JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Haigang Li,Jiaxuan Liu,Lei Zhang,Xinru Zhu,Jing Jiang,Zhaohui Ge,Yifei Zuo,Xiangzhu Chen,Chun Zhang
This study aims to achieve co-delivery of paeoniflorin (PF) and butyric acid (BA) to the colon through Eudragit S100 (EUS100)-coated halloysite nanotube/o-butyryl chitosan microspheres (EUS100-HNT-BUCHNPs). O-butyrylated chitosan (BUCH) was prepared by the acylation reaction of chitosan (CH) and butyric anhydride with methane sulfonic acid as a catalyst. PF-loaded halloysite nanotube/o-butyrylated chitosan microspheres (HNT-BUCHNPs) were prepared by emulsion crosslinking with glutaraldehyde as the crosslinking agent and then coated with EUS100 using the emulsion solvent evaporation method. X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy results indicated the presence of EUS100 coating on the surface of HNT-BUCHNPs. In vitro release studies demonstrated that the EUS100 coating effectively prevented the release of PF and BA at pH 1.2, while the halloysite nanotube slowed down PF release at pH 6.8. Sequential release experiments in different pH media showed lower release of PF and BA at pH 1.2 and pH 6.8, and higher release at pH 7.4, reaching approximately 80 % and 85 %, respectively. Gastrointestinal tract retention studies in mice confirmed that EUS100-HNT-BUCHNPs reduced the release of PF and BA in the upper digestive tract, facilitating delivery to the colon. In vivo and in vitro results indicated efficient transport of PF and BA to the colon, suggesting the potential of EUS100-HNT-BUCHNPs as colon-targeted carriers for PF and BA.
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JOURNAL OF ELECTRONIC MATERIALS
·
2025
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IF 2.5
Tan Shangrong,Yao Zhuo,Huang Hong,Liu Zechen,Guo Shiqi,Zhao Xinyun
Electrochemical supercapacitors, given their high power density and excellent cycling stability, have broad applications from electronic devices to electric vehicles. In this study, we have developed novel nanocomposites to serve as electrodes of high-performance supercapacitors. The nanocomposites, referred to as Cu/MnX x (X = O, S, C)-rGO (rGO: reduced graphene oxide), were fabricated through direct oxidation, sulfidation, and carbonization at elevated temperatures from their metal–organic framework origin, i.e., Cu/Mn-BTC-rGO (BTC: benzene–1,3,5-tricarboxylic acid). This process is cost-effective and scalable, and can be fine-tuned to achieve a variety of nanocomposites with the desired chemistry and structural characteristics. The carbonized product, Cu/MnC x -rGO, is made up of nanoparticles of MnO and copper in close contact supported on rGO nanosheets via strong coupling. This material demonstrates excellent charge storage, rate capability, and cycling stability, i.e., high specific capacitance of 718.6 F g −1 at a current density of 1 A g −1 , with 92.6% capacitance retention after 1000 cycles. The hierarchical 3D structured Cu/MnC x -rGO nanocomposite has unique chemistry, high surface area, and high electrical conductivity, and hence ensures rapid ion and electron transport beneficial to both pseudocapacitive and double-layer capacitive performance.
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LANGMUIR
·
2024
·
IF 3.7
Liye Ni,Guangjie Yang,Chenweijia He,Tiancheng Lan,Shuijian He,Haoqi Yang,Nan Wu,Rulan Chen,Li Liu,Fangdi Wu,Qian Zhang
The preparation of porous carbon is constrained by the extensive use and detrimental impact of activators and dopants. Therefore, developing green and efficient strategies that leverage the intrinsic properties and pretreatment of the materials to achieve self-activation and self-doping is particularly crucial for porous carbon materials. Herein, potassium histidine was utilized as the molecular salt precursor, attaining the efficient and streamlined preparation of porous carbon through a one-step carbonization process that enables self-activation, self-doping, and self-templating. More interestingly, the carbonization temperature significantly impacts the porous structure of the molecular salt precursors, the properties of the heteroatoms, and electrochemical performance. The designed electrodes exhibit high accessibility to electrolyte ions and effective ion-electron transport channels. Therefore, the optimal carbon material (KHis800) has an excellent mass-specific capacitance of 305.2 F g–1 at 0.2 A g–1, and a high capacitance retention rate of 115.6% (50,000 cycles at 5 A g–1). Notably, KHis800 also shows a maximum energy density of 19.6 Wh kg–1. This research is dedicated to exploring a more efficient preparation method for porous carbon material via molecular salts, offering insights for the sustainable development of carbon materials.
