JOURNAL OF MOLECULAR LIQUIDS
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2019
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IF 4.561
Qi Liu,Xiaoxiao Chen,Yan Guo,Chuanhong Han,Jing Li,Lihan Jia,Jie Liu,Xilian Wei
A ternary phase diagram of the system of 1-butyl-3-methylimidazolium tetrafluoroborate ([ Bmim ]BF4), sodium dodecylbenzenesulfonate (SDBS) and water using ocular estimate and turbidity method was drawn based on experimental data at 298.2 K. We got a narrow aqueous two-phase region near the side of water-ionic liquid (IL). A series of samples with different compositions around the phase diagram were chosen. The enthalpy change of these systems after injecting triply distilled water into these samples has been studied by using isothermal titration microcalorimetry (ITC). It is found that with increasing the water content there are weak endothermic and exothermic processes appearing, separately, which matches perfectly with the location of the formation and disappearance of the aqueous two-phase in the ternary phase diagram. This suggests the ITC is a feasible and effective method for the thermodynamic study of aqueous two-phase systems (ATPS) and was first reported. The experimental results show that the formation of the ATPS is endothermic (Δ H > 0), but the process of disappearing is exothermic (Δ H < 0). Due to the formation of aqueous two-phase is a thermodynamic spontaneous process under the isothermal constant pressure, we can judge that the formation of this ATPS is an entropy driven course and the vanishing is a synergy driven process by entropy and enthalpy.
研究领域:
物理化学
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热力学
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胶体与界面化学
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分离科学
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分析化学
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高影响因子
CHINESE CHEMICAL LETTERS
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2016
·Vol. 28
·期 1
·49-54
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IF 1.947
Qi-Feng Li,Chao Wang,Xiao-Zheng Lan
Latent heat storage performance of a layered perovskite-type compound, 1-C 14 H 29 NH 3 ) 2 ZnCl 4 (C 14 Zn), embedded in a series of silica gel (SG) with pore sizes of d = 15–200 nm is investigated using differential scanning calorimetry (DSC), and powder X-ray diffractions (XRD). C 14 Zn in the nanopores of silica gel shows size-dependent phase transition temperature, enthalpy change and supercooling. They have a stable transition temperature and heat capacity at each size in a short-term thermal cycling. Similar X-ray diffraction patterns are observed for the nano-sized and the bulk C 14 Zn. The encapsulation of a phase change material in nanopores is a new way of tuning its thermal energy storage properties for a wider range of temperature regulation.
研究领域:
材料科学
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热力学
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纳米科技
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能源存储
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功能材料
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高影响因子
ACS Omega
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2023
·
IF 4.1
Long Liu,Jinhu Bai,Ze Su,Yuan Yao,Zhixiang Zhou,Yangfeng Xia,Yanqiang Zhang
In this paper, a series of energetic ionic liquid plasticizers of 1-methyl-4-methoxyethyl-1,2,4-triazolium chloride (1), 1-methyl-4-methoxyethyl-1,2,4-triazolium bis(trifluoromethylsulfonyl)imide (1a), 1-methyl-4-methoxyethyl-1,2,4-triazolium nitrate (1b), 1-methyl-4-ethyl acetate-1,2,4-triazolium chloride (2), 1-methyl-4-ethyl acetate-1,2,4-triazolium bis(trifluoromethylsulfonyl)imide (2a), and 1-methyl-4-ethyl acetate-1,2,4-triazolium nitrate (2b) were synthesized and characterized. The results show that compounds 1a, 1b, 2a, and 2b have lower melting points (Tm, −72.60 to −32.67 °C) and good thermal stability (Td, 161–348 °C) and are suitable as plasticizers for hydroxyl-terminated polybutadiene (HTPB) curing systems. Among these four ionic liquids, ester-functionalized cations can help to improve the tensile strength (2a, 0.943 MPa; 2b, 1.113 MPa) of the cured system, while ether-functionalized cations are more beneficial to improve elongation at break (1a, 522.90%; 1b, 484.45%). Ester-functionalized ionic liquids are more beneficial to reduce the glass transition temperature of HTPB elastomers. The storage modulus of HTPB elastomers containing NO3– is higher, while that of HTPB elastomers containing NTf2– is lower. The crosslink densities of HTPB/TDI/2a and HTPB/TDI/2b plasticized by ester-functionalized ionic liquids are larger, which are 9369 and 9616 mol/m3, respectively. There are hydrogen bond interactions between the ionic liquid and the HTPB elastomer, and these interactions changed the distribution of the hard and soft segments in the polymer molecules.
