Insect Science
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2026
·
IF 3.7
Honglei He,Feng Lan,Bei Zhang,Tianzi Gu,Jianyang Bai,Qing-He Zhang,Jacob D. Wickham,Longwa Zhang
The olfactory system is pivotal for insects to detect external chemical signals and regulate essential life processes. Dendroctonus valens , an invasive forest pest, displays strong chemotaxis toward the plant kairomone (+)-3-carene. To unravel the molecular mechanism underlying olfactory recognition, we identified 28 odorant-binding proteins (OBPs) from D. valens via transcriptome sequencing and identified DvalOBP6 and DvalOBP18 as potential key candidates for this host kairomone component using qRT-PCR. Tissue expression analysis revealed that these two Minus-C OBPs are predominantly expressed in olfactory-related tissues (antennae, legs, and wings) with distinct sexual dimorphism. Homology modeling and molecular docking showed that both proteins adopt a typical six- α -helix fold, and bind (+)-3-carene primarily via hydrophobic interactions with binding energies of −5.53 kcal/mol and −4.96 kcal/mol, respectively. RNA interference of DvalOBP6 or DvalOBP18 significantly abolished the olfactory preference of D. valens adults for (+)-3-carene. Collectively, our findings demonstrate that DvalOBP6 and DvalOBP18 play critical roles in (+)-3-carene perception, providing a theoretical basis for the development of green pest control technologies targeting insect olfactory communication.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Huan Yang,Zishuo Ni,Xian Zhang,Qun Li,Zhongnian Yang
N, S co-doped carbon coated 3D porous Mn 0.5 Ti 2 (PO 4 ) 3 was fabricated via fulvic acid pyrolysis. • The carbon layer synergistically enhances electronic conductivity and Li + diffusion kinetics. • The designed composite anode revealed outstanding rate capability. NASICON-structured Mn 0.5 Ti 2 (PO 4 ) 3 (MTP) has emerged as a competitive anode candidate for lithium-ion batteries (LIBs), benefiting from its abundant lattice vacancies, robust structural integrity, and suitable operating voltage. Nevertheless, the practical scalability is constrained by intrinsically low electronic conductivity. Herein, fulvic acid (FA) is employed as a carbon precursor to composite with MTP via high-temperature carbonization, aiming to optimize the electrochemical performance of MTP. Electrochemical tests reveal that the composite with FA/MTP weight ratio of 0.30 carbonized at 800℃ achieves enhanced cycling stability and rate capability, delivering lithiation capacities of 391.4 and 198.9 mAh g −1 at 0.1 and 1.6 A g −1 , respectively. The superior performance is attributed to the formation of uniform N, S co-doped carbon coating layer derived from in-situ carbonization of FA. N, S co-doping not only facilitates rapid electron transport and buffers volume changes during repeated lithiation/delithiation but also introduces additional active sites for lithium storage. Simultaneously, the incorporation of a co-doped carbon layer on MTP improves the binding affinity with MTP, thereby conferring outstanding structural durability and electrical conductivity of the composite. This work provides a simple and effective strategy for utilizing natural biomass derivatives to improve the electrochemical performance of polyanionic compounds for advanced LIB anodes. Download: Download high-res image (150KB) Download: Download full-size image
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CHINESE JOURNAL OF CHEMISTRY
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2025
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IF 5.5
Shaohua Liu,Xiaoqin Ma,Xifa Long,Yun Yang
Comprehensive Summary Birefringent crystals exhibit significant advantages in the field of polarization state modulation due to their unique optical anisotropy properties. The property optimization between bandgap and birefringence depends on the crystal structure, which is always a key scientific problem in the field of functional crystal materials design. In this work, the fluorination-oriented strategy was applied to the design of crystals with large birefringence and deep ultraviolet (DUV) cutoff edges. By introducing the fluorinated [SiF 6 ] octahedron, the arrangement orientation of the π-conjugated [C(NH 2 ) 3 ] groups was accurately regulated, thereby achieving the design and preparation of a new crystal [C(NH 2 ) 3 ] 2 SiF 6 with a large bandgap (6.34 eV) and large birefringence (0.16 @546 nm). In addition, [C(NH 2 ) 3 ] 2 SiF 6 (GSF) can obtain large-sized crystals through a simple water solution evaporation method, and it has unique advantages such as low cost and easy growth. The synergistic mechanism between the core factors of significant birefringence and wide bandgap in [C(NH 2 ) 3 ] 2 SiF 6 was revealed through experimental characterization and theoretical calculation. This work provides promising candidates with exceptional properties for DUV applications.
