AICHE JOURNAL
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2026
·
IF 4.4
Qi Liu,Shanlei Han,Dong Xiong,Yuming Li,Qingxin Yang,Dan Zhao,Yuhang Zhong,Shihao Wang,Zhentao Chen,Dmitry E. Doronkin,Laiyong Zhang,Chunming Xu,Guiyuan Jiang
Tuning hydroxyl defects and constructing active sites at the molecular level is critical for rational design of propane dehydrogenation (PDH) catalysts and understanding the structure–activity relationship. For practical application, enhancing catalysts anti-coking performance is equally important. Herein, the simultaneous regulation of hydroxyl nests content and b -axis thickness was achieved by adjusting the urea/SiO 2 ratio during the preparation of Silicalite-1. The propylene formation rate of the catalysts prepared by introducing Zn species showed a linear positive correlation with the hydroxyl nests content, and the coking behavior was governed by the b -axis thickness of the support. The optimized ZnO x /Silicalite-1 exhibited a high propylene space time yield of 2.2 kg h −1 kg cat −1 with propane conversion of 31% at 550°C. This work provides novel insights into PDH catalyst design from both chemistry and chemical engineering views.
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FREE RADICAL BIOLOGY AND MEDICINE
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2026
·
IF 8
Zhan Wang,Cheng Zheng,Wenzhen Li,Kaung Myat Kyaw,Yunmin Zhu,Yihan Lin,Zhen Lin,Di Wu,Zhiqi Hu,Yang Sun,Kaitao Li
Introduction Androgenetic alopecia (AGA), the most common form of hair loss, lacks ideal therapies due to the limitations of current drugs. Natural compounds with low toxicity and good biocompatibility present promising alternatives. Ginkgolide B (GB), a bioactive component of Ginkgo biloba , possesses multiple biological activities, yet its efficacy and mechanism against AGA remain unexplored. Objectives This study aimed to investigate the hair growth-promoting effect of GB in a dihydrotestosterone (DHT)-induced hair loss model and to elucidate the underlying molecular mechanism. Additionally, a novel detachable microneedle delivery system was developed and evaluated to overcome GB's poor transdermal permeability, thereby enhancing its therapeutic efficacy. Methods The AGA microenvironment was first simulated using DHT-stimulated human dermal papilla cells (HDPCs) in vitro. The molecular mechanism by which GB improves the secretory function of HDPCs was investigated through network pharmacology, western blot, transmission electron microscopy, and immunofluorescence. Subsequently, a detachable microneedle system was designed, in which GB was encapsulated in poly (lactic-co-glycolic acid) (PLGA) microspheres and integrated with the sulfobutylether-β-cyclodextrin (SCD)-based matrix (GB@MS-MN). The therapeutic efficacy of this system was evaluated in a DHT-induced hair loss model. Results GB rescued DHT-induced dysfunction in HDPCs, reversing the aberrant secretion of hepatocyte growth factor (HGF) and dickkopf-1 (DKK1). Mechanistically, GB alleviated DHT-induced endoplasmic reticulum stress (ERS) in HDPCs by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. And GB promoted hair growth in DHT-induced hair loss mice. The GB@MS-MN system demonstrated excellent mechanical properties and targeted follicular delivery and showed superior hair growth promotion compared to free GB and minoxidil. It effectively suppressed follicular ERS, with no observed systemic toxicity. Conclusion In summary, this study confirms that GB protects HDPCs function by suppressing DHT-induced ERS through activation of the Nrf2/HO-1 pathway. Furthermore, a detachable microneedle delivery system based on a PLGA-SCD composite effectively overcomes the transdermal barrier of GB and demonstrates superior hair-promoting efficacy.