研究领域:
含能材料
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高分子科学
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推进剂化学
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材料工程
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
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2026
·
IF 3.4
Ruilan Xu,Junhui Cai,Kaipeng Zhang,Yongxuan Wang,Jingjing Kou,Xintu Lin,Lu Gan,Shangxi Zhang,Zhengbao Wang,Yong Peng
Hollow-structured MFI zeolite exhibits great potential as a high-performance catalyst, adsorbent, and low-k material. For the construction of interior voids in silicalite-1 (pure silica MFI-type) zeolite, alkaline etching by TPAOH aqueous solution is a typical top-down approach. However, tough conditions like high temperature (around 170 °C) and high pressure (generated in autoclave), which are unfavorable for the safety operation and large-scale application, are necessary for the creation of a hollow structure in the zeolite. In this work, alkaline etching at mild conditions of typically 80 °C and atmospheric pressure by using TMAOH, TEAOH, and TBAOH as etchants is comparatively investigated in detail on the basis of the preliminary study that concentrated on the TPAOH etchant. Hierarchical hollow silicalite-1 zeolites are successfully obtained at different processing times for TEAOH-/TBAOH-etching, while TMAOH-etching only leads to the formation of plate-like crystals even at relatively harsh treatment conditions. The thinning trend of the wall thickness of hollow silicalite-1 against etching time varies depending on the employed etchant. The adsorption affinity of organocations on the zeolite surface of silicalite-1 decreases in the order TMA+ > TEA+ ≥ TBA+ > TPA+. The protection-dissolution etching mechanism associated with different etchants is analyzed. Two more detailed routes of protection-dissolutioninternal (p-din) and protection-dissolutionexternal (p-dex) are, for the first time, identified for TEAOH/TPAOH/TBAOH and TMAOH, respectively. The zeolite film layers prepared from the hollow silicalite-1 seeds possess internal cavities, exhibiting good anticorrosion ability and low dielectric constant k values.
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高影响因子
Chinese Medicine
·
2026
·Vol. 21
·期 1
·20
·
IF 5.7
Yang Yanan,Shao Yuwei,Tian Jun,Wang Yuezhu,Zhu Ye,Pan Siying,Wei Xiali,Jiang Linyan,Wang Xiaoke,Shu Qing
Background Electroacupuncture (EA) has demonstrated efficacy in ameliorating obesity through its marked appetite-suppressing effects. This study aims to elucidate the peripheral-central communication mechanism underlying EA's appetite inhibition mediated by the “vagal afferent fiber–nucleus tractus solitarius (NTS)–hypothalamic arcuate nucleus (ARC)” neural circuit. Methods High-fat diet-induced obese rats received EA or transcutaneous auricular vagus nerve stimulation (taVNS) for 8 weeks. Furthermore, we employed chemogenetic approaches to activate NTS glucagon-like peptide-1 (GLP-1) neurons (NTS GLP−1 ) and utilized capsaicin for gastric vagal deafferentation (GVND). Outcomes included metabolic profiles, vagal electrophysiology, expression of NTS GLP−1 and hypothalamic appetite-regulating neuropeptides, and neuronal activation markers. Results We observed reduced expression of GLP-1 in the NTS of obese rats. Chemogenetic activation of NTS GLP−1 significantly suppressed appetite, mitigated obesity, and modulated hypothalamic pro-opiomelanocortin (POMC) and neuropeptide Y (NPY). Following EA intervention in obese rats, concurrent activation of NTS GLP−1 and vagal afferent fibers was observed. Similar to chemogenetic NTS GLP−1 activation, EA upregulated the anorexigenic peptide POMC while downregulating the orexigenic peptide NPY in the ARC. Chemogenetic inhibition of GLP-1 neurons during EA application partially