MEDICAL SCIENCE MONITOR
·
2019
·
IF 1.98
Guomin Li,Lirong Zeng,Haiyan Cheng,Jingxian Han,Xuezhu Zhang,Hui Xie
Background Alzheimer’s disease (AD) is an age-associated neurodegenerative disorder. This study aimed to investigate effects of acupuncture administration on cognitive function and associated mechanisms. Material/Methods Senescence-accelerated prone 8 (SAM-P8) mice were randomly divided into 3 groups: the SAM-P8 group (P8-CN), the SAM-P8 administrating with acupuncture (P8-Acup) group, and the SAM-P8 administrating without acupuncture (P8-Sham) group. Morris water maze test was conducted to evaluate cognitive functions (memory and learning ability). PDK1, nPKC, and Rac1 inhibitors were used to treat SAM-P8 mice. Transmission electron microscope analysis was used to examine nuclear damage hippocampal tissues. Hematoxylin and eosin (H&E) staining was employed to evaluate inflammation. Western blot was used to detect PI3K, PDK1, nPKC, and Rac 1 expression in hippocampal tissues. Results Acupuncture administration significantly reduced PI3K, PDK1, nPKC, and Rac 1 levels compared to P8-CN group ( P <0.05). Both acupuncture and enzyme inhibitors (NSC23766, Rottlerin, {"type":"entrez-protein","attrs":{"text":"OSU03012","term_id":"1188654652","term_text":"OSU03012"}} OSU03012 ) significantly improved cognitive functions, reduced inflammation, and alleviated nuclear damages of SAM-P8 mice compared to P8-CN group ( P <0.05). Acupuncture significantly enhanced effects of inhibitors on inflammation and nuclear damages compared to inhibitor treatment single ( P <0.05). Acupuncture significantly enhanced down-regulative effects of {"type":"entrez-protein","attrs":{"text":"OSU03012","term_id":"1188654652","term_text":"OSU03012"}} OSU03012 on PI3K and PDK1 levels, increased down-regulative effects of Rottlerin on nPKC and Rac 1 levels and enhanced effects of Rottlerin on Rac 1 compared to P8-CN group ( P <0.05). Conclusions Acupuncture administration improved cognitive functions and alleviated inflammatory response and nuclear damage of SAM-P8 mice, by downregulating PI3K/PDK1/nPKC/Rac 1 signaling pathway. This study could provide potential insight for treating cognitive dysfunction and aging of AD patients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Chong Yang,Yuyao Xie,Shimin Xu,Yuwei Luo,Huaiyu Zhu,Hui Wang
Liquid–liquid equilibrium (LLE) data for the ternary system of dodecane + 1-methylnaphthalene + solvent were experimentally determined at 298.2 K and 101.3 kPa using N-methylimidazole, trimethyl phosphate, furfural, N,N-dimethylacetamide, benzyl alcohol, triethyl phosphate, and ethylene glycol as extractants. Using the obtained LLE data, the distribution constant, separation factor, and performance index were calculated to evaluate the performance of these extractants in extracting and separating 1-methylnaphthalene from dodecane. The reliability of the LLE data was examined using the Hand and Othmer–Tobias equations, with the correlation coefficients of the fitted equations exceeding 0.96. Furthermore, the nonrandom two-liquid (NRTL) and universal quasichemical (UNIQUAC) thermodynamic models were used to correlate the LLE data and obtain binary interaction parameters. The root-mean-square deviations between the experimental and calculated results were 0.15–0.97 for NRTL and 0.13–1.05 for UNIQUAC. The derived binary interaction parameters were validated using GMcal_TieLinesLL, a specialized software package for LLE calculations. These findings highlight that both the NRTL and UNIQUAC thermodynamic models can accurately describe the liquid–liquid phase equilibrium behavior of ternary systems, providing a theoretical basis for the industrial application of catalytic cracking diesel extraction and aromatics removal technology.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Xiaolong Tan,Xiangguo Zhang,Yushi He,Zeyi Jiang,Cheng Bao,Nien-Chu Lai
Carbon monoxide selective methanation (CO-SMET) holds promise for removing low-concentration CO in the hydrocarbon reforming for hydrogen (H 2 ) production process and is a deep CO removal technology suitable for low-temperature fuel cells. However, developing highly efficient CO-SMET catalysts remains a significant challenge. Herein, we report a supported catalyst (Ru 1.0 (Cl)/TiO 2 ) with highly dispersed ruthenium (Ru) metal on a high-specific-surface-area mesoporous titanium dioxide (TiO 2 ) catalyst. This catalyst exhibits excellent performance in CO-SMET. It can reduce the CO concentration to below 10 ppm in a wide temperature range of 190–300 °C, and the outlet CO concentration can reach an ultra-low level of 0.2 ppm in the optimal temperature zone (210–220 °C). Through XPS and in situ DRIFTS characterizations, the crucial role of Ru–Cl species at the metal-support interface is revealed. The presence of chlorine atoms leads to electron enrichment in the Ru metal, enhancing its adsorption and activation of CO.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Haiyang Shao,Chen Wang,Miaomiao Zheng,Yafei Cheng,Lihai Fan,Haiyang Yan,Xiaocheng Lin
