ACS Omega
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2019
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IF 2.584
Yanping Huang,Nianhua Dan,Weihua Dan,Weifeng Zhao
A novel clay-reinforced polycaprolactone/chitosan/curcumin (PCl/CS/Clay/Cur) composite film was fabricated in this study. The prepared Cur-loading composite films were characterized with attenuated total reflection Fourier transformed infrared spectroscopy, scanning electron microscopy, atomic force microscopy, water contact angle, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction, and the results showed good dispersion of clay in the composite films. The addition of nanoclay was found to significantly increase the tensile strength. Also, the clay-enhanced drug-loading films exhibited better controlled-release profiles of Cur than those membranes without clay. Skin disinfection test demonstrated that the curcumin-loaded film could protect wound from bacterial infection. Cytotoxicity analysis proved the good biocompatibility of the composite films. The clay-enhanced Cur-loading films might be promising candidates for wound care.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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2019
·Vol. 191
·期 2
·605-622
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IF 2.14
Bai Rubing,Yu Yuanyuan,Wang Qiang,Shen Jinsong,Yuan Jiugang,Fan Xuerong
Chitosan oligosaccharide (COS), a water-soluble carbohydrate obtained from chemical or enzymatic hydrolysis of chitosan, has similar structure and properties to non-toxic, biocompatible, and biodegradable chitosan. However, COS has many advantages over chitosan due to its low molecular weight and high water solubility. In the current work, COS was incorporated in the laccase-catalyzed polymerization of hydroquinone. The laccase-catalyzed polymerization of hydroquinone with or without COS was investigated by using simple structure of glucosamine hydrochloride as an alternative to COS to understand the mechanism of COS-incorporated polymerization of hydroquinone. Although polyhydroquinone can be regarded as the polymeric colorant with dark brown color, there is no affinity or chemical bonding between polyhydroquinone and cotton fibers. Cotton fabrics were successfully in-situ dyed into brown color through the laccase-catalyzed polymerization of hydroquinone by incorporating with COS as a template. The presence of COS enhanced the dye uptake of polyhydroquinone on cotton fibers due to high affinity of COS to cotton and covalent bonding between COS and polyhydroquinone during laccase catalysis. This novel approach not only provides a simple route for the biological coloration of cotton fabrics but also presents a significant way to prepare functional textiles with antibacterial property.
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2019
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IF 2.263
Yajing Pan,Chao Xiao,Huaping Tan,Guoliang Yuan,Jianliang Li,Shengke Li,Yang Jia,Dangsheng Xiong,Xiaohong Hu,Xiaohong Niu
Microspheres and injectable hydrogels derived from natural biopolymers have been extensively investigated as drug carriers and cell scaffolds. In this study, we report a preparation of composite scaffolds basing microspheres and hydrogel via the Schiff’s base reaction. Hybrid gelatin/heparin microspheres loading insulin-like growth factor-1 (IGF-1) with a diameter of 5–10 µm were fabricated using an emulsion cross-linking method. Synchronously, water-soluble carboxymethyl chitosan (CMC) and oxidized chondroitin sulfate (OCS) were prepared for cross-linking of hydrogels, which were embedded with microspheres to produce a composite microspheres/gel scaffold. The mechanism of scaffold cross-linking is attributed to the Schiff’s base reaction between amino and aldehyde groups of biopolymers. Currently, gelation rate, morphology, mechanical properties, swelling ratio, weight loss, and IGF-1 release of the composite scaffolds were examined in vitro. The results show that mechanical and bioactive properties of CMC-OCS hydrogel can be significantly improved by embedding gelatin/heparin microspheres containing IGF-1. Compressive modulus of composite gel scaffolds containing 3 wt% of microspheres was 16 kPa, which was higher than the control hydrogel without microspheres. Cumulative release of IGF-1 during 7 days from microspheres embedded hydrogel was 70%, which was significantly lower than those of microspheres and hydrogels. Moreover, the composite microspheres/gel scaffolds exhibited higher swelling ratio and slower degradation rate than the control. Potential of the composite scaffolds was demonstrated by encapsulation of human adipose-derived stem cells (ASCs) in vitro. Cell culture showed that this composite hydrogel could support survival and proliferation of ASCs. These results demonstrate the potential of gelatin/heparin microspheres embedded CMC-OCS hydrogels as an injectable scaffold in soft tissue engineering.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Dalin Hu,Zhenwei Lian,Hongyi Xian,Ran Jiang,Nan Wang,Yingying Weng,Xiaowu Peng,Sanming Wang,Xiao–Kun Ouyang
