE
·
2022
·Vol. 37
·期 7
·1109-1119
·
IF 2.613
Yongjuan Meng,Jinling Pu,Jiamei Gan,Jianping Li
A composite of the metal–organic framework compound ZIF-8 doped with CdSe quantum dots (QDs) with sensitive and stable luminescence was synthesized, and a molecularly imprinted electrochemiluminescence (ECL) sensor was constructed based on this composite. The ZIF-8@CdSe molecularly imprinted ECL sensor combines the high sensitivity of ECL and the high selectivity of molecular imprinting to realize the sensitive and specific detection of estriol. CdSe QDs and gold nanoparticles were encapsulated within ZIF-8 to obtain the ZIF-8@CdSe QDs/GNP (ZIF@CdSe/GNP) composite. Subsequently, the GNPs were further loaded on the surface of this composite to obtain the GNP/ZIF@CdSe/GNP composite. l -Cysteine was used to immobilize the GNP/ZIF@CdSe/GNP composite on the surface of a gold electrode to obtain the GNP/ZIF@CdSe/GNP-modified gold electrode. A molecularly imprinted polymer (MIP) film was prepared on the surface of the modified electrode by electropolymerization with o -phenylenediamine as the functional monomer and estriol as the template molecule. After elution, estriol could be specifically recognized by the cavities. The readsorption of estriol by the MIP can prevent the coreactant from reaching the electrode surface through the cavities, thereby weakening ECL. A good linear relationship existed between the ∆ECL and lg C of estriol concentrations of 1 × 10 −14 to 1 × 10 −9 mol·L −1 . The detection limit was as low as 8.9 × 10 −16 mol·L −1 . The sensor was applied in the determination of estriol in serum samples with a recovery of 97.0–102%.
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Hanxiao Duan,Xiang Hu,Zhirong Sun
Zeolitic imidazolate framework-8 (ZIF-8) was synthesized by solvothermal method and the adsorption pore size was adjusted by changing the amount of template agent. The ZIF-8@SiO 2 @Fe 3 O 4 derived from self-assembly of ZIF-8 and SiO 2 @Fe 3 O 4 were then synthesized and used for ceftazidime (CAZ) removal. ZIF-8 was a regular dodecahedral particle with uniform particle size. The pore diameter was 6.47 nm and the specific surface area was 1182.5 m²·g −1 in ZIF-8@SiO 2 @Fe 3 O 4 . The adsorption of CAZ on ZIF-8@SiO 2 @Fe 3 O 4 as a function of adsorption temperature, contact time, ionic strength solution pH, and humic acid concentration were investigated. The error of equilibrium adsorption capacity between model fitting and actual experiments is only 1.19%. Kinetics for CAZ removal on ZIF-8@SiO 2 @Fe 3 O 4 was found to follow pseudo-second-order kinetics. Langmuir, Freundlich and Sips isotherm fitted the adsorption data well and gave similar correlation coefficients, suggesting a single layer adsorption of CAZ on ZIF-8@SiO 2 @Fe 3 O 4 . The ZIF-8@SiO 2 @Fe 3 O 4 showed no apparent loss in CAZ adsorption after five cycles. These features indicate that the ZIF-8@SiO 2 @Fe 3 O 4 may be a promising adsorbent for CAZ removal from aqueous solution.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Mengmeng Zhang,Kun Yang,Junshuo Cui,Haibiao Yu,Yuejiao Wang,Weijun Shan,Zhenning Lou,Ying Xiong
With the ever-increasing of Rare Earth Elements (REEs) in various high technology applications, efficient recovery of REEs from liquid sources is becoming significantly important. In this work, ZIF-8 and UiO-66-NH 2 (U6N) are combined to form a 3D-agaric like core-shell structure hybrid material (U6N@ZIF-8-20), which exhibits good performance in REEs extraction. Due to the abundant adsorption sites of ZIF-8 and the excellent water stability of UiO-66-NH 2 , 3D-agaric like U6N@ZIF-8-20 showed quick adsorption rate (only 10 min to reach equilibrium), high adsorption capacity and selectivity for REEs from water compared to other reported adsorbents. Maximum adsorption capacities of U6N@ZIF-8-20 for neodymium (Nd(III)), europium (Eu(III)), gadolinium (Gd(III)) and erbium (Er(III)) achieved to 249.90, 295.28, 316.22 and 340.95 mg g -1 , respectively. U6N@ZIF-8-20 has superiority in selective adsorption of REEs from Cd(II), Zn(II), Cu(II), Mn(II) and Co(II) coexistence solution. The order of adsorption capacities for REEs is in agreement with the order of their electronegativity, ionic radius and charge density. Moreover, U6N@ZIF-8-20 showed better water stability and recyclability than single MOF. Overall, MOF@MOF hybrid material has efficiency in REEs separation from solutions, and has great advantage in the application of wastewater treating.
