Small
·
2024
·
IF 13
Yun-Yun Quan,Tingting Pan,Zhongda Zhang,Shihua Wang,Guiyun Wang,Lichao Yu,Ye Wang,Xu-Feng Zang,Fangjun Zhang,Xiaoxia Ye,Xuebo Pan,Zu-Sheng Huang
Bacterial infections are closely correlated with the genesis and progression of cancer, and the elimination of cancer-related bacteria may improve the efficacy of cancer treatment. However, the combinatorial therapy that utilizes two or more chemodrugs will increase potential adverse effects. Image-guided photodynamic therapy is a highly precise and potential therapy to treat tumor and microbial infections. Herein, four donor–acceptor–π-bridge–acceptor (D–A–π–A) featured near-infrared (NIR) aggregation-induced emission luminogens (AIEgens) ( TQTPy , TPQTPy , TQTC , and TPQTC ) with type I and type II reaction oxygen species (ROS) generation capabilities are synthesized. Notably, TQTPy shows mitochondria targeted capacity, the best ROS production efficiency, long-term tumor retention capacity, and more importantly, the three-in-one fluorescence imaging guided therapy against both tumor and microbial infections. Both in vitro and in vivo results validate that TQTPy performs well in practical biomedical application in terms of NIR-fluorescence imaging-guided photodynamic cancer diagnosis and treatment. Moreover, the amphiphilic and positively charged TQTPy is able to specific and ultrafast discrimination and elimination of Gram-positive (G+) Staphylococcus aureus from Gram-negative (G−) Escherichia coli and normal cells. This investigation provides an instructive way for the construction of three-in-one treatment for image-guided photodynamic cancer therapy and bacteria elimination.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Reaction Chemistry & Engineering
·
2020
·Vol. 5
·期 3
·531-538
·
IF 3.441
Xiaolin Pei,Jiapao Wang,Haoteng Zheng,Pengfei Cheng,Yifeng Wu,Anming Wang,Weike Su
D-(−)-Pantolactone (D-PL) is the key chiral intermediate used to synthesize calcium D-pantothenate. In a previous study, a conjugated polyketone reductase (CduCPR) was discovered to efficiently catalyse ketopantolactone (KPL) to D-PL with a high stereoselectivity. Nevertheless, this method was limited due to the expensive coenzyme, nicotinamide adenine dinucleotide phosphate hydrate (NADPH), and the poor stability of substrate KPL in pure aqueous buffer. Here, to overcome these problems, we developed a whole-cell biotransformation process to produce D-PL in a biphasic reaction system. Recombinant CduCPR and glucose dehydrogenase (BsuGDH) were co-expressed in Escherichia coli to simultaneously achieve the synthesis of D-PL and the regeneration of NADPH. The biphasic reaction system contained 15% dichloromethane (v/v) which significantly inhibited the undesirable hydrolysis of KPL. Approximately, 2.8% of 100 mM KPL was spontaneously hydrolysed to ketopantoic acid in the biphasic system, which was lower than 54% of pure aqueous buffer. The biphasic reaction system was optimized and scaled up to prepare D-PL. In a fed-batch biphasic reaction, the substrate KPL was continuously fed into the reactor after a batch reaction. The D-PL concentration reached 0.77 mol L−1 in the reaction mixture at 7 h, and its enantiomeric excess was 99%. This study presented an alternative method to asymmetrically synthesize enantiopure D-PL for further industrial application.
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Renjie Zhou,Jiahao Yu,Shuo Li,Jian Zhang,Chenqiang Wang,Lianfu Zhang
Amadori compounds (ACs; N-(1-deoxy-d-fructos-1-yl)-amino acid) are superior flavor precursors and potential functional ingredients in food processing. In this study, vacuum dehydration as an excellent and universal method for the formation of ACs in both simulation systems and food processing was revealed. In total, 12 amino acids referring to all six categories were selected to conduct simulated reactions with glucose in aqueous models. At 90 °C, yields of 11 ACs were significantly increased by vacuum dehydration, reaching 4–198 times compared to a heat sealing reaction in aqueous systems, and formation of 5-hydroxymethyl-2-furaldehyde (5-HMF) and browning were slower than that by a dry powder reaction. In particular, the yields of Fru-Arg, Fru-His, and Fru-Glu reached 87.03, 90.73, and 89.88 mol %, respectively. The order of promotion effect was acid ACs > basic ACs > unique ACs > polar neutral ACs > aliphatic ACs > aromatic ACs. The excellent effect was mainly attributed to the control of water activity (Aw) and pH, which enabled the models to reach the optimal reaction state quickly by adjusting the vacuum degree at mild temperatures. The method was also applied to AC enrichment in tomato sauce processing; the AC content could rise to 30.72 mg/g, which was more than 17 times than those in samples without vacuum dehydration and two commercial tomato sauces.
