SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Yuheng Zhao,Yuemao Dou,Shounian Ding,Xuedong Wang,Chunyang Chen
Monitoring pyrethroid residues is essential due to their environmental persistence and toxicity. However, conventional laboratory-based techniques are inadequate for real-time, on-site screening. Herein, we report the development of a novel coumarin-derived near-infrared (NIR) fluorescent probe featuring an ultralong Stokes shift of 330 nm, for the intelligent handheld detection of pyrethroids. Leveraging a twisted intramolecular charge transfer (TICT) to intramolecular charge transfer (ICT) transition mechanism, the probe achieves high-sensitivity turn-on response at 705 nm. In an optimized H 2 O/DMSO (19:1, v/v) system, the probe exhibited exceptional selectivity and anti-interference capability, with a limit of detection (LOD) of 1.33 nM. Furthermore, a portable fluorescence-to-vision transduction (FVT) integrating optoelectronic conversion and wireless communication was fabricated via 3D printing. This portable platform, connected to a smartphone via Bluetooth, enables automated data acquisition and concentration quantification. Spiked recovery assays in Kyoho grapes yielded results ranging from 98.36% to 100.83%, demonstrating high accuracy in complex matrices. This work not only provides a design strategy for ultralong Stokes shift NIR probes but also establishes a paradigm for handheld rapid analysis of pesticide.
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高影响因子
MINERALS ENGINEERING
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2026
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IF 6
Tianbei Wang,Hao Li,Bingduo Xing,Zhijian Xu,Xuecheng Zhang,Yongjun Xian
Magnetite significantly deteriorates spodumene flotation by preferentially consuming sodium oleate. • Fe 3+ activates spodumene flotation by promoting oleate adsorption through hydrolyzed Fe species. • Molecular dynamics simulations reveal stronger oleate adsorption on magnetite than on spodumene. Low-grade lithium ores are abundant and have gradually emerged as key lithium sources for the energy storage industry; however, effective ore enrichment remains a challenge. Moreover, a key consideration factor is that common iron minerals severely interfere in the lithium flotation process. In this context, this study investigates the mechanism governing the adverse effect of magnetite on spodumene flotation. Specifically, flotation tests in a magnetite–spodumene–oleate flotation system showed that sodium oleate preferentially collects magnetite (recovery >65%), and spodumene recovery significantly decreases with an increase in magnetite content. Additionally, zeta potential measurements and adsorption tests indicated that the Fe ions dissolved from magnetite do not contribute to decreases in spodumene flotation, owing to Fe 3+ addition observably activating spodumene flotation. Such activation was achieved via the formation of hydroxyl–iron complexes as bridges for enhancing oleate collector adsorption on spodumene surface. Molecular dynamics simulations confirmed that the hydration film thickness at the mineral–water interface decreased with the addition of oleic acid, and the degree of thinning of the hydration film at the magnetite–water interface far exceeds that at the lithium–spodumene–water interface. This resulted from magnetite inherently possessing abundant surface Fe sites binding directly and strongly with oleate, although some Fe 3+ also adsorbed on the spodumene. An interfacial adsorption energy between magnetite and sodium oleate (–4.01 kcal · mol −1 · Å -2 ) significantly exceeding that of spodumene (–1.03 kcal·mol −1 ·Å -2 ) was obtained from calculations, further proving that the structural-preferential adsorption of oleate on magnetite surface is a key factor influencing spodumene flotation. Ultimately, these findings may provide a theoretical foundation for developing strategies to mitigate the interference of iron minerals in low-grade lithium ore flotation. Download: Download high-res image (121KB) Download: Download full-size image
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Wang Lei,Shao Meiyu,Wang Huizhi,Han Chunlei,Ma Nan,Qu Wei,Liu Jun,Lin Xiangyun,Jiang Mai,Xu Xiangmei,Meng Fangang,Tang Yan,Zhang Wei
Neural electrodes capable of precise interrogation and biofunctional regulation—encompassing both long-term electrophysiological signal recording and tunable control of neuronal or pathological cell behavior via surface biofunctionalization—hold significant promise for advancing the diagnosis and treatment of neurological disorders. A critical challenge lies in mitigating the immune-mediated foreign body response, which often leads to glial scar formation that encapsulates implants like “cement,” severely compromising functionality. To address this, we develop a benzyloxycarbonyl (Cbz)-substituted poly(ornithine-alt-glycine) (OG Cbz ) interface, which inherently resists biofouling and immunogenic rejection without degrading electrical performance. Notably, substituting the Cbz group with various functional moieties not only maintains these excellent antifouling and biocompatibility properties but also imparts corresponding functionalities. As a proof-of-concept, replacing Cbz with the peptide sequence IKVAV and the antibody cetuximab successfully endows the interface with neuron-affinity and tumor cell proliferation inhibition, while retaining its inherent antifouling and anti-foreign-body reaction properties. During a six-month in vivo implantation period, the IKVAV-functionalized electrodes exhibit a significantly enhanced operational lifetime with improved electrophysiological signal fidelity. This work presents a reliable and versatile interfacial strategy for developing durable and multifunctional neural interfaces.
