Journal of Energy Chemistry
·
2026
·
IF 15.6
Yun Tian,Menghao Jiang,Jinxing Long
Developing in-situ catalysts featuring good activity for lignin hydrogenolysis is highly desirable, yet remains a great challenge. In this work, we proposed an efficient strategy for selective hydrodeoxygenation of lignin to a versatile petrochemical of alkylcyclohexanol (ACH) using the in-situ Ru nanoparticles anchored on MgO-modified TS-1. The results demonstrated that, with HRO 5 -MgO 20 @TS-1 catalyst, a total monomer yield of 36.4% was shown from the one-pot cascade process of lignin hydrogenolysis and phenolics hydrodeoxygenation. Importantly, 55.8% of obtained monomers were identified as ACH (20.2% yield), which has been widely used as an oxygenated fuel, solvent, and intermediate for functionalized materials. Intensive catalyst characterizations using TEM, XPS, and XAFS revealed that the highly dispersed in-situ Ru 0 species, together with the suitable acid-base properties, are responsible for the superior catalytic performance of HRO 5 -MgO 20 @TS-1 in lignin depolymerization. In addition, a plausible reaction pathway for ACH formation has been proposed, according to the results of comparative characterization of raw and regenerated lignin, and the performance of lignin model conversion. Therefore, this work provides a new insight into producing value-added alkylcyclohexanol from the renewable lignin.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Qi Zhang,Dongsheng He,Wei Xu,Yanhong Fu,Yuan Tang,Zhili Li,Wanqing Li,Jiayu Ma,El-Sayed R.E. Hassan
[C 8 mim]Br selectively floats quartz (88.13%) over fluorapatite (4.43%) at pH 7.01. • Binary mixture flotation with [C 8 mim]Br achieves a P 2 O 5 grade of 31.49% with 91.59% recovery, confirming superior selectivity over conventional DDA. • [C 8 mim] + selectively adsorbs on quartz via electrostatic attraction with Si-O − sites and C–H···O hydrogen bonding with silanol groups, while fluorapatite lacks these active sites. • Short-chain imidazolium ionic liquids serve as promising collectors for reverse flotation desilication of phosphate ores, offering a new reagent strategy for phosphate mineral processing. The reverse flotation separation of quartz from fluorapatite using 1-octyl-3-methylimidazolium bromide ([C 8 mim]Br) ionic liquid as a novel collector was investigated, with dodecylamine (DDA) employed as a benchmark. Micro-flotation tests showed that [C 8 mim]Br selectively collected quartz (88.13%) with negligible flotation of fluorapatite (4.43%) at pH 7.01 and 50 mg/L, demonstrating superior selectivity over DDA. Binary mixture flotation (fluorapatite: quartz = 1:1) achieved a P 2 O 5 grade of 31.49% with a recovery of 91.59%. Zeta potential and contact angle measurements revealed that [C 8 mim]Br increased the zeta potential of quartz by 14.05 mV and enhanced its contact angle from 19.41° to 79.75°, while exerting minimal influence on fluorapatite. Microcalorimetry demonstrated that the adsorption heat of [C 8 mim]Br on quartz (0.237 J/g) was significantly higher than that on fluorapatite (1.6 × 10 −3 J/g). FTIR and XPS analyses indicate that [C 8 mim]Br is adsorbed on the quartz surface mainly through electrostatic attraction between the imidazolium cation and deprotonated Si-O − sites. The optimized configuration obtained from DFT calculations shows that C-H···O hydrogen bonds exist between the protons at the C4/C5 positions of the imidazole ring and surface oxygen atoms (H···O = 1.971 Å, C-H···O = 141°), whereas no stable adsorption configuration is obtained on the fluorapatite surface. These findings demonstrate that [C 8 mim]Br is a promising selective collector for the reverse flotation desilication of siliceous-calcareous phosphate ores. [C8mim] + adsorbed on the quartz surface through electrostatic attraction with deprotonated Si-O − sites, supplemented by hydrogen bonding between the C–H proton and surface silanol groups. In contrast, the fluorapatite surface lacks such active sites for anchoring of [C8mim]+, which accounts for the selective separation. Download: Download high-res image (120KB) Download: Download full-size image