✓ 已验证
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2022
·
IF 9.336
Ruyue Zhang,Yilong Zhang,Yating Sun,Hang Yu,Fangwei Yang,Yahui Guo,Yunfei Xie,Weirong Yao
This study evaluated how the generation of pyrazines was promoted by high-intensity ultrasound (HIU) in a Maillard reaction (MR) model system of glucose-glycine. Carbohydrate module labeling (CAMOLA) technique was adopted using D-glucose- 13 C 6 to elucidate the carbon skeleton of both intermediate and final MR products (MRPs). In the D-glucose- 13 C 6 -glycine HIU-MR model system, the concentration of 11 types of pyrazines was significantly higher than their counterparts in the thermal MR. Results of CAMOLA analysis showed that a significantly lower proportion of [M] + in pyrazines with long-length side chains was observed when compared with the pyrazines generated in thermal MR. This phenomenon may suggest the aldol-type condensation was promoted by the HIU, which is a conversion from pyrazines with short-length side chains to those with long-length side chains involving carbonyl compounds. Furthermore, the analysis of isotopomers distribution in 2,3-dimethyl-quinoxaline as the o-phenylenediamine-derivatized 2,3-butanedione indicated that the increased proportion of [M + 4] + in 2,3-dimethyl-quinoxaline (15.74% ± 0.11%) was attributed to a cleavage of D-glucose- 13 C 6 promoted by the HIU. The above-mentioned findings elucidate that the aldol-type condensation and cleavage of D-glucose contribute to the promoted synthesis of pyrazines. The HIU would generate an extremely high temperature and pressure environment that is favored by the aldol-type condensation as a high-pressure favored reaction. The HIU, therefore, can be further developed as a promising technique to promote flavor generation through the MR.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Jixu Wu,Huarong Shao,Jinhua Zhang,Yong Ying,Yanling Cheng,Dan Zhao,Xixi Dou,Huimin Lv,Shuaiguang Li,Fei Liu,Peixue Ling
We isolated and characterized a Mussel polysaccharide, α -D-glucan (MP-A), from Mytilus coruscus earlier. In this work, the pharmacological activity and mechanisms of MP-A as an oral supplement for non-alcoholic fatty liver disease (NAFLD) were explored. High fat diet (HFD) was utilized to induce NAFLD in Sprague Dawley male rats and MP-A (0.6 g/kg) was supplemented for 4 weeks. The results showed that MP-A supplementation reduced blood lipid levels, intrahepatic lipid accumulation and NAFLD activity score in HFD-fed rats. Additionally, the analysis of 16S rDNA sequencing on gut microbiota samples revealed that HFD could induce microbial dysbiosis. However, MP-A supplementation could remodel gut microbiota structure, inhibit LPS-TLR4-NF- κ B pathway activation, and restrain subsequent inflammation factors secretion. Furthermore, MP-A regulated the lipid metabolism by promoting the production of short chain fatty acids and suppressing PPAR γ and SREBP-1c expression. Our results support that MP-A can prevent against NAFLD and act as an oral supplementation for hepatoprotection via modulating gut microbiota and related gut-liver axis signaling pathways.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Fanqiang Bu,Bing Zhao,Wei Kan,Liyan Wang,Bo Song,Jianxin Wang,Zhe Zhang,Qigang Deng,Guangming Yin
Ag + and SCN − play extremely important roles in the fields of the physiology and environment. In this work, on the basis of phenanthro[9,10- d ]imidazole derivative ( DIPIP ) which can exhibit the aggregation-induced emission (AIE) properties in aqueous solution, we achieved a sequential on-off-on switch for Ag + and SCN − with high selectivity and sensitivity. A remarkable fluorescence quenching effect of Ag + on the probe DIPIP was observed with 1:2 stoichiometry , Subsequently, the fluorescence intensity of in situ generated DIPIP -Ag + ensemble was easily switched on after the interaction between Ag + and SCN − , which was attributed to the stronger affinity of SCN − to capture Ag + . In particular, the extreme limits of detection (LOD) for Ag + and SCN − in standard solutions were as low as to be 74.5 nM and 7.8 nM, respectively. Furthermore, the probe DIPIP and the DIPIP -Ag + ensemble could be used to detect Ag + in the real water and SCN − in smoker saliva samples, respectively. In addition, the sequential “on-off-on” fluorescence mode of DIPIP to Ag + and SCN − were also successfully applied in living HeLa cells.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2013
·
IF 4.612
Mei Zhang,Jun-Hui Zhang,Yan Zhang,Bang-Jin Wang,Sheng-Ming Xie,Li-Ming Yuan
This study focused on exploring the chromatographic characteristic of a homochiral MOF [Cu 2 ( d -Cam) 2 (4,4′-bpy)] n with 3-D six-connected self-penetrating architectures for the separations of positional isomers and chiral compounds. Some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also have been investigated. Among thirteen tested racemates, six compounds, namely three alcohols, a diol, a naphthol and a ketone were successfully discriminated, and ten useful positional isomers which have never been separated on other MOFs stationary phases in HPLC except dichlorobenzene and cresol isomers, were also analyzed by this chiral stationary phase. The results indicated that [Cu 2 ( d -Cam) 2 (4,4′-bpy)] n exhibited good selectivity for positional isomers and enantiomers. Therefore, it is practicable that the separation of positional isomers and enantiomers are carried out on the chiral MOF column.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLoS One
·
2025
·Vol. 20
·期 1
·e0317825
·
IF 2.6
Yuanqiang Lv,Jie Chu,Xiaoxiao Zhang,Xuan Li,Aijiao Yin,on behalf of The Industrial Microbiology Laboratory
Backgrounds
Abuse of feed supplement can cause oxidative stress and inflammatory responses in Gallus gallus . Synbiotics are composed of prebiotics and probiotics and it possess huge application potentials in the treatment of animal diseases.
