TALANTA
·
2021
·
IF 6.057
Yunhe Yang,Yang Yang,Shuangshuang Wang,Huihui Li,David D.Y. Chen
The formation of G-quadruplex (G4) structures in oncogenic G-rich promoter regions are implicated in their biological functions, especially the inhibition of transcription. The binding of cations is thought to contribute to the stabilization of the G4 formation and competition against the duplex formation in the genomic sequence. Furthermore, it might affect the recognition of DNA-binding proteins. Therefore, measuring the interaction between G4 DNA and cations in a free solution environment is critical for evaluating G4 DNA biological functions. However, how binding to cations (K + and NH 4 + ) affects the folding equilibrium of the G4 structure remains unclear. In this work, a Taylor dispersion analysis (TDA) method using a capillary electrophoresis (CE) instrument was established for the quantitative characterization of the cation-dependent G4 formation in the human c-KIT oncogene promoter region, as well as diffusivities and hydrodynamic radii of DNA variations before and after folding. Our results showed that both K + and NH 4 + can induce the random-coiled c-KIT DNA to unfold and form a more unstretched intermediate state and then fold into tightly structured G4s with smaller size. The G4 size induced by NH 4 + was smaller than that induced by K + ions, though these two cations induced the c-KIT G4 DNA formation with similar binding constants (order of magnitude around 10 6 M −1 ). The TDA method can be widely used for rapid structural analyses of trace amounts of DNA mixtures, which effectively differentiate DNA variations or DNA-ligand complex conformations.
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高影响因子
Scientific Reports
·
2021
·Vol. 11
·期 1
·1-10
·
IF 4.38
Yang Kun,Xu Jialu,Zhang Ming,Lin Daohui
Biochar supported nanoscale zero-valent iron (NZVI/BC), prepared commonly by liquid reduction using sodium borohydride (NaBH 4 ), exhibits better reduction performance for contaminants than bare NZVI. The better reducing ability was attributed to attachment of nanoscale zero-valent iron (NZVI) on biochar (BC) surface or into the interior pores of BC particles due to observations by scanning electron microscopy (SEM) and plan transmission electron microscopy (P-TEM) techniques in previous studies. In this study, cross-sectional TEM (C-TEM) technique was employed firstly to explore location of NZVI in NZVI/BC. It was observed that NZVI is isolated from BC particles, but not located on the surface or in the interior pores of BC particles. This observation was also supported by negligible adsorption and precipitation of Fe 2+ /Fe 3+ and iron hydroxides on BC surface or into interior pores of BC particles respectively. Precipitation of Fe 2+ and Fe 3+ , rather than adsorption, is responsible for the removal of Fe 2+ and Fe 3+ by BC. Moreover, precipitates of iron hydroxides cannot be reduced to NZVI by NaBH 4 . In addition to SEM or P-TEM, therefore, C-TEM is a potential technique to characterize the interior morphology of NZVI/BC for better understanding the improved reduction performance of contaminants by NZVI/BC than bare NZVI.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Chen Yang,Xijun Xu,Wajid Ali,Yaojin Wang,Yiping Wang,Ying Yang,Lang Chen,Guoliang Yuan
Ultrasonic sensors are widely applied in industries near room temperature; however, their application at high temperature is still a challenge mainly due to the lack of high-performance piezoelectric ceramics. Here, the 0.364BiScO3–0.636PbTiO3–0.005CaTiO3 ceramic exhibits excellent piezoelectric performances at 20–440 °C. Its piezoelectric coefficient d33 increases from 475 pC/N at 20 °C to 853 pC/N at 360 °C, and then it gradually decreases to 669 pC/N at 440 °C. Furthermore, the planar electromechanical coupling factor kp gradually increases from 0.59 at 20 °C to 0.67 at 200 °C, and then it remains at a stable value of 0.65–0.67 at 150–350 °C. These achievements are because the ceramic morphotropic phase boundaries have a flat Gibbs free energy versus polarization curve and a wide temperature range. Since the piezoelectric ceramic shows satisfactory piezoelectric properties at 20–440 °C, the corresponding ultrasonic sensors can in situ monitor many high-temperature devices, such as engines, wheels, drills, boilers, etc.