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JOURNAL OF ETHNOPHARMACOLOGY
·
2026
·
IF 6.8
Chuanqi Wan,Jiamin Lu,Lingyun Xu,Mei Jiang,Chen Zhu,Wen Zhang,Pingping Han,Jirong Zhang,Jing Wang,Weiwei Ren,Hui Chu,Bingzhi Zhou,Jiancheng Zhang,Guangjun Jin,Bangjiang Fang,Yuzhou He
Shenhuang Granules (SHG) attenuate sepsis-induced lung injury via the NLRP3/Caspase-1/GSDMD pathway. • (−)-Epicatechin gallate and gallic acid are the core bioactive monomers of SHG against PMVEC pyroptosis. • SHG inhibits pyroptosis by suppressing inflammasome assembly and pore formation. Ethnopharmacological relevance Shenhuang Granules (SHG) is a traditional Chinese medicine (TCM) formula composed of six medicinal materials: Panax ginseng C.A. Mey. (Ginseng Radix et Rhizoma), Rheum palmatum L. (Rhei Radix et Rhizoma), Sargentodoxa cuneata (Oliv.) Rehder & E.H. Wilson (Sargentodoxae Caulis), Taraxacum mongolicum Hand. -Mazz. (Taraxaci Herba), Aconitum carmichaelii Debeaux (Aconiti Lateralis Radix Praeparata), and Whitmania pigra Whitman (Hirudo). According to TCM theory, this formula is designed to replenish Qi and strengthen the body's resistance, clear heat and remove toxins, and promote blood circulation to eliminate blood stasis. In clinical practice, SHG has been used as an adjunctive therapy for sepsis, showing beneficial effects in ameliorating systemic inflammatory responses and microcirculatory disturbances. However, the underlying pharmacological mechanisms remain largely unclear. Aim of the study To validate that SHG and its active monomers alleviate sepsis-induced lung injury through targeted suppression of the NLRP3-driven PMVEC pyroptosis pathway. Materials and methods The chemical composition of SHG was analyzed by UHPLC-MS/MS. In vivo, SA-ARDS was induced in C57BL/6J mice by cecal ligation and puncture (CLP), with SHG (61.85 mg/mouse/d), its monomers, (−)-epicatechin gallate (ECG) and gallic acid (GA) (20 mg/kg/d), or the NLRP3 inhibitor MCC950 (10 mg/kg/d), were administered via intraperitoneal injection for 3 days prior to modeling. Lung injury severity and activation of the pyroptosis pathway were evaluated using histopathology, transmission electron microscopy, RT-qPCR, Western blotting, immunohistochemistry, immunofluorescence, and ELISA. In vitro, LPS-stimulated (1 μg/mL) PMVECs were used to screen 43 monomers, and the underlying mechanisms were subsequently verified. Results Compared with the Model group, SHG treatment significantly attenuated body weight loss in mice ( P < 0.001), reduced the lung wet-to-dry (W/D) weight ratio ( P < 0.05), and decreased Evans blue extravasation in lung tissues ( P < 0.01). SHG also significantly downregulated the mRNA expression levels of pyroptosis-related genes, including Twik2 , Nlrp3 , Asc , Caspase-1 , and Gsdmd , in lung tissues (all P < 0.01), and markedly reduced the protein expression of NLRP3, ASC, pro-Caspase-1, and Caspase-1 (all P < 0.05). ELISA results further demonstrated that SHG significantly decreased serum levels of the inflammatory cytokines TNF-α, IL-1β, IFN-γ, IL-18, pro-IL-1β, and pro-IL-18 in mice (all P < 0.05). In vitro, compared with the Model group, SHG significantly suppressed the transcriptional levels of Twik2 , Nlrp3 , Asc , Caspase-1 , and Gsdmd in PMVECs (all P < 0.05), and reduced the protein expression of NLRP3, ASC, GSDMD, GSDMD-NT, and IL-1β (all P < 0.05). Additionally, SHG markedly decreased lactate dehydrogenase (LDH) release ( P < 0.0001) and attenuated extracellular potassium ion (K + ) efflux ( P < 0.0001). Notably, ECG and GA individually exhibited potent inhibitory effects on PMVEC pyroptosis. Compared with the Model group, both ECG and GA significantly suppressed mRNA expression of Twik2, Nlrp3, Asc, Caspase-1, and Gsdmd (all P < 0.05) and reduced protein levels of NLRP3 , ASC , Caspase-1 , and GSDMD (all P < 0.05). Moreover, ECG significantly inhibited GSDMD-NT and IL-1β protein expression (all P < 0.05). Both ECG and GA markedly