APPLIED CATALYSIS B-ENVIRONMENTAL
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2018
·
IF 11.698
Yu Han,Dongting Yue,Miao Kan,Yunwen Wu,Jun Zeng,Zhenfeng Bian,Yixin Zhao,Xufang Qian
Improving the photocatalytic efficiency of commercial TiO 2 has important significance for practical application of TiO 2 based photocatalysts. A novel photocatalyst [Mo 3 S 13 ] 2− /TiO 2 was fabricated by combining [Mo 3 S 13 ] 2− with commercial TiO 2 by an impregnation method. This composite photocatalyst presented a remarkable enhancement on photocatalytic mineralization of acetone in comparison with commercial TiO 2 . The optimum loading amount of [Mo 3 S 13 ] 2− was 1.7wt%, which is more efficient than the Pt/TiO 2 (1.5wt%). Electrochemical impedance spectroscopy (EIS) showed the smooth electron transfer pathway in [Mo 3 S 13 ] 2− /TiO 2 composite, facilitating the photo-charges separation during the photocatalysis process. Reactive oxygen species scavenging test illustrated that superoxide radical ( O 2 − ), hydroxyl radical ( OH) and photo-induced hole (h + ) were all contributing to the acetone degradation. The [Mo 3 S 13 ] 2− /TiO 2 photocatalyst was deposited on non-woven fabrics which showed obvious promotion on the photocatalytic degradation of acetone in comparison with pristine commercial TiO 2 .
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ACS Nano
·
2026
·
IF 17.3
Wenxiang Hou,Yusheng Zhang,Xuefei Chen,Xun Wang,Dayu Li,Wendai Cheng,Xixi Gong,Qu Wang,Ruofan Huang,Guanyuan Su,Chunmei Zhang,Liang Yang
Abstract Transition-metal hydroxides and oxides are widely used in optoelectronic and electrochemical devices, yet precise control over their three-dimensional (3D) microarchitecture and morphology remains a major challenge for microscale device fabrication. Here, we report a laser-confined interfacial nucleation and hierarchical growth (LCING) strategy that enables direct laser printing of Ni(OH)2/NiO microarchitectures with high spatial resolution and programmable porous structures. The localized photothermal field drives interfacial nucleation and hierarchical growth, allowing conformal integration of hydroxide microstructures and flexible construction of complex 3D geometries. We further elucidate the coupled mechanisms of mass transport, heat transfer, and reaction kinetics governing the LCING process. By rationally tuning laser printing parameters, the morphology and porosity of the resulting microstructures can be precisely controlled. The printed Ni(OH)2/NiO microdevices enable high-resolution structural color patterning and enhanced sensing performance, with the 3D porous Ni(OH)2/NiO architectures showing improved gas-sensing responses compared with lower-dimensional and nonporous counterparts. This work presents a versatile and programmable approach for high-precision manufacturing of functional metal-oxide microdevices.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2018
·
IF 4.816
Le-Mao Yu,Zhu Hu,Yu Chen,Azhar Ravji,Sophia Lopez,Caroline B. Plescia,Qian Yu,Hui Yang,Monica Abdelmalak,Sourav Saha,Keli Agama,Evgeny Kiselev,Christophe Marchand,Yves Pommier,Lin-Kun An
Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a recently discovered enzyme specifically repairing topoisomerase II (TOP2)-mediated DNA damage. It has been shown that inhibition of TDP2 synergize with TOP2 inhibitors . Herein, we report the discovery of the furoquinolinedione chemotype as a suitable skeleton for the development of selective TDP2 inhibitors. Compound 1 was identified as a TDP2 inhibitor as a result of screening our in-house compound library for compounds selective for TDP2 vs. TDP1 . Further SAR studies provide several selective TDP2 inhibitors at low-micromolar range. The most potent compound 74 shows inhibitory activity with IC 50 of 1.9 and 2.1 μM against recombinant TDP2 and TDP2 in whole cell extracts (WCE), respectively.