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高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 22
·6687-6703
·
IF 6.177
Furong Cao,Yun Wang,Xing Wang,Wenjuan Zhang,Gregory A. Solan,Rui Wang,Yanping Ma,Xiang Hao,Wen-Hua Sun
Five types of N-(2-(diphenylphosphino)ethyl)-2-R-5,6,7,8-tetrahydroquinolin-8-amines (R = H L1, Me L2, iPr L3, Cl L4, Ph L5) along with one example of an N-isopropyl-5,6,7,8-tetrahydroquinolin-8-amine (L6) have been prepared and employed as neutral ligand supports for zinc(II) chloride complexes, LZnCl2 (Zn1–Zn6). All zinc compounds were characterized by multinuclear NMR spectroscopy (1H/13C/31P) and elemental analysis, while the structures of Zn2 and Zn5 were further studied by single crystal X-ray diffraction: distorted tetrahedral geometries with the diphenylphosphine moieties non-coordinated were a feature. Pre-treatment of Zn1–Zn5 with two equivalents of either LiCH2SiMe3 or LiN(SiMe3)2 led to catalysts displaying good to exceptionally high activity for the ring opening polymerization (ROP) of ε-caprolactone (ε-CL) at 50 °C. For example, Zn4/2LiCH2SiMe3 displayed a TOF of 2.1 × 104 h−1 with 71% conversion seen within 10 minutes with the ε-CL : Zn molar ratio at 5000 : 1; the resulting polycaprolactone (PCL) comprised predominately cyclic structures along with lower levels of trimethylsilylmethyl-capped linear PCL. By comparison, Zn1–Zn5 on treatment with two equivalents of LiN(SiMe3)2 at the same high monomer to zinc ratio, led to catalysts exhibiting an order of magnitude higher activity. Zn1/2LiN(SiMe3)2 in the presence of BnOH exhibited a remarkable TOF of 1.35 × 105 h−1 with 90% monomer conversion within two minutes. In these cases, a distinct selectivity towards linear polymers capped with CH3O end-groups (derived from the quenching solvent) was observed with cyclic polyesters only observable with larger amounts of ε-CL. As a general observation, the 2-R substituent on the chelating ligand showed noticeable effects on the efficiency and on the molecular weight of the PCLs, with 2-Cl-containing Zn4 in combination with LiCH2SiMe3 and BnOH affording the highest molecular weight PCL of the study (9.57 × 104 g mol−1). Based on the microstructural properties of the PCL, distinct mechanisms (viz., coordination–insertion and ring expansion) have been proposed to account for the mode of propagation mediated by Zn/2LiCH2SiMe3 and Zn/2LiN(SiMe3)2. In addition, a zinc silylamido L1−HZn[N(SiMe3)2] (Zn7) species has been tentatively assigned (obtained via deprotonation of L1 with Zn[N(SiMe3)2]2), that proved inactive for the ROP of ε-CL but displayed good activity for ROP of rac-LA.
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DOI
高影响因子
Advanced Membranes
·
2021
·
IF 0
Ao-Shuai Zhang,Shen-Hui Li,Heng Mao,Li-Hao Xu,Ming-Yu Lv,Zhi-Ping Zhao
Organophilic pervaporation (PV) mixed matrix membranes (MMMs) possess huge potential in organic wastewater treatment with merits of environmentally friendly and high-efficiency. The filler dispersion structure inside MMMs is required to explore in depth to upgrade the PV performance. In this study, an ethoxysilyl functionalized ionic liquid (IL-PTES) modified ZIF-8 nanoparticles (IL-PTES@ZIF-8) were synthesized by one-pot method, and then incorporated into the PDMS matrix to prepare MMMs for PV separation of ethyl acetate (EtOAc) from its diluted aqueous solution. The preferential adsorption performances to EtOAc by IL-PTES, especially for the functions of specific chemical groups in IL-PTES, were researched via molecular dynamicssimulation approach. Furthermore, the IL-PTES covered on ZIF-8 surface could crosslink with PDMS chains, thereby enhancing the interfacial compatibility between ZIF-8 and PDMS. Importantly, the self-aggregated IL-PTES subtly “glued” the nanoparticles together to lead IL-PTES@ZIF-8 a relatively continuous and defect-free distribution state. This condition would lead to a high-efficiency molecular pathway with less polymer phase and much relatively continuous ZIF-8 phase with high selectivity. PV results suggested that the MMMs with 15% IL-PTES@ZIF-8 loading displayed an optimal separation performance with an ultra-high separation factor of 492 (158.7% more than that of pristine PDMS membrane) and normalized EtOAc flux of 4.98 kg μm m −2 ·h −1 (2 times as much as that of pristine PDMS membrane) for separating 1 wt% EtOAc aqueous solution at 30 °C. These findings offered significant advancement toward developing high-performance MMMs enabled by the synergy of MOFs and ionic liquid.
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