Scientific Reports
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2026
·Vol. 16
·期 1
·16800
·
IF 4.9
Rong Wenqing,Zhang Minquan,Yang Siqi,Wang Kaiwen,Yang Xiaoping,Zhang Guolei,Li Zhe,Ding Yue,Zhang Tong,Gai Yun,Lan Jinshuai
Breast cancer (BC), the most common cancer in women, is closely related to ferroptosis, which is an iron-dependent form of cell death. Gambogic acid (GA), the main active ingredient extracted from the dry resin secreted by Garcinia cambogia, can effectively induce ferroptosis in tumor cells. However, its application is limited by poor water solubility, short half-life, and vascular irritation. Moreover, the sensitivity of cells to ferroptosis is positively correlated with the concentration of intracellular iron ions, which based on transferrin (Tf)-Tf receptor (TfR) pathway. Increasing intracellular iron ions within tumor cells may enhance GA-induced ferroptosis. Based on the high expression of TfR in tumor cells, Tf can be both a tumor-target modification and an Fe 3+ carrier. Therefore, GA-loaded Tf-modified liposomes (GA@Tf-Lip) with pH-responsive properties were developed. GA@Tf-Lip increased the intracellular iron ion content of MCF-7 cells, promoted the Fenton reaction to increase the level of ROS, downregulated the GSH content, and accelerated lipid peroxide accumulation. The distribution of the formulation by in vivo imaging experiments showed that the prepared GA@Tf-Lip had a higher drug accumulation at tumor sites and exhibited a good antitumor effect by promoting ferroptosis. Overall, GA@Tf-Lip exerted a good anti-BC effect, which is expected to provide a new strategy for the treatment of BC and the clinical transformation of GA.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 25
·18097-18110
·
IF 4.4
Wu Pingping,Cao Wenjia,Hao Xuegang,Chang Mingwei,Su Weichao,Zhang Sijing,Zhou Yuanzhen
Skin-mimetic conductive hydrogels capable of simultaneously integrating mechanical compliance, stable charge transport, and multifunctional signal output are highly desirable for next-generation biointegrated electronics, yet remain challenging due to intrinsic trade-offs among conductivity, stretchability, and interfacial stability. Herein, we report an interfacial-coupling-engineered MXene–PEDOT:PSS conductive hydrogel that enables dynamically reconfigurable charge transport within a polymer network. In this design, MXene nanosheets function as a two-dimensional conductive scaffold, while PEDOT:PSS acts as a conjugated polymer bridge to construct continuous electron transport pathways within a polyacrylamide matrix. The synergistic integration of hydrogen bonding, electrostatic interactions, and coordination interactions between MXene, PEDOT:PSS, and polymer chains enables simultaneous optimization of mechanical and electrical properties. The hydrogel exhibits a tensile strength of 74.9 kPa and a fracture strain of 586%, robust adhesion to porcine skin (32 kPa), and excellent self-healing capability with a healed fracture strain of 442% (75.4% of the pristine sample). It also demonstrates high sensitivity across 0–500% strain with a gauge factor of 11.03. Furthermore, it maintains stable signal output under high-frequency strain (0.4 Hz). Its overall performance surpasses that of conventional PEDOT:PSS-based conductive hydrogels. Beyond mechanical sensing, the hydrogel enables motion-driven information encoding and transmission via wearable Morse-code demonstrations. This work establishes an interfacial-coupling-driven materials design paradigm for multifunctional conductive hydrogels, offering new opportunities for multimodal sensing, biointegrated electronics, and intelligent soft communication systems. Graphical abstract
The alternative text for this image may have been generated using AI. Interfacial-coupling-engineered MXene–PEDOT:PSS conductive hydrogels enable dynamically reconfigurable charge transport, combining high stretchability, strong tissue adhesion, and sensitive strain response. The hydrogel further enables motion-driven wearable information encoding, providing a versatile platform for multimodal sensing and soft biointegrated electronic communication.