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Journal of Energy Storage
·
2023
·
IF 9.4
Shuting Wei,Álvaro Pérez Ramos,Jing Peng,Álvaro Ridruejo,Peng Diao
Microemulsion-based redox flow batteries (RFBs) are gaining popularity due to the characteristics of microemulsions that decouple the solubility of redox species and ionic conductivity, affording a fantastic opportunity to simultaneously extend the electrochemical window and increase the ionic conductivity of electrolytes. In this work, we report a novel microemulsion-based RFB employing with 2-methylanthraquinone and ferrocene as anolyte and catholyte, respectively. Molecular dynamics and density function theory analysis investigated the electrochemical mechanism of redox species, including the intricate process of interface mass transport. The redox flow chemistry exhibits outstanding charge transfer rates and mass diffusion as well as good cycling stability under both cyclic voltammetry and linear sweep voltammetry. The flow cell demonstrated a coulombic efficiency of 96 %, voltage efficiency of 80 % and energy efficiency of 76.6 % after 300 cycles, making it one of the most stable and high-efficiency microemulsion-based RFBs reported so far. Although more advancement is still required to spark practical interest, this study opens a promising pathway to raise the energy density for redox flow batteries and is anticipated to inspire more in-depth studies of stable and high-efficient microemulsion-based RFBs.
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ENVIRONMENTAL TOXICOLOGY
·
2023
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IF 4.5
Xia Wang,Dinggang Li,Xiangqin Zheng,Yifan Hong,Jie Zhao,Wei Deng,Mingxin Wang,Lianju Shen,Chunlan Long,Guanghui Wei,Shengde Wu
Di-(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, has been shown to cause reproductive toxicity, but the precise mechanism remains unclear. This study aimed to investigate the possible molecular mechanism of DEHP-induced testicular damage. In vivo study, we administered different doses of DEHP (0, 250, and 500 mg/kg/day) to male C57BL/6 mice from 22 and 35 days after birth. We found that DEHP exposure induced histopathological alterations in prepubertal testes, and testicular lipidomics indicated notable alterations in lipid metabolism and significant enrichment of ferroptosis. Further tests showed that ferrous iron (Fe 2+ ) and malondialdehyde (MDA) levels significantly increased after DEHP exposure. Western blotting revealed that DEHP exposure reduced glutathione peroxidase 4 (GPX4) expression, and elevated acyl coenzyme A synthetase long-chain member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) expression. The in vitro results were consistent with the in vivo results. When Leydig cells and Sertoli cells were treated with ferrostatin-1 and monoethylhexyl phthalate (MEHP), MEHP-induced increases in Fe 2+ and MDA levels, accumulation of lipid reactive oxygen species, downregulation of GPX4, and upregulation of ACSL4 and LPCAT3 were reversed. Collectively, our findings suggested that aberrant lipid metabolism and ferroptosis may be involved in prepubertal DEHP exposure-induced testicular damage.
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ACS Omega
·
2023
·
IF 4.1
Jin Han,Xin-Yi Tong,Chen-Ying Rao,Jian-Ming Ouyang,Bao-Song Gui
Nano-hydroxyapatite (nano-HAP) is often used as a crystal nest to induce calcium oxalate (CaOx) kidney stone formation, but the mechanism of interaction between HAP crystals of different properties and renal tubular epithelial cells remains unclear. In this study, the adhesion and endocytosis of HAP crystals with sizes of 40 nm, 70 nm, 1 μm, and 2 μm (HAP-40 nm, HAP-70 nm, HAP-1 μm, and HAP-2 μm, respectively) to human renal proximal tubular epithelial cells (HK-2) were comparatively studied. The results showed that HAP crystals of all sizes promoted the expression of osteopontin and hyaluronic acid on the cell surface, destroyed the integrity of the lysosomes, and induced the apoptosis and necrosis of cells. Nano-HAP crystals had a higher specific surface area, a smaller contact angle, a higher surface energy, and a lower Zeta potential than those of micro-HAP. Therefore, the abilities of HK-2 cells to adhere to and endocytose nano-HAP crystals were greater than their abilities to do the same for micro-HAP crystals. The order of the endocytosed crystals was as follows: HAP-40 nm > HAP-70 nm > HAP-1 μm > HAP-2 μm. The endocytosed HAP crystals entered the lysosomes. The more crystal endocytosis and adhesion there is, the more toxic it is to HK-2 cells. The results of this study showed that nanosized HAP crystals greatly promoted the formation of kidney stones than micrometer-sized HAP crystals.
