CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Fengjiao Zhang,Sufeng Zhang,Shuyuan Cui,Xiaokai Jing,Yao Feng,Sergiu Coseri
In this study, the quaternized carboxymethyl chitosan (QCMCS), oxidized hyaluronic acid (OHA), 3,3′-dithiobis-(propionohydrazide) (DTP) were used as raw materials for the synthesis of hydrogels with excellent properties as carriers for drug release. The hydrogels were prepared by a simple “one-pot” method without external stimuli on the basis of interactions between formed dynamic covalent bonds (imine bonds, acylhydrazone bonds, disulfide bonds) and hydrogen bonds . The hydrogels had rapid self-healing properties, with a self-healing rate of 96 % after 30 min, as well as good pH responsiveness and excellent cytocompatibility (up to 98 % cell survival). The compressive stress of the hydrogels reached 423 kPa. Moreover, a representative drug (acetylsalicylic acid) demonstrated sustained release in the hydrogels (>72 h). The drug release behaviour was shown to be consistent with the Fick diffusion mechanism by kinetic modelling. Collectively, the findings demonstrate that the QCMCS + OHA + DTP injectable self-healing hydrogels are a potential material for the construction of pH-controlled drug delivery platforms.
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ACS Sustainable Chemistry & Engineering
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2023
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IF 8.4
Jingxian Yang,Gangwen Chen,Jianhong Chen,Yong Liu,Ziying Yang,Xugang Shu,Fan Luo
The development of biobased antibacterial nanomaterials for normal-temperature food preservation is important to prevent foodborne pathogenic infections and achieve low-carbon life. Herein, we developed a biodegradable self-assembling polymer-based nanocomposite with efficient antibacterial activity through the copolymerization of chitosan units with Astragalus polysaccharides and functional dihydromyricetin. The as-prepared irregular spherical-type nanocomposite exhibited multidimensional antibacterial action such as cell membrane devastation, cellular leakages, and respiratory disturbance (ATP pathway), thereby achieving an efficient inhibition in vitro against Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus). After the natural deposition of the designed nanocomposite onto a commercial fiber paper (FP), the resulting modified FP was found to possess remarkable pathogen eradication, enhanced UV shielding, and improved water vapor barrier properties. As a proof-of-concept demonstration, the shelf life of salt-baked chicken (processed food) packaged in the modified FP was extended to 5 days in a room-temperature environment. Therefore, the simple design and validation of polymer-based nanocomposite in this work will provide a good reference for room-temperature food preservation technology.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2015
·Vol. 26
·期 8
·924-931
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IF 1.757
Feng Su,Jingzhao Wang,Shoujin Zhu,Shuilian Liu,Xiaoqin Yu,Suming Li
Novel carboxymethyl chitosan-polylactide (CMCS- g -PLA) hydrogels were prepared by using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) as crosslinking agent and catalyst at room temperature. Solid-state 13 C-NMR, SEM, and FT-IR measurements showed that PLA blocks are successfully grafted onto the CMCS main chains. DSC measurements confirmed the effective crosslinking of carboxymethyl chitosan. With increasing the amount of EDC/NHS, the crosslink destiny of CMCS- g -PLA copolymers is improved. The swelling ratio of CMCS- g -PLA hydrogels is pH dependent, showing a minimum in the pH range of 3 to 5. Rheological studies confirmed the formation of hydrogels. The higher the crosslinking density, the higher the storage modulus of hydrogels. CMCS- g -PLA hydrogels only slightly degrade in PBS for 10 days. In the presence of lysozyme, however, hydrogels with low crosslink density are totally degraded in 10 days. Drug release studies show that after 96 h, 95% of thymopentin is released under in vitro conditions. Copyright © 2015 John Wiley & Sons, Ltd.
