JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Xu-mei Wang,Zong-cai Tu,Yun-hua Ye,Guang-xian Liu,Hui Wang,Yue-ming Hu
Physical-assisted chemical modification is effective to reduce the allergenicity of α-lactalbumin (ALA). However, there are few in-depth studies on the allergenicity changes of physical-assisted chemical-modified ALA during digestion. The effect of gastroduodenal digestion on the allergenicity changes of ALA treated by sonication-assisted glycation was assessed. Digestion of both ALA and its glycated forms generated peptide fractions, and intact undigested glycated ALA in the hydrolysates still covalently bound to d-galactose. High-resolution mass spectrometry revealed that a higher glycation degree was discovered in sonication-preprocessed ALA compared to native ALA. Enzyme-linked immunosorbent assay and basophil degranulation showed that sonication-assisted glycation could significantly reduce ALA allergenicity. The allergenicity of both gastric and gastroduodenal hydrolysates was further increased, and the hydrolysates of sonication-assisted glycated ALA showed the lowest allergenicity. The reason could be the shielding effect of the linear epitope found to be caused by a higher glycation degree; although linear epitopes were exposed, d-galactose covalently bound to intact undigested glycated ALA in the hydrolysates retained its masking role. These results indicated that sonication-assisted glycation could be a promising method to prepare immunotherapeutic agents for allergen immunotherapy to achieve the purpose of allergy desensitization.
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DOI
PubMed
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 4.446
He Li,Dongbang Yao,Jingru Ying,Xudong Han,Xuecheng Zhang,Xiuju Fang,Zemin Fang,Yazhong Xiao
A strategy that combines signal peptide (SP) optimization and translation efficiency improvement was used to enhance the extracellular production of raw starch-degrading α-amylase AmyZ1 from Pontibacillus sp. ZY in Bacillus subtilis . The optimal SP YpuA screened from 173 B. subtilis SPs mediated a 1.28-fold higher AmyZ1 activity than the original SP amyQ . Then, strategies of translation efficiency improvement, including optimizing the Shine-Dalgarno-like (SD-like) sequence, constructing a dual 5′-untranslated region (dual-UTR), optimizing the spacer region of the UTR, and optimizing the 5′-proximal coding sequence, were used to enhance AmyZ1 production. The resulting recombinant strain (BZYACO6) containing SD-like3, dUTR2, and an optimized 5′-proximal coding sequence (O6) produced the highest extracellular α-amylase activity of 2974.0 U/mL in shake flask, 2.07-fold higher than that of the original strain BZd34 (1437.6 U/mL). After fermentation optimization, the BZYACO6 strain produced an extracellular AmyZ1 activity of 3915.2 U/mL in shake flask and 25,070 U/mL in 3-L fermenter, representing the highest level of recombinant raw starch-degrading α-amylase production reported to date. Furthermore, this work provides a strategic reference for enhancing the extracellular production of other recombinant proteins in B. subtilis .
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高影响因子
Polymers
·
2025
·Vol. 18
·期 1
·64
·
IF 4.9
Ruijun Zhang,Ziyi Dong,Qiqi He,Junhua Li,Yuexin Hu,Jianhua Qian
Accurate knowledge of phase behavior in polyolefin–solvent mixtures is critical for ensuring stable operation and safe scale-up of industrial solution polymerization processes. The binary (n-hexane + ethylene/1-octene copolymer, POE96k-10) and ternary (α-olefin +n-hexane + POE96k-10) phase behaviors were investigated via a visual high-pressure cell (POE96k-10:Mw= 96 kg·mol–1,Mw/Mn= 3.87, 1-octene mole fraction = 10.31 mol%) at temperatures of 380~480 K and pressures as high as 14 MPa. To systematically analyze the effects of α-olefin mass fraction and type on phase transition, four industrially relevant α-olefins (ethylene, 1-butene, 1-hexene, and 1-octene) were investigated. The results show that the phase transition temperature and pressure for liquid–liquid and liquid–vapor transitions show an approximately linear dependence on α-olefin mass fraction. Ethylene, 1-butene, and 1-hexene lower the phase transition temperature, whereas 1-octene increases it. Ethylene exhibits a strong anti-solvent effect, significantly lowering the transition temperature while increasing the phase transition pressure. The modified Sanchez-Lacombe equation of state (MSL EOS) effectively correlates and reproduces the phase equilibrium data of the α-olefin +n-hexane + POE96k-10 ternary systems, though its accuracy decreases with increasing α-olefin chain length.