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AppliedChem
·
2026
·Vol. 6
·期 3
·66
·
IF 2.3
Xinxin Cui,Haoran Shi,Yue Long,Xiqi Zhang,Kai Song
Derivatives of 2-amino-4H-chromene possess diverse pharmacological activities. However, traditional multicomponent synthesis suffers from toxic solvents, long reaction times, and difficulties in balancing catalytic activity and selectivity, which violates green chemistry requirements. Inspired by the nanoconfinement effect in enzymatic catalysis, this work uses graphene oxide (GO) as a two-dimensional scaffold to graft creatine (CR) and construct bifunctional catalytic sites. Thermal regulation of GO interlayer spacing yields an interlayer-confined flow membrane reactor for the three-component condensation of benzaldehyde, malononitrile and dimedone. A near-quantitative conversion of 99.0 ± 1.7% (mean ± SD,n= 3) was achieved within 18 s at room temperature. This nanoconfined membrane catalyst overcomes the defects of classic catalytic systems and provides a novel, practical route for continuous, green and high-yield synthesis of 2-amino-4H-chromene derivatives.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Dongxing Dong,Xiaoli Lv,Qiushi Jiang,Jingjing Zhang,Zhengyi Gu,Weimin Yu,Zhaolian Han,Ning Wang,Wenli Hou,Zhiqiang Cheng
In this study, a multifunctional nanofiber dressing that can promote antibacterial, analgesic and healing was prepared by electrospinning technology. Hydrophobic polycaprolactone (PCL)/chitosan (CS)/lidocaine hydrochloride (LID) and epidermal growth factor (EGF) were used as scaffold materials and dissolved in trifluoroacetic acid to prepare spinning solution. The morphology of PCEL dressing was observed by scanning electron microscopy. The fiber structure was dense and the average diameter was 297.0 nm. The water absorption capacity test and water contact angle measurement showed that the fiber had good water absorption and hydrophilicity (1302 %, 139.258°). Drug release was 84 % within 60 h. In the results of antibacterial experiment, the dressing showed certain antibacterial properties . The results of cell experiments show that the dressing can promote cell proliferation . In addition, coagulation experiments showed that the dressing could quickly coagulate the blood within 4 min. In addition, PCEL dressing promoted collagen deposition and vascularization through animal models of pressure sores. Therefore, multifunctional dressing can be used as an ideal auxiliary means for the treatment of pressure sores, and it is a promising alternative to chronic wound healing.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Zhen Rong,Zhi-Hao Ding,Yue-Hong Wu,Xue-Wei Xu
Low-density polyethylene (LDPE), which accounts for 20% of the global plastic production, is discharged in great quantities into the ocean, threatening marine life and ecosystems. Marine microorganisms have previously been reported to degrade LDPE plastics; however, the exploration of strains and enzymes that degrade LDPE is still limited. Here, an LDPE-degrading bacterium was isolated from seawater of the Changjiang Estuary, China and identified as Rhodococcus sp. C-2, the relative abundance of which was dramatically enhanced during PE-degrading microbial enrichment. The strain C-2 exhibited the degradation of LDPE films, leading to their morphological deterioration, reduced hydrophobicity and tensile strength, weight loss, as well as the formation of oxygen-containing functional groups in short-chain products. Sixteen bacterial enzymes potentially involved in LDPE degradation were screened using genomic, transcriptomic, and degradation product analyses. Thereinto, the glutathione peroxidase GPx with exposed active sites catalyzed the LDPE depolymerization with the cooperation of its dissociated superoxide anion radicals. Furthermore, an LDPE degradation model involving multiple enzymes was proposed. The present study identifies a novel PE-degrading enzyme (PEase) for polyethylene bioremediation and promotes the understanding of LDPE degradation.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 10