reduced TNF-α, IL-1β, and pro-IL-18 levels (all P < 0.05), and GA additionally suppressed IL-18 and pro-IL-1β expression (all P < 0.01). Furthermore, both ECG and GA significantly decreased LDH release ( P < 0.0001) and inhibited extracellular K + efflux ( P < 0.0001). However, this study has several limitations, including a small sample size, the absence of dose-gradient and time-course analyses, insufficient functional validation of the TWIK2 channel, and the lack of quantitative pharmacokinetic and synergy analyses, which should be addressed in future studies. Conclusion Shenhuang Granules attenuated PMVEC pyroptosis and ameliorated sepsis-induced lung injury by suppressing TWIK2 and the downstream NLRP3/Caspase-1/GSDMD pathway, with GA and ECG as the key active components. Download: Download high-res image (484KB) Download: Download full-size image
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PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Qing Kang,Yidi Liu,Xiubing Cui,Jianming Chu,Tong Lin,Jingbo Jiao,Xinjun Du,Shuo Wang
Herein, we developed a novel “4 + 1” biosensing platform based on cascaded nucleic acid amplification and nanozyme activity, enabling fluorescence-colorimetric dual-mode detection and efficient inactivation of Salmonella Typhimurium (S. typhimurium). The “4 + 1” system incorporates a multi-component strategy featuring multivalent aptamers for enhanced target recognition, coupled with a quadruple signal amplification strategy involving exponential amplification reaction (EXPAR), hybridization chain reaction (HCR), multivalent aptamers, and functional nanozymes (Fe3O4 and Fe-PDs), thereby achieving synergistic antibacterial effects. It achieves a wide linear range of 3 × 101–3 × 107 CFU/mL, with detection limits of 7.7 CFU/mL for fluorescence and 8.7 CFU/mL for colorimetry. Furthermore, the system exhibits antibacterial capability by catalytically generating reactive oxygen species (ROS), reducing the risk of secondary contamination. When applied to spiked milk samples, the biosensor showed satisfactory recovery rates and reproducibility. The study provides a high-precision, low-cost analytical solution for detecting and inactivating foodborne pathogens, demonstrating significant potential for rapid on-site food safety monitoring.
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高影响因子
NANO
·
2025
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IF 1.1
Peixuan Zou,Yusong Pan,Kuen-Song Lin,Wei-Chin Tsai,Yinghai Xie,Wenjie Luo,Run Huang,Xiuling Lin
The use of nanocarriers with combined photothermal and chemotherapeutic methods has been widely accepted as a promising anti-tumor treatment strategy. Leveraging the tumor-specific microenvironment, these nanocarriers enhance therapeutic outcomes. Our research developed an innovative drug carrier platform, which was composed of the Metal-Organic Framework (MOF) HKUST-1 as a drug carrier and the Fe 3 O 4 nanoparticles as a photothermal functional phase. This novel carrier demonstrated an impressive drug loading rate of 110% for Doxorubicin (DOX), suggesting a high capacity for drug delivery. Additionally, the as-prepared nanocarrier also displayed excellent photothermal conversion capability, which can efficiently convert light into heat under near-infrared light with 980 nm irradiation, thus utilizing photothermal therapy for tumors. The release mechanism of pH sensitivity of the carrier expedited drug release under acidic conditions, aligning with the tumor microenvironment. Biocompatibility assays confirmed the excellent compatibility of Fe 3 O 4 @HKUST-1 with normal tissue cells. While photothermal therapy alone successfully induced apoptosis in tumor cells, the treatment’s efficacy requires improvement as cell viability remained at 80%. Conversely, combining chemotherapy with photothermal therapy decreased cell viability to 30%, thereby effectively inhibiting proliferation. In sum, the Fe 3 O 4 @HKUST-1 drug delivery system exhibits significant potential in medical applications due to its dual-therapy approach.