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FOOD HYDROCOLLOIDS
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2024
·
IF 11
Lianghua Xie,Zineb Ould Yahia,Ahmed K. Rashwan,Qiang Han,Qingying Liu,Bolai Paul,Shiyu Liu,Ahmed I. Osman,Wei Chen
Cyanidin-3 -O -glucoside (C3G) is a flavonoid with various biological properties, susceptible to degradation and instability under different external factors. Thus, this study aimed to develop novel gum Arabic (GA)-coated nano-nutriosomes (NUs) to improve the stability of C3G and facilitate its controlled delivery and cellular uptake as well as investigate the potential of GA-coated NU as a delivery system for C3G. The optimum concentration of GA to coat C3G-NU was 0.5% (w/v). The properties of NU systems were studied through DLS, HPLC, TEM, DSC, and FTIR. The results showed that C3G was successfully loaded in NUs and GA-NUs with a high encapsulation efficiency of 93.04% and 93.37%, nanosized 175.46 nm and 157.66 nm, with a PDI of 0.27 and 0.22, respectively. Besides, FTIR and DSC analysis showed a successful conjugation between GA and NUs, where GA-C3G-NU showed better physicochemical stability under thermal, pH, and ionic conditions, as well as GA can significantly control the release of C3G preserving around 90.16%. Furthermore, GA-C3G-NU showed better performance in C3G retention under different food simulants ≥89%. Moreover, the antioxidant activity of C3G-NU and GA-C3G-NU was DPPH (50.33 and 43.64 μg VCE/mL, respectively), and ABTS (68.50, and 44.22 μg VCE/mL, respectively). All NUs showed biocompatibility in Caco-2 cells with no cytotoxicity, with higher cellular uptake for GA-C3G-NU. Therefore, GA-NU could be a promising nanocarrier for encapsulating, controlling, and delivering functional ingredients.
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Advanced Optical Materials
·
2024
·
IF 8
Xipeng Dong,Wanqing Li,Xue Chen,Er Zhuo,Zizhuo Zhai,Hongxia Qi,Yu Kang,Pudun Zhang
O -phenylenediamine (OPD) is commonly used as a precursor in the preparation of red emissive carbon quantum dots (R-CQDs) due to the sp 2 hybridized structure. However, the low fluorescence quantum yield (QY) of the OPD-based R-CQDs limits its application. Although some efforts have been made, the improvement of QY is still limited. In this paper, a strategy is proposed to improve the QY of OPD-based R-CQDs by introducing ethylenediamine (EDA), which plays a key role as a nitrogen (N) dopant due to its high N content. The molar ratio of OPD to EDA (M OPD /M EDA ), the reaction time (t) and temperature (T), and the amount of concentrated H 2 SO 4 (V H2SO4 ), are optimized. The R-CQDs with QY as high as 32.65% and full width at half maximum (FWHM) emission as narrow as 25 nm are obtained via a hydrothermal procedure under the optimal experimental conditions (i.e., M OPD /M EDA = 1/3, t = 6 h, T = 180 °C and V H2SO4 = 4 mL). Such a QY is higher than most of the reported OPD-based R-CQDs. Besides, it is found that concentrated H 2 SO 4 acts as the catalyst in addition to protonation. The enhancement of QY is attributed to the increase of the aromatic N-containing heterocyclic structures (C═N) after the introduction of EDA and catalysis by H 2 SO 4 .
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Hong Jiang,Hang Zhu,Zhenchen Tang,Jiuxuan Zhang,Zhengyan Qu,Weihong Xing,Rizhi Chen
The green production process of o-methylcyclohexanol is particularly important due to its widespread industrial applications. Addressing the issue of low mass transfer efficiency of hydrogen in traditional liquid-phase hydrogenation processes, multichannel ceramic membranes as hydrogen dispersion tools are introduced, successfully achieving uniform and efficient dispersion of hydrogen in the o-cresol cyclohexane solution, thereby promoting the efficient hydrogenation of o-cresol to o-methylcyclohexanol within a fixed-bed reactor. The results show that compared to conventional single-tube feeding methods, the introduction of ceramic membranes significantly enhances the o-cresol conversion and o-methylcyclohexanol selectivity. By optimizing the pore size (200 nm), channel number (19 channels) of the ceramic membranes, and operating conditions, o-cresol conversion and the o-methylcyclohexanol selectivity of no less than 99.5% are achieved under optimal operating conditions. Furthermore, a macro-kinetic model for the membrane-dispersion-enhanced liquid-phase hydrogenation of o-cresol is established, which incorporates an empirical equation for hydrogen solubility. Validation results show that the model-calculated reaction rates of o-cresol are highly consistent with experimental data, with errors controlled within 5%, providing theoretical support for the precise regulation of experimental operating conditions. The work offers a new strategy for the green production of o-methylcyclohexanol.