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DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2026
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IF 2.5
Pengcheng Rao,Tairan Zhang,Ju Li,Weideng Wei,Xiaoqiang Xia,Qianming Chen,Xiaoping Xu,Xiaodong Feng
Cisplatin-based chemotherapy responses are highly heterogeneous across cancers, with the mechanisms governing drug sensitivity remaining incompletely understood. Using genome-wide CRISPR-Cas9 knockout screening, we systematically characterized regulators of cisplatin response and uncovered a counterintuitive finding: mTOR inhibition promotes cisplatin tolerance, contradicting the canonical view that PI3K-AKT-mTOR activation confers chemoresistance. Mechanistically, both mTOR suppression and cisplatin treatment converge to activate cytoprotective autophagy, which enhances cancer cell survival under therapeutic stress. The amino acid transporter SLC7A5 was identified and validated as a key integrator of the mTOR-autophagy axis that modulates cisplatin sensitivity. SLC7A5 expression positively correlates with cisplatin sensitivity across cancer cell lines, and its downregulation is associated with cisplatin resistance in multiple cancer types, supporting its potential as a mechanistically grounded predictive biomarker. Translationally, leucine supplementation sensitizes cancer cells to cisplatin in an SLC7A5-mTOR-autophagy-dependent manner. Collectively, our study defines a novel mTOR-autophagy adaptive loop governing cisplatin tolerance, positions SLC7A5 as a central regulatory node with both biomarker and therapeutic target value, and proposes leucine supplementation as a simple, translatable strategy to improve cisplatin efficacy in SLC7A5-expressing tumors.
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高影响因子
LANGMUIR
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2026
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IF 4.4
Yun-yun Song,Wei Wang,Zhong-yang Wang,Yang Zhang,Zhao-peng Yu,Zhong-qiang Zhang
Oily wastewater, with its complex composition, is creating a growing demand for smart materials with tunable wettability that can adapt to changing environmental conditions. However, their practical application in oil–water separation is still limited by issues such as long response time and operational complexity. An ethanol/ammonia dual-responsive mixed cellulose ester membrane was prepared by grafting SiO2 with fluorocarbon molecules (FS-61). Through inducing the polar hydrophilic groups (−COO–) and nonpolar oleophobic groups (−C6Fx) by ammonia and ethanol, the FS@SiO2 membrane achieves a switchable wettability: initially superhydrophilic, turning hydrophobic (WCA: 142°) upon ethanol exposure, and reverting to superhydrophilic after ammonia stimulation, with stable reversibility over several cycles. The wettability transition enables the membrane to separate complex oil–water mixtures, including interface oil and emulsions, utilizing ethanol and ammonia as wettability triggers. For the emulsions, after 10 cycles, the separation efficiency remained at 98.76% (oil-in-water) and 97.95% (water-in-oil). These findings provide a crucial theoretical foundation and technical support for the development of highly efficient and tunable oil–water separation materials, while also paving the way for solutions to treat complex oil–water mixtures such as industrial oily wastewater and marine oil spills.
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PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2026
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IF 12.2
Yiyi Shu,Biao Zhou,Haoqi Zhang,Xianjing Shi,Furong Guo,Junning Zu,Chuan Liang,Falong Jia,Zhihui Ai
The widespread use of glyphosate (PMG), the most abundant herbicide globally, poses substantial ecological risks owing to the persistence of both PMG and its toxic metabolite, aminomethylphosphonic acid (AMPA). While ubiquitous transition-metal ions strongly influence PMG transformation in water systems, their specific role in the conversion of PMG and AMPA remains insufficiently understood. Here, we reveal that ferrous ions (Fe2+) mediate the sequential transformation and ultimate mineralization of PMG and AMPA by activating molecular oxygen through a dual-chelation mechanism. Initially, Fe2+ chelates the phosphonate group of PMG to form an Fe(II)-PMG complex that activates O2, generating superoxide (O2•–) and oxidizing to Fe(III)-PMG. The resulting O2•– then attacks the C(2)–N of PMG to yield AMPA. Critically, the AMPA intermediate subsequently chelates Fe2+ to form a distinct Fe(II)-AMPA complex that exhibits enhanced O2 activation to O2•– and substantially lowers the energy barrier for C(3)-P cleavage by 0.78 eV. This sustained cycle of complexation and radical generation drives the complete mineralization of PMG to inorganic end products. Our findings elucidate an overlooked pathway─continuous complexation-activated conversion of intermediates─providing new insight into the environmental fate of PMG.
