MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Xingcan Qian,Xiu He,Zihao Zhou,Yujia Su,Mingyu Xiang,Yingping Luo,Chaoli Wang,Tianxin Zhang,Jun Liu,Bing Wang,Shiwei Liang
Real-time monitoring of hydrogen peroxide (H 2 O 2 ) within the cellular microenvironment plays a pivotal role in early cancer diagnosis. Conventional H 2 O 2 detection methods are largely constrained by their narrow pH adaptability and limited operational modes, failing to meet the demands of complex physiological environments. We developed a rationally designed nanozyme-based platform capable of dual-mode H 2 O 2 detection across acidic and neutral pH conditions. The Fe x N y @C nanozyme, synthesized through electrospinning and controlled pyrolysis of MIL-53-derived precursors, exhibits tunable peroxidase-like activity that can be optimized by adjusting the mass ratio of MOF to polymers. Designed to simulate the horseradish peroxidase (HRP) structure, the Fe x N y @C system allows for quantitative H 2 O 2 detection in acidic environments through the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to oxidized TMB, resulting in a color change from colorless to blue. Simultaneously, a smartphone-assisted visual detection platform based on red-green-blue (RGB) color analysis was developed and thus serves as a practical tool for point-of-care testing (POCT). Owing to the facilitated Fe 2+ /Fe 3+ redox cycling and rapid electron transfer within its conductive framework, the Fe x N y @C nanozyme demonstrates high electrocatalytic activity for H 2 O 2 reduction in phosphate-buffered saline (PBS, pH 6.8). This enabled the development of an electrochemical sensor for real-time detection of H 2 O 2 released from cancer cells, highlighting its potential for tracking disease progression and monitoring therapeutic responses. This dual-mode sensor achieves high-performance H 2 O 2 detection by combining the strengths of electrochemical and colorimetric readouts. The electrochemical mode provides rapid response (1 s) and high sensitivity (1049.82 μA∙mM −1 ∙cm −2 ), while the colorimetric mode offers unique simplicity and visualizability, enabling rapid quantitative analysis within 10 min without the need for sophisticated instrumentation. Together, both modes demonstrate excellent selectivity, reproducibility and stability, making the platform adaptable to diverse application scenarios from laboratory precision to POCT.
研究领域:
纳米技术
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生物传感器
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分析化学
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生物医学工程
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癌症诊断
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电化学
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材料科学
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产品关联
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 4
·470-482
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IF 4.5
Wang Yitong,Zhang Yue,Wang Li
Amino-functionalized zirconia was synthesized by the co-condensation method using zirconium butanol and 3-aminopropyltriethoxy silane for the simultaneous removal of various impurities from aqueous 30% H 2 O 2 solution. The results of Fourier transform infrared (FTIR) and Zeta potential showed that the content of N in amino-functionalized zirconia increased with the added amount of 3-aminopropyltriethoxy silane. Accordingly, the removal efficiency of total oxidizable carbon, phosphate and metallic ions from the H 2 O 2 solution increased. The adsorbent with an N content of 1.62% exhibited superior adsorption performance. The removal efficiency of 82.7% for total oxidizable carbon, 34.2% for phosphate, 87.1% for Fe 3+ , 83.2% for Al 3+ , 55.1% for Ca 2+ and 66.6% for Mg 2+ , with a total adsorption capacity of 119.6 mg·g −1 , could be achieved. The studies conducted using simulated solutions showed that the adsorption process of phosphate on amino-functionalized zirconia is endothermic and spontaneous, and the behaviors could be well described by the pseudo-second-order model and Langmuir model with a maximum adsorption capacity of 186.7 mg·g −1 . The characterizations of the spent adsorbents by Zeta potential, FTIR and X-ray photoelectron spectroscopy revealed that the adsorption mechanism of phosphate is predominantly electrostatic attraction by the protonated functional groups and complementary ligand exchange with zirconium hydroxyl groups.
研究领域:
环境科学
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化学工程
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材料科学
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DOI
高影响因子
Bioactive Materials
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2021
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IF 14.593
Zhongqiang Zhu,Qiang Gao,Ziyue Long,Qiuyi Huo,Yifan Ge,Ntakirutimana Vianney,Nishimwe Anodine Daliko,Yongchun Meng,Jia Qu,Hao Chen,Bailiang Wang
Implanted biomaterials such as medical catheters are prone to be adhered by proteins, platelets and bacteria due to their surface hydrophobicity characteristics, and then induce related infections and thrombosis. Hence, the development of a versatile strategy to endow surfaces with antibacterial and antifouling functions is particularly significant for blood-contacting materials. In this work, CuSO 4 /H 2 O 2 was used to trigger polydopamine (PDA) and poly-(sulfobetaine methacrylate) (PSBMA) co-deposition process to endow polyurethane (PU) antibacterial and antifouling surface (PU/PDA(Cu)/PSBMA). The zwitterions contained in the PU/PDA(Cu)/PSBMA coating can significantly improve surface wettability to reduce protein adsorption, thereby improving its blood compatibility. In addition, the copper ions released from the metal-phenolic networks (MPNs) imparted them more than 90% antibacterial activity against E. coli and S. aureus . Notably, PU/PDA(Cu)/PSBMA also exhibits excellent performance in vivo mouse catheter-related infections models. Thus, the PU/PDA(Cu)/PSBMA has great application potential for developing multifunctional surface coatings for blood-contacting materials so as to improve antibacterial and anticoagulant properties.