Methods
This study examined the effect of d-tagatose on the probiotic properties of L . rhamnosus GG , L . paracasei , and S . lactis so as to screen the best synbiotic combinations. Treat Gallus gallus exhibiting oxidative stress and immune response caused by aflatoxin b1 with optimal synbiotics for 14 days, detect the changes of inflammatory markers and oxidative stress markers of Gallus gallus using qRT-PCR, and identified the intestinal bacteria genera and their metabolites in the cecum of Gallus gallus using gut microbiota and metabolomics analysis.
Results and conclusion
The results indicated that oxidative stress and immune response factor expressions quantity in Gallus gallus decreased significantly after 14 days of treatment, compared with model group, the low-dose treatment group’s SOD1, SOD3, GPX1, GPX2, GSR, H6DP, and HO-1 genes in liver were downregulated by 36.03%, 40.01%, 45.86%, 40.79%, 37.68%, 25.04%, and 29.89%, the IL-1, IL-2, IL-4, IL-6, IgA, IgM, and IgG genes in blood and spleen were downregulated by 26.59%, 34.19%, 21.19%, 28.18%, 35.93%, 12.67%, 21.81 and 35.93%, 22.85%, 21.19%, 28.78%, 35.93%, 15.36%, 29.73%. The intestinal bacteria genera and metabolomics analysis results indicated that the abundance of beneficial bacteria genus was up-regulated, and the proportion of pathogenic bacteria genera decreased. The amount of beneficial metabolites associated with antioxidant and anti-inflammatory effects was upregulated. The synbiotic composed of d-tagatose and L. rhamnosus GG can treat oxidative stress and immune response by altering the structure of intestinal bacteria genera and the production of metabolites.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SYNTHETIC METALS
·
2021
·
IF 3.266
Yueqiang Ma,Yuchang Du,Chunxia Li,Yan Zhang,Hongmei Du,Jinsheng Zhao,Junhong Zhang,Yu Xie
In this work, starting from cyclopenta[2,1-b;3,4-b′]dithiophene (CPDT) and tris(thienothiophene) (3TT) as donor units, and diketopyrrolopyrrole (DPP) as the acceptor unit, three new solution-processable donor-acceptor conjugated copolymers (P1, P2, P3) were successfully synthesized through the palladium-catalyzed Stille coupling reaction. The monomer molar feeding ratios (CPDT:DPP:3TT) of the three polymers are 3:2:1, 2:1:1, 3:1:2, respectively, which are named as PCPT-1, PCPT-2, and PCPT-3. For comparison purpose, we also synthesized the binary copolymers between CPDT and DPP (PCP), CPDT and 3TT (PCT), and compared their properties with the ternary copolymers. The optical band gaps of the five polymers were all lower than 1.9 eV, and they all showed abundant color changes. During the oxidation process , PCPT-1 changed from purple to cyan-gray and turned to earthy brown finally, PCPT-2 changed from purple in a neutral state to blue-gray in an oxidized state. Similarly, PCPT-3 turned from purple to cement gray and finally oxidized to light blue. PCP polymer changed from dark green in a neutral state to cement gray in an oxidized state, PCT polymer changed from purple in a neutral state to Light gray purple in an oxidized state. The electrochromic kinetic performance study showed that the response time of the five polymers was about 1 s within a 4-second interval. In the dynamic stability test of 750 cycles (6000 s), the five polymers demonstrated good stability. The contrast retention of polymer PCPT-2 at 570 nm reached to as high as 96.17%.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 3
·期 7
·3777-3784
·
IF 0
Guojian Tian,Shengyun Cai,Xin Li,Hans Ågren,Qiaochun Wang,Jinhai Huang,Jianhua Su
Two new D–A–π–A configuration metal-free organic sensitizers (T1–T2) based on 5,7-dihexyl-6,12-diphenyl-5,7-dihydroindolo[2,3-b]carbazole and a DPP unit with a bulky branched alkyl chain have been synthesized for dye-sensitized solar cells. Due to a bulky branched alkyl chain being attached to the donor and DPP unit, both compounds obtain high Voc values. Under standard global AM 1.5 solar light conditions, the T1 based-device gives a high conversion efficiency of 8.24% with a Jsc of 15.72 mA cm−2, a Voc of 0.74 V and a FF of 0.71. These excellent performances make the donor dihydroindolo[2,3-b] carbazole and DPP unit promising candidates for further application in DSCs.