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CARBOHYDRATE POLYMERS
·
2022
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IF 10.723
Danya Chen,Pei Liu,Mengna Li,Changqing Zhang,Youshui Gao,Yaping Guo
Nacre, exhibiting excellent mechanical strengths due to its hierarchical structures, becomes a potential model to design bone implants. Herein, we firstly fabricated nacre-mimetic hydroxyapatite/chitosan/gelatin (HA/CS/Gel) layered scaffolds and incorporated substance P (SP) peptides. The CS scaffolds with a layered architecture could regulate the deposition of HA nanoplates on the interlamellar CS sheets by using CaCO 3 as precursors. The HA/CS/Gel layered scaffolds exhibited a great flexure strength of 11.42 MPa due to a brick-and-mortar structure. The biocompatible components, layered macropores and SP peptides in the HA/CS/Gel therapeutic scaffolds facilitated the spreading and proliferation mesenchymal stem cells (MSCs). Notably, the incorporation of SP peptides induced MSC osteogenic differentiation and extracellular matrix mineralization . Rabbit knee subchondral defect models further proved that the HA/CS/Gel-SP layered scaffolds promoted in vivo subchondral bone regeneration . Hence, the combination of nacre-mimetic bone implants and therapeutic drugs may become an attractive strategy for subchondral bone regeneration.
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Hua Wei,Shengkai Yu,Yansheng Zhang,Hua Zhang,Yuxi Ma,Mengjia Xu,Peng An,Yang Zhou,Sami Halila,Yen Wei,Jing Chen
Delayed or chronic wound healing is one of severe clinical issues. Developing scaffold materials capable of supporting cells and inducing tissue regeneration remains a challenge. Here, a polysaccharide-based hydrogel is constructed for promoting full-thickness skin wound healing in mouse model. The engineering hydrogel consists of a dynamic crosslinking network formed by the Schiff base reaction between aldehyde-containing xyloglucan and methacrylated chitosan. Its reversible gel-sol-gel transition upon shearing force is highly beneficial to completely cover and fill irregular wound shape. The second covalent cross-linking network achieved by photo-initiated polymerization offers a feasible way to tune the mechanical property of hydrogel after injection, with an ideal mechanical adaptivity for clinical application. Remarkably, both in vitro and in vivo evaluations demonstrate that the hydrogel with endogenously bioactive galactoside units can promote cell spheroid formation and accelerate wound healing by expediting re-epithelialization, collagen deposition, angiogenesis as well as the formation of hair follicles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Yuyuan Luo,Junjie Wang,Tianyi Lv,Hongxia Wang,Hongyuan Zhou,Liang Ma,Yuhao Zhang,Hongjie Dai
The physical and chemical properties of cellulose nanocrystals (CNC) were regulated by physical crosslinking with chitosan particles (CSp). At a fixed concentration (0.5 wt%) of CNC, varying CSp concentration (0.02–0.5 wt%) influenced the morphologies and chemical properties of the obtained complex particles (CNC-CSp). The results of Fourier transform infrared spectroscopy (FTIR) and zeta potential confirmed the electrostatic and hydrogen bonding interactions between CSp and CNC. At a low CSp concentration (0.02–0.05 wt%), the charge shielding effect induced the formation of particle aggregation networks, thus showing increased viscosity, turbidity and size (153.4–2605.7 nm). At a higher CSp concentration (0.1–0.5 wt%), the hydrogen bonding interaction promoted CSp adsorption onto the surface of CNC, thus facilitating the dispersion of CNC-CSp due to electrostatic repulsion caused by surface-adsorbed CSp. In addition, CSp improved the thermal stability, hydrophobicity (41.87–60.02°) and rheological properties of CNC. Compared with CNC, CNC-CSp displayed a better emulsifying ability and emulsion stability, in which CSp could play a dual role (i.e., charge regulator and stabilizer). This study suggests that introducing CSp can improve the properties and application potentials of CNC as food colloids.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Chengyuan Sun,Xuelian Zeng,Shihang Zheng,Yulan Wang,Zhiyu Li,Haining Zhang,Lanlan Nie,Yufeng Zhang,Yanbing Zhao,Xiangliang Yang