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PubMed
高影响因子
Cell Reports Methods
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2026
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IF 5.8
Zhaohui Cao,Wenlong Zuo,Lanxiang Wang,Lei Dai
Spatial mapping of microbial communities at single-cell resolution is opening up dimensions to understand microbiome organization and function. However, current fluorescence in situ hybridization (FISH) methods for microbiomes are limited by multiplexity and scalability. Here, we present the sequential error-robust FISH spatial mapping platform (SEER-Map) for fully automated imaging of complex microbial communities. We show that an integrated platform of fluidics control and fluorescence microscopy can perform 40 rounds of sequential FISH. We apply SEER-Map to profile complex microbial communities colonized on plant roots and identify distinct spatial patterns and species co-occurrence at the micron-scale. Our work establishes SEER-Map as a high-throughput and scalable platform for high-resolution spatial profiling of microbiomes.
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Zhigang Yang,Hui Yuan,Lu Guo,Mei Wang,Weiman Zhang,Gidion Wilson,Jingui Ma,Lingling Yang,Fen Ma,Yuping Sa,Xiyuan Li,Guoning Chen,Xueqin Ma
Abstract Exosomes, nanoscale extracellular vesicles carrying native membrane proteins, play crucial roles in intercellular communication and are critically involved in colorectal cancer progression and drug resistance, thereby offering a biologically relevant platform for targeted drug discovery. In this study, we developed an innovative immobilized exosome affinity screening platform (Exo@SiO2–NH2) using HT-29 cell-derived exosomes to selectively capture antitumor bioactive compounds from Sophora flavescens. Through UHPLC-MS/MS analysis, four compounds─Kushenol I, Kurarinone, 2′-O-MethylKurarinone, and Isoxanthohumol were successfully enriched and identified. To explore potential exosome-associated targets, systematic molecular docking and molecular dynamics simulations were conducted on representative exosome-enriched proteins against these four compounds. Further combinatorial alanine scanning mutagenesis within the predicted binding pockets (<5.0 Å) suggested CD81 and HSP90 as probable protein targets. Subsequent functional validation via siRNA-mediated knockdown of CD81 and HSP90, combined with IC50 determination via CCK-8 assays, confirmed target-dependent alterations in drug responsiveness, supporting their role as key functional mediators. Together, this integrated strategy provides a practical and novel approach for discovering anti-colorectal cancer molecules targeting exosome-associated protein interfaces.
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高影响因子
ANALYTICAL CHEMISTRY
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2026
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IF 7.3
Shichen Liu,Jinwei Xiao,Tsegu Lijalem,Jiyang Liu,Xufan Zhao,Yutong Liu,Guobao Xu
Abstract For the luminol-H2O2 chemiluminescence (CL) system, developing high-performance nanocatalysts remains a major challenge. Inspired by the ion migration phenomenon in the electrode materials for ion batteries, we synthesized sodium cobalt phosphate nanosheets (NaCoPO4 NSs) with the hexagonal β-phase polymorphic structure consisting of tetrahedral Co (CoO4), in which Na+ occupied relatively open and low-coordination sites that facilitated ion migration. NaCoPO4 NSs achieve a CL enhancement factor of over 3000. Mechanistic studies revealed that the superior catalytic activity of NaCoPO4 NSs was mainly attributed to rapid Na+ ion migration during the catalytic reaction, which facilitated charge separation and transfer and further enhanced the decomposition of H2O2 into reactive oxygen species. Meanwhile, the high proportion of surface oxygen vacancies in NaCoPO4 NSs provided abundant catalytically active sites. Based on the quenching effect of l-ascorbic acid (ascorbic acid (AA)) on the luminol-H2O2 CL signal, a sensitive, rapid, and highly selective CL method for AA determination was developed, exhibiting a linear range from 100 to 5000 nM and a detection limit (limit of detection, S/N = 3) of 69.0 nM. Moreover, the proposed method was successfully applied to the accurate determination of AA in commercially available vitamin C beverage, with spiked recoveries ranging from 97.7% to 100.1%. This work highlights ion migration regulation as a promising strategy for designing high-performance nanocatalysts for CL analysis.