inhibited its anti-obesity and anorectic effects. Further investigations revealed that both EA and taVNS effectively reduced food intake and alleviated obesity. While both interventions activated vagal pathways and NTS GLP−1 , EA induced a significantly stronger activation of vagal afferent fibers compared to taVNS. Critically, GVND prior to EA application attenuated its anti-obesity effects. Conclusion The therapeutic benefits of EA in appetite suppression and obesity mitigation are mediated by selective regulation of the “vagal–GLP-1–ARC” neural circuit. Graphical s
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PubMed
高影响因子
Journal of Physical Chemistry C
·
2026
·
IF 3.4
Jiaying Liu,Shiwei Wang,Dong Wang,Zhihao Yu,Lin Zhu,Chunzheng Wu,Hongbo Yu
Modifying noble metal catalysts with transition metal oxides (MOx) is an effective strategy to enhance both catalytic activity and selectivity through interfacial synergy. However, achieving precise spatial colocalization of the metal and oxide phases remains a challenge. Herein, Pd1-(CuOx)1 hybrid nanostructures confined within KIT-6 mesoporous silica were rationally synthesized via in situ oxidative transformation of PdCu bimetallic nanoparticles (NPs) under controlled thermal treatment. The resulting Pd1-(CuOx)1/KIT-6 catalysts exhibited markedly enhanced activity and chemoselectivity for the hydrogenation of acetophenone to 1-phenylethanol compared with monometallic Pd/KIT-6 and PdCu/KIT-6. The optimal catalyst with a Pd/Cu molar ratio of 1:1 achieved 93.1% acetophenone conversion and 98.2% selectivity toward 1-phenylethanol, and demonstrated broad applicability across a range of ketone substrates. Comprehensive structural characterization revealed that the Pd-CuOx interfacial sites are central to the observed performance enhancement: metallic Pd facilitates H2 dissociation, while adjacent CuOx species are proposed to facilitate carbonyl adsorption, contributing to the overall synergistic enhancement. This interface-driven synergistic mechanism provides a general, efficient, and cost-effective strategy for the selective hydrogenation of multifunctional molecules.
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高影响因子
Applied Biological Chemistry
·
2026
·Vol. 69
·期 1
·42
·
IF 4.2
Gao Xinyue,You Long,Qi Luyao,Jin Lei,Zhang Jianmei,Liu Yanan,Niu Zhiqiang
As a disease of high mortality rate, acute lung injury (ALI) has been getting increased attention. Heme oxygenase-1 (HO-1), which plays an essential role in alleviating the pathological symptoms of ALI. There have few studies noted that the improvement effect of HO-1 on ALI may associated to NOD-like receptor protein 3 (NLRP3) inflammasome. However, the roles of HO-1 in the process of NLRP3 inflammasome activation is remains unknown. This study investigated the mechanism that HO-1 blocking NLRP3 inflammasome in ALI. The sepsis model induced by LPS was used in C57BL6 mice, LPS triggered obviously pulmonary damage and edema formation, increased the expression of NLRP3 inflammasome component proteins and IL-1β, but those negative effects were reversed by the pretreatment of hemin. NOD-like receptor signaling pathway was down-regulated after hemin treatment through RNA-Seq. Meanwhile, hemin pretreatment exerted significantly inhibit effect on the activation of NLRP3 inflammasome, and the component proteins of NLRP3 inflammasome were not influenced in immortalization of bone marrow-derived macrophages (iBMDMs). Moreover, the immunoprecipitation and immunofluorescence experiments were indicated that HO-1 could bind to NLRP3, silencing HO-1 prevented the block effect of hemin on NLRP3 inflammasome activation. Our study suggested that hemin-inhibited NLRP3 inflammasome activation involved HO-1 bind to NLRP3 and alleviated ALI mice induced by LPS.