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Nature Communications
·
2026
·
IF 18.1
Fei Shiyuan,Yang Shuai,He Zejin,Li Ji,Mei Bingbao,Xu Qing,Liu Xiaosong,Jiang Zheng
Creating efficient catalytic sites on covalent organic polymers (COPs) is a promising approach for green energy conversion and industrial catalysis. Although the post-synthetic modification of COPs has made progress in constructing single-atom sites and metal nanoparticles, this method remains limited in terms of the types, quantities, and overall performance of the constructing sites. To address these limitations, we develop a template-source construction strategy for catalytic site establishment. This strategy successfully yields hollow COPs with a high content of Co-O active species (H-COP-Co), demonstrating high activity as oxygen electrocatalysts. Comparing to traditional post-synthetically modified COPs with single Co sites (S-COP-Co), H-COP-Co demonstrates an increase in active metal content, from 2.96% to 56.86%, with enhanced catalytic activity for oxygen evolution reaction (OER). Unlike single Co sites that operate via the adsorbate evolution mechanism (AEM), comprehensive spectroscopic characterization and theoretical calculations reveal that the initial and reconstructed Co oxide nanoparticles in COPs operate via the oxide path mechanism, serving as the origin of the superior OER performance. These findings provide valuable insights into the design of multifunctional composite COP materials, underscoring the importance of intrinsically structural designing and modulating reaction mechanisms to enhance energy conversion efficiency.
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Scientific Reports
·
2026
·
IF 4.9
Li Wentao,Zhang Qian,Liu Zuohua,Tao Changyuan,Zheng Guocan,Chen Nanxiong,Wang Dong,Chen Hufei
Manganese residue is a dangerous industrial by-product and has traditionally been stored. Conventional harmless treatment can stabilize Mn2+, but its resource utilization is relatively difficult due to the complex composition of manganese residue. This study proposes a sustainable development approach for synthesizing high-performance M-type ferrite BaFe11.6Mn0.4O19 from manganese residue rich in Fe and Mn for microwave absorption. By optimizing roasting conditions, we controlled oxygen vacancy concentration, enhancing the ferrite’s dielectric and magnetic properties for superior microwave absorption. By simulating the composition of rare earth solid waste, rare earth elements La2O3 and CeO2 were incorporated into ferrite. Further optimize the loss matching mechanism and shielding effect. Characterization techniques confirmed a multiphase-phase M-type ferrite structure with a minimum reflection loss of -33.42 dB. It is clarified that the main reason for the performance improvement mechanism after the incorporation of rare earths is that the formation of new phases and the appearance of solid solutions promote the synergistic effect in polarization and electromagnetic energy dissipation. This method provides a scalable model for industrial waste recycling. This method provides a scalable model for industrial waste recycling.
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Nature Nanotechnology
·
2026
·Vol. 21
·期 5
·689-698
·
IF 37.5
Zhang Xin,Xia Guanglin,Li Chaoqun,Shen Wanping,Lu Yunhao,Zhang Wenxuan,Liu Huifeng,Huang Zhenguo,Sun Wenping,Gao Mingxia,Liu Yongfeng,Pan Hongge
Lithium borohydride (LiBH 4 ) is a promising hydrogen carrier owing to its high hydrogen storage capacity. However, the low reactivity of its dehydrogenation products, boron and LiH, towards dihydrogen molecules makes the re-generation of borohydrides extremely challenging. Here we theoretically unravel that the dissociation of H 2 into H atoms and its adsorption by the active B spike atoms (surface-protruding boron atoms with low coordination and high reactivity) is a prerequisite for the formation of B–H bond, rather than the direct reaction between H 2 and B. Moreover, the proportion of B spike atoms increases exponentially as the size of B clusters decreases, indicating that reducing B particle size to the ultrasmall scale is critical for enhancing hydrogenation reactivity. Thereby, we experimentally synthesize nanocomposites consisting of ultrafine LiBH 4 nanoparticles decorated with 3 nm Ni catalytic clusters for hydrogen storage. Upon dehydrogenation, these nanocomposites form B and LiH clusters in close proximity at 5–10 nm scale, while the Ni clusters remain intact. The Ni clusters not only facilitate the dissociation of H 2 into H atoms but also strongly interact with the B clusters, weakening B–B bond, which enables the hydrogenation of B/LiH back to LiBH 4 at temperatures as low as 30 °C under 100 bar H 2 .