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产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2020
·
IF 3.724
Li ML,Huang HW,Mo RB,Sheng XX,Jiang X,Zhang XY
Epoxy resin is widely used in the field of anticorrosive coatings for its outstanding properties. However, environmentally friendly two-component waterborne epoxy coatings often have micropores in its films, making their barrier properties against corrosive media unsatisfactory. α-zirconium phosphate (α-ZrP), known as a kind of flexibly designable two-dimensional nanoparticle , has outstanding mechanical and barrier properties. However, the common problem of incorporating such inorganic fillers into epoxy resins is the poor interface compatibility. In this work, α-ZrP was firstly exfoliated by Tris-(hydroxymethyl)-aminomethane (Tris) aqueous solution, then acidified by diluted hydrochloric acid (HCl) and finally covalently functionalized by 3-aminopropyltriethoxy silane (KH-550). Subsequently, waterborne epoxy composite coatings (KWEPc) with K-ZrP as functional filler were prepared and applied on Q235 carbon steel substrates by blade-coating. With KH-550 modifying, K-ZrP showed an improved dispersion in waterborne epoxy coatings (WEPc). The structure and morphology of prepared K-ZrP was characterized and confirmed by FTIR spectra, XPS and EDS-mapping. The results showed that K-ZrP is evenly modified with amino siloxane. Electrochemical tests revealed that the corrosion rate of KWEPc was one order of magnitude lower than that of WEPc. KH-550 act as a “bridge” among inorganic filler, epoxy resin matrix and Q235 carbon steel substrates.
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高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Xin Liu,Meng Xu,Yingying Hao,Jinghua Fu,Fangbao Wang,Binbin Zhang,Stephanie Bennett,Paul Sellin,Wanqi Jie,Yadong Xu
Compared with the widely reported MAPbBr3 single crystals, formamidinium-based (FA-based) hybrid perovskites FAPbBr3 (FPB) with superior chemical and structure stability are expected to be more efficient and perform as more reliable radiation detectors at room temperature. Here, we employ an improved inverse temperature crystallization method to grow FPB bulk single crystals, where issues associated with the retrograde solubility behavior are resolved. A crystal growth phase diagram has been proposed, and accordingly, growth parameters are optimized to avoid the formation of NH4Pb2Br5 secondary phase. The resulting FPB crystals exhibit a high resistivity of 2.8 × 109 Ω·cm and high electron and hole mobility–lifetime products (μτ) of 8.0 × 10–4 and 1.1 × 10–3 cm2·V–1, respectively. Simultaneously, the electron and hole mobilities (μ) are evaluated to be 22.2 and 66.1 cm2·V–1·s–1, respectively, based on the time-of-flight technique. Furthermore, a Au/FPB SC/Au detector is constructed that demonstrates a resolvable gamma peak from 59.5 keV 241Am γ-rays at room temperature for the first time. An energy resolution of 40.1% is obtained at 30 V by collecting the hole signals. These results demonstrate the great potential of FAPbBr3 as a hybrid material for γ-ray spectroscopy and imaging.
