Coatings
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2020
·Vol. 10
·期 10
·936
·
IF 2.436
Ting Liu,Jingfan Wang,Fumin Chi,Zhankun Tan,Liu Liu
The effects of fennel essential oil (FEO) and peppermint essential oil (PEO) on chitosan-based films were evaluated in this study. The results showed that the addition of FEO and PEO slightly increased the density and thickness, while significantly decreasing the moisture content, water swelling, and solubility properties. The color values (L,a,b, ΔEand whiteness index (WI)) of the composite films containing FEO and PEO changed obviously with a tendency toward yellowness, which was beneficial in resisting food decomposition caused by ultraviolet light. The differential scanning calorimetry (DSC) and fourier-transform-infrared (FTIR) results indicated that the addition of FEO and PEO affected the structure of the chitosan films, while the interaction between the chitosan and polyphenols in FEO and PEO established new hydrogen bonds and improved the thermal stability. The environmental scanning electron microscopy (ESEM) illustrated that the surfaces of the composite films containing FEO and PEO were smooth, but the cross-section was rougher than in pure chitosan film. Furthermore, the composite films containing FEO and PEO exhibited prominent antioxidant activity. In short, the novel active chitosan-based films with incorporated FEO and PEO present broad application prospects in fresh-cut meat or vegetable packaging.Keywords:active packaging;composite film;fennel essential oil;peppermint essential oil;antioxidant activity
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Zhihui Chai,Chenglin Li,Yuan Zhu,Xiaorong Song,Manyi Chen,YuLing Yang,Dong Chen,Xinquan Liang,Junhua Wu
The presence of phenolic substances in sugarcane juice seriously affects the color value of sugar products. Magnetic chitosan (MCS) was prepared using an ionic cross-linking technique, and then was modified with arginine to prepare arginine-modified magnetic chitosan (AMCS) for use as a new sucrose clarifying adsorbent. Gallic acid (GA) is a representative phenolic substance and was used to test the adsorption properties of the prepared AMCS. The adsorption kinetics indicated that the adsorption of GA on AMCS conformed to the pseudo-second-order model, the main adsorption mechanism was chemisorption. The Langmuir equation fit well and with good linearity, and indicated a maximum adsorption capacity of 48.38 mg g −1 . The adsorption process was consistent with monolayer adsorption and spontaneous endothermic process. The prepared AMCS exhibited excellent regenerability, and can effectively remove GA in sugarcane juice to improve product safety.
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CARBOHYDRATE POLYMERS
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2020
·
IF 7.182
Dong-Wei Wang,Shu-Juan Li,Xue-Ying Tan,Jin-Hui Wang,Ying Hu,Zeng Tan,Jing Liang,Jing-Bo Hu,Yan-Guo Li,Yu-Fen Zhao
Acute kidney injury (AKI) is a common and serious clinical syndrome of acute renal dysfunction in a short period. One of therapeutic interventions for AKI is to reduce ROS massively generated in the mitochondria and then ameliorate cell damage and apoptosis induced by oxidative stress. In this study, stepwise-targeting chitosan oligosaccharide, triphenyl phosphine-low molecular weight chitosan-curcumin (TPP-LMWC-CUR, TLC), was constructed for sepsis-induced AKI via removing excessive ROS in renal tubular epithelial cells. Benefiting from good water solubility and low molecular weight, TLC was rapidly and preferentially distributed in the renal tissues and then specifically internalized by tubular epithelium cells via interaction between Megalin receptor and LMWC. The intracellular TLC could further delivery CUR to mitochondria due to high buffering capacity of LMWC and delocalized positive charges of TPP. Both in vitro and in vivo pharmacodynamic results demonstrated the enhanced therapeutic effect of TLC in the treatment of AKI.
