ACS Applied Energy Materials
·
2026
·
IF 5.5
Chao Dong,Rong Liu,Wenbo Cao,Weili Meng,Mingtai Wang
Herein, for the first time, we have fabricated superstrate-type CuInS2 planar heterojunction solar cells configured as FTO/SnOx/CdS/CuInS2/Spiro-OMeTAD/Au, in which an amorphous tin oxide (SnOx) interfacial layer is prepared by a straightforward solution-processing method at low temperatures (≤200 °C), and 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene (Spiro-OMeTAD) is used as a hole-transporting material. It is revealed that the solar cells exhibit a performance that is strongly dependent on the SnOx layer thickness and deliver a peak power conversion efficiency of 6.56% for a 25 nm-thick SnOx layer, which is higher by 78% than that of the control devices without the SnOx interfacial layer. This is attributed to the reduced interfacial charge recombination at the CdS/CuInS2 interfaces due to the fast extraction of photogenerated electrons from the CdS layer into the SnOx film for collection. This work offers promising interfacial access to efficient CuInS2 planar heterojunction solar cells.
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2026
·
IF 4.8
Tianhao Zhou,Zihan Cheng,Yanbing Zhu,Yiyan Chen,Xiaomu Qiao,Jia Huang
Transient receptor potential vanilloid (TRPV) channels formed by Nanchung (Nan) and Inactive (Iav) subunits are essential for mechanosensation and coordinated locomotion in insects and represent validated targets of several commercial insecticides that act as channel agonists. Indazapyroxamet is a recently developed insecticide with high efficacy against piercing–sucking pests; however, its molecular target and mode of action remain unclear. Here, we investigated the mode of action of indazapyroxamet using molecular pharmacology, Drosophila genetics and structural modeling. Calcium imaging in Drosophila S2 cells expressing the brown planthopper ( Nilaparvata lugens ) TRPV channel revealed that while indazapyroxamet exhibits low-efficacy partial agonism, it potently antagonizes nicotinamide-induced calcium influx with an IC 50 of 8.1 nM. Consistently, dietary exposure to indazapyroxamet caused dose-dependent impairment of negative geotaxis in wild-type Drosophila melanogaster , whereas this behavioral effect was completely abolished in nan and iav loss-of-function mutants, demonstrating that its in vivo effects require functional TRPV channels. Molecular docking analysis showed that indazapyroxamet occupies a binding pocket overlapping that of known TRPV agonists and forms aromatic interactions with a conserved residue W322 in the Iav subunit, but lacks interactions with key residue Y178 in Nan subunit required for stabilizing the open-channel conformation. Together, these results identify indazapyroxamet as a TRPV antagonist and reveal a previously unrecognized mode of action for TRPV-targeting insecticides, with important implications for insecticide development and resistance management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Jingyi Zheng,Fangjun Wang,Zhengyu Jin,Tao Zhang,Ming Miao
Enzymatic assembly forms pH-responsive CMPG-Gel ensuring high load efficiency. • pH-triggered volume/zeta potential shifts enable targeted intestinal drug release. • High metformin loading (97.5%) via H-bonding and pH-dependent release • Structural analysis confirms Met entrapment and rheology shows elastic dominance. • Enzymatic assembly with PG creates sustainable oral delivery platform. Oral metformin (Met) delivery is limited by gastric degradation and low bioavailability, necessitating intestinal-targeted systems. A pH-responsive carboxymethylated phytoglycogen (PG) hydrogel (CMPG-Gel) was fabricated via enzyme-catalyzed assembly to address this issue. Optimal preparation conditions of gel were: 8% PG or CMPG substrate concentration, 1:6 substrate/glucose -1- phosphate (Glc-1-P) monomer ratio, 0.6 mL enzyme dosage, and 0.25 degree of substitution (DS). The xerogel exhibited excellent water-swelling capacity and efficient Met loading. Enzyme-assisted assembly achieved a 39.00 ± 1.49 mg/g loading capacity and 97.50% ± 0.90% efficiency, superior to physical adsorption. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and independent gradient model (IGM) analyses confirmed Met stabilization in the hydrogel network via hydrogen bonding. Rheological data (G' > G”) indicated solid-like viscoelastic behavior. The pH-responsive mechanism of CMPG-Gel relied on carboxyl group ionization: low-pH protonation of carboxyl group caused gel contraction, whereas high-pH deprotonation enhanced gel swelling via electrostatic repulsion. In vitro studies demonstrated pH-dependent Met release, 52.28% in simulated gastric fluid (SGF) and 98.05% in simulated intestinal fluid (SIF), achieving effective intestinal-targeted delivery.