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MOLECULES
·
2024
·Vol. 29
·期 4
·780
·
IF 4.2
Boxiao Wu,Churan Li,Huan Kan,Yingjun Zhang,Xiaoping Rao,Yun Liu,Ping Zhao
Vaccinium dunalianumleaf buds make one of the most commonly used herbal teas of the Yi people in China, which is used to treat articular rheumatism, relax tendons, and stimulates blood circulation in the body. In addition, 6′-O-caffeoylarbutin (CA) is a standardized extract ofV. dunalianum, which has been found in dried leaf buds, reaching levels of up to 31.76%. Because of the uncommon phenomenon, it is suggested that CA may have a potential therapeutic role in hyperlipidemia and thrombosis. This study was designed to study the efficacy of CA on treating hyperlipidemia and thrombosis and the possible mechanisms behind these effects. Hyperlipidemia and thrombosis zebrafish models were treated with CA to observe variations of the integrated optical density within the vessels and the intensity of erythrocyte staining within the hearts. The possible mechanisms were explored using network pharmacology and molecular docking. The results demonstrate that CA exhibits an excellent hypolipidemic effect on zebrafish at concentrations ranging from 3.0 to 30.0 μg/mL and shows thrombosis inhibitory activity in zebrafish at a concentration of 30.0 μg/mL, with an inhibition rate of 44%. Moreover, network pharmacological research shows that MMP9, RELA, MMP2, PRKCA, HSP90AA1, and APP are major targets of CA for therapy of hyperlipidemia and thrombosis, and may relate to pathways in cancer, chemical carcinogenesis-receptor activation, estrogen signaling pathway, and the AGE–RAGE signaling pathway in diabetic complications.
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Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 21
·12712-12720
·
IF 10.7
Tianhao Yu,Peng Gao,Hong Du,Ling Dong
Metal–organic frameworks (MOFs) have recently been reported as promising catalysts for the oxygen evolution reaction (OER). Hence, we chose hydroxyl-rich 2,5-dihydroxyterephthalic acid as the ligand to prepare a novel MIL-100 and wrapped it on the NiCo-ZIF-67 surface to obtain an amorphous hollow material (NiCo-ZIF-67@Fe-MIL-100, denoted as NiCo-ZIF@MIL). The composite material presents a low overpotential (η ≈ 139 mV @ 10 mA cm−2), a small Tafel slope (119 mV dec−1) and great stability for the OER in 1 M KOH solution. Density Functional Theory (DFT) calculations show that the hydroxyl-rich structure, which accelerates OH− transfer and promotes the formation of the Co–O–Fe bridge, effectively reduces the reaction energy barrier (from 2.67 eV for NiCo-ZIF-67 to 2.08 eV for NiCo-ZIF@MIL). This work provides an important reference for the development of double-MOF materials.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yanyu Song,Xianbo Sun,Long D. Nghiem,Jun Duan,Wen Liu,Yongdi Liu,Zhengqing Cai
Building a heterojunction is a fascinating option to guarantee sufficient carrier separation and transfer efficiency, but the mechanism of charge migration at the heterojunction interface has not been thoroughly studied. Herein, MIL-53(Fe)/Bi 4 O 5 I 2 photocatalyst with a Z-scheme heterojunction structure is constructed, which achieves efficient photocatalytic decontamination under solar light. Driven by the newly-built internal electric field (IEF), the formation of Fe-O-Bi electron migration channel allows for rapid separation and transfer of charge carriers at the heterojunction interface, confirmed by the material characterization and density functional theory (DFT) calculation. The narrower band gap and improved visible light response also contribute to the enhanced photocatalytic activity of composite materials. With levofloxacin as the target pollutant, the optimal MIL-53(Fe)/Bi 4 O 5 I 2 achieves complete removal of pollutant within 150 min, the photocatalysis rate of which is ca. 4.4 and 26.0 times that of pure Bi 4 O 5 I 2 and MIL-53(Fe), respectively. Simultaneously, the optimal composite material exhibits satisfactory photodegradation of seven fluoroquinolones, and the photocatalysis rates are as follows: lomefloxacin > ciprofloxacin > enrofloxacin > norfloxacin > pefloxacin > levofloxacin > marbofloxacin. DFT calculations reveal a positive relationship between degradation rate and Fukui index (ƒ 0 ) of main carbon atoms in seven fluoroquinolones. This study sheds light on the existence of electron migration channels at Z-scheme heterojunction interface to ensure sufficient photoinduced carrier transfer, and reveals the influence of pollutant structure on photolysis rate.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Tao Zhao,Dazhong Zhong,Qiang Fang,Xin Zhao,Runxin Du,Genyan Hao,Guang Liu,Jinping Li,Qiang Zhao