A creative combination of chitosan with polyacrylic acid (PAA) improves the acidity resistance of chitosan and increases its potential in the field of adsorption. In order to facilitate recovery, magnetic nanoparticles were incorporated in CS–PAA to obtain a magnetic-CS–PAA (MCS–PAA) nanocomposite. The physical and chemical characteristics of the composite adsorbent MCS–PAA were determined by SEM, TEM, FTIR, EDX , XRD, and XPS. This environmental-friendly, magnetic, composite adsorbent showed significantly better adsorption performance than those of the individual adsorbents alone. The maximal adsorption capacity was 204.89 mg/g according to the Langmuir isotherm model, when the concentration of Pb(II) was 100 mg/L at the equilibrium time of 70 min. The main adsorption mechanism was the complexation between the carboxyl, amino, and hydroxyl groups in MCS–PAA and Pb(II). Further, introduction of PAA also improved the acid resistance of CS. The new adsorbent MCS–PAA is thus expected to facilitate a wider range of applications for chitosan in the adsorption of Pb(II).
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Marine Drugs
·
2019
·Vol. 17
·期 10
·575
·
IF 3.772
Yingjun Gao,Xing Zhang,Xiangyu Jin
As derivatives from marine natural biomaterials, alginate-based and chitosan-based biomaterials are commonly used in wound dressings. Calcium alginate fiber (CAF) dressings possess excellent absorption and unique gel forming performance, but the low bioactivity limits its application in wound healing. Carboxymethyl chitosan (CM-Chit) has excellent antibacterial activity, but the gel structure with weak mechanical properties restricts its application. In this study, minocycline (Mino)/CM-Chit solution was coated on the surface of plasma treated CAF needle-punched nonwovens, and then Mino loaded CM-Chit gel/CAF nonwovens composite dressings were fabricated by EDC/NHS (1-3-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide) crosslinking. The dressings had a porous composite structure, which allowed them to quickly absorb and store a large number of wound exudates. Skin-like tensile performance allowed the dressings to provide a better healing environment. Antibacterial assay againstEscherichia coliandStaphylococcus aureusindicated that the addition of Mino significantly improved the antibacterial activity of the wound dressings. The tight structure of CM-Chit gel prevented the burst release of Mino so that the dressings had antibacterial activity in a certain period of release time. Cell culture assay showed that the dressings had excellent cell biocompatibility. As new functional dressings, the prepared composite dressings had excellent potential in the clinical healing of wounds.Keywords:alginate fibers;carboxymethyl chitosan;wound dressings;antibacterial activity;drug release
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Catalysts
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2022
·Vol. 12
·期 11
·1469
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IF 4.501
Yilin Huang,Jia Wang,Mengwei Li,Zhixiong You
We have successfully synthesized dithiocarbamate chitosan modified SBA-15 (CS2C@SBA) composites, with promise in vanadium (V(V)) elimination. Among the three composites using different mass ratios of dithiocarbamate chitosan to SBA-15, CS2C@SBA−3, which had the highest CS2substitution, showed the best performance on V(V) removal of which the maximum adsorption capacity could achieve 218.00 mg/g at pH 3.0. The adsorption kinetics were best fitted with a pseudo−second order reaction model, suggesting a chemisorption mechanism. Meanwhile, the Langmuir model fitted better with the adsorption isotherm, revealing a monolayer adsorption behavior. Through FTIR and XPS analysis, the functional group −SH was identified as dominating reduction sites on this composite, which reduced 73.1% of V(V) into V(IV) and V(III). The functional group −NH− was the main adsorption site for vanadium species. This reaction followed a catalytic reduction coupled adsorption mechanism reducing most of V(V) into less toxic vanadium species. Furthermore, CS2C@SBA−3 showed great selectivity towards V(V) in the presence of various co−existing ions in synthetic wastewater and real water samples. Moreover, CS2C@SBA−3 could retain a removal efficiency over 90% after five adsorption−desorption cycles. Based on the aforementioned results, we can conclude that CS2C@SBA−3 has great potential to be applied in efficient remediation of vanadium water−pollution.Keywords:vanadium elimination;adsorption;catalytic reduction;thiol function group;dithiocarbamate chitosan modified SBA-15