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高影响因子
Journal of Materials Chemistry B
·
2026
·
IF 6.2
jing Shi,Tao Wang,mengyuan Dai,qinling Liu,Qingxin Fan,Lu Li,Sha Wan,Chen Fan,Yu Wang,Qingquan Kong
Osteoarthritis (OA) is a highly prevalent degenerative joint disease affecting over 500 million people globally, imposing substantial social and economic burdens. Current treatments, including platelet-rich plasma (PRP), are limited by rapid growth factor release, failing to achieve long-term efficacy. To address this, we developed an injectable PRP-loaded hydrogel via in situ assembly of metal-phenolic networks (MPNs), leveraging MPNs' multi-scale porous structure, adjustable mesh size, and dynamic drug interactions to enable "dynamic adhesion" and sustained growth factor release.In vitro studies with OA chondrocytes demonstrated stable PRP release for 14 days, while in vivo evaluations in OA rodent (rat) models confirmed therapeutic effects, including anti-inflammatory, antioxidant, and cartilage repair-promoting activities.This MPN-based hydrogel system validates a novel strategy for sustained PRP delivery, offering a convenient, safe, and effective approach to enhance long-term OA treatment outcomes with potential for clinical translation.
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MOLECULES
·
2015
·Vol. 20
·期 4
·6033-6047
·
IF 2.416
Xueqin Zhang,Mingjie Chen,Chuanfu Liu,Aiping Zhang,Runcang Sun
The amidine organocatalyst 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is an effective nucleophilic catalyst. Biocomposites with tuneable properties were successfully synthesized by ring-opening graft polymerization (ROGP) of propylene carbonate (PC) onto xylan using DBU as a catalyst in the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl). The effects of reaction temperature, reaction time and the molar ratio of PC to anhydroxylose units (AXU) in xylan were investigated. The physico-chemical properties of xylan-graft-poly(propylene carbonate) (xylan-g-PPC) copolymers were characterised by FT-IR, NMR, TGA/DTG, AFM and tensile analysis. The FT-IR and NMR results indicated the successful attachment of PPC onto xylan. TGA/DTG suggested the increased thermal stability of xylan after the attachment of PPC side chains. AFM analysis revealed details about the molecular aggregation of xylan-g-PPC films. The results also showed that with the increased DS of xylan-g-PPC copolymers, the tensile strength and Young’s modulus of the films decreased, while the elongation at break increased.
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POLYMER TESTING
·
2016
·
IF 2.35
Ravi Muchakayala,Shenhua Song,Shang Gao,Xiaoling Wang,Youhua Fan
The influence of ethylene carbonate (EC) addition on 85poly(ε - caprolactone):15Lithium thiocyanate (85PCL:15LiSCN) polymer electrolyte is investigated using X-ray diffraction, impedance spectroscopy , Wagner's polarization and electrochemical measurements. The results reveal that the amorphicity of the 85PCL:15LiSCN system increases with increase of EC content up to an optimal level of 40 wt.%. This is reflected in the electrical properties of the gel polymer electrolytes, i.e., the 40 wt.% EC-incorporated gel polymer electrolyte exhibits both high amorphicity and high electrical conductivity as compared to the other samples. The EC concentration dependences of dielectric constant and electrical conductivity show a similar trend, indicating that these properties are closely related to each other. The total ionic transference numbers of EC-incorporated gel polymer electrolytes are in the range 0.989–0.993, demonstrating that they are almost completely ionic conductors . The electrochemical stability window of the 40 wt.% EC-incorporated gel polymer electrolyte is ∼4.1 V along with the electrical conductivity of 2.2 × 10 −4 S cm −1 , which is significantly improved as compared to the 85PCL:15LiSCN system (3.0 V and 1.04 × 10 −6 S cm −1 ). Consequently, the addition of EC in the 85PCL:15LiSCN polymer electrolyte leads to a promising improvement in its various properties.