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CARBOHYDRATE POLYMERS
·
2020
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IF 7.182
Wenbo Zhang,Henghui Deng,Lijuan Xia,Lan Shen,Chaoqun Zhang,Qiming Lu,Shaolong Sun
A series of vegetable oil-based waterborne polyurethane composites were prepared through construction of novel semi-interpenetrating polymers network using carboxymethyl chitosan (CA) as the secondary polymer phase. The effects of CA contents on storage stability, and particle size distribution of the composite dispersions and thermal stability, mechanical properties and surface wettability of composite films were investigated and discussed. The results showed that the composite dispersions displayed excellent storage stability and the biomass contents of resulting films were high up to 80 %. A significant increase in crosslinking density and glass transition temperature of the composite films were observed as the CA contents increased, which was attributed to the increasing hard segment of films and strong hydrogen bonding interaction between polyurethanes and CA. This work provided a simple method to tailor the performance of environmentally friendly vegetable oil-based waterborne polyurethane, which could find application in the field of coatings, adhesives, ink and so on.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2020
·Vol. 138
·期 12
·50065
·
IF 2.52
Jingqi Luo,Chuanjie Fan,Xiaodong Zhou
A new type of polydopamine functionalized graphene oxide/carboxymethyl chitosan (DGO/CMC) composite aerogels was synthesized via sol–gel once-forming self-assembly and lyophilization. Polydopamine (PDA) on the surface of GO nanosheets replaced those traditional crosslinking agents to connect CMC chains via hydrogen bonding for the establishment of 3D porous aerogels. With the increasing proportion of CMC, the microstructure of aerogels changed from small pores to large plate-bridge-like pores. In addition, their maximum compressive strengths were 6.767, 11.94, and 16.98 MPa under 90% compressions, respectively, which increased in accordance with CMC content. Furthermore, the adsorption system of the aerogels was simulated well by the pseudo second-order kinetic model and the Langmuir isotherm model, with maximum mass adsorption capacities of 170.3, 186.8, and 312.8 mg/g for Cu 2+ , Ni 2+ , and Pb 2+ ions, respectively. These composite materials have potential applications for water purification because of their simple and efficient synthesis and excellent recyclability and reusability.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Zichao Yin,Xiaojun Sun,Mutai Bao,Yang Li
Hydrophobic/oleophilic absorbents have been largely studied and used in recovering spilled oil. However, they still suffer from several drawbacks and two of them are poor biocompatibility and hard to thoroughly rinse. In order to address these problems, here a hydrophobic magnetic chitosan-based aerogel is fabricated via electrostatic interactions between chitosan (CS), itaconic acid (IA) and Fe 3 O 4 nanoparticles and dip-coating in ethanol solution of Candelilla wax (CW). Due to the interconnected porous structure of chitosan-based aerogel, the magnetism of Fe 3 O 4 nanoparticles and the hydrophobicity of CW, the prepared aerogel exhibits high absorption capacities (from 17.7 to 43.8 g/g) towards various types of organic liquids, excellent magnetic controllability with saturation magnetization of 15.93 emu/g and good water repellency with water contact angle (WCA) of 147.9°. In addition, the aerogel can also continuously separate immiscible oil/water mixtures and water-in-oil emulsions as the form of filter. More significantly, the absorbed organic liquids can be completely recovered by simply placing the aerogel in water solution of IA at 75 °C, which can avoid cleaning agent consumption. As a consequence, this renewable, biodegradable and eco-friendly oil scavenger presents a bright prospect in practical applications.
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CARBOHYDRATE POLYMERS
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2020
·
IF 7.182
Chao Xu,Shui Guan,Jianqiang Xu,Weitao Gong,Tianqing Liu,Xuehu Ma,Changkai Sun
In this study, protocatechuic acid (PCA) was grafted onto carboxymethyl chitosan (CMCS) via EDC/NHS to improve the antioxidant effect. The grafting ratio of PCA-g-CMCS conjugates could be controlled by adjusting the pH value and feed ratio of raw materials. The conjugates exhibited similar pH sensitivity to CMCS and showed dramatic enhancements of DPPH and ABTS radicals scavenging activities, total antioxidant capacity, reducing power, and Fe 2+ -chelating activity. Three-dimensional porous PCA-g-CMCS hydrogel was prepared by lyophilization and secondary cross-linking. The shaped hydrogel preserved its antioxidant activity, and the sustained release of PCA-containing degraded fragment from biodegradable hydrogel could be achieved with the aid of lysozyme in vitro (15 days). PCA-g-CMCS hydrogel also showed excellent biocompatibility and protective effect on H 2 O 2 -induced oxidative damage in SH-SY5Y cells. These results suggested that PCA-g-CMCS conjugates and its hydrogel would appear to be a promising oxidation-resistant material for applications such as drug release and tissue engineering.
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ACS Applied Materials & Interfaces
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2020
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IF 8.758
Yinying Sheng,Junjie Yang,Xueyang Zhao,Hui Liu,Shaogang Cui,Lianxi Chen,Rong Zeng,Xiaojian Wang,Chi-Hsien Huang,Wei Li
Zinc (Zn) alloys are promising alternatives to magnesium (Mg)- and iron (Fe)-based alloys because of their moderate corrosion rate and superior biocompatibility. To reduce the mass release of Zn2+ and improve the biocompatibility of Zn implants, the biomimetic zwitterionic polymer layer (phosphorylcholine chitosan—PCCs) was immobilized on the plasma-treated Zn1Mg surface. It is the chemical bonds between the −NH2 groups of the PCCs chain and O–C═O (C═O) groups on the plasma-treated Zn1Mg (Zn1Mg-PP) that contributes to the strong bonding strength between the film and the substrate, by which the PCCs (approx. 200 nm thick) layer can bear a 5.93 N normal load. The electrochemical impedance spectroscopy (EIS) results showed that the PCCs layer remarkably increased the resistance against corrosion attack, protecting substrates from over-quick degradation, and the protective effect of the layer with a thickness of 200 nm lasts for about 24 h. The corrosion products of Zn1Mg-PP-PCC in NaCl solution were determined as Zn5(OH)8Cl2·H2O and Zn3(PO4)2. Besides, the bulk Zn1Mg can trigger more aggressive macrophage activity, while the surface of Zn1Mg-PP and Zn1Mg-PP-PCC and their corrosion products (Zn3(PO4)2) tend to promote the differentiation of macrophages into the M2 phenotype, which is beneficial for implant applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Yingbi Chen,Jiali Tang,Shixing Wang,Libo Zhang
A chitosan-based adsorbents (CS-Ninhydrin) was prepared by grafting ninhydrin for Pb(II) ions adsorption. SEM-EDS, XRD and FTIR analysis were used to characterize the synthesized CS-Ninhydrin. The static adsorption experiments showed that CS-Ninhydrin had a good removal rate for Pb(II) ions in a wide range of pH 3 to 7, quickly reached equilibrium (120 min) and had a higher adsorption capacity (196 mg/g). Pseudo second-order and Langmuir models showed that the adsorption process of Pb(II) by CS-Ninhydrin was a single-layer chemical adsorption. Temperature experiments showed that the reaction was a spontaneous exothermic process. In the wastewater experiment, CS-Ninhydrin showed an excellent selectivity to Pb(II) ions. The reusability of CS-Ninhydrin was perfect after five adsorption-desorption cycles. The main adsorption mechanism was the chelating and electrostatic action between N and O groups in CS-Ninhydrin and Pb(II) ions. Therefore, the new adsorbent CS-Ninhydrin was expected to promote the wide application of chitosan in Pb(II) adsorption.