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MATERIALS TECHNOLOGY
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2022
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IF 3.297
Siqi Tan,Yueshan Huang,Jun Lan,Xiao Han,Renjing Cen,Xiuhua Zhao,Lao Yonghua
Mechanical properties of hyaluronic acid (HA) hydrogels are too poor to be prepared as an ultra-thin hydrogels, so to provide a supporting skeleton for them is important. Herein, the porous film based on chitosan(CS)、PEG-20000 and graphene oxide (GO) were prepared for ultra-thin hydrogels. CS is a suitable polymer to prepare films. The added PEG-20000 endowed the film porosity. And the addition of GO improved the mechanical of the film. When CS:PEG = 3:2 and the GO solution proportion was 15%, the porous film exhibited the best comprehensive properties, with a tensile strength of 5.593 MPa, an elongation at break of 45.833%, a water permeation of 1.4099 g at 12 h, a porosity of 62.3% and an average pore size of 1.88 um. Blood compatibility experiments and cell experiments have proved that the film hydrogel has strong biocompatibility, indicating it can be a promising biomaterial.
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JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Xiaogeng Lin,Li Chen,Chang Chen,Jianqing Rao,Jianhua Chen,Yasan He
Covalent organic frameworks (COFs) based membranes have demonstrated great potentials in molecular separation. Currently, most studies focus on developing continuous COF membranes. However, their low crystallinity compared with COF powders due to the more restricted synthesis conditions impedes their application in precise separation. Herein, we explored the assembly of highly crystalline COF powders with chitosan (CS) to construct precise-sieving membranes with high COFs loading. A post-carboxylated COFs (TATP-COOH) was synthesized, and a facile and scalable strategy was developed for constructing the assembled COF membranes (TATP-COOH@CS/TATP-COOH/CA) with TATP-COOH loading as high as 40 wt% (82 v%). Characterizations revealed TATP-COOH particles could interact with CS via H-bonding to form dense TATP-COOH@CS layers, and the TATP-COOH layer on the CA substrate was essential to obtain mechanically stable membranes. The prepared membranes exhibited precise rejection to Congo red, Coomassie brilliant blue (BB), Alcian blue and Direct blue 19 with 100% rejection and ultrafast permeance (>1350 L m −2 h −1 MPa −1 ). It also showed superior precision in separating Methyl orange and BB mixed solution with only Methyl orange passing through. This study provides a significant concept and a facile strategy to the preparation of high precise-sieving COF membranes to take advantages of highly crystalline COFs.
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CARBOHYDRATE POLYMERS
·
2022
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IF 10.723
Danya Chen,Pei Liu,Mengna Li,Changqing Zhang,Youshui Gao,Yaping Guo
Nacre, exhibiting excellent mechanical strengths due to its hierarchical structures, becomes a potential model to design bone implants. Herein, we firstly fabricated nacre-mimetic hydroxyapatite/chitosan/gelatin (HA/CS/Gel) layered scaffolds and incorporated substance P (SP) peptides. The CS scaffolds with a layered architecture could regulate the deposition of HA nanoplates on the interlamellar CS sheets by using CaCO 3 as precursors. The HA/CS/Gel layered scaffolds exhibited a great flexure strength of 11.42 MPa due to a brick-and-mortar structure. The biocompatible components, layered macropores and SP peptides in the HA/CS/Gel therapeutic scaffolds facilitated the spreading and proliferation mesenchymal stem cells (MSCs). Notably, the incorporation of SP peptides induced MSC osteogenic differentiation and extracellular matrix mineralization . Rabbit knee subchondral defect models further proved that the HA/CS/Gel-SP layered scaffolds promoted in vivo subchondral bone regeneration . Hence, the combination of nacre-mimetic bone implants and therapeutic drugs may become an attractive strategy for subchondral bone regeneration.