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Reading & Writing Quarterly
·
2012
·
IF 0
Andrea García,Amy Gaddes
A decade ago, the subtractive schooling of many Latino youth in the United States resulted in a devaluing of cultural identity and heritage as resources to support learning. Today, educators are urged to revalue cultural resources toward literacy development. This study explores the experiences of Latina adolescent students as writers during an after-school writing project based in a culturally and linguistically responsive literacy instruction model. We report on the writing experiences of young women from diverse backgrounds as they examined issues of race, power, voice, and linguistic identity through the use of culturally authentic literature. Qualitative analyses of data from writing samples reveal (a) the process of Latina youth “authoring” themselves through writing and (b) the composing of meaning from a “transnational” perspective. We address implications for the education of minority youth.
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Advanced Healthcare Materials
·
2024
·Vol. 13
·期 22
·2400439
·
IF 10
Lihao Zhang,Lehao Ren,Yufei Chen,Yue Cao,Sunlong Li,Weipeng Lu,Yaoyuan Jia,Yachun Li,Cihui Liu,Chen Li,Qian Dong
Soft-bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspiration for the development of bionic robots with intricate movements. Traditional rigid components are being replaced by stimulus-responsive soft materials such as hydrogels and shape memory polymers, leading to the creation of dynamically responsive soft robots. In this study, the development of a bionic robot inspired by the shape of an octopus and the adsorptive properties of its tentacles, specifically tailored for targeted stimulation and pH sensing in the cervix, are presented. This approach involves the design of a soft, water-based Janus adhesive hydrogel patch that adheres to specific parts of the cervix and responds to pH changes through external stimuli. The hydrogel patch incorporates inverse opal microstructures mimicking the legs of an octopus, to facilitate efficient and stable locomotion, unidirectional transport of biofluids, and pH-responsive behavior. This miniature bionic robot showcases controlled adhesion and precise unidirectional fluid transport highlighting its potential for targeted stimulus response and pH sensing in the uterine cervical tract. This breakthrough opens new avenues for medical applications within the expanding field of soft-bodied robotics.
研究领域:
软体机器人
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生物医学工程
·
刺激响应材料
·
仿生学
·
pH传感器
·
水凝胶技术
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ACS Omega
·
2023
·
IF 4.1
Zheng Wang,Yanping Chu,Guozhong Zhao,Zhilin Yin,Tie Kuang,Feng Yan,Lei Zhang,Lu Zhang
The surface wettability of rocks in underground reservoirs affects the distribution of fluids in the reservoir, so the wettability of reservoir minerals is a key factor for crude oil recovery from reservoirs. In this paper, the wettability of quartz sand with different particle sizes in different polar solvents was determined by Washburn’s capillary rise method, and the C·cos θ values were calculated first. Next, the experimentally obtained macroscopic contact angle of water on the quartz surface of 15.0° was substituted into C·cos θ to obtain a linear equation between the particle size of quartz sand and the capillary constant C. The particle sizes of oil sand and mineral powder were then substituted into the equation to obtain their capillary constants C. Then, based on the Owens–Wendt–Rabel–Kaelbe (OWRK) equation and the obtained contact angles of solvent on quartz sand, oil sand, and mineral powder, the surface free energy of quartz sand with different particle sizes is calculated as 76.09, 76.65, and 76.42 mN/m, respectively, which are close to the literature results. In addition, the surface free energy of oil sand with different particle sizes was 23.22, 23.45, and 23.63 mN/m, and the results indicated that the polarity of oil sand was low. Meanwhile, the surface free energies of kaolinite, illite, feldspar, and montmorillonite were 61.59, 32.85, 35.87, and 25.91 mN/m, respectively. By the improved Washburn method in this paper, the wettability of different solvents on the surface of reservoir rocks was investigated, and the surface free energy of specific solid particles was calculated, which is important for studying the extraction of crude oil from subsurface reservoir rocks.