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高影响因子
Journal of the American Chemical Society
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2026
·
IF 16.6
Jiangning Liu,Baoyu Sun,Tuo Zhao,Caitian Lin,Zhishuo Zang,Caiwang Mao,Lingjie Meng,Jingying Xie,Jiangxuan Song
Stabilizing Li metal anodes remains a central challenge due to the difficulty of establishing the stable electrode/electrolyte interface, arising from dynamic potential fluctuations within the inner Helmholtz plane. Here, we propose a preoccupancy-guided interfacial regulation strategy that decouples electric-field effects from interfacial reduction processes. A Schiff-base polymer with terminal C–F fragments spontaneously establishes a preferential surface-normal orientation across the inner Helmholtz plane, thereby defining a preoccupied and spatially confined interfacial environment that suppresses solvent access to the Li surface. Coupled with the electron-withdrawing effect of its fluorinated moieties, the interfacial electronic environment is modulated, facilitating the preferential formation of a LiF-rich interphase on Li metal. Meanwhile, the abundant F/N coordination sites in the unreacted polymer serve as a soft organic outer layer that accelerates Li-ion desolvation and diffusion. Benefiting from these features, the fine-tuned solid electrolyte interphase integrates chemical stability, mechanical robustness, and efficient Li-ion transport, enabling the fabricated 4.81 Ah pouch cell to deliver an energy density of 502.43 Wh kg–1 and maintain ∼90.06% of its initial capacity after 240 cycles. Our findings reveal that precise tuning of the chemical environment within the inner Helmholtz plane effectively suppresses uncontrolled electrochemical-derived interphase formation, paving the way toward the rational design of a stable Li metal/electrolyte interface.
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高影响因子
Frontiers in Microbiology
·
2026
·
IF 5.8
Nesreen Aljahdali
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine (HCA) that is formed during high-temperature meat cooking, especially grilling, and is classified as a carcinogenic food-borne compound that can impact multiple physiological systems. The aim of this study was to evaluate how exposure to PhIP affects the composition of the cecal microbiota in mice. A total of 32 mice were randomly divided into four groups: A negative control group, a positive control group, and two groups treated orally with either 10 or 20 mg/kg PhIP for 2 months. The V3-V4 regions of the bacterial 16S rRNA gene were sequenced to characterize the cecal microbial communities. Microbial richness and diversity decreased in the PhIP-treated mice compared to the negative control group. At the phylum level, the relative abundance of Bacillota and Actinomycetota decreased significantly after PhIP exposure, while the abundance of Campylobacterota and Bacteroidota increased. At the genus level, the abundance of Roseburia, Lactobacillus, and Bifidobacterium decreased, while the abundance of Blautia, Lachnospiraceae-NK4A136 group, Bacteroides, Alistipes, Helicobacter, and Escherichia–Shigella increased. The results highlight that bacterial community composition and its relative abundance in the cecum change with PhIP exposure and offer further evidence of microbiota dysbiosis that occurs with PhIP exposure.