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DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 24
·8457-8466
·
IF 4.39
Shao Yan,Yanjie Liang,Yafei Chen,Jingwei Liu,Dongxun Chen,Zhengwei Pan
Visible and infrared persistent phosphors have gained considerable attention in recent years and are being widely used as glow-in-the-dark materials in dark environments. In contrast, the progress in persistent phosphors emitting at the other end of the spectrum, i.e., the shorter-wavelength ultraviolet-C (UVC; 200–280 nm), is rather slow. Here we report the design and synthesis of a well-performing Pr3+-doped UVC emissive persistent phosphor, Lu2SiO5:Pr3+, which exhibits intense UVC persistent luminescence peaking at 270 nm and a long persistence time of more than 12 h after excitation with a 254 nm UV lamp. Besides, the UVC persistent luminescence of a UV pre-irradiated sample can be repeatedly revived after repeated short-illumination with low-energy white light via a process called photostimulated persistent luminescence. Owing to the distinct spectral features of UVC light and the self-sustained luminescence properties, the UVC persistent luminescence of the Lu2SiO5:Pr3+ persistent phosphor can be clearly monitored and imaged using a corona camera in bright environments including direct sunlight and indoor light. The Lu2SiO5:Pr3+ persistent phosphor is expected to find promising applications in the covert optical tagging field.
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NANOTECHNOLOGY
·
2021
·Vol. 32
·期 38
·385602
·
IF 3.874
Ximing Zhang,Jingyu Wang,Yang Fan,Hengdong Ren,Zhenying Liu,Yanfen Wang,Yin Liu,Hongcun Bai,Lingbing Kong
In this work, we prepared NiCo alloy/C with rhombic dodecahedron structure and superior microwave absorption performance by using ZIF-67 as the raw material. The rhombic dodecahedron NiCo alloy/C was with rough particles on the surface was photographed by field emission scanning electron microscopy. By adjusting the doping amount of Ni and the temperature of pyrolysis, improved the impedance matching of NiCo alloy/C. Specifically, NiCo alloy/C exhibits a minimum reflection loss of −65.48 dB at 13.48 GHz, while the thickness is 1.63 mm. Defects introduced in the Ni doping process and the special rhombic dodecahedral structure can cause multiple loss mechanisms. Therefore, this NiCo alloy/C composite has the potential to be a potential microwave absorber material with lightweight and high microwave absorption properties.
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Yongpeng Wang,Yingyuan Zhang,Jianan Tao,Wei Sun,Mengzhu Liu,Xuejun Cui,Haibo Zhang,Zhenhua Jiang
High-performance electromagnetic (EM) wave absorption property could be achieved by architecture design of nanomaterials . Herein, two layer hybrid Co 0.2 Fe 2.8 O 4 /carbon nanofibers with porous three-dimensional (3D) hierarchical structure were synthesized successfully through facile electrospinning, carbonization and mild chemical treatment. The Co 0.2 Fe 2.8 O 4 particles grew along the carbon nanofibers , forming the enhanced heterogeneous interfaces and high specific areas. As expected, the EM wave absorbent showed an excellent absorbing capability. The composites achieved a maximum reflection loss (RL) of −43.45 dB at 11.1 GHz with thickness of 3.0 mm. More importantly, the effective bandwidth (RL ≤ −10dB) was 5.85 GHz, covering 30% of the entire measured bandwidth. The absorption intensity and bandwidth were superior to other typical CoFe-based composites. The intrinsic mechanism of the absorption revealed that the polarization losses, magnetic losses, magnetic natural resonance and exchanged resonance losses contributed to the high-performance microwave absorption. Moreover, good impedance matching and complex transmission paths that generated from unique porous network also played an important role. This study is expected to guide future exploration on designing and synthesizing high performance EM wave absorbents.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Wenkai Huang,Fuhua Xu,Xiang Liu
Sodium borohydride has been widely regarded as a promising hydrogen carrier owing to its greatly hydrogen storing capability (10.8 wt%), high weight density and excellent stability in alkaline solutions. Herein, we first design and synthesize a series of bimetallic M-Ru/C nanocomposites (including Fe–Ru/C, Co–Ru/C, Ni–Ru/C and Cu–Ru/C), via simply alloying of commercial Ru/C with nonprecious metal, for superior H 2 evolution from the NaBH 4 hydrolysis. The result exhibits that H 2 generation is synergetically improved by alloying Ru/C with Co or Ni, while it is hindered by alloying Ru/C with Fe or Cu. Indeed, Co–Ru/C presents the highest efficient catalytic activity for H 2 generation, with the TOF of 117.69 mol(H 2 )·mol Ru −1 ·min −1 , whereas Ru/C is only 57.08 mol(H 2 )·mol Ru −1 ·min −1 . In addition, the TOF of Co–Ru/C reaches to 436.51 mol(H 2 )·mol Ru −1 ·min −1 (96.7 L(H 2 )·g Ru −1 ·min −1 ) in the presence of NaOH.