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高影响因子
ACS Nano
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2026
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IF 17.3
Hang Qi,Shuaihua Zhang,Yuanheng Kuang,Yilan Yang,Chongling Sun,Bohua Liu,Zefang Wang,Yanyan Wang
Abstract Tumor cells (TCs) typically achieve brain metastasis through two distinct post-extravasation routes: invasion into the parenchyma or migration along the abluminal surface of vessels. However, the biomechanical cues dictating this route selection remain poorly understood. Here, we employed a triparallel extravasation-on-chip that enables independent modulation of key mechanical cues within the brain extravasation microenvironment. Traction force microscopy (TFM) and atomic force microscopy (AFM)-based mechanical characterization were used to quantify tumor-cell mechanical responses. We show that, compared with soft extravascular matrix, stiff extravascular matrix markedly suppresses invasion of TCs into the matrix after extravasation. Strikingly, this inhibitory effect can be reversed when vascular wall compactness is increased and fluid shear stress (FSS) is applied, even under stiff-matrix condition. To elucidate the mechanical basis underlying this adaptive invasion, AFM and TFM measurements revealed that tumor-cell stiffening, accompanied by increased F-actin organization, was associated with enhanced traction generation and matrix deformation, consistent with the increased matrix invasion observed under these conditions. These results suggest that tumor-cell stiffening represents a mechanoadaptive state, highlighting tumor-cell mechanical adaptation as an additional regulator of post-extravasation invasion beyond matrix compliance alone. This study provides a controllable platform to dissect TCs-matrix interfacial mechanics and elucidate how physical microenvironmental cues regulate organ-specific metastatic progression.
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Yujie Chen,Zhongxi Yu,Haochen Qi,Li Lv,Yun Jiang,Xiaojie Yuan,Qike Yin,Jian Zhang,Lei Zheng
Integrated ACET aptasensor, microfluidic patch, and portable detector. • Rapid sweat collection (10 μL in 15 s) via PDMS capillary micro-channels. • Ultra-low LOD (75.43 aM), wide linear range (0.1 fM–10 pM), and high selectivity (2069: 1). • 2-min turnaround time, 21-day stability, and $ 50 system cost. Hyperuricemia is closely linked to uric acid (UA) levels, and conventional serum UA detection is invasive and time-consuming, limiting its suitability for rapid monitoring. Herein, an alternating current electrothermal (ACET) capacitive aptasensor is developed for fast detection of sweat UA. Benefiting from the powerful ACET effect for target enrichment and ultrasensitive interfacial capacitance sensing, the sensor achieves a low calculated detection limit of 75.43 aM within 30 s, along with a wide linear dynamic range from 0.1 fM to 10 pM and a high selectivity ratio of 2069: 1. A point-of-care testing platform integrating a microfluidic sweat-collection patch and a self-developed portable micro-capacitance detector is further constructed, capable of harvesting 10 μL of sweat within 15 s and testing instantaneous capacitance, allowing the total testing in less than 2 min including a dilution step. The platform is validated using diluted, spiked human sweat samples, demonstrating the feasibility of the sensor for rapid and non-invasive UA detection. Download: Download high-res image (278KB) Download: Download full-size image
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高影响因子
MACROMOLECULES
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2025
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IF 5.2
Chuying Zhang,Haotong Guo,Na Zhang,Liming Jin,Jinbo Bai,Hang Zhao
Dielectric elastomers (DEs) can be deformed in response to an electric field. However, an excellent electro-actuated strain of DEs is usually achieved at high applied voltages, which severely limits their application range. Moreover, flexible DEs are susceptible to electromechanical breakdown, which directly affects their operational life. Herein, a novel all-organic DE composite was designed. First, isooctyl 3-mercaptopropionate (IOMP)-grafted methyl vinyl silicone (MVQ) was prepared to enhance the polarization and reduce cross-link density of macromolecular chains. Furthermore, 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTCDA) was incorporated into the MVQ–IOMP matrix. The positively charged NTCDA can capture free charges through strong electrostatic interaction, thus enhancing the breakdown strength of DEs. Ultimately, a 1 wt % NTCDA/MVQ–IOMP0.75 DE composite obtains an extremal actuated strain of 52.9% under 45.2 V/μm and a maximum actuated strain of 37.3% under its safe electric field (36.1 V/μm). Consequently, this work provides a feasible way for preparing advanced DE composites.
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高影响因子
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