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Journal of Water Process Engineering
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2026
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IF 6.6
Yanhua Liu,Yunpeng Luo,Geoffrey I.N. Waterhouse,Zhiming Zhang,Liangmin Yu
The rational design of charge-transfer interfaces is essential for high-performance photoelectrocatalytic (PEC) wastewater remediation. Herein, a novel ternary n-n-p heterojunction electrode, titanium dioxide/NH 2 -MIL-125(titanium)/polyaniline (TiO 2 /Ti-MOF/PANI), was successfully fabricated via a two-step hydrothermal and chemical polymerization strategy, followed by electrophoretic deposition. The optimized electrode exhibited a superior Rhodamine B (RhB) degradation efficiency of 96.1% and a total organic carbon mineralization rate of 67.19% within 70 min under visible light with a −0.8 V bias, significantly outperforming the individual photocatalytic and electrocatalytic processes. The superior performance originates from the synergistic integration of the ternary components. Ti-MOF and PANI broaden the visible-light response, promoting the generation of photogenerated electron-hole pairs under visible-light irradiation. Within this heterostructure, PANI functions as a narrow-band-gap sensitizer and p-type hole-transport layer, while n-type Ti-MOF provides a continuous pathway for rapid interfacial charge transfer. Meanwhile, n-type TiO 2 serves as a robust electron-transport backbone and offers stable surface active sites for subsequent redox reactions. The resulting n-n-p heterojunction establishes an internal electric field that, in conjunction with the applied negative bias, accelerates charge-carrier migration and accumulation at the electrode surface, thereby facilitating RhB degradation. Furthermore, PANI acts as an efficient conductive bridge, shortening electron-transport distances and reducing interfacial resistance. Mechanistic insights from radical trapping and electron spin resonance analysis confirm that •O 2 − and •OH are the predominant reactive species driving the oxidative cleavage of the xanthene chromophore. Overall, this work provides valuable design principles for multi-component PEC electrodes, offering insights into efficient environmental remediation.
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Microstructures
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2026
·Vol. 6
·期 2
·N
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IF 8.5
Zichen He\u003Csup\u003E1,\u003C\u002Fsup\u003E,Xingyu Chen\u003Csup\u003E1,2,\u003C\u002Fsup\u003E,Faqiang Zhang\u003Csup\u003E1\u003C\u002Fsup\u003E,Zhengqian Fu\u003Csup\u003E1\u003C\u002Fsup\u003E,Xiangyu Meng\u003Csup\u003E3\u003C\u002Fsup\u003E,Dongxiao Fan\u003Csup\u003E4\u003C\u002Fsup\u003E,Jiawei Zhang\u003Csup\u003E1\u003C\u002Fsup\u003E,Mingsheng Ma\u003Csup\u003E1\u003C\u002Fsup\u003E,Yongxiang Li\u003Csup\u003E5\u003C\u002Fsup\u003E,Zhifu Liu\u003Csup\u003E1\u003C\u002Fsup\u003E
With the ongoing miniaturization of multilayer ceramic capacitors (MLCCs), there is an increasing demand for dielectric materials that simultaneously exhibit high dielectric constant, excellent DC-bias stability, and high reliability. To address this challenge, B-site Ca doping was employed to regulate the polar structure of BaTiO3-based ceramics. In this study, we systematically investigated the effects of Ca doping on the crystal structure, defects, and microstructure by varying the dopant concentration and occupancy behavior. The B-site Ca-doped BaTiO3 ceramics exhibit a pseudo-cubic structure, characterized by the coexistence of tetragonal and cubic phases. Ca2+ substitution for Ti4+ disrupts the long-range ferroelectric order, leading to the formation of polar nanoregions (PNRs) interconnected and embedded within a non-polar matrix. Defect analysis and studies on reducing atmosphere sintering reveal that oxygen vacancies are effectively localized by cation defects, thereby suppressing long-range conduction. These structural features synergistically result in a high dielectric constant, superior DC-bias stability, enhanced insulation resistance, and strong non-reducibility. This work provides fundamental insights into the microstructural design of BaTiO3-based ceramics and highlights their potential for high-reliability MLCC applications.