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高影响因子
PLoS One
·
2026
·Vol. 21
·期 3
·e0344693
·
IF 2.8
JianJun Chu,Zhengfa Wen,Wenying Wu,Shoukun Wu
Aging impairs cartilage repair, with young animals exhibiting superior regenerative capacity due to enhanced tissue repairing and reduced inflammation compared to aged counterparts. This study employed single-cell omics to dissect age-dependent immune cell heterogeneity in cartilage injury, revealing a critical deficiency in anti-inflammation macrophage subsets in aged animals. We identified Arg-1 as a central regulator of macrophage polarization, demonstrating that its overexpression rescues impaired repair in aged animals. These findings establish Arg-1 as a novel therapeutic target to counteract age-related declines in cartilage regeneration, offering new insights into macrophage-driven tissue repair mechanisms. The integration of single-cell analysis with functional validation provides a framework for developing precision interventions for age-impaired tissue regeneration.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
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IF 8.8
Haiyang Shao,Chen Wang,Miaomiao Zheng,Yafei Cheng,Lihai Fan,Haiyang Yan,Xiaocheng Lin
To advance industrial acid recovery via diffusion dialysis, the crucial step is to engineer anion exchange membranes (AEMs) with superior acid permeability and selectivity. Herein, a PIM-1-based AEM was fabricated via liquid bromine-induced bromination followed by a non-crosslinking alkylation with 1-methylimidazole, which preserves the rigid polymer backbone and intrinsic microporosity. The optimized, mechanically robust membrane exhibited a specific surface area of 549 ± 18 m 2 g −1 , providing abundant free volume for rapid proton transport, and a pore size distribution precisely centered between 0.40 and 0.75 nm, enabling selective acid recovery via size sieving in a typical HCl/FeCl 2 wastewater system. This membrane achieved a proton dialysis coefficient of 59.4 ± 4.3 × 10 −3 m h −1 and a selectivity of 74.4 ± 2.7 over Fe 2+ , outperforming the commercial DF-120 AEM by sevenfold and fourfold, respectively. This work provides a scalable, non-crosslinking functionalization route to fabricate mechanically robust AEMs from PIMs, leveraging their preserved microporosity for efficient and selective acid recovery.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
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IF 8.7
Qiang-Ming Li,Qiao-Qiao Zhang-Yang,Ya-Yi Tan,Xiang-Ling Wu,Xue-Qiang Zha,Zhen-Zi Shang,Jian-Ping Luo,Feng-Yun Zhang
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. The stem of Dendrobium huoshanense is a traditional medicinal food. This study aimed to investigate the effect of cultivated D. huoshanense stem polysaccharide (cDHPS) on AD and elucidate its mechanisms using an Aβ 1–42 -induced AD mouse model. Results showed that cDHPS significantly improved the cognitive dysfunction and ameliorated the hippocampal neuronal injury of AD mice. Meanwhile, cDHPS effectively alleviated the neuroinflammation of AD mice not only by decreasing the expression of caspase-1, NOD-like receptor family pyrin domain-containing 3 (NLRP3), and apoptosis-associated speck-like protein containing a CARD (ASC), as well as their downstream inflammatory cytokines, but also by inhibiting the activation of microglia and astrocytes. Furthermore, the levels of glucagon-like peptide-1 (GLP-1) in the hippocampus, plasma, and intestine of AD mice were markedly elevated by cDHPS, along with an increase in intestinal short-chain fatty acids (SCFAs) levels. However, the treatment of exendin 9–39, a GLP-1 receptor antagonist, weakened the protective effect of cDHPS against AD, and the depletion of SCFAs reversed the beneficial effects of cDHPS on cognitive dysfunction, hippocampal neuronal injury, neuroinflammation, and GLP-1 secretion in AD mice. These results suggest that cDHPS could protect against AD by modulating the SCFAs/GLP-1 axis-mediated neuroinflammation suppression.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Kai Jia,Yihao Zhao,Mingyuan Shao,Fangqi Yu,Yongqing Wang,Shanbing Mao,Zhendong Liu
The demand for zeolites is expected to grow rapidly due to their expanding applications in catalysis and separation, which drives the need for efficient synthesis routes based on economical raw materials. To overcome the limitations of time-consuming conventional zeolite synthesis, an ultrafast and low-cost route has been developed using industrial-grade sodium silicate as the silica source. This approach enables minute-level synthesis of silicalite-1 zeolite through a combination of acid neutralization and seeding strategies. Notably, carbon dioxide was also demonstrated as an effective neutralizing agent, offering a sustainable alternative. This ultrafast route further enabled the in-situ encapsulation of metal nanoclusters during zeolite crystallization, which resulted in well-defined metal-zeolite catalysts. Using Pt–Zn as a model system, the catalysts exhibited high activity and long-term stability in propane dehydrogenation. This work presents a scalable and economical route for producing high-performance zeolite catalysts and highlights the potential for broader application in commercial dehydrogenation processes and beyond.