To advance industrial acid recovery via diffusion dialysis, the crucial step is to engineer anion exchange membranes (AEMs) with superior acid permeability and selectivity. Herein, a PIM-1-based AEM was fabricated via liquid bromine-induced bromination followed by a non-crosslinking alkylation with 1-methylimidazole, which preserves the rigid polymer backbone and intrinsic microporosity. The optimized, mechanically robust membrane exhibited a specific surface area of 549 ± 18 m 2 g −1 , providing abundant free volume for rapid proton transport, and a pore size distribution precisely centered between 0.40 and 0.75 nm, enabling selective acid recovery via size sieving in a typical HCl/FeCl 2 wastewater system. This membrane achieved a proton dialysis coefficient of 59.4 ± 4.3 × 10 −3 m h −1 and a selectivity of 74.4 ± 2.7 over Fe 2+ , outperforming the commercial DF-120 AEM by sevenfold and fourfold, respectively. This work provides a scalable, non-crosslinking functionalization route to fabricate mechanically robust AEMs from PIMs, leveraging their preserved microporosity for efficient and selective acid recovery.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Qiang-Ming Li,Qiao-Qiao Zhang-Yang,Ya-Yi Tan,Xiang-Ling Wu,Xue-Qiang Zha,Zhen-Zi Shang,Jian-Ping Luo,Feng-Yun Zhang
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. The stem of Dendrobium huoshanense is a traditional medicinal food. This study aimed to investigate the effect of cultivated D. huoshanense stem polysaccharide (cDHPS) on AD and elucidate its mechanisms using an Aβ 1–42 -induced AD mouse model. Results showed that cDHPS significantly improved the cognitive dysfunction and ameliorated the hippocampal neuronal injury of AD mice. Meanwhile, cDHPS effectively alleviated the neuroinflammation of AD mice not only by decreasing the expression of caspase-1, NOD-like receptor family pyrin domain-containing 3 (NLRP3), and apoptosis-associated speck-like protein containing a CARD (ASC), as well as their downstream inflammatory cytokines, but also by inhibiting the activation of microglia and astrocytes. Furthermore, the levels of glucagon-like peptide-1 (GLP-1) in the hippocampus, plasma, and intestine of AD mice were markedly elevated by cDHPS, along with an increase in intestinal short-chain fatty acids (SCFAs) levels. However, the treatment of exendin 9–39, a GLP-1 receptor antagonist, weakened the protective effect of cDHPS against AD, and the depletion of SCFAs reversed the beneficial effects of cDHPS on cognitive dysfunction, hippocampal neuronal injury, neuroinflammation, and GLP-1 secretion in AD mice. These results suggest that cDHPS could protect against AD by modulating the SCFAs/GLP-1 axis-mediated neuroinflammation suppression.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Kai Jia,Yihao Zhao,Mingyuan Shao,Fangqi Yu,Yongqing Wang,Shanbing Mao,Zhendong Liu
The demand for zeolites is expected to grow rapidly due to their expanding applications in catalysis and separation, which drives the need for efficient synthesis routes based on economical raw materials. To overcome the limitations of time-consuming conventional zeolite synthesis, an ultrafast and low-cost route has been developed using industrial-grade sodium silicate as the silica source. This approach enables minute-level synthesis of silicalite-1 zeolite through a combination of acid neutralization and seeding strategies. Notably, carbon dioxide was also demonstrated as an effective neutralizing agent, offering a sustainable alternative. This ultrafast route further enabled the in-situ encapsulation of metal nanoclusters during zeolite crystallization, which resulted in well-defined metal-zeolite catalysts. Using Pt–Zn as a model system, the catalysts exhibited high activity and long-term stability in propane dehydrogenation. This work presents a scalable and economical route for producing high-performance zeolite catalysts and highlights the potential for broader application in commercial dehydrogenation processes and beyond.