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COMPOSITES PART B-ENGINEERING
·
2021
·
IF 9.078
Qian Zhang,Yansha Qiao,Jianhua Zhu,Yimeng Li,Chaojing Li,Jing Lin,Xiaoli Li,Hui Han,Jifu Mao,Fujun Wang,Lu Wang
Surgical sutures pervade almost all surgeries; however, their clinical therapy effects are barely satisfactory due to the lack of physiological signal responsiveness and the prone surgical site infection (SSI). Herein, the functional sutures (PCGT@S) with electroactivity and antibacterial properties were fabricated by decorating the suture surfaces with chitosan-gelatin/tannic acid/polypyrrole (CS-GE/TA/PPy) composite coating . Thanks to the assistance of CS-GE/TA on the polymerization of PPy, the inherent brittleness of PPy was alleviated and ensured PCGT@S excellent conductivity even under knotted state, thereby providing stable physiological electrical signal transmission among cells and regulating cell behaviors actively. Meanwhile, the synergistic effects of CS-GE/TA and PPy offered PCGT@S outstanding antibacterial rates of over 99% against E. coli and S. aureus without involving any additional drugs. Furthermore, in vivo studies revealed that PCGT@S could enhance wound healing dramatically, as evidenced by less inflammatory reaction, better angiogenesis, cell proliferation , re-epithelization, granulation tissue, and collagen regeneration. This study successfully demonstrates the feasibility of the electroactive and antibacterial sutures for promoting tissue regeneration and provides a new idea for exploring the next generation bioactive suture.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Yuyuan Luo,Junjie Wang,Tianyi Lv,Hongxia Wang,Hongyuan Zhou,Liang Ma,Yuhao Zhang,Hongjie Dai
The physical and chemical properties of cellulose nanocrystals (CNC) were regulated by physical crosslinking with chitosan particles (CSp). At a fixed concentration (0.5 wt%) of CNC, varying CSp concentration (0.02–0.5 wt%) influenced the morphologies and chemical properties of the obtained complex particles (CNC-CSp). The results of Fourier transform infrared spectroscopy (FTIR) and zeta potential confirmed the electrostatic and hydrogen bonding interactions between CSp and CNC. At a low CSp concentration (0.02–0.05 wt%), the charge shielding effect induced the formation of particle aggregation networks, thus showing increased viscosity, turbidity and size (153.4–2605.7 nm). At a higher CSp concentration (0.1–0.5 wt%), the hydrogen bonding interaction promoted CSp adsorption onto the surface of CNC, thus facilitating the dispersion of CNC-CSp due to electrostatic repulsion caused by surface-adsorbed CSp. In addition, CSp improved the thermal stability, hydrophobicity (41.87–60.02°) and rheological properties of CNC. Compared with CNC, CNC-CSp displayed a better emulsifying ability and emulsion stability, in which CSp could play a dual role (i.e., charge regulator and stabilizer). This study suggests that introducing CSp can improve the properties and application potentials of CNC as food colloids.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
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IF 1.6
Zhang Yizhe,Cai Tingting,Zhao Zhiwei,Han Bing
The development of high-performance adsorbents is highly demanded in sustainable production of nuclear power. Herein, porous chitosan-poly(imide dioxime) (Cs-PIDO) hydrogel with semi-interpenetrating structure was prepared. Cs-PIDO-1 showed rapid kinetics, high adsorption capacity and excellent regeneration capability. Impressively, the capture speed of Cs-PIDO-1 reached 0.35 mg g −1 d −1 during the first 2-week extraction and its 4-week adsorption capacity was up to 5.75 mg g −1 in real seawater. The superior uranium harvesting performance originated from the cooperation effect of hierarchically porous structure and PIDO groups. This work highlights the importance of rational designed structure and functionality in enhancing the uranium uptake capability. Graphical abstract
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危险品化学品经营许可证（带存储）