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PHYTOMEDICINE
·
2021
·
IF 5.34
Xiaohan Wei,Baoping Zhang,Xiao Liang,Changshun Liu,Ting Xia,Yingjie Xie,Xue Deng,Xiaomei Tan
ABSTRACT Background Allergic rhinitis (AR) is an inflammatory, immunoglobulin E (IgE)-mediated disease characterized by the typical symptoms of sneezing, rhinorrhea , nasal itching , and congestion. Higenamine (HG) is a plant-based alkaloid, possesses a wide range of activities, including vascular and tracheal relaxation, antioxidative, antiapoptotic , anti-inflammatory, and immunomodulatory activities. So far, the effect and the underlying mechanism of HG on AR have not been studied. Hypothesis/Purpose The purpose of this study was to evaluate the effects of HG on AR and investigate its underlying mechanism. Methods The effects of HG on AR were evaluated in an ovalbumin-induced AR mouse model. Network pharmacology-based methods such as target prediction, protein-protein interaction (PPI) network analysis, pathway analysis, and molecular docking were used to identify the likely HG targets. Finally, we validated the mechanism of action of HG through its effects on these targets in human nasal epithelial cells (HNEpCs). Results Oral administration of 30, 60, and 120 mg/kg HG significantly alleviated rubbing and sneezing in AR mice and attenuated histopathological changes in the lung and nasal tissues . Additionally, HG reduced the levels of IgE, histamine, and IL-4 in the serum of AR mice, and regulated imbalance in Th1/Th2 cells. Using network pharmacology-based methods, we identified 29 HG targets related to AR. These targets are mainly involved in the PD-L1, relaxin, estrogen, HIF-1, Th1 and Th2 cell differentiation , T cell receptor , and the Th17 cell differentiation signaling pathways . Molecular docking showed that HG may well be suited to the receptor binding pockets of key target AKT1 , EGFR, c-Jun, NOS2 , and JAK2 . In HNEpCs, HG inhibited the histamine-induced mRNA expression and secretion of interleukin (IL)-6, and IL-8, as well as the expression of MUC5AC and the phosphorylation of NF-κB. Moreover, HG affected the changes of AKT1, EGFR, c-Jun, iNOS, and JAK2 induced by histamine. Conclusion Overall, our results suggest that HG may alleviate AR by activating AKT1 and suppressing the EGFR/JAK2/c-JUN signaling. HG, therefore, has great potential as a therapeutic agent for the treatment of AR.
