CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Pengheng Li,Xing Zhu,Min Lin,Henglong Li
Chemical-looping preferential oxidation (CL-PROX) technology has become an efficient method for removing CO from hydrogen-rich gases. In this study, by introducing hydroxyl groups to regulate the interaction between Cu and Ce, the efficient conversion of CO and the retention of H 2 were successfully achieved, thus bringing excellent CL-PROX performance. Characterizations show that 10CuCe-OH with introduced hydroxyl groups exhibit small particle size, low crystallinity, high surface concentrations of Cu + and Ce 3+ , abundant oxygen vacancies, excellent reducibility and strong oxidation activity. This is attributed to the fact that hydroxyl groups strengthen the interaction between Cu–O–Ce, forming more Cu + –O v –Ce 3+ structures. At 200 °C, the conversion of CO over 10CuCe-OH exceeds 90 %, while the conversion of H 2 is less than 4 %, which is far superior to that of 10CuCe. The results of in-situ Fourier transform infrared spectroscopy ( In-situ FTIR) and DFT calculations indicate that 10CuCe-OH possesses excellent adsorption and CO conversion capabilities. Overall, this work provides a new strategy for the design of high efficiency CL-PROX catalysts.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Wang Yin,Liu Tian,Shenchun Wang,Dezhen Zhang,Shengrong Guo,Meidong Lang
This study reported a co-delivery system of paclitaxel (PTX) and doxorubicin (DOX) based on a functionalized poly(ϵ-caprolactone) (FC) conjugated with folate (FA) and PTX prodrug (FA-FC-PTX). PTX was conjugated to pendant carboxyl groups of FC by esterification, and FA was modified to PEG block of FC. The release behaviors of DOX and PTX from the micelles of FA-FC-PTX loaded with DOX (FA-FC-PTX/DOX) were obviously different. DOX was almost completely released in the initial 24 h, while a small amount of PTX was only released for 24 h, and continued to be released for 7 days. The cellular uptake results showed that FA-FC-PTX/DOX could be more effectively internalized by 4T1 cell than the non-folate drug-loaded micelles. In vitro cytotoxicity assays demonstrated that FA-FC-PTX/DOX revealed synergistic effect in inhibiting the proliferation of 4T1 mouse breast cancer cells. Cell apoptosis assays showed that FA-FC-PTX/DOX had the highest apoptosis rate in all drug formulations, indicating that it had high ability to induce cell apoptosis. Furthermore, it was found that FA-FC-PTX/DOX exhibited better inhibition effect on 4T1 tumor growth compared with free PTX/DOX combination or non-folate drug-loaded micelles and there was no obvious side effect on the 4T1 tumor-bearing mice. Thus, this work provides a promising drug co-delivery system for targeted therapy of breast cancer.