The rational design of metal-organic frameworks (MOFs) provides potential opportunities for improving energy conversion efficiency. However, developing efficient MOF-based electrocatalysts remains highly challenging. Herein, a strategy involving strain engineering is developed to promote the electrocatalytic performance of MOFs by optimizing electronic configuration and improving the active site. As expected, the optimized CoFe–BDC NO 2 exhibits a low overpotential of 292 mV at 10 mA cm –2 and a small Tafel slope of 31.6 mV dec –1 as oxygen evolution reaction (OER) electrocatalyst. Notably, when CoFe–BDC NO 2 is prepared on Nickel foam (NF), the overpotential is only 345 mV at 1 A cm –2 , which ensures efficient water oxidation properties. Integrating CoFe–BDC NO 2 /NF anode in membrane electrode assembly (MEA) for overall water splitting and CO 2 reduction reaction (CO 2 RR) tests, the results show that the cell voltages of CoFe–BDC NO 2 /NF are 3.14 and 3.09 V at 300 mA cm –2 (25 °C), respectively, indicating that MOFs have various practical application prospects. The research of the structure-performance relationship reveals the lattice oxygen oxidation mechanism (LOM) where the Co-O-Fe bond is formed during the OER process by changing the electronic environment and coordination structure of CoFe–BDC NO 2 , and with high valence Co as active center, which provides a deep understanding of the structure design of MOFs and their structural transformation during OER.
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GREEN CHEMISTRY
·
2025
·
IF 9.2
Yukang Fan,Dongjie Yang,Fangbao Fu,Xueqing Qiu,Wenli Zhang
Nitrogen and oxygen co-doped porous carbon holds considerable potential for enhancing zinc-ion hybrid capacitors (ZIHCs) in large-scale energy storage. However, designing high-performance carbonaceous cathodes with accessible active sites and efficient ion transport pathways remains challenging. Herein, we employed a multi-scale assembly strategy to construct lignin-based organic–inorganic supramolecular aggregates (LSA) to prepare nitrogen and oxygen co-doped porous carbon nanosheets (S-NLPC), achieving an exceptionally high specific surface area of 2848.1 m2 g−1, a hierarchical porous structure, and substantial levels of nitrogen and oxygen doping (N: 4.0 at% and O: 8.9 at%). The carbon nanosheets saturated with customized micro–mesopores significantly enhance the kinetics of ion transport and storage, while the nitrogen and oxygen doping improves the accessibility of high-density active sites and introduces additional chemisorption sites. As a result, the ZIHCs utilizing S-NLPC as the cathode demonstrate an enhanced specific capacitance of 433 F g−1 (192.4 mA h g−1), superior energy density of 154.3 W h kg−1 at 80.2 W kg−1, and remarkable cycling stability with a capacity retention of 90.2% after 20 000 cycles at 5 A g−1. Furthermore, ex situ characterization reveals that the superior zinc ion storage performance of S-NLPC is primarily attributed to the reversible chemisorption of oxygen functional groups and the co-adsorption mechanism of Zn2+ and H+. This work presents a novel strategy for constructing lignin-based inorganic–organic aggregates utilizing multi-scale forces, providing new insights into the structural design of carbon-based cathodes for high-performance ZIHCs.
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APPLIED CATALYSIS A-GENERAL
·
2017
·
IF 4.339
Huaying Gao,Yuming Zhou,Xiaoli Sheng,Shuo Zhao,Chao Zhang,Jiasheng Fang,Beibei Wang
Cross-linked poly acidic ionic liquids (MPM-C 6 V-SO 3 CF 3 -IL) with mesoporous and macroporous network structure have been synthesized in different solvents. The novel solid acid catalyst with special network structure has a large surface area (103.83 m 2 /g), large pore volume (0.72 cm 3 /g) and abundant mesopores and macropores, which help to improve the contact between active site and reactants. Catalytic performance of catalyst was investigated through alkylation of o -xylene and styrene. Different reaction parameters specifically solvent on obtained catalyst and production of PXE were systematically investigated. Under optimal reaction conditions (reaction time was 3 h, reaction temperature was 120 °C, catalyst amount was 0.17 g (0.5 wt%), and o -xylene/styrene mass ratio was 7.5:1), a high conversion of styrene (100%) and 1,2-diphenylethane (PXE) yield of 99.67% was obtained, which is superior to commercial acid in liquid and even previous acids synthesized by our own group. Moreover, catalyst could keep relatively high thermostability under reaction and are easy to be separated and recycled from the solution, which are critical for heterogeneous solid catalysts. Thus, this novel catalyst can be potentially applied in other acidic reactions.
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