ACTA PHARMACOLOGICA SINICA
·
2026
·
IF 10.4
Chen Chuan-jun,Guo Ding-wen,Yuan Qing-yun,Zhuo You-qiong,Yang Shi-fen,Xu Hao-min,Wang You-rong,Guan Xiao-hui,Deng Ke-yu,Xin Hong-bo
Macrophage migration inhibitory factor (MIF) is a cytokine that possesses multiple enzymatic activities, such as keto-enol tautomerase and thiol-oxidoreductase. We previously found that lack of MIF tautomerase activity significantly alleviated high fat diet (HFD)-induced obesity in mice. In this study, we investigated the regulatory mechanisms of MIF tautomerase in obesity. HFD-induced obese mouse model was established. Adipogenic differentiation was induced in mouse preadipocyte cell line 3T3-L1 and mouse adipose-derived mesenchymal stem cells (ADSCs) in vitro. We showed that MIF tautomerase inhibitors ISO-1 or 4-IPP dose-dependently promoted lipid degradation and mitochondrial thermogenesis by enhancing basal oxygen consumption rate and proton leak, accompanied by increased expression of browning markers (UCP1, PGC-1α, DIO2, CD137) in 3T3-L1 cells under adipogenic induction conditions. In HFD-induced obese mice, administration of 4-IPP (5, 10 mg/kg, i.p.) every 2 days for 12 weeks significantly ameliorated HFD-induced obesity, improved insulin sensitivity, and enhanced energy expenditure. In white adipocytes, 4-IPP (1, 5, 10 μM) dose-dependently promoted CD137 expression, and restored CD137-mediated activation of the PI3K/AKT signaling to improve lipid metabolism. CD137 deficiency abrogated the browning effect of 4-IPP in white adipocytes in vitro. CD137 −/− mice exhibited increased susceptibility to HFD-induced obesity and almost abolished the anti-obesity effects of 4-IPP. Simulation of the protein interaction revealed a direct interaction between MIF and CD137: MIF competitively bound to CD137 on white adipocytes with the endogenous ligand of CD137, which was further confirmed by co-immunoprecipitation. Furthermore, 4-IPP and recombinant CD137 protein inhibited the tautomerase activity of MIF in vitro. In conclusion, MIF promotes obesity by binding CD137 through its tautomerase domain, suppressing CD137-mediated the activation of the PI3K/AKT signaling. MIF tautomerase inhibitors disrupt this interaction, restore CD137 function, and enhance adipocyte browning, offering a promising therapeutic strategy for obesity management.
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2026
·
IF 6.2
Yiming Chen,Zhan Zhao,Yuanyuan Liu,Kelei Huang,Xiangchao Meng
Adopting reverse osmosis (RO) for seawater desalinating is well-established, suitable for coupling with alkaline water electrolysis (ALK) systems. The progressive accumulation of residual ions during the reaction, along with the limited energy efficiency of industrial ALK cells, drives the requirement to explore scalable strategies for engineering highly active catalysts. Herein, a facile water bath followed by rapid Joule heating method has been reported for scalable fabrication of large-scale electrodes. Typically, a cathode of NiMoO 4 /MoO 2 with a size of 10 cm × 10 cm were grown on nickel mesh (NM) substrate.The NiMoO 4 /MoO 2 achieved an overpotential of 345.2/349.2 mV at 500 mA cm -2 in alkaline freshwater/seawater, with stability at 1 A cm -2 for 1000 h. Further experiments in ALK device adopting quasi-industrial condition (6 M KOH RO seawater, 60°C) showed that NiMoO 4 /MoO 2 ||NM delivered a current density of 500 mA cm -2 with a reduction of the required voltage by 1 V in comparison with NM||NM, displaying impressive Faraday efficiency of 90.2% and electricity consumption of 4.48 kWh/Nm 3 H 2 , demonstrating the potential for industrial applications. The characterization and experimental results verified the vital role of Joule heating and the optimised electronic structure in NiMoO 4 /MoO 2 heterostructure, resulting in efficient hydrogen evolution reaction (HER).