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Catalysts
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2026
·Vol. 16
·期 5
·377
·
IF 4.5
Sining Wei,Mahwish Aziz,Yilin Zhang,Jian Xiong,Cheng Cheng,Bin Wu
This study addressed the issue of insufficient activity in CALB lipase during the catalytic synthesis of key chiral intermediates for moxifloxacin. A structure-guided protein engineering strategy was employed to systematically modify its functional domains. Through molecular dynamics simulations of CALB-I189K, multiple regions exhibiting high conformational flexibility were preliminarily identified. Subsequently, by integrating 3D structural alignment with active site pocket distance analysis, the functionally most critical region (143–146) was selected. A site-directed saturation mutation library was constructed specifically targeting this region. Building upon the previously reported CALB-I189K, a mutant I189K/L144R/A146K was ultimately obtained through high-throughput screening combined with chiral HPLC validation. This mutant maintains excellent stereoselectivity (E = 206.52) while enhancing catalytic efficiency (kcat/Κm) to 273.73 min−1·mM−1, approximately 4.5-fold that of I189K. At a substrate concentration of 1 M, it achieves 50% conversion within 2.6 h, demonstrating kinetic resolution capabilities approaching industrial standards. Molecular simulation analysis indicates that the L144R and A146K mutations synergistically enhance catalytic performance primarily by optimizing spatial distances between catalytic residues. This study not only provides a high-performance catalyst for the efficient biosynthesis of moxifloxacin chiral intermediates but also offers new insights for enzyme rational design based on dynamic structural information.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Yanqing Yang,Yuchen Yang,Zhixian Du,Weike Zhang,Jin Liu
A Z-scheme BiOBr/COF-1 heterojunction was synthesized via a solvothermal method. • The catalyst exhibited enhanced visible-light absorption and charge separation. • A mechanism for the simultaneous removal of RhB and Cr(VI) was revealed. The construction of heterojunctions is commonly employed to boost the separation efficiency of photogenerated charge carriers and the overall photocatalytic performance. In this study, a novel Z -scheme BiOBr/COF-1 heterojunction photocatalyst was synthesized via a facile solvothermal method. Comprehensive characterization confirmed the effective formation of the heterojunction, which exhibited enhanced visible-light absorption and improved separation efficiency of photogenerated charge carriers. Compared with pristine COF-1 and BiOBr, the optimized BiOBr/COF-1 composite (BC-1) demonstrated superior photocatalytic activity for both rhodamine B (RhB) degradation and Cr(VI) reduction. Notably, the reduction efficiency of Cr(VI) was significantly enhanced in a coexisting system of RhB and Cr(VI). In addition, BiOBr/COF-1 exhibited good structural stability over multiple reaction cycles. This work provides an effective strategy for designing Z -scheme photocatalysts to treat complex wastewater containing organic and heavy metal pollutants. Download: Download high-res image (339KB) Download: Download full-size image
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JOURNAL OF POWER SOURCES
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2026
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IF 8.4
Yuntong Li,Cheng Liu,Hong Zhong,Wei Huang,Xiaodan Li,Xiahong Xu,Conghui Yuan,Lizong Dai
A facile strategy has been developed for preparing B, N, P co-doped hollow carbon spheres (BNP-HCSs) with adjustable shell thicknesses through a straightforward pyrolysis process of poly (styrene-co-(2-(dimethylamino)ethyl methacrylate))@boronate polymers. The shell thickness of the BNP-HCSs can be relatively controlled by manipulating the monomer concentration. The BNP-HCSs with a moderate shell thickness of 24 nm (BNP-HCS 24 ) exhibits a high capacitance of 357.4 F/g in a 1 M H 2 SO 4 electrolyte at 0.2 A/g. Furthermore, by analyzing the slopes of the discharge curves, we investigate the contributions of faradaic capacitance and electric double-layer capacitance (EDLC) to the total specific capacitance. The results indicate that faradaic capacitance is primarily linked to the effective utilization of heteroatoms, whereas EDLC capacitance correlates with the effective utilization of the BET surface area. The symmetrical two-electrode supercapacitor based on BNP-HCS 24 electrodes delivers an energy density of 8.16 Wh/kg at a power density of 125 W/kg. This study presents a valuable approach for fabricating heteroatom co-doped hollow carbon spheres with tunable shell thicknesses, offering a potential pathway to enhance supercapacitance performance through tailored carbon shell thicknesses. Moreover, the insight into the contributions of EDLC and faradaic capacitance is pivotal for the future development of heteroatom-doped carbon materials for supercapacitors.