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CORROSION SCIENCE
·
2021
·
IF 7.205
Jian Zhang,Jin Huang,Ruxia Liu,Guoqiang Luo,Qiang Shen
Immersion tests of AlN in LiF-LiCl-LiBr-Li salt have been performed at 500 °C to study the corrosion behaviour of AlN. The results show that AlN initially corroded at a higher rate (2⋅10 −5 mg/(mm 2 ⋅h)) during 0−50 h than during 50−300 h (6⋅10 -6 mg/(mm 2 ⋅h)) because the formation of an alumina corrosion layer protected the AlN from further corrosion. The addition of metallic Li at low concentrations (<0.1 wt. %) to the molten salt inhibited the corrosion of AlN by preferentially depleting oxygen impurities, while Li at high concentrations (>0.1 wt. %) accelerated corrosion by reacting with YAG in AlN.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Xin Ge,Weili Song,Xinzhi Chen,Chao Qian,Shaodong Zhou,Xuemin Liu
A tandem process of micellar catalysis and cloud point extraction (CPE) is developed for copper-catalyzed Ullmann C-S coupling reactions in water. The functional nonionic surfactant, amine terminated polyether M2070, affords nano-micelle environment in the aqueous system; the latter splits to two phases above the cloud point temperature (CPT). The nature of the micellar catalysis in M2070 aqueous was investigated by DLS, EDS, XPS, IR, TEM and 1 H NMR. M2070 was verified to provide nano-space for encapsulation and aggregation of the substrates. More importantly, the metallic micelle formed by M2070 chelating copper was identified. It is noteworthy that excellent productivity in pre-micellar catalysis of C-S coupling reactions was obtained with good tolerance of substrate. Finally, the water-micelle system was separated into two phases above the CPT thus to achieve the product separation. Furthermore, the M2070/water system can be recycled and reused.
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Reaction Kinetics Mechanisms and Catalysis
·
2020
·Vol. 131
·期 2
·997-1007
·
IF 1.52
Li Yan,Jian Li-Juan,Li Xue,Liu Fang-Ting,Dong Xiao-Fei,Wang Jian,Zhao Yun,Wang Cheng-Wei
A new sphere-like nano-heterostructure of Cu 3 SnS 4 @C (CTS@C) was well designed and fabricated by two-step hydrothermal route, which is ideally suited for synergistic physical adsorption and photodegradation of anionic dye. Compared to the pure C or CTS nanospheres, CTS@C nano-heterostructure has smaller surface area but exhibits excellent performance. It possesses high adsorption efficiency of 97.04% for removal of methyl orange (MO) at pH 5.5. And also, the superior synergistic adsorption and photodegradation performance makes it exhibit 99.38% degradation efficiency within 210 min at pH 7.5, which is about 1.8 times higher than that of simplex adsorption (56.23%). These might be attributed to the higher light harvesting, effective charge separation, lower charge-transfer resistance and high photocurrent response properties of CTS@C nanostructures. Moreover, the CTS@C nano-heterostructured photocatalyst can effectively avoid surface passivation during the process of synergistic adsorption and photodegradation, and be easily regenerated from the reaction system for recycling, suggesting a promising candidates for synergistic adsorption and photocatalysis applications.
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APPLIED CATALYSIS A-GENERAL
·
2020
·
IF 5.006
Wenyan Wang,Yunlan Xu,Dengjie Zhong,Nianbing Zhong
Removal of complexation metal from plating effluents is always a problem. In this work, a core-shell structure zero-valent iron@nitrogen/graphite carbon nitride doped carbon (ZVI@C-N/g-C 3 N 4 ) composite was prepared and used to activate peroxymonsulfate (PMS) to treat complexation nickel simulated wastewater. Compared with ZVI, ZVI@C-N/g-C 3 N 4 significantly enhanced the efficiency and repeatability of PMS activation. For 45 min treatment, the removal efficiency of 50 ppm Ni-EDTA and Ni-citrate simulated wastewater reached 95.8 % and 100 %, respectively. The excellent performance of ZVI@C-N/g-C 3 N 4 is attributed to that the amino groups of nitrogen in C-N/g-C 3 N 4 shell can regulate the transmission rate of electrons released from ZVI core by adjusting the transmission rate of H + , so as to improve the electron utilization efficiency of PMS activation.
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危险品化学品经营许可证（带存储）