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高影响因子
Molecular Catalysis
·
2026
·
IF 4.3
Yanping Dong,Xiqiang Tian,Muhammad Zahid
Amine-functionalized dendritic mesoporous silica nanospheres (DMSN‑NH 2 ) was developed to confine and stabilize Pt nanoparticles. • Pt@DMSN-NH 2 showed higher TOF (968 h −1 ) than Pt@DMSN (312 h −1 ). • Pt@DMSN-NH 2 exhibits higher k value (1.23 min −1 ) and lower Ea value (36.9 kJ·mol −1 ) than Pt@DMSN (0.298 min −1 , 46.5 kJ·mol −1 ). • The excellent performance of Pt@DMSN‑NH 2 is attributed to its dendritic architecture and amine-functionalities. • Pt@DMSN-NH 2 catalyst exhibited excellent stability for up to five consecutive cycles. Stabilizing precious Pt nanoparticles on conventional supports remains challenging, as their high surface energy makes them prone to early destabilization. In this work, Pt nanoparticles synthesized via a polyol method were uniformly dispersed and firmly anchored on dendritic mesoporous silica nanospheres (DMSN), which were fabricated through a simple hydrothermal route and later functionalized with amine groups (DMSN‑NH 2 ). Remarkably, the as-synthesized Pt@DMSN-NH 2 catalyst exhibited 4.12 times enhancement in the catalytic hydrogenation of 4-nitrophenol (4-NP), achieving significantly excellent rate constant and turnover frequency values ( k = 1.23 min −1 , TOF = 968 h −1 ), compared with those of the Pt@DMSN catalyst ( k = 0.298 min −1 , TOF = 312 h −1 ). A comprehensive investigation of the structure-activity relationship, supported by a suite of bulk and surface characterization analysis, obviously attributes the highly efficient catalytic hydrogenation behavior of Pt@DMSN-NH 2 to the dendritic mesoporous architecture and the amine functionalities lining the pore walls. These two features jointly regulate the size of Pt nanoparticles (3.2 nm) and facilitate their uniform distribution (36.2% dispersion), thereby generating a higher number of key active Pt 0 species on the surface of Pt@DMSN-NH 2 , which enhances the hydrogenation of 4‑NP. The fabricated Pt@DMSN-NH 2 showed remarkable activity in the hydrogenation of 4-Nitrophenol. Download: Download high-res image (160KB) Download: Download full-size image
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Yanping Dong,Xiqiang Tian,Jinhui An,Pengyu Xu,Xinrui Wei,Muhammad Zahid
Achieving high activity, superior selectivity, and durable performance remains challenging for pristine MOFs in heterogeneous hydrogenation catalysis. Herein, nitrogen-doped carbon-wrapped Cu@Cu 2 O/NC heterogeneous catalysts enriched with Cu 0 –Cu + interfacial sites were readily derived by calcining Cu-MOF under an air atmosphere. Comprehensive characterization was conducted to examine synthesis-induced variations in bulk crystallinity, surface chemistry, and catalytic activity for Cu-MOF-250, Cu-MOF-350, and Cu-MOF-450. Compared to its counterparts, the Cu-MOF-350 catalyst exhibited optimal performance in the preferential hydrogenation of noxious 4-nitrophenol (4-NP) to valued 4-aminophenol (4-AP), maintaining high activity for up to ten consecutive rounds. The enhanced catalytic hydrogenation efficiency of the Cu-MOF-350 catalyst is ascribed to its distinctive nanostructural features, which originate from the synergistic interplay between Cu and Cu 2 O species. In addition, the improved uniform distribution of Cu@Cu 2 O nanoparticles generates higher concentration of interfacial exposed reactive Cu 0 /Cu + sites on the Cu-MOF-350 surface, which are considered crucial for the promoted hydrogenation of 4-NP.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Jiawei Liu,Xiaole Yu,Kaibiao Xi,Xueting Wang,Kailong Huang,Zichen Liu,Jingbo Wang,Junyan Wang,Lei Dai
Bi 4 Ti 3 O 12 -based high-temperature piezoceramics are promising for applications in harsh environments such as aerospace and oil exploration. However, their low piezoelectric coefficient ( d 33 ) and high leakage current at elevated temperatures limit their use. Herein, a B-site isovalent ion-pair co-doping strategy is proposed. Ferroelectric active Zn 2+ and higher-valent W 6+ are co-introduced in a nominal (Zn 1/2 W 1/2 ) 4+ ion-pair substitution scheme to isovalently replace the B-site Ti 4+ in the Bi 3.96 Ce 0.04 Ti 3 O 12 matrix, thereby enhancing d 33 and resistivity ( ρ ) while maintaining a high Curie temperature ( T C ). The optimal ceramic Bi 3.96 Ce 0.04 Ti 2.95 (Zn 1/2 W 1/2 ) 0.05 O 12 achieves a balanced performance profile: a respectable d 33 of 28.9 pC/N, a high T C of 654 °C, and an excellent resistivity of 8.5 × 10 6 Ω·cm at 500 °C. This balanced combination of properties is attributed to the synergistic effect of Zn 2+ and W 6+ , which promotes grain growth, enhances polarization, and reduces the concentration of mobile oxygen vacancies. This work offers a promising material for high-temperature piezoelectric applications.