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MOLECULES
·
2021
·Vol. 26
·期 3
·560
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IF 4.412
Wei Zhou,Ce Cheng,Li Ma,Liqiang Zou,Wei Liu,Ruyi Li,Yupo Cao,Yuhuan Liu,Roger Ruan,Jihua Li
There is growing interest in developing biomaterial-coated liposome delivery systems to improve the stability and bioavailability of curcumin, which is a hydrophobic nutraceutical claimed to have several health benefits. The curcumin-loaded rhamnolipid liposomes (Cur-RL-Lips) were fabricated from rhamnolipid and phospholipids, and then chitosan (CS) covered the surface of Cur-RL-Lips by electrostatic interaction to form CS-coated Cur-RL-Lips. The influence of CS concentration on the physical stability and digestion of the liposomes was investigated. The CS-coated Cur-RL-Lips with RL:CS = 1:1 have a relatively small size (412.9 nm) and positive charge (19.7 mV). The CS-coated Cur-RL-Lips remained stable from pH 2 to 5 at room temperature and can effectively slow the degradation of curcumin at 80 °C; however, they were highly unstable to salt addition. In addition, compared with Cur-RL-Lips, the bioavailability of curcumin in CS-coated Cur-RL-Lips was relatively high due to its high transformation in gastrointestinal tract. These results may facilitate the design of a more efficacious liposomal delivery system that enhances the stability and bioavailability of curcumin in nutraceutical-loaded functional foods and beverages.Keywords:liposomes;chitosan;curcumin;rhamnolipids;stability;in vitro digestion
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ACS Biomaterials Science & Engineering
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2020
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IF 4.152
Lei Liu,Yali Miao,Xuetao Shi,Huichang Gao,Yingjun Wang
Phosphorous-containing biopolymers have been applied to expedite the regeneration of damaged bone tissue by stimulating the function of phosphorous groups in natural bones. However, the underlying mechanism of phosphorous-containing biopolymers in promoting osteogenic differentiation is unclarified. Herein, we synthesized phosphorylated chitosan hydrogels by incorporating phosphocreatine into chitosan molecular chains under mild conditions. The introduction of phosphate groups improved properties of protein adsorption and calcium deposition without affecting the morphology of hydrogels. Our results showed that phosphorylated chitosan hydrogels could not only promote alkaline phosphatase activity and mineralization but also upregulate the expression of osteogenic-related genes and proteins. Meanwhile, application of c-Jun N-terminal kinase inhibitor SP600125 and p38 mitogen-activated protein kinase inhibitor SB203580 repressed the expression of osteogenic-related markers in gene and protein levels. To the best of our knowledge, it is reported for the first time that phosphorous-containing biopolymers promote osteogenic differentiation of osteoblasts via JNK and p38 signaling pathways.
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ACS Biomaterials Science & Engineering
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2020
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IF 4.152
Shuang Yang,Xiaoming Li,Ping Liu,Maolan Zhang,Chao Wang,Bo Zhang
Electrospinning-based wound dressings with multifunctional properties, including hemostasis-promoting, antibacterial, drug release, and therapeutic effects, are of great interest in military and civilian trauma healthcare. Herein, we designed lidocaine hydrochloride (LID) and mupirocin-loaded chitosan/polycaprolactone (CSLD-PCLM) scaffolds with multiple functions as wound dressings. Through the dual spinneret electrospinning technique, the scaffolds achieved a nanofiber structure, which enhanced the interfacial interaction between the scaffold and blood cells and showed excellent blood coagulation capacity. In particular, the scaffolds loaded with LID and mupirocin exhibited rapid release of LID and sustained release of mupirocin. The CSLD-PCLM scaffold containing mupirocin exhibited outstanding antibacterial activity. Moreover, the scaffold significantly enhanced the wound healing process with complete re-epithelialization as well as collagen deposition in a full-thickness skin defect model. Thus, CSLD-PCLM nanofibrous scaffolds may ideally meet the various requirements of the wound healing process and are promising candidates for wound dressings in future clinical applications.
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