✓ 已验证
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2018
·
IF 4.556
Yijia Yin,Qian Hu,Chenfeng Xu,Qi Qiao,Xianya Qin,Qingle Song,Yang Peng,Yongdan Zhao,Zhiping Zhang
A dual-sensitive nanoparticle delivery system was constructed by incorporating an acid sensitive hydrazone linker into thermosensitive nanoparticles (TSNs) for co-encapsulating doxorubicin (DOX) and interferon γ (IFNγ) and to realize the co-delivery of chemotherapy and immunotherapy agents against melanoma. DOX, a chemotherapeutic drug, was conjugated to TSNs by a pH-sensitive chemical bond, and IFNγ, a potent immune-modulator, was absorbed into TSNs through the thermosensitivity and electrostatics of nanoparticles. Consequently, the dual sensitive drug-loaded TSN delivery systems were successfully built and showed an obvious core–shell structure, good encapsulation efficiency of drugs, sustained and sensitive drug release, prolonged circulation time, as well as excellent synergistic antitumor efficiency against B16F10 tumor bearing mice. Moreover, the combinational antitumor immune responses of hydrazone bearing DOX/IFNγ-TSN (hyd) were strengthened by activating Th1-type CD4+ T cells, cytotoxic T lymphocytes, and natural killer cells, downregulating the expression levels of immunosuppressive cytokines, such as IL10 and TGFβ, and upregulating the secretion of IL2 and TNFα. Taken together, the multifunctional TSNs system provides a promising strategy for multiple drugs co-delivery with distinct properties.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yaqi He,Xinhua Li,Zhu Qian,ZuPeng Yan,Guizhen Shi,Xia Sun,Zongqing Ma
In this paper, we innovatively introduced Sn and B into the Nb-Al system at the same time and successfully prepared high-performance Nb 3 Al bulks through mechanical alloying and subsequent low-temperature sintering processes. The influence of different doping amounts of B in the Sn-B co-doping on the superconducting properties of Nb 3 Al superconductors was also investigated. It was found that Sn-B co-doping greatly improves the superconducting properties of Nb 3 Al, especially the J c properties, compared with the undoped sample. The optimal doping amount of Sn-B co-doping is finally determined to be 4 at% Sn-2.6 at% B. At this time, the superconducting transition temperature of Nb 3 Al is up to 16.2 K, and the critical current density reaches up to 1.3 × 10 5 A⋅cm −2 (4.2 K, 5 T), which is almost twice higher than that of Sn-doped Nb 3 Al, and one order of magnitude higher than that of general undoped Nb 3 Al. Combined with the phase composition analysis and microstructure observation, we find that with the co-doping of Sn and B, the grain size of Nb 3 Al is refined, and the diffusely distributed Nb 2 Al nanoparticles are introduced, which greatly enhance the magnetic flux pinning effect of Nb 3 Al. Secondly, the intergranular connectivity of Nb 3 Al is significantly improved. The Sn-B co-doped Nb 3 Al superconductors combine the advantages of Sn doping to enhance flux pinning and B doping to improve intergranular connectivity, which synergistically promotes the dramatic improvement of Nb 3 Al superconductivity Nb 3 Al.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Biye Niu,Feixiang Gao,Zekun Jing,Taiping Fu,Yufeng Liu,Yakun Guo,Maobing Shuai
In confined environments, hydrogen accumulation presents significant safety hazards, necessitating the development of efficient hydrogen uptake materials. Conventional Pd/C-DEB hydrogen getter is severely compromised by CO poisoning. This study introduces a one-step mechanochemical ball milling approach that integrates Pd/C catalysts with DEB to fabricate a CO-tolerant hydrogen getter. A DEB conversion rate of 75.2 % is achieved under an H 2 atmosphere containing 1 % CO, representing a sixfold improvement over the untreated sample. Ball milling refines Pd nanoparticles, increases surface area, generates multiscale defects, strengthens metal-support interactions, enhances electron transfer, modulates the Pd d-band structure, and reduces CO adsorption energy, thereby exposing more active sites for hydrogen uptake. This approach is also applicable to Pt/C, Rh/C, and other platinum-group metal systems, providing a versatile strategy for designing durable and CO-resistant getters in energy storage and conversion technologies.
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2022
·
IF 5.318
Yao Liu,Songyi Lin,Shengjie Hu,Di Wang,Hui Yao,Na Sun
A specific peptide (EEEFDATR) that is released during the hydrolysis of Antarctic krill contains three glutamic acids that cover calcium-binding ligands, and might act as a potential role in enhancing the osteogenetic activity. In this study, EEEFDATR and calcium alone and in combination were examined for their effects on the proliferation, differentiation, and mineralization of MC3T3-E1 osteoblastic cells. Co-administration of CaCl 2 and EEEFDATR showed a superior proliferation rate (70.94%) of MC3T3-E1 cells, which was about 2.07 and 1.74 times higher than CaCl 2 and EEEFDATR alone, respectively. Osteoblast proliferation improvements were associated with increased cell cycle in S phase after co-administration of CaCl 2 and EEEFDATR. The CaCl 2 + EEEFDATR group further exhibited a significantly higher alkaline phosphatase (ALP) activity as compared to other groups ( p < 0.05) and showed obvious differentiation of MC3T3-E1 cells. The magnitude of mineralization in the extracellular matrix (calcium deposition) was also higher in MC3T3-E1 cells treated with combined administration, although EEEFDATR alone did not induce significant mineralization. These data suggest that co-administration of CaCl 2 and EEEFDATR was superior to mono-administration in improving osteogenetic activity.