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CHIRALITY
·
2025
·Vol. 37
·期 7
·e70043
·
IF 3
Min Wei,Yinxin Yang,Ruoxi Huang,Linxu Dong,Haikuan Yuan,Lijuan Zhang,Jie Lu
In this work, a novel pair of chiral ionic liquids (CILs) based on cis- and trans-myrtanol was designed, synthesized, and applied in the enantioselective liquid–liquid extraction (LLE) of DL-3-phenyllactic acid (DL-3-PLA). DL-3-PLA, a naturally occurring broad-spectrum antimicrobial compound, exhibits distinct biological activities in its enantiomeric forms, making its separation of significant interest for pharmaceutical and food applications. The CILs were synthesized starting from (1S)-(−)-β-pinene via oxidative hydroboration, followed by subsequent functional group modifications, and were fully characterized using 1 H NMR, FTIR, DSC, and TGA. Optimization of the LLE parameters (0.10-M CILs in n-octanol, 0.10-M DL-3-PLA in water, pH 6.8, 298.15 K) yielded a single-stage enantiomeric excess ( ee ) of 15.68%. Using five consecutive extractions with the trans-CILs isomer, a cumulative ee of 95.18% was achieved. Quantum mechanical calculations, including electrostatic potential analysis, IGMH isosurface mapping, and binding energy evaluations, revealed that both the cis- and trans-CILs isomers exhibited strong chiral recognition toward D-3-PLA, with the trans-CILs isomer showing superior recognition performance compared to the cis-CILs isomer. These results underscore the potential of the designed CILs as effective chiral selectors for the DL-3-PLA separation and provide a promising strategy for practical applications in enantioselective separations.
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Marine Drugs
·
2025
·Vol. 23
·期 11
·423
·
IF 5.4
Pingting Liu,Fengyuan Li,Zhicong Liu,Yang Liu
Galectin-3 (Gal-3) is a histologic marker of pancreatic cancer and a potential therapeutic target. This study aimed to characterize a novel sulfated agarose-derived oligosaccharide (DP9) from marine algae,Gracilaria lemaneiformis, evaluate its Gal-3 inhibitory activity, and investigate its anti-pancreatic cancer mechanisms. Through controlled acid hydrolysis, a series of odd-numbered oligosaccharides (DP3-11) were obtained, in which DP9 showed the strongest Gal-3 inhibition in hemagglutination assays. Structural analysis confirmed DP9’s unique composition including an alternating β (1→4)-D-galactose and α (1→3)-3,6-anhydro-L-galactose backbone, featuring partial 6-O-methylation on β-D-galactose and 6-O-sulfation on 3,6-anhydro-α-L-galactose residues. Molecular docking revealed DP9’s binding to Gal-3’s carbohydrate recognition domain through key hydrogen bonds (His158, Arg162, Lys176, Asn179 and Arg186) and hydrophobic interactions (Pro117, Asn119, Trp181 and Gly235), with the sulfate group enhancing binding affinity. In vitro studies demonstrated DP9’s selective anti-pancreatic cancer activity against BxPC-3 cells, including inhibition of cell proliferation; S-phase cell cycle arrest; induction of apoptosis; and suppression of migration and invasion. Mechanistically, DP9 attenuated the Gal-3/EGFR/AKT/FOXO3 signaling pathway while showing minimal cytotoxicity to normal cells. This study first demonstrated that agarose-derived odd-numbered oligosaccharides (DP9) can serve as effective Gal-3 inhibitors, which proved its potential as a marine oligosaccharide-based therapeutic agent for pancreatic cancer.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Xiangyue Liao,Shuhan Yi,Min Xie,Xiaoying Li,Binghao Lin,Yufan Chen,Yangjie Li,Xuemei He,Qiaoji Zheng,Kwok-Ho Lam,Dunmin Lin
Na3V2(PO4)3 (NVP) is regarded as a promising cathode for sodium-ion batteries (SIBs) owing to its high operating voltage and robust NASICON-type framework. However, its practical application is hindered by poor rate capability and limited long-term cycling stability. In this work, a high-entropy substituted cathode, Na3V1.75(Ca, Zr, Al, Mn, Mg)0.25(PO4)3 (denoted as HE-NVP), is successfully synthesized via a conventional solid-state method. The introduction of multiple aliovalent cations leads to local structural regulation, where elongation of Na(1)–O bonds and contraction of Na(2)–O bonds enhance structural stability and facilitate fast Na+ migration. Simultaneously, the V4+/V5+ redox couple is activated at ∼4.0 V, significantly boosting energy density and cycling stability. High-entropy substitution also promotes pseudocapacitive behavior through the modulation of the local chemical environment and vanadium redox chemistry. As a result, HE-NVP delivers excellent rate performance with a high specific capacity of 93.2 mAh g–1 at 50 C and outstanding long-term durability, retaining 81.8% of its initial capacity after 2,000 cycles at 20 C. Even under harsh conditions of 50 C, it maintains 78% capacity retention after 4,000 cycles, with an ultralow capacity decay rate of 0.006% per cycle after 6,000 cycles. Ex-situ XRD analysis confirms a single-phase solid-solution reaction mechanism with a minimal volume change of only 1.5% during Na+ insertion/extraction. This study highlights a practical and effective strategy for designing high-performance SIB cathodes through rational high-entropy engineering of the crystallographic structure and redox chemistry.