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高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2016
·Vol. 30
·期 8
·722-725
·
IF 2.452
Peipei Zou,Meisong Wang,Liang Zhao,Liyi Dai,Yuanyuan Wang
A Pt@three-dimensional graphene (Pt@3DG) composite hydrogel with a unique porous nanostructure was prepared and used as an efficient, recyclable and robust catalyst for the reduction of 4-nitrophenol to 4-aminophenol under mild conditions. The influence of graphene architecture on catalytic activities was comparatively investigated by loading the same amount of Pt on reduced graphene oxide. Pt@3DG exhibits a very high catalytic activity owing to the three-dimensional macroporous framework with high specific surface area, numerous activation sites and efficient transport pathways. Moreover, catalyst separation can be easily achieved by simple filtration, and the catalyst can be reused for at least five runs, maintaining its high catalytic activity. Copyright © 2016 John Wiley & Sons, Ltd.
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高影响因子
BIOMATERIALS
·
2026
·
IF 12.9
Zeguo Chen,Zhongshi Wu,Can Huang,Qiying Wu,Chao Xie,Sicheng Chen,Liang Yi,Haoyong Yuan,Sixi Liu,Abdulraheem Mustapha,Siyao Chen,Wansong Chen,Ting Lu,Zhenjie Tang,Yuhong Liu
Delayed endothelialization and inadequate matrix remodeling remain major obstacles in the development of small-diameter vascular grafts (SDVGs; <6 mm). To address these challenges, we developed an immunomodulatory tissue-engineered vascular graft (iTEVG) by integrating hollow mesoporous silica nanoparticles (HMSNs) with tailored mesopore sizes as delivery carriers for immunoregulatory factors. VEGF was selectively immobilized on the intimal surface, while the adventitia incorporated a sequential release system for VEGF and IL-4. VEGF exhibited rapid release (64.04 ± 4.44% in 7 days), promoting monocyte recruitment and adventitial neovascularization, while IL-4 showed sustained release (65.94 ± 2.06% over 28 days), driving long-term M2 macrophage polarization. In rats, iTEVGs achieved 88% endothelial coverage and smooth muscle cell infiltration within 1 month, full-thickness cellularization with a complete trilaminar structure by 3 months, and maintained mechanical integrity without aneurysm formation up to 6 months. This spatially partitioned platform, built on an acellular vascular scaffold, enables precise spatiotemporal regulation of the immune microenvironment and offers a design paradigm that synergistically promotes endothelialization and vascular matrix remodeling. The “intima-targeted regeneration and adventitia-sequential-release” strategy provides a promising template for SDVG design that may be extended to other complex organ constructs.
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DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 4
·850
·
IF 4.2
Meng Guo,Dou Wu,Hongyu Yang,Xiao Zhang,Dong-Xu Xue,Weiqiang Zhang
The use of gaseous CO in Pd-catalyzed carbonylative quinolone synthesis presents challenges related to safety and precise pressure control. In response, a streamlined non-gaseous synthesis of 4-quinolone compounds has been developed. This study introduces a tunable CO-releasing system utilizing Fe(CO)5activated by a dual-base system of piperazine and triethylamine. This alternative liquid CO resource facilitates the palladium-catalyzed carbonylative C-C coupling and subsequent intramolecular cyclization. By tuning the tandem kinetics of carbonylation and cyclization, this non-gaseous method achieves the successful synthesis of 22 distinct 4-quinolones with excellent yields. This is achieved through the three-component condensation of sub-stoichiometric amounts of Fe(CO)5with 2-iodoaniline and terminal alkynes. Operando mechanistic studies have revealed a novel CO transfer mechanism that facilitates homogeneous carbonylative cyclization, distinguishing this method from traditional techniques. In addition to addressing safety concerns, this approach also provides precise control over selectivity, with significant implications for pharmaceutical research and the efficient synthesis of pharmaceutical and bioactive compounds.