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高影响因子
JOURNAL OF POWER SOURCES
·
2019
·
IF 7.467
Yunzhao Liu,Xiaowei Chi,Qi Han,Yuexiu Du,Jiaqi Huang,Yu Liu,Jianhua Yang
Rechargeable Zn-ion batteries (ZIBs) have attracted extensive attention, but their practical application is hindered by the limited cycling life and complicated preparation process of cathode materials . Here, we develop a facile yet scalable chemical precipitation/spray-granulation combined methodology for the fabrication of α-MnO 2 nanofibers/carbon nanotubes hierarchically assembled microspheres (α-MnO 2 /CNT HMs) as the cathode material for aqueous ZIBs . The α-MnO 2 evenly anchoring to the CNTs-based framework shows significantly increased tap density compared with pristine α-MnO 2 , which can effectively enhance the electrochemical stability. Owing to the synergistic merits of highly conductive carbon nanotubes network and α-MnO 2 nanofibers with desirable structure features, within our knowledge, the highest areal energy density of 0.98 Wh cm −2 at 0.2 A g −1 and the record cycling stability with 96% capacity retention over 10000 cycles at 3 A g −1 among the reported cathodes for ZIBs are achieved. Zn 2+ and H + co-insertion reaction mechanism with high reversibility is further revealed. Fast kinetic of the H + insertion/extraction process renders the cell excellent cycling stability. Facile preparation of nanofibrous α-MnO 2 based micro-composite, cost benefit of the source materials, and the superior battery performance provide new approaches for the practical applications of ZIBs.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Qingdong Qin,Ting Liu,Jiaxuan Zhang,Rui Wei,Shijie You,Yan Xu
Hematite (α-Fe 2 O 3 ) has been commonly used as an eco-friendly catalyst for peroxymonosulfate (PMS) to generate free radicals (SO 4 •- and/or •OH). However, the activation efficiency of PMS relies heavily on the conversion of Fe(III) to Fe(II) that is slow and rate-limiting. In this study, oxygen vacancies enriched α-Fe 2 O 3 was prepared from thermally treated goethite (α-FeOOH) and employed as a PMS activator. Systematic characterization demonstrated that α-Fe 2 O 3 with most abundant oxygen vacancies could be obtained by heating α-FeOOH at 300 °C. The as-prepared α-Fe 2 O 3 exhibited excellent catalytic activity in activation of PMS for oxidation of sulfamethoxazole (SMX, k = 0.04 min −1 ). The SMX degradation rate was found to be positively correlated with the concentration of oxygen vacancies. Quenching experiments, EPR, LC/MS and XPS analysis revealed that singlet oxygen ( 1 O 2 ) was the predominant reactive oxygen species . The effects of pH, PMS dosage, catalyst loading, temperature, and anions on SMX degradation were comprehensively investigated. Moreover, the plausible degradation pathways of SMX in the α-Fe 2 O 3 /PMS system were proposed. This work not only provides a valuable insight into the mechanism of PMS activation by α-Fe 2 O 3 but also establishes a new strategy for the design of more efficient and practical iron-based catalyst for PMS activation.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2020
·Vol. 31
·期 17
·14681-14690
·
IF 2.22
Gao Dahai,Yu Liyuan,Li Mengjiao,Wang Shumao,Dai Yuhua
In this work, we prepared the epoxy-based adhesives with a binary filler system, which was composed of organosilicon modified hexagonal BN ( h -BN) and α-Al 2 O 3 . H -BN platelets and α-Al 2 O 3 nanoparticles were decorated by aminopropyltrimethoxysilane (APTMS) and glycidylpropyltrimethoxysilane (GPTMS), respectively, to form covalent links to the filler/polymer matrix interface. The surface chemical composition was investigated by Fourrier transform infrared spectroscopy (FTIR) and thermogravimetry analysis (TGA), which demonstrated that the modifiers were successfully grafted onto the surface of fillers. This modification has been confirmed beneficial to thermal conductivity so that the thermal conductivity of adhesives incorporated with modified binary fillers could reach 0.85 w/m k, which is 10% more than specimen filled with unmodified fillers, because covalent links strengthened the interface and prohibited heat diffusion. Modified Hashin–Shtrikman model was utilized to analyze thermal resistance of the binary filler system, indicating that adhesives filled with modified fillers displayed lower thermal resistance. The enhancement of interface also brought about some other positive effect, especially in the decreasing of dielectric constant (< 4.3 at 1000 Hz) and the low values of dielectric loss tangent (10 –3 ) and high electronic resistance (> 10 14 ). Furthermore, the mechanical strength is significantly improved when the modified binary fillers were used.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Changwei Bai,Gang Yang,Shirong Zhang,Shihuai Deng,Yanzong Zhang,Chao Chen,Jingsong He,Min Xu,Lulu Long