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GREEN CHEMISTRY
·
2026
·
IF 10.6
Yankai Zhang,Chenxi Zhu,Haoyi Wang,Yunbiao Qi,Ping Sun,Quanxing Zhang,Wei Jiang
Poly(3-hydroxybutyrate) (PHB) is a biodegradable, bio-based polymer with significant application potential. The development of efficient chemical recycling strategies for PHB is essential for advancing a circular bioeconomy. However, existing methods for depolymerizing PHB into crotonic acid (CA), a valuable platform chemical, often rely on harsh reaction conditions, suffer from low selectivity, or require high energy input. Herein, we report a novel catalytic system based on sodium crotonate (NaCA) and stearyl alcohol (StOH), which enables high-yield conversion of PHB to CA under mild conditions (150 °C, 3 Torr). Owing to the synergistic action of NaCA and StOH, rapid depolymerization of PHB is achieved, affording a CA yield of 80.8% with 99.6% purity. Further enhancement using the NaCA/StO-CA synergistic system increases the CA yield to 96.1% with 99.4% purity. Mechanistic investigations, supported by NMR, FTIR, and density functional theory (DFT) calculations, reveal that StOH serves dual roles: it acts as a transesterification agent to reduce the molecular weight of PHB and as a high-boiling solvent to promote continuous removal of CA. Meanwhile, NaCA catalyzes C–O bond cleavage and double bond formation, enabling sustained CA production. The catalytic system was successfully applied to post-consumer PHB waste and PHB in plastic blends, achieving CA yields exceeding 94%. Moreover, a sequential batch recycling strategy was developed for PLA/PHB mixed plastics, in which PLA is first depolymerized to lactide, followed by the selective conversion of PHB to CA, thereby avoiding cross-contamination. The catalytic system exhibits excellent recyclability, maintaining high efficiency over multiple cycles, and thus offers a promising and sustainable approach for closed-loop recycling of bio-based polyesters.
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BRAIN BEHAVIOR AND IMMUNITY
·
2026
·
IF 7.5
Tao Ye,Xinhuang Lv,Qiyao Li,Xiaolan Liao,Lu Zhan,Conghui Dai,Kun Xiang,Xiaoou Lin,Jing Sun,Jiaming Liu
Gut microbial metabolites abnormity links to Alzheimer’s disease (AD) progression, yet the mechanism remains unknown. Here, we observed a markedly decreased level of indole-3-acetic acid (IAA) in AD patients, and the IAA level was negatively correlated with cognitive impairment. IAA supplementation improved cognitive dysfunction and synaptic damage, and suppressed microglial activation and synaptic phagocytosis in AD mouse and cell models. RNA sequencing revealed an increase in phagocytosis-associated pathway activity and gene expression, and C-C chemokine receptor 4 (CCR4) was identified as a key regulator of this process. IAA could inhibit the expression level of CCR4, and siRNAs CCR4 markedly inhibited microglia-mediated phagocytosis of synapse. We further demonstrated that microglial CCR4 interacts with aryl hydrocarbon receptor (AHR), a key receptor of IAA, and proposed the hypothesis that AHR binds to the CCR4 promoter, thereby inhibiting its transcriptional activity. Moreover, we further revealed that bacteria producing IAA supplementation inhibited microglia-mediated synaptic loss by down-regulating CCR4, thus delaying Alzheimer’s progression. These findings elucidate the mechanisms underlying microbial metabolite IAA’s impact on AD, highlighting that targeting CCR4 inhibition in microglia-mediated synaptic phagocytosis represents a promising therapeutic strategy for AD.