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CERAMICS INTERNATIONAL
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2026
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IF 6
Yuhang Zhang,Yanzhao Zhang,Meiling Yang,Kunpeng Lin,Zhe Zhao,Ning Xie,Guoxiang Zhou,Zhihua Yang,Dechang Jia,Yu Zhou
Microwave dielectric ceramics with high dielectric constant and low dielectric loss are essential for miniaturized communication devices, yet their further optimization is hindered by inherent trade-offs among intrinsic properties. While A-site rare-earth doping or B-site complex-ion doping has been explored to enhance perovskite performance, such approaches still encounter limitations stemming from suboptimal selection of A-site and B-site ions. Here, we fabricating B-site doped and A/B-site co-doped SrTiO 3 -based microwave dielectric ceramics selectively using Ga/Ta complex ions and Ce ions, respectively. Phase analysis confirms that both materials retain a single-phase cubic perovskite structure. Notably, the B-site doped ceramic develops exceptionally large grains, which elevate its quality factor ( Q×f ) beyond 10,000 GHz despite incomplete densification, underscoring the dominant role of grain size. With Ce incorporation, a dense microstructure is achieved, accompanied by a marked reduction in Ti 3+ content. Crucially, DFT calculation verifies that the valence transition of Ce, in synergy with the Ga/Ta complex ions, creates a cooperative electron-pinning effect that localizes free electrons and markedly suppresses Ti 4+ reduction. This synergistic mechanism boosts the Q×f value to over 15,000 GHz. Furthermore, by coordinating the reduction in ionic polarizability with enhanced octahedral distortion, the dielectric constant ( ε r ) is maintained above 120 while the temperature coefficient ( τ f ) is drastically improved from +1431 ppm/°C to +336 ppm/°C. Therefore, at a Ce doping level of 0.25, the co-doped material exhibits outstanding comprehensive performance: ε r = 128.8, Q×f = 15,919 GHz, and τ f = +381 ppm/°C. This study demonstrates the considerable potential of a rational co-doping strategy for enhancing material properties.
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ADVANCED MATERIALS
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2026
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IF 29.1
Yuting Ren,Chenlong Su,Chao Qiu,Ping Zhu,Xuan Li,Lihui Yuan,Yihan Yang,Ying Zhao,Dujin Wang,Xia Dong
Developing transparent materials combining superior optical and mechanical properties with robust service stability remains a significant challenge. Herein, an amorphous alicyclic poly(ether-b-amide) (PEBA) copolymer is synthesized by incorporating bis(4-aminocyclohexyl) methane (PACM) into the hard segment (HS) to suppress crystallization, combined with low-molecular-weight poly(tetramethylene ether glycol) (PTMEG) as the soft segment (SS) to enhance segmental compatibility. Such molecular design results in a weakly microphase-separated structure with diffused boundaries between the nanometer microdomains. This “interface-erasing” strategy yields a hot-pressed film with a miscible-dominated morphology with phase regions ranging from 50 to 100 nm, significantly smaller than visible-light wavelengths. Finite element analysis (FEA) simulations further demonstrate that these small phase regions, together with the miscible phase acting as a refractive index (RI) buffer, collectively reduce off-axis scattering, achieving excellent optical clarity (91.1% transmittance, 5.80% haze). The material also shows robust mechanical properties (>30 MPa, >1000% elongation), low-temperature impact resistance, service reliability, solvent resistance, and damping performance. By integrating multiscale characterization and theoretical modeling, this work provides a simple yet effective molecular design strategy and a multiscale mechanistic insight for transparent high performance elastomers, promising for applications as transparent protective layers.
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PubMed
高影响因子
SOLID STATE SCIENCES
·
2025
·
IF 3.3
Huadong Liu,Xiaoyu Sun,Jingliang Cheng,Zhonghao Zhao,Cong Zhang
Bi 2 MoO 6 , a Bi-based semiconductor catalyst, exhibits effective degradation of organic pollutants. Nevertheless, its photocatalytic performance is constrained by several limitations, such as inadequate sunlight absorption, poor charge mobility, and fast charge carrier recombination upon photoexcitation. In this research, we successfully synthesized a Bi 2 MoO 6 composite modified with carbon quantum dots (CQDs), which demonstrates a significant improvement in photocatalytic performance. A series of characterizations and photocatalytic experiments were performed on the synthesized CQDs/Bi 2 MoO 6 samples. Degradation experiments revealed that under simulated sunlight, the CQDs/Bi 2 MoO 6 composite achieved a 95 % degradation rate for Rhodamine B (RhB) within 70 min, with a kinetic constant of 0.03994 min −1 . In comparison, the undoped Bi 2 MoO 6 sample degraded only 46 % of RhB under the same conditions, exhibiting a kinetic constant of 0.00658 min −1 . The primary reactive species, ·O 2 − and h + , were unequivocally identified through combined ESR spectroscopy and radical scavenging experiments as the drivers of pollutant degradation. Furthermore, after four consecutive reaction cycles, the catalyst maintained 90.05 % of its initial activity, confirming its high stability. In summary, this study successfully developed a CQDs-doped Bi 2 MoO 6 composite photocatalyst, offering a promising strategy for advancing photocatalysis research.