✓ 已验证
产品关联
DOI
高影响因子
Catalysis Science & Technology
·
2026
·
IF 4
Ziheng Li,Junxin Guo,Haoze Liu,Dule Huhe,Zhao Wang
Despite their high methanol selectivity in CO2 hydrogenation, In2O3-based catalysts still face limitations in CO2 conversion and long-term stability. This work addresses these challenges by designing a highly dispersed Pd/In2O3 catalyst supported on self-pillared silicalite-1 (SP-S-1) zeolite. The well-defined channels and abundant surface silanol groups of SP-S-1 effectively anchor and disperse In2O3 nanoparticles. This structure also spatially isolates Pd species, which prevents their sintering and inhibits the formation of inactive Pd–In alloys. Comprehensive characterization reveals that the strong metal-support interaction stabilizes oxygen vacancies and prevents over-reduction of In3+ species, which are crucial for CO2 activation and methanol selectivity. The optimized Pd/In2O3/SP-S-1 catalyst achieves a methanol space-time yield of 2.57 gMeOH·gIn+Pd-1·h-1 at 300 °C, approximately five times higher than that of the unsupported counterpart. More importantly, it demonstrates high stability, retaining 95% of its initial activity after 100 hours on stream, far outperforming the unsupported catalyst. This work highlights zeolite confinement as a versatile strategy for designing robust and efficient CO2-to-methanol catalysts.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Huili Cui,Zhu Liu,Kongze Wei,Jia Yu,Lei Wang,Changhao Chen,Jie Deng,Junyan Zhu,Chaoling Wei,Yue Fei
Varietal character is a key factor in determining the flavor and quality of tea. Lu’an Guapian (LAGP) is a historical Chinese green tea, yet it lacks a representative elite cultivar. To address this, we explored the varietal characteristics of LAGP processed from the recently bred elite cultivar ‘Jinyu 1’ (JY1). Using molecular sensory science and metabolomics, we analyzed its volatile and non-volatile compounds. LAGP possessed from JY1 presents a unique flavor, with floral, coconut-like, and citrus-like aromas, along with a fresh and mellow taste. This aroma was attributed to high contents of (Z) -jasmone, decanal, 1-nonanol, methyl jasmonate, δ -decalactone, β -ionone, geraniol and jasmine lactone. High levels of theanine and a low content of bitter amino acids contribute to its taste. This study confirms that JY1 is a high-quality source material for producing premium-grade LAGP, highlighting the critical role of cultivars in enhancing tea quality and market competitiveness.
✓ 已验证
产品关联
DOI
高影响因子
PLANT JOURNAL
·
2026
·Vol. 125
·期 1
·e70678
·
IF 5.7
Yueqiao Wang,Pengfei Cheng,Ke Jiang,Jiaxin Gong,Ziyu Liu,Wenbiao Shen
SUMMARY The endogenous hydrogen (H 2 ) synthesis pathway in higher plants has been a mystery for nearly a century. Here, we report that the tomato Nuclear Architecture Related 1 (NAR1) protein is an enzymatic source of plant-based H 2 . Mutation experiments found that the H 2 -producing hydrogenase activity is closely related to four H-cluster coordinating cysteine residues and is positively regulated in darkness. Contrary changes in H 2 production and lateral root (LR) branching were individually observed in SlNAR1 overexpression and mutant lines. The homozygous lethal effect of knocking out tomato NAR1 was also observed. Genetic and anatomic evidence confirmed that NAR1 control of endogenous H 2 is a signaling mechanism that manipulates the expression of polar auxin transporters. Auxin accumulation in LR primordium and oscillation zone and LR branching stimulation were subsequently observed. Pot-cultured transgenic tomato plants overexpressing SlNAR1 display a luxuriant root system. These findings identify a mechanism for genetic engineering to regulate root organogenesis through alteration of NAR1-dependent H 2 .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemical and Biological Technologies in Agriculture
·
2026
·
IF 5.2
Chen Yao,Li Dongyang,Liu Yan,Cheng Yongjia,Zhang Juan,Li Chaojie,Lei Zhiwei,Yang Wen
Background Plants synthesize and emit a wide variety of volatile compounds that serve different defense-related functions in response to both abiotic and biotic stresses. Results In this study, 1-nonanol was identified as the most active volatile against Epicoccum sorghinum among those co-up-regulated in the tea cultivar of ‘Qianmei 601’ infected by three strains of E. sorghinum. Its antifungal results in vitro indicated that the minimum inhibitory concentration and the minimum bactericidal concentration were 0.1 mg/mL and 0.15 mg/mL, respectively. Scanning electron microscopy, transmission electron microscopy, calcofluor whiteand and propidium iodide staining solutions demonstrate that 1-nonanol inhibited the normal growth of E. sorghinum mycelia by affecting the cell membrane