✓ 已验证
DOI
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Jiaqi Hu,Mingyue Wang,Min Wang,Dandan Wang,Yuqiang Xiao,Yue Lan,Lingling Li,Meiling Yang,Minmin Wang,Leijiao Peng,Famin Ke,Xiurong Guo,Die Gao
Considering the efficient utilization of resources and the simultaneous detection of multiple analytes, achieving selective detection of diverse analytes on one fluorescent covalent organic framework (COF) is of great significance. Herein, a carboxyl-carbazole-rich fluorescent COF (COF-DABT) was strategically synthesized using 3,6-diamino carbazole, capable of forming halogen bonds with analytes, and 2,5-bis(4′-formylphenyl) terephthalic acid, rich in carboxyl groups, which interacts with various analytes and adjusts fluorescence performance via its electron-withdrawing properties. The introduction of carbazole imparts fluorescence to COF-DABT through the intramolecular charge transfer (ICT) effect, while enabling selective fluorescence quenching. Specifically, the ICT of carbazole can be disrupted via linear halogen bond interactions with TBBPS, resulting in selectively detection of TBBPS in a fluorescence-off mode. Furthermore, efficient enrichment of TBBPS is facilitated by halogen bonds with carbazole and hydrogen bonds with carboxyl groups on COF-DABT. Selective fluorescence quenching of COF-DABT by Fe 3 + is achieved through chelating effect around carboxyl group, as well as cation-π interaction with carbazole benzene ring. This enables high selectivity detection of Fe 3+ via a fluorescence-off mode. Additionally, Fe 3+ can be reduced by ascorbic acid through REDOX reaction, mitigating interference with TBBPS detection and facilitating fluorescence-off-on mode detection of AA. Besides, rich carboxyl groups on COF-DABT exert a negative regulatory effect on the carbazole ICT mechanism. To counter this, D/L-Arg, with a size complementary to the adjacent carboxyl groups on COF-DABT, is introduced. Hydrogen bond interactions between D/L-Arg and carboxyl groups reduce the negative regulatory effect, allowing fluorescence enhancement for highly selective detection of D/L-Arg. Through rational design and functional optimization of fluorescent COF structures, multi-mode detection methods enable simultaneous detection of different analytes, achieving the goal of "one stone, several birds."
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2021
·Vol. 25
·期 6
·1847-1859
·
IF 2.647
Li Chunxia,Guo Xin,Du Hongmei,Zhao Jinsheng,Liu Lixia,Yuan Qing,Fu Chonggang
Two novel donor-acceptor (D-A)-conjugated polymers, poly[(thiophene-2,5-yl)-((benzo[1,2-b:6,5-b′]dithiophene-4,5-dione)-2,7-yl)] (PTDT) and poly[((2,3-dihydrothieno[3,4-b] [ 1 , 2 ]dioxine)-5,7-diyl)-((benzo[1,2-b:6,5-b′]dithiophene-4,5-dione)-2,7-diyl)] (PTDO), have been synthesized with the same acceptor unit of benzo[1,2-b:6,5-b′]dithiophene-4,5-dione and different donor units of thiophene (Th) and 3,4-ethylenedioxothiphene (EDOT), respectively. And then, two composites (PTDT@C and PTDO@C) are made by coating the polymers on the surface of active carbon with an in situ method, which are used as the electrode materials of lithium-ion battery. The reversible capacities of PTDT@C and PTDO@C are 246.9 and 322.3 mAh g −1 at 0.1 A g −1 after 300 cycles running, respectively. By deducing the capability contribution of pure carbon, the theoretical capacities of the pure polymers are calculated to be 596 and 991 mAh g −1 , respectively, for PTDT and PTDO, which correspond to the lithium storage number of 6.7 and 13.3, respectively, for the least repeating unit of the polymers. With the help of theoretical calculations, the underlying mechanisms for the different electrochemical performances of the polymers are discussed and revealed. The structure-activity relationship discussed in this work may provide the design principle for the construction of the D-A-type polymers used as high-capacity electrode materials for organic rechargeable batteries.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）