研究领域:
材料科学
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生物材料
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生物医学工程
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表面化学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
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2014
·Vol. 2
·期 48
·8528-8537
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IF 0
Guangfei Wu,Fang Zeng,Changmin Yu,Shuizhu Wu,Wensheng Li
Hydrogen peroxide is a biologically important reactive oxygen species (ROS) and plays crucial roles in living organisms. Herein, a FRET-based ratiometric fluorescent probe has been developed for detecting H2O2in vitro and in vivo. In this nanoprobe, carbon dots serve as the energy donor and carrier for the H2O2 recognition element. This nanoprobe exhibits fast-response, low toxicity, high sensitivity (with a detection limit of 0.5 μM) and selectivity towards H2O2 over other reactive oxygen or nitrogen species. The nanoprobe has been successfully applied in the detection of H2O2 in live cells and in zebrafish larvae. By incubating the nanoprobe with zebrafishes, the nanoprobe can be absorbed by the fishes within 1 h and accumulates mainly in the abdominal region. Due to its small size (∼4 nm), the nanoprobe is gradually excreted by zebrafishes without long-term accumulation. Moreover, as the first ratiometric chemoprobe that can detect H2O2in vivo, the nanoprobe has been found capable of detecting and locating endogenous H2O2 in zebrafishes as a result of drug-induced oxidative damage. The successful detection of H2O2 by the nanoprobe in vivo may support its eventual use in clinical applications.
研究领域:
分析化学
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生物医学工程
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药学
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毒理学
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DOI
PubMed
TALANTA
·
2026
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IF 6.7
Wenteng Qiao,Caihong Yin,Boyuan Chen,Yue Zhai,Xiuling Song
Total antioxidant capacity represents a critical parameter for assessing food quality and freshness, while conventional detection methodologies are often constrained by operational intricacy or insufficient efficiency. Herein, we developed a rapid and user-friendly colorimetric sensing platform based on manganese oxide (MnOx) nanozymes for the quantification of antioxidants in fruit juice samples. MnOx nanozymes can efficiently catalyze the oxidation of the colorless substrate 3,3′,5,5′-tetramethylbenzidine, yielding a blue reaction product; however, the presence of antioxidants significantly suppresses this catalytic activity, inducing concentration-dependent color shifts in the reaction system. After systematic optimization of key reaction parameters (e.g., nanozyme concentration, TMB dosage, reaction temperature, and incubation time), the proposed platform achieved a detection limit of 1.79 μM, with a naked - eye visual detection limit of 5 μM and a total detection time of <10 min. Practical validation in real fruit juice samples verified the accuracy of the developed method for antioxidant quantification, as evidenced by recovery rates of 88.76%–109.10% and RSDs of all below 3.44%.This work introduces a novel, efficient, and stable approach for the rapid monitoring of TAC in food products, exhibiting considerable potential for food quality control and safety assessment.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
·
IF 10.652
Yin Wang,Ruotong Wang,Lan Yu,Yun Wang,Chuanhui Zhang,Xiaodong Zhang
A series of new layered composite catalysts LaCu 0.5 Co 0.5 O 3 -MMT 0.2 /CN x (x = 0.025, 0.075, 0.125) were prepared by montmorillonite (MMT) and g-C 3 N 4 (CN) in situ intercalation of B-site double perovskite. The experimental results showed that the appropriate MMT and CN loading of LaCu 0.5 Co 0.5 O 3 -MMT 0.2 /CN 0.075 were beneficial to the increase of catalytic performance because perovskites were evenly distributed between the layers of MMT and CN and effectively avoided the loss of active components. The sample had a smaller particle size distribution, a larger specific surface, a higher ratio of O ads /O latt and excellent microwave