·1-8
·
IF 5.7
Qiu Minghao,Ren Yuqing,Huang Lumin,Zhu Xueying,Liang Tikai,Li Meijin,Tang Dianping
The proof-of-concept of sensitive electrochemical immunoassay for the quantitative monitoring of human epidermal growth factor receptor 2 (HER2) is reported. The assay is carried out on iron nitrogen-doped carbon (FeNC) nanozyme-modified screen-printed carbon electrode using chronoamperometry. Introduction of target HER2 can induce the sandwiched immunoreaction between anti-HER2 monoclonal antibody-coated microplate and biotinylated anti-HER2 polyclonal antibody. Thereafter, streptavidin-glucose oxidase (GOx) conjugate is bonded to the detection antibody. Upon addition of glucose, 3,3′,5,5′-tetramethylbenzidine (TMB) is oxidized through the produced H 2 O 2 with the assistance of GOx and FeNC nanozyme. The oxidized TMB is determined via chronoamperometry. Experimental results revealed that electrochemical immunosensing system exhibited good amperometric response, and allowed the detection of target HER2 as low as 4.5 pg/mL. High specificity and long-term stability are acquired with FeNC nanozyme-based sensing strategy. Importantly, our system provides a new opportunity for protein diagnostics. Graphical Abstract
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Caizhi Lv,Pengchong Jiao,Hui Xin,Lan Wu,Gangfeng Ouyang,Xiandeng Hou
Insulator hydroxyapatite (HAp) was chosen as a candidate to construct full-spectrum photocatalyst. Glucose as a functional precursor was incorporated into HAp by coprecipitated method, and the glucose-modified HAp was then calcined under nitrogen atmosphere. With the loss of OH - group in HAp and the decomposition of glucose during the calcination, oxygen vacancies (OVs) for regulating the band gap, graphitic carbon (GC) as a good electron acceptor, and a channel for rapid carrier separation via the C-O-Ca forming between OV-HAp and GC can be simultaneously achieved. The as-prepared OV-HAp/GC displayed full-spectrum response and rapid separation of carriers. Moreover, it showed high degradation performance for 2, 4-dichlorophenol (2, 4-DCP), phenol, and tetracycline under visible, NIR, and full-spectrum. This strategy is not only facile, but also exhibits a certain universality. This work opens a new window for full-spectrum photocatalysts construction based on insulators, and large-scale production for practical use can be expected.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Xiaochen Han,Chongyang Guo,Yugao Wang,Gang Liu,Jun Shen
Furan-2,5-dicarboxylic acid (FDCA) is an important biomass-derived diacid, and it is the most promising substitute for terephthalic acid. The common method of FDCA usually involves 5-hydroxymethylfurfural oxidation. Edible fructose is often used as the feedstock of 5-hydroxymethylfurfural, and the oxidation step would generate undesirable impurities. Herein, FDCA was novelty synthesized by carboxylation of formate and 2-furoic acid (FA) derived from unedible-biomass. This route is potentially advantageous because it is simple to operate and does not require any additional additives. The reaction mechanism has been elucidated by density functional theory (DFT) calculations. In the carboxylation process, the C(sp 2 )-H bond of formate (HCOOM) undergoes cleavage, generating the carbon dioxide radical anion (CO 2 •− ). Subsequently, CO 2 •− attacks the C 5 of FA, forming the C C bond and ultimately yielding FDCA. The conversion of HCOOM to CO 2 •− is an effective way to achieve carboxylation reaction. The rate-determining step of the carboxylation reaction is the cleavage of the C(sp 2 )-H bond of HCOO − with activation barrier of 159.11 kJ⋅mol −1 . The investigation would provide a new strategy for the mechanism of carboxylation reactions, and hold the potential to establish pathways for FDCA production.
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