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高影响因子
PHYSICAL REVIEW B
·
2026
·Vol. 113
·期 14
·144407
·
IF 3.9
Fuguang Han,Jun Li,Huantong Wu,Shuang Wang,Zhengyu Zhang,Zegeng Chen,Zhongxiang Zhou
The application of most multiferroic ceramic composites is severely hindered by their zero or near-zero magnetoelectric response under zero magnetic field. Currently, there has been no in-depth theoretical exploration into the causes of self-biased magnetoelectric coupling effects in these ceramics or how to regulate them. In this study, we report the observation of self-biased magnetoelectric coupling effect in a $(1\ensuremath{-}x)\mathrm{BaTi}{\mathrm{O}}_{3}\ensuremath{-}(x)\mathrm{CoF}{\mathrm{e}}_{2}{\mathrm{O}}_{4}(x=0.1,0.2,0.3,0.4\phantom{\rule{0.16em}{0ex}}\mathrm{and}\phantom{\rule{0.16em}{0ex}}0.5)$ particle composites. P-E and M-H hysteresis loops confirmed the presence of both ferroelectricity and ferromagnetism in the $(1\ensuremath{-}x)\mathrm{BaTi}{\mathrm{O}}_{3}\ensuremath{-}(x)\mathrm{CoF}{\mathrm{e}}_{2}{\mathrm{O}}_{4}$ composites. By measuring the magnetoelectric voltages of the composites, we confirmed the existence of self-biased magnetoelectric coupling effects in the $\mathrm{BaTi}{\mathrm{O}}_{3}$ and $\mathrm{CoF}{\mathrm{e}}_{2}{\mathrm{O}}_{4}$ phases. The highest self-biased magnetoelectric coupling coefficient (1.65 mV/(Oe cm)) was found at $x=0.3$ composite sample. Based on nonlinear magnetoelectric coupling theory, we established a correlation model between magnetic parameters and magnetoelectric coupling coefficients. We demonstrated that the origin of self-biased magnetoelectric coupling lies in the hysteresis dependence of magnetization and proposed that regulating magnetic parameters can effectively control the self-biased magnetoelectric coupling effect. Finite element simulations visually demonstrate displacement variations under different magnetic field conditions, enabling more intuitive observation of changes in internal magnetization and displacement within the material. This lays the foundation for developing high-performance self-biased magnetoelectric coupling devices.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2026
·
IF 6.8
Chuanqi Wan,Jiamin Lu,Lingyun Xu,Mei Jiang,Chen Zhu,Wen Zhang,Pingping Han,Jirong Zhang,Jing Wang,Weiwei Ren,Hui Chu,Bingzhi Zhou,Jiancheng Zhang,Guangjun Jin,Bangjiang Fang,Yuzhou He
Shenhuang Granules (SHG) attenuate sepsis-induced lung injury via the NLRP3/Caspase-1/GSDMD pathway. • (−)-Epicatechin gallate and gallic acid are the core bioactive monomers of SHG against PMVEC pyroptosis. • SHG inhibits pyroptosis by suppressing inflammasome assembly and pore formation. Ethnopharmacological relevance Shenhuang Granules (SHG) is a traditional Chinese medicine (TCM) formula composed of six medicinal materials: Panax ginseng C.A. Mey. (Ginseng Radix et Rhizoma), Rheum palmatum L. (Rhei Radix et Rhizoma), Sargentodoxa cuneata (Oliv.) Rehder & E.H. Wilson (Sargentodoxae Caulis), Taraxacum mongolicum Hand. -Mazz. (Taraxaci Herba), Aconitum carmichaelii Debeaux (Aconiti Lateralis Radix Praeparata), and Whitmania pigra Whitman (Hirudo). According to TCM theory, this formula is designed to replenish Qi and strengthen the body's resistance, clear heat and remove toxins, and promote blood circulation to eliminate blood stasis. In clinical practice, SHG has been used as an adjunctive therapy for sepsis, showing beneficial effects in ameliorating systemic inflammatory responses and microcirculatory disturbances. However, the underlying pharmacological mechanisms remain largely unclear. Aim of the study To validate that SHG and its active monomers alleviate sepsis-induced lung injury through targeted suppression of the NLRP3-driven PMVEC pyroptosis pathway. Materials and methods The chemical composition of SHG was analyzed by UHPLC-MS/MS. In vivo, SA-ARDS was induced in C57BL/6J mice by cecal ligation and puncture (CLP), with SHG (61.85 mg/mouse/d), its monomers, (−)-epicatechin gallate (ECG) and gallic acid (GA) (20 mg/kg/d), or the NLRP3 inhibitor MCC950 (10 mg/kg/d), were administered via intraperitoneal injection for 3 days prior to modeling. Lung injury severity and activation of the pyroptosis pathway were evaluated using histopathology, transmission electron microscopy, RT-qPCR, Western