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ACTA PHYSICO-CHIMICA SINICA
·
2026
·
IF 13.5
Sijia Wang,Wen-Cui Li,Rui-Ping Zhang,An-Hui Lu
The selective hydrogenation of alkynols to alkenols is an industrially important route to fine chemicals, yet competing over-hydrogenation pathways make it challenging to maintain alkenol selectivity at high conversion. Herein, we report an ultrathin two-dimensional porous carbon support with a thickness of 13 nm and an aspect ratio of up to 615. Compared with conventional bulk carbon supports, this two-dimensional architecture provides a larger externally accessible surface area, thereby promoting Pd dispersion and facilitating liquid-phase molecular diffusion. The resulting Pd catalyst achieves an exceptional reaction rate of 28617 mol mol Pd −1 h −1 for the semihydrogenation of 2-methyl-3-butyn-2-ol under mild conditions (298 K, 0.2 MPa H 2 ), representing a 31-fold enhancement relative to the commercial Lindlar catalyst, while maintaining 93% selectivity at 99% conversion. Moreover, the catalyst exhibits good stability over five consecutive cycles, with no detectable Pd agglomeration or leaching. This work highlights dimension control of carbon supports as an effective strategy to enhance external surface accessibility, offering new insights into the design of high-performance semihydrogenation catalysts. Download: Download high-res image (220KB) Download: Download full-size image Two-dimensional porous carbon supports promote Pd dispersion and molecular diffusion for efficient semihydrogenation of 2-methyl-3-butyn-2-ol.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Xiaofang Liu,Guangli Luo,Fan Shi,Qun Wang,Fei Deng,Jingzhou Hou,Danqun Huo,Changjun Hou
DNAzyme-driven DNA walker combined with bimetallic nanozyme for synergistic signal amplification in an electrochemical biosensor. • Enzyme-free and Zn 2+ -dependent operation, which simplifies the assay workflow and enhances robustness. • Quantitative release of nanozymes triggered by target-induced DNA cleavage, enabling highly sensitive and specific detection. Early and accurate detection of breast cancer is essential for improving patient prognosis. Carbohydrate antigen 15-3 (CA15-3) is a key serum biomarker used in clinical monitoring, yet its low abundance in early stages requires highly sensitive detection methods. Herein, we report an electrochemical biosensor that synergistically integrates a DNAzyme-driven DNA walker with bimetallic MnAu nanozymes for CA15-3 detection. Target recognition activates the DNAzyme walker, which progressively cleaves substrate strands and releases MnAuNP signal probes from the electrode surface. This process attenuates the nanozyme-catalyzed electrochemical signal for quantitative analysis. The core-shell MnAuNP provides robust oxidase-like activity, while the DNA walker enables efficient enzyme-free signal amplification. This synergistic amplification strategy achieves a wide linear range (0.05 U/mL–200 U/mL) and a low limit of detection (LOD) of 0.0017 U/mL with excellent selectivity. Satisfactory recovery rates (97.58–105.35%) in human serum confirm clinical potential. This work presents a novel strategy for breast cancer biomarker detection by combining DNA walker with nanozyme catalysis amplification, demonstrating promising potential for point-of-care breast cancer diagnostics. Download: Download high-res image (133KB) Download: Download full-size image
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PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2017
·
IF 0.809
Jin Luo,Anlin Zhao,Caihua Zheng,Tao Wang
GRAPHICAL Display full size
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Yijin Peng,Wenhui Zou,Qisheng Yue,Yunxia Yang,Zhenzhen Xu,Zhongxiang Fang,Linyan Zhou
This study investigated the copigmentation mechanism between punicalagin (PUN) and cyanidin-3-O-glucoside (C3G) using spectroscopic analysis, thermodynamic evaluation, and quantum chemical modeling. UV-VIS spectra revealed enhanced absorbance and red shifts upon increasing PUN concentration to the C3G solution, indicating intensified color. Copigmentation was most effective at acidic pH (3–6) and declined at higher temperatures. Thermodynamic parameters indicated a spontaneous, exothermic interaction between PUN and C3G, involving hydrogen bonding and π–π stacking. FT-IR, 1 H NMR, and IGMH analyses confirmed these interactions and revealed that α -PUN formed more stable complexes with C3G than β -PUN, due to cooperative aromatic-polar interactions and more favorable stacking geometry. Quantum calculations supported the greater stability of α -C3G/PUN complexes. Furthermore, PUN significantly improved the thermal, light, and storage stability of C3G. These findings provide molecular-level insights into anthocyanin-ellagitannin copigmentation and demonstrate the potential of PUN as a natural copigment for improving color stability in food systems.
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