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Analytical Methods
·
2025
·
IF 2.6
Jia Chen,Longtao Jin,Xinyan Zhang,Qiaoqiao Shi
As an essential trace nutrient, vitamin B 12 (VB 12 ) plays a crucial role in maintaining normal metabolic processes and physiological functions in the human body, particularly in neurological development, overall growth, and energy metabolism in children. Therefore, the accurate and sensitive determination of VB 12 levels in blood is of great significance for monitoring and evaluating children's growth and developmental status. In this study, a surface-enhanced Raman scattering (SERS) aptasensor was designed for ultrasensitive detection of VB 12 in blood samples. The VB 12 aptamer was modified on the surface of Fe 3 O 4 @Au nanoparticles (Fe 3 O 4 @Au NPs) to serve as the capture probe. Meanwhile, complementary DNA (cDNA) was immobilized on the surface of gold nanoparticles (Au NPs) functionalized with the Raman reporter molecule 5,5'-dithiobis (2-nitrobenzoic acid) (DTNB), serving as the signal probe. In this sensor, the VB 12 aptamer hybridizes with the cDNA, forming a dual-layer core-satellite plasmonic nanostructure (Fe 3 O 4 @Au NPs-Apt/ Au NPs-DTNB-cDNA). Quantitative detection was achieved by measuring the SERS signal intensity of DTNB at 1033 cm -1 . Based on this design, the developed aptasensor exhibits high sensitivity toward VB 12 with a detection limit as low as 0.73 pg/mL. Furthermore, the SERS aptasensor demonstrates excellent specificity and stability when applied to the detection of VB 12 in blood samples.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Haiyan Chen,Haibo Xu,Yeyin Li,Zhibin Li,Xin Wang,Bo Jiang,Rongshun Lai,Wenbin Fan,Chuntao Xiang,Zhi Yang,Xiao Chi,Qiang Ma
Selective chlorination has been proven to be an energy-efficient and environmentally friendly method for recycling rare earth elements (REEs) from Nd-Fe-B waste. However, little attention has been paid to the in-depth study of Nd-Fe-B sludge chlorination until now. In this work, four isoconversion methods combined with an unreacted shrinkage core model were employed for the first time to investigate the kinetic behavior of the chlorination reaction between FeCl 3 and Nd-Fe-B sludge. Through thermodynamic calculations, TG-DSC, SEM-EDS, and XRD analysis, the chlorination process and phase transformation behavior of Nd-Fe-B sludge were elucidated. The results show that under optimal conditions (350 °C, FeCl 3 /RE=3:1, 2 h), the RE components in Nd-Fe-B sludge are selectively chlorinated to RECl 3 , avoiding the formation of REOCl, while the iron components primarily exist in the leaching residue as Fe 2 O 3 or FeOCl. And 97.32 % of REEs are selectively extracted into the leachate, while the iron leaching rate is only 4.02 %. Besides, the STA method is the most accurate, yielding E α-STA and A values of 75.01 kJ/mol and 2.6 × 10 6 min −1 , respectively. The reaction control mechanism was analyzed in three steps. In Step 1 (0.05 < α < 0.63) and Step 2 (0.63 < α < 0.75), the diffusion reaction mechanism controls the overall reaction, In Step 3 (0.75 < α < 0.95), the nucleation reaction takes over the control, which provides a good explanation for the change in E α-STA . However, the control step of the entire chlorination reaction is dominated by the internal diffusion process.
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