and cell wall structure of E. sorghinum mycelia. Additionally, exposure to 1-nonanol resulted in increased levels of intracellular malondialdehyde, soluble proteins, and chitinase, while superoxide dismutase content decreased. Transcriptome analysis revealed that regulatory genes associated with 1-nonanol were involved in starch and sucrose metabolism, glycerophospholipid metabolism, and fatty acid synthesis pathways. Treatment with 1-nonanol significantly up-regulated genes linked to exo-1,3- β -glucanase and hexokinase, while genes related to chitin synthase, aminophospholipid translocase, 3-oxoacyl-[acyl-carrier-protein] synthase, and mitochondrial 2-enoylthioester reductase were down-regulated. Conclusions These results indicate that 1-nonanol disrupts the integrity of cell walls and cell membranes, inhibiting the growth of normal hyphae and potentially causing cell death. This study is the first to confirm that 1-nonanol is a crucial component of the defense-related volatile compounds produced by ‘Qianmei 601’ in response to stress from E. sorghinum . We discussed these results and emphasized the importance of this interaction in plant–microbe interactions. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
·
2024
·Vol. 64
·期 2
·107225
·
IF 4.9
Yali Zhang,Mengyue Liu,Jiangfeng Zhang,Jie Wu,Lijuan Hong,LiQiang Zhu,Jinzhao Long
bla NDM-1 and bla KPC-2 are responsible for the global increase in carbapenem-resistant Klebsiella pneumoniae , posing a great challenge to public health. However, the impact of phylogenetic factors on the dissemination of bla NDM-1 and bla KPC-2 is not yet fully understood . This study established a global dataset of 4051 bla NDM-1 + and 10,223 bla KPC-2 + K. pneumoniae genomes, and compared their transmission modes on a global scale. The results showed that bla NDM-1 + K. pneumoniae genomes exhibited a broader geographical distribution and higher sequence type (ST) richness than bla KPC-2 + genomes, indicating higher transmissibility of the bla NDM-1 gene. Furthermore, bla NDM-1 + genomes displayed significant differences in ST lineage, antibiotic resistance gene composition, virulence gene composition and genetic environments compared with bla KPC-2 + genomes, suggesting distinct dissemination mechanisms. bla NDM-1 + genomes were predominantly associated with ST147 and ST16, whereas bla KPC-2 + genomes were mainly found in ST11 and ST258. Significantly different accessory genes were identified between bla NDM-1 + and bla KPC-2 + genomes. The preference for bla KPC-2 distribution across certain countries, ST lineages and genetic environments underscores vertical spread as the primary mechanism driving the expansion of bla KPC-2 . In contrast, bla NDM-1 + genomes did not display such a strong preference, confirming that the dissemination of bla NDM-1 mainly depends on horizontal gene transfer. Overall, this study demonstrates different phylogenetic drivers for the dissemination of bla NDM-1 and bla KPC-2 , providing new insights into their global transmission dynamics.
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2013
·
IF 3.172
Jingjing Jiao,Bing Han,Meijia Lin,Ni Cheng,Li Yu,Min Liu
A series of salt-free catanionic surface active ionic liquids (SAILs), 1-alkyl-3-methylimidazolim alkyl sulfates (denoted as [C n mim][C m SO 4 ], n = 6, 8, 10; m = 12 and n = 4; m = 10, 14) were synthesized by an ion exchange reaction and their surface properties in aqueous solution were examined systematically by surface tension, fluorescence and electrical conductivity measurements. As catanionic surfactants, these SAILs exhibit notably higher surface activity, compared to the cationic or anionic analogues. Increment in both cationic and anionic alkyl chain lengths for [C n mim][C m SO 4 ] can both improve the amphiphilic character remarkably. This can be ascribed to cooperative interactions as formation of catanionic pairs between alkyl-substituted imidazolium cations and alkyl sulfate anions. The negative micellization Gibbs free energy values prove that the micellization of all the 1-alkyl-3-methylimidazolim alkyl sulfates investigated is a spontaneous process. Any additional CH 2 group makes the micellization process easier regardless if it is on a cation or an anion. When keeping the total carbon atom number constant, we find that the [C n mim][C m SO 4 ] molecules with greater asymmetric alkyl chains display superior surface activity. This work indicates that the self-assembly of these imidazolium-based salt-free catanionic SAILs can be tailored by adjusting the mismatch of alkyl chains. These SAILs are expected to have potential applications in the fields of colloidal and interface and nanomaterial synthesis.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）