blotting, immunohistochemistry, immunofluorescence, and ELISA. In vitro, LPS-stimulated (1 μg/mL) PMVECs were used to screen 43 monomers, and the underlying mechanisms were subsequently verified. Results Compared with the Model group, SHG treatment significantly attenuated body weight loss in mice ( P < 0.001), reduced the lung wet-to-dry (W/D) weight ratio ( P < 0.05), and decreased Evans blue extravasation in lung tissues ( P < 0.01). SHG also significantly downregulated the mRNA expression levels of pyroptosis-related genes, including Twik2 , Nlrp3 , Asc , Caspase-1 , and Gsdmd , in lung tissues (all P < 0.01), and markedly reduced the protein expression of NLRP3, ASC, pro-Caspase-1, and Caspase-1 (all P < 0.05). ELISA results further demonstrated that SHG significantly decreased serum levels of the inflammatory cytokines TNF-α, IL-1β, IFN-γ, IL-18, pro-IL-1β, and pro-IL-18 in mice (all P < 0.05). In vitro, compared with the Model group, SHG significantly suppressed the transcriptional levels of Twik2 , Nlrp3 , Asc , Caspase-1 , and Gsdmd in PMVECs (all P < 0.05), and reduced the protein expression of NLRP3, ASC, GSDMD, GSDMD-NT, and IL-1β (all P < 0.05). Additionally, SHG markedly decreased lactate dehydrogenase (LDH) release ( P < 0.0001) and attenuated extracellular potassium ion (K + ) efflux ( P < 0.0001). Notably, ECG and GA individually exhibited potent inhibitory effects on PMVEC pyroptosis. Compared with the Model group, both ECG and GA significantly suppressed mRNA expression of Twik2, Nlrp3, Asc, Caspase-1, and Gsdmd (all P < 0.05) and reduced protein levels of NLRP3 , ASC , Caspase-1 , and GSDMD (all P < 0.05). Moreover, ECG significantly inhibited GSDMD-NT and IL-1β protein expression (all P < 0.05). Both ECG and GA markedly reduced TNF-α, IL-1β, and pro-IL-18 levels (all P < 0.05), and GA additionally suppressed IL-18 and pro-IL-1β expression (all P < 0.01). Furthermore, both ECG and GA significantly decreased LDH release ( P < 0.0001) and inhibited extracellular K + efflux ( P < 0.0001). However, this study has several limitations, including a small sample size, the absence of dose-gradient and time-course analyses, insufficient functional validation of the TWIK2 channel, and the lack of quantitative pharmacokinetic and synergy analyses, which should be addressed in future studies. Conclusion Shenhuang Granules attenuated PMVEC pyroptosis and ameliorated sepsis-induced lung injury by suppressing TWIK2 and the downstream NLRP3/Caspase-1/GSDMD pathway, with GA and ECG as the key active components. Download: Download high-res image (484KB) Download: Download full-size image
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PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Fu Danning,Zhang Feifei,Sheng Jie,Wang Lijun,Zhang Xuejin,Li Lin,Hua Feiguo,Jia Zhixin
With the rapid advancement of wearable sensors and the Internet of Things (IoT), self-powered systems have become essential for sustainable, low-maintenance electronics. Triboelectric nanogenerators (TENGs) are promising candidates; however, achieving high electrical output together with mechanical robustness remains challenging. Herein, we report an ultra-tough, stretchable TENG based on a conductive hydrogel reinforced with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibrils (TOCNFs). The design delivers a dual benefit: abundant carboxyl groups on TOCNFs enhance triboelectric charge transfer and boost electrical output, while TOCNFs form a robust triple cross-linked network that imparts durability. The resulting TENG achieves an open-circuit voltage of 69.4 V, a short-circuit current of 2.8 μA, a power density of 12.15 μW/cm 2 , a tensile strength of 3.05 MPa at 908% elongation, and a compressive strength of 4.10 MPa at 80% strain, outperforming most reported hydrogel-based TENGs. For sensing, it exhibits a sensitivity of 0.36 V·kPa –1 , fast response and recovery times (298/270 ms), and stable operation over 5000 cycles. Additionally, the device powers microelectronics, enables wireless Morse-code communication, and supports self-powered health monitoring. This work resolves the common trade-off between performance and durability in TENG design and provides a versatile platform for self-powered wearable electronics and IoT applications.
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高影响因子
危险品化学品经营许可证（带存储）