absorption capabilities. The removal rate reached 98.7% in 6 min under optimal conditions with catalyst dosage of 9.5 g/L, H 2 O 2 dosage of 350 μL, pH of 4, MW power of 500 W, and bisphenol A (BPA) concentration of 50 mg/L. LCCOM 0.2 /CN 0.075 also showed good reusability with a degradation efficiency of 95.7% even after the 5th cycle. And the microwave-catalyzed degradation followed pseudo first-order kinetics. Combining relevant characterization and experimental results of free radical capture, possible reaction mechanisms were discussed. The surface active sites of the catalyst can be excited by microwaves to produce oxidized free radicals, thereby degrading bisphenol A through electron-hole transport.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2010
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IF 5.429
Shujun Ji,Qingqing Guo,Qiaoli Yue,Lei Wang,Huaisheng Wang,Jinsheng Zhao,Ruixin Dong,Jifeng Liu,Jianbo Jia
Fabrication of sub-monolayer array of Pt nanoparticles (PtNPs) assembled at nucleobases terminated layers and their application into H 2 O 2 and glucose sensing were reported. To prepare such a PtNPs assembly, 3-mercaptopropionic acid (MPA), Zr 4+ , nucleotide-5′-monophosphate (NTMP including guanosine, adenosine, cytidine, uridine-5′-monophosphate, and abbreviations were GMP, AMP, CMP, UMP, respectively) were adsorbed onto Au substrate sequentially to form nucleobases terminated surface and Zr 4+ acted as binder to link carboxylic and phosphoric groups (NTMP/Zr 4+ /MPA/Au). Complexation of cisplatin, cis-Pt(NH 3 ) 2 Cl 2 , with terminated nucleobases and following electrochemical reduction of surface-bound cisplatin gave PtNPs attached surface. Different PtNPs coverage or particle density was obtained depending on the NTMP used and decreased in the order: PtNPs/GMP/Zr 4+ /MPA/Au > PtNPs/AMP/Zr 4+ /MPA/Au > PtNPs/CMP/Zr 4+ /MPA/Au > PtNPs/UMP/Zr 4+ /MPA/Au. The surface loading of Pt was between 160 and 16 ng/cm 2 . The as prepared PtNPs can be used as electrocatalysts for H 2 O 2 sensing (detection limit of H 2 O 2 < 100 nM) and the sensitivity increased with decreasing PtNPs density. After adsorption of glucose oxidase, the modified electrode can be used as enzymatic electrode for glucose sensing and a detection limit of 38.5 μM was achieved. This study provided an example of fabricating PtNP arrays utilising surface complexation of cisplatin with nucleobases. The advantage of this method is that the NP density can be controlled through changing nucleobases or Pt complexes used to obtain suitable kinetics of the complexation reactions. Additionally, the PtNPs sub-monolayer as prepared has high sensitivity for H 2 O 2 sensing even at a very low loading of Pt.
研究领域:
生物化学
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材料科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
CATALYSIS TODAY
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2018
·
IF 4.667
Bo Wang,Masakazu Anpo,Jing Lin,Can Yang,Yongfan Zhang,Xinchen Wang
The preparation of ternary hexagonal boron carbon nitride (h-BCN) nanosheets was carried out by doping biomass glucose in situ into hexagonal boron nitride (h-BN). With this method, the construction of a two-dimensional (2D) semiconductor with tunable bandgap and characteristic adsorption ability toward organic molecules was achieved by maintaining the specific structure of h-BN and π-π interactions toward aromatic compounds. The ternary 2D h-BCN nanosheets worked effectively not only as a desirable adsorbent but also as an activator to benzene. Furthermore, the unique 2D h-BCN nanosheets were found to work as effective photocatalysts to convert benzene into phenol with less over-oxidation, leading to the development of a new type of Fenton oxidation reaction as the one-step visible light-driven hydroxylation of benzene. An optimal yield of 14.0% and its selectivity of 88.3% for the photocatalytic production of phenol from benzene were achieved by using h-BCN in the presence of FeCl 3 and H 2 O 2 in sustaining the same reactivity even after 4 cycles. This present study reports the latest development of phenol production from benzene by applying 2D h-BCN nanosheets as an artificial photosynthetic catalyst.