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Advanced Composites and Hybrid Materials
·
2026
·
IF 15.5
You Qi,Zhao Yiqi,Zhong Ya,Xu Fuhao,Zhang Xuanfeng,Cui Sheng
The rapid advances in aerospace technology have intensified challenges related to extreme thermal and electromagnetic environments. The excellent thermal conductivity and low dielectric loss of AlN limit its use in applications requiring thermal insulation and microwave absorption. Herein, a sealing enhancement strategy (SES) was designed to fabricate silane-modified phenolic resin-reinforced AlN (PRSi/AlN) aerogel composites that combine high strength with spontaneous high-temperature ceramization. The directional pore channels of the AlN/C aerogel are filled with continuous silane-modified phenolic resin (PRSiO 2 ) aerogels, forming a unique sealed structure. Impressively, the composites achieve a compressive strength 492 times that of the AlN/C skeleton, coupled with a low axial thermal conductivity of 0.0382 W·m − 1 ·K − 1 . The oxidation of AlN is followed by spontaneous mullitization with SiO 2 during thermal exposure, leading to the formation of a stable mullite phase. Under a short-duration oxyacetylene flame (1.2 MW·m − 2 ), the composites maintained a backside temperature between 53.4 °C and 68.4 °C, with a linear ablation rate of 0.071 mm·s − 1 . Furthermore, the excellent microwave absorption results from synergistic effects within the carbonized layer, where interfacial polarization, dipole polarization, and conduction loss collectively enhance electromagnetic wave (EMW) dissipation. Both composites show excellent performance: PRSi1.0/AlN has a minimum reflection loss (RL min ) of -61.84 dB and an effective absorption bandwidth (EAB) of 5.83 GHz, while PRSi2.0/AlN achieves an even broader EAB of 7.06 GHz. This SES effectively strengthens PRSi/AlN composites by harnessing the advantages of both the reinforcement phase and skeleton, offering a novel paradigm for fabricating thermal protection composites.
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Scientific Reports
·
2026
·
IF 4.9
Min Wenchao,Guo Bin,Zhao Zhenjie,Hu Shunfeng,Shang Jingqi,Bai Yuhan,Zhang Xizhi,Zhong Ximing
To alleviate environmental pollution and energy crisis, the development of biopolymers with degradability is highly desirable. Polyhydroxyalkanoates (PHA) are produced and accumulated in bacteria cells, possessing good mechanical properties and the features of biodegradability and biocompatibility, becoming a promising substitute of petroleum-based polymers. In this work, seashell powders (SP) are adopted as a renewable biofiller to blend with PHA to obtain the PHA/SP biocomposites. It is found that the seashell powders are uniformly distributed in PHA matrix. Although 10 wt% seashell powder content increases the crystallinity of these biocomposites, their thermal transition temperatures and thermal stability decrease with seashell powder contents. Also, the tensile strength and elongation at break values decrease with seashell powder contents, while the elastic modulus of these biocomposites increase to 3104 MPa due to the enhanced rigidity of filler effect. Of note, these PHA/SP biocomposites can degrade under alkaline conditions within six days, and more seashell powder content facilitates the degradation process. Additionally, they can be used in 3D printing applications to fabricate various items via fused deposition modelling (FDM) technique. Therefore, this work develops a PHA/SP biocomposite system with good mechanical properties and degradability, and they are potential for 3D printing applications to serve diverse fields by fabricating customized items.
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CYTOTECHNOLOGY
·
2026
·Vol. 78
·期 3
·122
·
IF 2.2
Yang KaiYu,Li QingSong
To systematically characterize the chemical constituents and serum metabolites of Qijingmingmu decoction (QJMM) and to explore its potential anti-aging mechanisms using an integrated strategy combining UPLC-Q-TOF-MS and network pharmacology. The chemical components of QJMM were identified using UPLC-Q-TOF-MS. Rats were administered QJMM at different doses, and serum samples were collected for metabolite profiling. The absorbed prototype components and metabolites were analyzed. Potential targets of QJMM were predicted using public databases, and protein–protein interaction (PPI) analysis, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed. A total of 66 compounds were identified in QJMM, and 38 metabolites were detected in rat serum, including both prototype compounds and their transformed products. Several representative metabolites, such as dihydroferulic acid 4-O-glucuronide, ferulic acid sulfate, and wedelolactone glucuronide, were identified as key in vivo components. Network pharmacology analysis suggested that QJMM may exert anti-aging effects by regulating multiple targets, including RELA, ESR1, TNF, and HSP90AB1, and modulating signaling pathways such as the NF-κB, TNF, and HIF-1 pathways. This study provides a preliminary characterization of the chemical and metabolic profiles of QJMM and offers insights into its potential multi-target mechanisms underlying anti-aging effects.