研究领域:
石油工程
·
表面科学
·
储层表征
·
胶体与界面化学
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TETRAHEDRON
·
2017
·Vol. 73
·期 14
·1895-1903
·
IF 2.651
Xue-Yang Jiang,Xin-Chen Li,Wen-Yuan Liu,Yun-Hui Xu,Feng Feng,Wei Qu
Hydrolyzing flavonoid glucuronides into corresponding aglycones posed some significant challenges. To improve acid-catalyzed hydrolysis process of flavonoid glucuronide, structures of glucuronide, hydrolysis parameters and post-processing were optimized. The optimized condition was performed by hydrolysis flavonoid glycoside methyl ester in a mixed solvent consisting of 2 mol/L H 2 SO 4 /EtOH/H 2 O (1/8/1, v/v/v) at 95 °C for 7 h and resulted in up to 90% aglycone yields, minimal byproduct formations and milder hydrolysis conditions. Furthermore, the optimized method avoids tedious purification steps and is easily conducted on a relatively large-scale using economical and commercially available reagents.
研究领域:
天然产物化学
·
药物化学
·
分析化学
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 140
·期 4
·e53363
·
IF 3.057
Mali Xie,Kexin Peng,Yangyang Luo,Qi Zhang,Linjun Shao,Shaofeng Zhong,Shujing Zhou,Jinjing Li,Chenze Qi
Pd/C embedded polystyrene fibers were successfully prepared by electrospinning. The polystyrene molecules were then cross-linked by paraformaldehyde in sulfuric acid to improve the solvent resistance of composite fibers. SEM images conformed the preparation of uniform and smooth composite fibers. FT-IR spectra demonstrated that the polystyrene molecules inside fibers have been sulphonated and crosslinked. Heck reactions were used to evaluate the catalytic performance of these novel composite fibers. The catalysis results show that this composite fiber mat catalyzed Heck reactions could be evidently promoted by using preferred reducing alcohol agent and solvent. Under the optimized reaction conditions, this composite fiber mat could effectively catalyze the Heck reactions of aromatic iodides with n-butyl acrylate to afford the products with satisfied yields. Especially, compared with the particulate Pd/C catalyst, the separation and recycling of this fibrous catalyst from the reaction mixture were significantly improved due to the larger fibrous structure. At last, this fiber catalyst was successfully reused for eight times with little loss of initial catalytic activity, which was even better than the pristine Pd/C catalyst. Hence, embedment of particulate supported metal catalysts inside the crosslinked polystyrene fibers can effectively improve their catalytic performance and handiness.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2022
·
IF 3.915
Fengmao Zou,Honghui Zhao,Aijinxiu Ma,Danni Song,Xiangrong Zhang,Xu Zhao
To improve the solubility and anti-hyperuricemia activity of the insoluble natural flavonoid isorhamnetin (ISO), an isorhamnetin phospholipid complex (ISO-PC) was prepared. ISO-PC was prepared through solvent evaporation and its prescription process was optimized. The formation of ISO-PC was verified via multiple characterization methods. Parameters such as drug loading, solubility, octanol-water partition coefficient, stability, and in vivo anti-hyperuricemia activity of ISO-PC were investigated. The complexation efficiency of ISO-PC was 95.1% ± 0.56%. The characterization results confirmed that ISO-PC was bound by intermolecular interactions between ISO and phospholipids. Compared with ISO, the solubility of ISO-PC in water and 1-octanol increased by 122 and 16.5 times, respectively. In addition, the octanol-water partition coefficient decreased to 1.08. Pharmacodynamic studies have reported that ISO-PC has a more significant effect on reducing serum uric acid levels and renal protection. In conclusion, the findings of this study suggested that ISO-PC could be used as a promising formulation to improve the solubility and the anti-hyperuricemia activity of ISO.
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