研究领域:
催化化学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
ECS Journal of Solid State Science and Technology
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2019
·Vol. 8
·期 5
·P3075
·
IF 1.795
Peng He,Bingbing Wu,Shuai Shao,Tong Teng,Peng Wang,Xin-Ping Qu
Cobalt has been applied as liners in current Cu interconnect and even as interconnect conductors in next-generation interconnect. In this work, effects of corrosion inhibitors 1, 2, 4-triazole (TAZ) on Co chemical corrosion, galvanic corrosion between Cu and Co, and Co polishing properties in the H2O2 based acidic slurry have been systematically investigated. Results show that 5 mM TAZ yields a low static etching and removal rate with a selectivity of about 1: 1 for Co to Cu, applicable for Co barrier/ Cu CMP, while 100 mM TAZ yields a high removal rate with same selectivity, applicable for Co via and trench CMP. It demonstrates that TAZ can effectively inhibit the galvanic corrosion between Co and Cu. Additionally, the adsorption behavior of TAZ on Co surface is both physisorption and chemisorption. In case of 5 mM TAZ, self-assembly TAZ molecules absorb on native Co oxide. In case of 100 mM TAZ, more soluble Co-TAZ complexes form, which reduces the stability of the passivation layer and results in pitting corrosion.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
Chemistry-An Asian Journal
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2020
·Vol. 15
·期 8
·1315-1323
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IF 4.056
Xin Zhang,Yanfang Gao
Graphical A 2D/2D hexagonal boron nitride (h-BN) and nitride doped molybdenum disulfide (N−MoS 2 ) heterostructure (h-BN/N−MoS 2 ) catalyst was prepared by sonication using a solvothermal method. The catalyst breaks down H 2 O 2 to produce hydroxyl radical and further oxidizes the colorless TMB to produce blue oxTMB. Recently, nanozymes have attracted extensive attention because of their advantages of combining nanomaterials with enzymes. Herein, hexagonal boron nitride (h-BN) and nitride-doped molybdenum disulfide (N−MoS 2 ) nano-composites (h-BN/N−MoS 2 ) were synthesized by facile and cost-effective liquid exfoliation with a solvothermal method in nontoxic ethanol solution. The results show that h-BN, as a co-catalyst, can not only dope into the lattice of MoS 2 but also form a heterogeneous structure with MoS 2 NSs. It expanded the layer spacing and specific surface area of MoS 2 NSs, which was beneficial to the contact between the catalyst and the substrate, and resulted in a synergistic enhancement of the catalytic activity of hydrogen peroxide (H 2 O 2 ) with MoS 2 . A colorimetric determination platform of h-BN/N−MoS 2 -TMB-H 2 O 2 was constructed. It exhibited a wide linear range of 1–1000 μM with a low limit of detection (LOD) of 0.4 μM under optimal conditions, high sensitivity and stability, as well as good reliability (99.4–110.0%) in practice, making the measurement system more widely applicable.1. Introduction
研究领域:
材料科学
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催化
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分析化学
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生物化学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL GEOLOGY
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2021
·
IF 4.015
Fuwei Sun,Haibo Liu,Ziyang Chu,Peixun Zhai,Tianhu Chen,Hanlin Wang,Xuehua Zou,Dong Chen
To investigate the effect of isomorphic substitution on siderite activation of hydrogen peroxide, different X-substituted siderite (X = Mn, Co, Ca, and Mg) was artificially synthesized and utilized to activate hydrogen peroxide (H 2 O 2 ) over a pH range from 5 to 9. The results indicated that the addition of siderite generally accelerated the conversion process of H 2 O 2 to ·OH regardless of initial pH values. However, the conversion ability from H 2 O 2 to ·OH was only enhanced under the acidic condition. Then, X-substituted siderite generally enhanced the conversion rate and inhibited the capacity of H 2 O 2 to ·OH under neutral and alkaline conditions. The Mn, Ca, and Mg-substituted siderite facilitated both conversion rate and capacity of H 2 O 2 to ·OH under weakly acidic conditions, while Co-substituted siderite inhibited both compared to the raw siderite. The element substitution mainly affected the stability of siderite, which resulted in the dissolution of siderite to generate Fe 2+ and contributes to the H 2 O 2 decomposition and the ·OH generation. Findings from this research suggested that the isomorphic substitution of siderite had a non-negligible impact on the transformation of H 2 O 2 to ·OH.
研究领域:
环境科学
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化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Jundie Hu,Tingyu Yang,Junjie Chen,Xiaogang Yang,Jiafu Qu,Yahui Cai
Hydrogen peroxide (H 2 O 2 ) is a significant green oxidant for environment and new energy, especially for Fenton-like system. Onsite production and sustainable consumption of H 2 O 2 are the two critical challenges. Here, a fantastic 2D/1D hierarchical layered ZnIn 2 S 4 /TiO 2 heterojunction is reported as an efficient catalyst for in- situ H 2 O 2 production via 2-electrons oxygen reduction (ORR) process and be rapidly activated to high concentration hydroxyl radical (•OH) for water purification under visible light irradiation. The high-quality catalyst enables superior H 2 O 2 production rate of 1530.59 μmol h −1 g −1 with an external quantum efficiency of 10.39% illuminated at 400 nm, is much higher than that of reported photocatalysts. The bimetallic sulfide ZnIn 2 S 4 can effectively promote the activation of H 2 O 2 due to the unsaturation of sulfur atoms, so that the wastewater containing tetracycline (50 ppm) can be degraded by 90% only within 60 min by ZnIn 2 S 4 /TiO 2 via this cascade reaction. This work provides a novel strategy and ZnIn 2 S 4 -based catalyst for photocatalytic Fenton-like reaction.
研究领域:
环境科学
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材料科学
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化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）