For clinical traumas and surgeries, adhesives that can be used in humid environments is considerably challenging. Inspired by the adhesive proteins of mussel, a gallic acid-modified chitosan-based (CS-GA) hydrogel was prepared through discharge plasma technology, which was first reported to realise polysaccharide-macromolecule-grafted phenolic acids. CS-GA hydrogels with different grafting amounts were successfully prepared, and their structures were characterised using ultraviolet, 1 H nuclear magnetic resonance and Fourier-transform infrared spectroscopy. The modified material exhibited excellent antioxidant properties, which were verified using classical DPPH radical scavenging and reducibility experiments. CS-GA was oxidised in air under physiological conditions and cross-linked to form a hydrogel, with unusual toughness and adhesion properties. The high biocompatibility and haemocompatibility of this hydrogel were showed through cytotoxicity and haemolysis experiments. Furthermore, the abilities of the hydrogel to promote wound healing and haemostasis were evaluated using in vivo rat whole layer skin defect and liver haemorrhage models, respectively. These abilities can provide many possibilities for the development of multifunctional biomedical adhesives.
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POLYMER ENGINEERING AND SCIENCE
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2023
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IF 3.2
Jingyu Du,Junzhuo Sun,Daohai Zhang
As one of the most common pollutants in wastewater, heavy metals seriously threaten human health and survival, and among the current removal methods, the adsorption method has attracted the most attention because of its simple and safe operation. Zeolite is a substance with a unique spatial structure, cheap cost, and environmental friendliness. Zeolite is a substance with a unique spatial structure, cheap cost, and environmental friendliness. Due to its size and high surface area-to-volume ratio, zeolite exhibits excellent adsorption and ion exchange properties and is a promising adsorbent. In this paper, the modified zeolite chitosan composite film was prepared by solution method by dissolving chitosan in acetic acid solution as the solvent, and the effects of zeolite content, modifier type, initial pH, pore-making agent, adsorption time, adsorption temperature, initial concentration, and feeding amount were studied. The optimal conditions for Pb 2+ adsorption were 40% modified zeolite content, 293 K in 100 mg/L solution, a feeding amount of 1 g/L, pH = 5.5, and a removal rate of 96.6% in 24 h. The isotherm is consistent with the Langmuir adsorption model, which is manifested as single-molecule chemical adsorption, and the highest saturated adsorption capacity is 139.6 mg/g. After five cycles, it still has a greater than 90% initial adsorption effect. Highlights Chitosan-modified zeolite composite membranes are inexpensive. After adsorption, the sorbent is easy to recover.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2023
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IF 1.6
Zhang Yizhe,Cai Tingting,Zhao Zhiwei,Han Bing
The development of high-performance adsorbents is highly demanded in sustainable production of nuclear power. Herein, porous chitosan-poly(imide dioxime) (Cs-PIDO) hydrogel with semi-interpenetrating structure was prepared. Cs-PIDO-1 showed rapid kinetics, high adsorption capacity and excellent regeneration capability. Impressively, the capture speed of Cs-PIDO-1 reached 0.35 mg g −1 d −1 during the first 2-week extraction and its 4-week adsorption capacity was up to 5.75 mg g −1 in real seawater. The superior uranium harvesting performance originated from the cooperation effect of hierarchically porous structure and PIDO groups. This work highlights the importance of rational designed structure and functionality in enhancing the uranium uptake capability. Graphical abstract
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Journal of Food Measurement and Characterization
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2023
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IF 3.4
Xu Ya,Ji Zheng,Wei Bangchang,Kong Shengnan,Wang Yang,Li Chuanrun,Wang Huchuan