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Catalysis Science & Technology
·
2026
·
IF 4
Ziheng Li,Junxin Guo,Haoze Liu,Dule Huhe,Zhao Wang
Despite their high methanol selectivity in CO2 hydrogenation, In2O3-based catalysts still face limitations in CO2 conversion and long-term stability. This work addresses these challenges by designing a highly dispersed Pd/In2O3 catalyst supported on self-pillared silicalite-1 (SP-S-1) zeolite. The well-defined channels and abundant surface silanol groups of SP-S-1 effectively anchor and disperse In2O3 nanoparticles. This structure also spatially isolates Pd species, which prevents their sintering and inhibits the formation of inactive Pd–In alloys. Comprehensive characterization reveals that the strong metal-support interaction stabilizes oxygen vacancies and prevents over-reduction of In3+ species, which are crucial for CO2 activation and methanol selectivity. The optimized Pd/In2O3/SP-S-1 catalyst achieves a methanol space-time yield of 2.57 gMeOH·gIn+Pd-1·h-1 at 300 °C, approximately five times higher than that of the unsupported counterpart. More importantly, it demonstrates high stability, retaining 95% of its initial activity after 100 hours on stream, far outperforming the unsupported catalyst. This work highlights zeolite confinement as a versatile strategy for designing robust and efficient CO2-to-methanol catalysts.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Sun Ruize,Liu Xiaonan,Chen Jingge,Chen Zhangguo,Zhou Jicheng,Xu Wentao
Propane direct dehydrogenation (PDH) is an important way for the high-value utilization of propane (C 3 H 8 ). However, the conventional thermal catalytic reaction process is limited by the thermodynamic equilibrium of the strong endothermic reaction, and usually needs to be operated at high temperature, which makes it difficult to balance high conversion and high selectivity. In this study, a new method of microwave catalytic dehydrogenation of C 3 H 8 to propylene (C 3 H 6 ) at low temperature and high efficiency was proposed, and Pt-ZnO/S-1 + SiC microwave catalyst was developed. It was found that microwave significantly improved the conversion and selectivity of the catalyst, and the reaction was carried out efficiently at lower temperatures. Under low temperature microwave catalysis (MCRM) at 450 ° C, the conversion of C 3 H 8 was as high as 46.4%, and the selectivity of C 3 H 6 was as high as 99.3%, which were significantly better than 18.4% conversion and 95.1% selectivity under conventional thermal catalysis (CRM). Further study shows that the microwave action reduces the apparent activation energy of the catalyst from 75.5 kJ·mol −1 under CRM to 48.7 kJ·mol −1 under MCRM. This study provides a new strategy for the low-temperature and efficient conversion of low-carbon alkanes such as C 3 H 8 and provides a new idea for the application of microwave catalytic technology in other catalytic reactions.
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高影响因子
ACS Nano
·
2026
·
IF 17.3
Zhuo Xiqian,Li Yunfeng,Qiu Ling,Aishajiang Reyida,Lei Pengpeng,Wang Tiejun,Yu Duo
Radiotherapy plays a pivotal role in the management of
nonsmall-cell
lung cancer (NSCLC), particularly for patients who are not candidates
for surgical intervention. Despite its significance, the issue of
radioresistance remains a substantial challenge in the treatment of
the NSCLC. Therefore, it is crucial to uncover new targets to enhance
radiotherapy and investigate the mechanisms underlying radioresistance.
Cuproptosis, as an emerging form of cell death dependent on intracellular
copper (Cu) ions, remains unclear in its role in radioresistant NSCLCs.
This study investigates the development of radioresistant NSCLC models,
focusing on the role of the FOS-like antigen 1 (FOSL1) as a significant
factor in mediating radioresistance. The FOSL1 gene is downregulated
in radioresistant cells. Overexpression of FOSL1 induces mitochondrial
damage and dysfunction, causing cuproptosis in radioresistant cells.
To tackle the challenge of radioresistance in NSCLC, we propose an
innovative nanostrategy focused on cuproptosis, aiming to enhance
the efficacy of radiotherapy specifically in radioresistant NSCLC.
This intervention could significantly enhance an increase in intracellular
Cu 2+ concentration and glutathione depletion while also
increasing irradiation (IR)-induced oxidative stress and mitochondrial
damage. The resulting mitochondrial dysfunction leads to tricarboxylic
acid cycle disruption and Fe–S cluster protein destabilization.
These cumulative effects ultimately induced cuproptosis and enhanced
the response of radioresistant NSCLC cells to IR. Our findings highlight
the potential of combining cuproptosis targeting with nanotechnology
to enhance the efficacy of radiotherapy, presenting a promising strategy
to address radioresistance in clinical contexts.
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