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JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 4
·163
·
IF 3.5
Wang Jing,Bai Wei,Wang Gongying,Li Chen,Wang Qingyin
Bisphenol-fluorene-type polycarbonate as a transparent thermoplastic resin, exhibits low birefringence due to the rigid fluorene. In this paper, a series of random co-polycarbonates (BPEF/BPA-PC) were prepared from bisphenol A(BPA), 9,9-bis[4-(2-hydroxyethoxy) phenyl] fluorene (BPEF) and diphenyl carbonate (DPC) using melt transesterification method by adjusting molar ratios of raw materials. The effects of catalyst dosage, polycondensation temperature and polycondensation time on the molecular weight of the products were systematically investigated, and the copolymer structures were characterized by FT-IR, 1 H NMR and 13 C NMR spectra tests; the thermal performance were determined by Differential Scanning Calorimeter (DSC) and thermogravimetric analysis. The molecular weights and their distributions( Đ ) were determined by Gel Permeation Chromatography. The results of GPC showed that the max M w of copolymers reached to 6.8*10 4 g/mol and Đ was 1.81. The maximal thermal decomposition temperature ( T d,5% ) of the co-polycarbonate reached to 359.3 °C. The refractive index of the materials was characterized using an Abbe refractometer and it showed refractive index (n d ) up to 1.640 under visible light. Mechanical property tests showed that the tensile strength of co-polycarbonate were significantly increased when the contents of BPEF was higher, reflecting the enhancement effect of fluorene unit on the rigidity of molecular chain.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2026
·
IF 2.6
Ma Guoliang,Zhang Shaohua,Li Wenwen,Dai Sheng,Zhang Meng,Wang Jinfang,Zhu Dongdong,Zhu Liu
Silicon carbide whiskers (SiC w ) are promising reinforcements for ceramic materials due to their high strength and elastic modulus. In this work, SiC/SiC w -Y 2 O 3 composite ceramics were fabricated by hot-press sintering at 1800 °C and 40 MPa, using 7.5 vol.% Y 2 O 3 and varying SiC w contents (0-15 vol.%). The effects of SiC w on microstructure, mechanical properties, and tribological behavior were systematically studied. The results show that 10 vol.% SiC w yields the best overall performance, with improvements in relative density (97.0%), Vickers hardness (21.6 GPa), fracture toughness (7.7 MPa m 1/2 ), and flexural strength (573.2 MPa). However, excessive SiC w (15 vol.%) led to decreased densification and wear resistance due to whisker agglomeration and increased porosity. The main toughening mechanisms include whisker pull-out, crack deflection, and bridging. These findings suggest that a moderate SiC w content effectively enhances the mechanical and tribological properties of SiC/SiC w -Y 2 O 3 ceramics, providing a feasible strategy for developing advanced structural ceramics.
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Nature Communications
·
2026
·
IF 18.1
Guo Pan,Dai Yunkun,Zhang Yunlong,Liu Bing,Ma Miao,Liu Bo,Zhang Ziyu,Zhao Zigang,Chen Aibing,Shen Lixiao,Zhao Lei,Wang Zhenbo
Atomically dispersed catalysts based on 3 d metals have been extensively explored in the catalytic field, but stabilizing 4 d and 5 d metals like Ru, Pd, and Pt as single atoms remains a challenge due to their high cohesive energies. Herein, we develop a hydrogen-embrittlement-inspired strategy that leverages H 2 permeation to weaken metal-metal cohesion in 4 d /5 d metal clusters during high-temperature synthesis. Hydrogen diffuses into the clusters, driving their dissociation into individual atoms, which are subsequently stabilized by nitrogen dopants in carbon supports, resulting in the formation of stable M-N 4 single-atom sites. Taking Ru as a model system, ex-situ microscopy and spectroscopy offer definitive evidence that hydrogen permeation disrupts Ru-Ru bonding interactions, facilitating the conversion of Ru clusters into isolated RuN 4 sites during the H 2 -assisted thermal activation process. Consequently, the prepared NC-Ru-950 catalyst achieves satisfactory activity and stability for acidic oxygen reduction and proton exchange membrane fuel cells. This work introduces a robust and universal strategy for stabilizing 4 d and 5 d transition metals as single-atom catalysts, offering a promising route to develop high-performance electrocatalysts.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Li Xuan-Ran,Sun Xiao-Han,Tian Hua-Feng,Lu Ang
Ionic thermoelectric gels based on the Soret effect play an important role in realizing the efficient conversion of thermal and electrical energy, which is crucial for renewable energy utilization and efficient energy management. In this study, chitosan hydrogels were fabricated by complexation of chitosan and various metal ions via a freeze-casting approach for unitization as ionic thermoelectric materials. Various aggregate structures, including loosely fibrous networks, oriented porous structures, and lamellar porous structures, were obtained owing to the different interactions between chitosan and metal ions. As a result of the synergy of both the aggregate structure and intermolecular interaction, the as-prepared chitosan hydrogels demonstrated wide thermoelectric coefficient ranging from +1.6 mV·K −1 to −18.4 mV·K −1 , which can be achieved by simply involving different metal ions. The present work not only demonstrates the correlation between gel structure, intermolecular interactions, and thermoelectric performance, but also provides a simple approach for the fabrication and regulation of natural polymer-based thermoelectric materials.
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