Propolis has a wide range of biological activity, as a drug in the world has a long history. In this study, the components of propolis essential oil (PEO) were analyzed by gas chromatography-mass spectrometry (GC-MS), and 62 compounds were identified. The main components were β-eudesmol (15.16%), γ-eudesmol (12.35%), α-Bisabolol (11.88%) and guaiol (10.14%). The modified chitosan/hydroxyapatite biomimetic (PMCH) material was prepared to load PEO (PMCH/PEO). Moreover, the optimum preparation process was explored: the mass ratio of material to essential oil was 3:1 (w/w), the ratio of hydroxyapatite to chitosan in load material was 2:1 (w/w), and the time was 40 min. PMCH/PEO showed good storage stability at room temperature. In addition, the antioxidant capacity of PEO and PMCH/PEO was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-diazo-bis-3-ethylbenzothiazoline-6- sulfonic acid (ABTS) and ferric reducing antioxidant power (FRAP) assays. The results showed that PEO and PMCH/PEO had significant antioxidant capacity. PEO and PMCH/PEO could significantly inhibit the secretion of nitric oxide (NO), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). The inhibition of PMCH/PEO on NO, IL-6 and TNF-α can reach 7.61%, 10.92% and 11.79%, respectively. PMCH/PEO biomimetic material could successfully load PEO. PMCH/PEO have good antioxidant and anti-inflammatory activity and can be effectively used in food, pharmaceutical and other industries.
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Polymers
·
2023
·Vol. 15
·期 19
·4011
·
IF 5
Huan-Jun Lu,Jian-Ke Cen,Yu Ren,Mei-Xian Li
Nanoparticle delivery of functional molecules or vaccines is an effective method for the treatment of many diseases. This study aims to design ginsenoside Rh2-conjugated O-carboxymethyl chitosan (O-CMC/Rh2) as a drug delivery system and explore its anti-nociceptive effects. O-CMC/Rh2 was synthesized with an esterification reaction, and its chemical composition and morphology were evaluated using proton nuclear magnetic resonance (1H NMR), the attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, and scanning electron microscopy (SEM). In addition, the in vitro cumulative release of Rh2 from the O-CMC/Rh2 was also evaluated under different pH conditions. The results showed that the ginsenoside Rh2 was successfully conjugated to the O-CMC matrix and exhibited a highly porous structure after conjugation, facilitating the release of Rh2 from O-CMC. Complete Freund’s adjuvant (CFA) and burn injury-induced pain models were used to evaluate the anti-nociceptive effects of O-CMC/Rh2 on inflammatory pain. O-CMC/Rh2 reduced CFA-induced pain hypersensitivity in a dose-dependent manner and had a longer analgesic effect than Rh2. In addition, O-CMC/Rh2 also relieved the chronic pain induced by bury injury. These results indicated that O-CMC/Rh2 could be useful in reducing inflammatory pain, thus possessing a potential medicinal application in pain therapy.Keywords:O-carboxymethyl chitosan;ginsenoside Rh2;anti-nociception;inflammatory pain
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Yanghui Song,Guanglei Zhao,Sihan Zhang,Chong Xie,Runde Yang,Xiaofeng Li
Separators are indispensable components in lithium-ion batteries (LIBs), providing efficient pathways for lithium ions to travel and isolating the positive and negative electrodes to avoid short circuits. However, traditional polyolefin-based separators exhibit inferior electrolyte affinities, limited porosities, and low thermal stabilities. In this study, a novel method was developed to prepare chitosan micro/nanofiber membranes as LIB separators using natural materials. The pore sizes of the chitosan micro/nanofibers separators were modulated by changing the diameters of the chitosan fibers. The results demonstrated that the chitosan nanofiber separators (CSNFs) had superior electrolyte uptake (281 %), excellent thermal dimensional stability, and electrochemical performance in LiFePO 4 /Li half-cell, as indicated by the higher discharge capacity after 100 cycles, and higher rate capacity than commercial Celgard2325 separator. This study paves the way for the fabrication of eco-efficient and environment-friendly separators for high-performance LIBs.
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