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高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Yuan Chen,Keqiang Hu,Yuancai Chen
In this study, we screened a new aerobic bacterium ( Bacillus megaterium Y-4) that can efficiently reduce Pd(II) with different electron donors. The best electron donor was sodium formate and the best reduction of Pd(II) were by log growth phase cells. The high removal capacity of Pd(II) (1658.3 mg/g) was obtained with 30 mg/L dry cell weight and 50 mg/L Pd (II) in the presence of 5 mM sodium formate. The removal amount of Pd(II) increased with initial Pd(II) concentrations ranging from 50 to 200 mg/L with 100 mg/L Pd(II) being completely removed by 148 mg/L dry cell weight in 6 h. The cell wall, periplasmic space and intracellular contents of B . megaterium Y-4 contains different kinds of enzymes for reducing Pd(II). In addition, the activity of extracellular and periplasmic enzymes was more sensitive to temperature than intracellular enzymes . XRD and XPS analysis revealed that the enzyme for reducing Pd(II) in B. megaterium Y-4 can tolerate a broad range of temperatures (20–60 °C) and pH (2.0–7.0) but was sensitive to oxygen. TEM analysis showed that biogenic palladium nanoparticles (Pd-NPs) were mainly distributed evenly in the periplasmic space of the live cells and were released from cells into aqueous solution, which reduced the toxicity of Pd(II), allowing Pd-NP recovery without cell destruction. B. megaterium Y-4 is a potential bacterium for efficient treatment and reclamation of Pd(II) pollution and formation of Pd-NPs.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Yao Zhang,Leyu Zhan,Xiangyang Zhuang,Yunfeng Zhu,Neng Wan,Xinli Guo,Jian Chen,Zengmei Wang,Liquan Li
LiBH 4 possesses high ionic conductivity (σ) at a temperature over 373 K and wide window voltage over 5 V, but low σ value below 373 K. Li 2 NH owns excellent ionic conductivity at low temperature but performs in a narrow window voltage (only 0.7 V). xLiBH 4 -Li 2 NH composites (x = 1, 2, 4) were therefore synthesized to eliminate their respective drawbacks. By alternating current impedance spectra, we observed that xLiBH 4 -Li 2 NH (x = 1, 2, 4) composites offer σ of 10 −2 Scm −1 at a temperature over 373 K, and lift σ value by 100 times from that of LiBH 4 at a temperature below 373 K. According to the cyclic voltammetry (CV for 10 cycles) results, the window voltage of 3 V can be achieved for LiBH 4 -Li 2 NH (1:1). X-ray diffraction (XRD) and Fourier Transform infrared spectroscopy (FTIR) measurements on xLiBH 4 -Li 2 NH (x = 1, 2, 4) samples inform that original phases were well preserved after ball milling and temperature ramping. Their chemical stabilities were also demonstrated by differential scanning calorimetry (DSC) measurements. The enhanced lithium mobility at low temperature in LiBH 4 -Li 2 NH should be ascribed to the favorable boundaries between both phases according to the investigations by both in-situ nuclear magnetic resonance (NMR) and high-resolution transmission electron microscope (HRTEM). However, at a temperature above 373 K, the enhanced ionic mobility of LiBH 4 -Li 2 NH should be mainly contributed by HT-LiBH 4 phase.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 30
·期 2
·1699-1705
·
IF 2.324
Teng Fei,Chen Dong,Ma Yuzhe,Ji Shaohua,Liu Jiaojiao,Wang Tianhua,Tang Jie,Cao Lifeng,Teng Bing
N,N -dimethylamino-4′-N′-methylstilbazolium 2,4,6-trimethylbenzenesulfonate (DSTMS)-graphene ex-situ and in-situ composite films with 2% concentration of graphene were first prepared and systematically investigated. The crystallinity of DSTMS-based composite films were confirmed by XRD analysis, and the functional groups of composite films can be obtained by FT-IR. Optical absorptions were recorded using UV–Vis-NIR spectral analysis, and the band gap and extinction coefficient of the films were calculated. The thermal stability of the composite films were analyzed by TG/DSC. The pressure sensitive resistance test showed that the pressure sensitive signal of the composite films were significantly increased after graphene added, while the signal of DSTMS film eventually disappears. This work expands the application of organic nonlinear crystal DSTMS in optics and electricity by doping graphene.
研究领域:
材料科学
·
凝聚态物理
·
功能材料
·
非线性光学
·
纳米复合材料
·
电学性能
·
光学性能
·
热分析
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2018
·
IF 3.779
G.Q. Wang,Y.P. Lin,R. Ye,Y.N. Feng,L.Y. Li
In this work, Pr 3+ and Tb 3+ coactivated Na 5 Gd(WO 4 ) 4 (NGW) phosphors have been synthesized by high-temperature solid-state reactions and the scheelite crystal structure was determined for the first time. A color-tunable emission in NGW: Pr 3+ , Tb 3+ phosphors can be realized by the modulation of excitation wavelengths, namely, the fluorescence intensity ratio of Pr 3+ to Tb 3+ in this material could be changed by different excitation. With increasing temperature, the luminescence of NGW: Pr 3+ , Tb 3+ phosphor decreases almost linearly with the CIE coordinate variation from (0.306, 0.392) to ((0.375, 0.465) and result in the color of the photoluminescence variation from the blue-green to yellow. These results demonstrated that the investigated phosphors are attractive for application in display lighting and optical temperature sensing.
研究领域:
材料科学
·
发光材料
·
光学性质
·
固态化学
·
温度传感
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高影响因子
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