A novel electrocatalytic anode (ECA)/α-MnO 2 /peroxymonosulfate (PMS) synergistic system was developed and evaluated for the removal of combined tetracycline (TC) and hexavalent chromium (Cr(VI)) pollution from waste waters. The factors affecting the efficiency of the removal of the combined pollutants, such as the synthesis time of the electrode, the amounts of raw materials, the PMS dose, the voltage, the initial pH and the coexisting ions were investigated. The breakdown products of PMS in the ECA/α-MnO 2 /PMS system improved the conductivity of the solution and the electrical current promoted the conversion of the valence state of Mn ions, resulting in a synergistic effect between the ECA and PMS activation processes, which improved the efficiency of removal of TC. The cathode chamber was fully utilized to simultaneously reduce Cr(VI). Synergistic effects occur in the ECA/α-MnO 2 /PMS system in appropriate ranges of the voltage or PMS dose, although the efficiency of the removal of TC depends mainly on the electrical current in the system. Both hydroxyl (•OH) and sulfate (SO 4 •− ) radicals played important parts in the degradation of TC. The main degradation products of TC were identified and degradation pathways proposed. The synergistic effects between the ECA process and a Fenton-like process was studied, providing a new approach for the study of electro-Fenton technology and the removal of combinations of TC and Cr(VI) from waste waters.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Wenjing Pan,Yong Zhang,Sujing Yu,Xiaohua Liu,Dongzhi Zhang
The metal-organic framework (MOF)-derived alpha-iron oxide hollow nanosphere/molybdenum diselenide nanoflower (α-Fe 2 O 3 /MoSe 2 ) composite is fabricated via simple hydrothermal route. Multiple characterization methods have proved the successful synthesis of α-Fe 2 O 3 /MoSe 2 composites. The nanocomposite with a mass ratio of α-Fe 2 O 3 and MoSe 2 of 4:1 shows high response to H 2 S gas sensing. Moreover, the gas sensitivity test of the system shows that the α-Fe 2 O 3 /MoSe 2 composite sensor exhibits a faster response/recovery rate, outstanding repeatability and anti-humidity interference toward H 2 S sensing at room temperature, which also shows excellent selectivity for H 2 S compared to various potentially interfering gases. Further studies have shown that α-Fe 2 O 3 /MoSe 2 nanocomposites have improved H 2 S gas sensing performance due to the increased active sites and specific surface area, and the formation of n-n heterojunctions at the interface between α-Fe 2 O 3 hollow nanospheres and MoSe 2 nanoflowers.
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DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Tianyue Su,Junsheng Wang,Chun Cai
The nickel phosphides have garnered increasing attention as an excellent catalytic site in the fields of electrocatalysis and hydrotreating, but their application in organic synthesis remains infrequent. In this study, ammonium phosphate and nickel chloride were employed as the doping sources for the first time to synthesize the Ni-based ZIF-8 precursor via the host–guest method. Subsequently, the precursor was pyrolyzed to obtain Ni2P nanoparticles (NPs) supported on N, P co-doped carbon. The composite materials exhibit elevated metal loading and effective dispersion due to the synergistic combination of phosphorus and nickel. Specifically, compared with Ni-NC, the optimal Ni2P-NCP-1 exhibits enhanced catalytic activity in the α-alkylation of arylacetonitriles with alcohols using KOH as the base. It shows a wide broad substrate scope at 140 °C for 12 h in n-octane using a hydrogen borrowing strategy. Through characterizations and mechanistic studies, it has been discovered that the introduction of P source not only provides more basic sites on carbon matrix but also leads to the formation of Ni2P NPs, which facilitates the catalytic efficiency by modifying the electronic structure of Ni. Compared with the metallic Ni species, the synergistic effect between Ni2P and acid-basic sites significantly influences the dehydrogenation of alcohols to generate Ni–H species. This study successfully achieves simultaneous phosphating of both the metal and support, and it also demonstrates that the N2P-NCP-1 catalyst has significant potential in the heterogeneous organic transformation field.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Shuaifeng Liu,Edouard Asselin,Zhibao Li
An industrially feasible process was proposed to produce α-calcium sulfate hemihydrate (α-HH) from FGD gypsum without any additives. In this process, an AlCl3 solution was used to promote the conversion of calcium sulfate dihydrate (DH) to hexagonal prismatic α-HH with high strength at atmospheric pressure. The phase transition kinetics of FGD gypsum was experimentally investigated under conditions: AlCl3 (2–2.5 m), MgCl2 (0–0.4 m) existing in raw FGD gypsum, and the solid–liquid ratio (or solid content %) range of 0.1–2 at 363 K. It was found that increasing the concentrations of MgCl2 in AlCl3 solution accelerated the conversion. The uniform large hexagonal prism HH product was obtained at the folowing optimal conditions: 2.5 mol/kg AlCl3, 0.4 mol/kg MgCl2, solid–liquid ratio of 2, and equilibration time of 2 h at 363 K. The phase diagram of the AlCl3-MgCl2-H2O system was determined by measuring solubility of solids. The E-NRTL activity model was used to construct the phase transition diagram of CaSO4 in AlCl3–MgCl2 media and to judge the stable range of DH and HH.
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高影响因子
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