✓ 已验证
DOI
高影响因子
ACS Sensors
·
2025
·
IF 9.1
Xinhua Zhao,Xiaxia Xing,Zhenxu Li,Yi Zhang,Zhu Zhang,Tingting Wang,Dachi Yang
In the emerging ammonia (NH3) economy, both olfactory and visual sensing are desired for leakage detection, in which olfactory sensing enables a fast response and wide detection range, while visual sensing ensures high selectivity. However, little is reported on the sensing material as a mediator to synergistically combine the dual-modality NH3 sensing. Here, Co3[Co(CN)6]2 microcubes (Co–CN MCBs) mediators have been developed for olfactory and visual dual-modality NH3 sensing. In olfactory sensing, porous chitosan-decorated Co3O4/Co3[Co(CN)6]2 microcages (CS@Co–O/Co–CN MCGs) have been obtained via [Co(CN)6]3–-governed self-assembly, glycerol-assisted reduction, and Kirkendall effect-driven hollowing. Beneficially, MCGs exhibit a 1 s fast response (500 ppm) and a 0.5–10,000 ppm wide detection range at room temperature. In visual sensing, colorimetric sensing paper (CSP) incorporated with anthocyanin, Co–CN, and poly(vinyl alcohol) has been achieved, which presents 10–320 ppm visual NH3 detection through a pink-to-brown transition. Further, highly selective NH3 sensing has been acquired through machine learning-powered classification of MCGs’ response and CSP’s specific NH3 chromogenic behavior. Notably, combining dual-modality sensing has achieved desired NH3 detection due to the boosted NH3 adsorption on Co–CN MCBs’ active sites and the synergistic effect of their-mediated heterostructures. Practically, our dual-modality sensing device has been integrated to detect NH3 with reliable responses.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2022
·Vol. 29
·期 10
·1-9
·
IF 3.061
Li Chen,Long Xin,Wang Qingyin,Li Jianguo,Zhang Hua,Wang Gongying
Copolycarbonate was synthesized by melt transesterification method, using diphenyl carbonate, isosorbide and 1,4-cyclohexanedimethanol (CHDM) as raw materials. The copolymer composition and random structure of the copolymer were determined by Fourier transform infrared and 1 H NMR analysis. The DSC and TGA analysis showed that CHDM was introduced into the isosorbide polycarbonate chain, which effectively lowered the glass transition temperature of the polymer without lowering the thermal decomposition temperature. The glass transition temperature of the copolymer can be controlled by the addition amount of CHDM, and its processing performance can be improved. In addition, the introduction of CHDM did not reduce the high light transmittance (> 91.5%) of isosorbide polycarbonate. With the gradual increase of the amount of CHDM added, the refractive index of the copolymer decreases slightly. When the CHDM content is 30 mol%, the glass transition temperature (Tg)of the copolymer is 132.2 °C, the thermal decomposition temperature is > 350 °C, the refractive index is 1.4960, the Abbe number is 51, and the transmittance is 91.6%, and the haze is 1.07%.
✓ 已验证
DOI
高影响因子
PROPELLANTS EXPLOSIVES PYROTECHNICS
·
2021
·Vol. 46
·期 10
·1598-1610
·
IF 1.887
Xiaoxia Ma,Xi Chen,Yuxiang Li,Zhiqiang Qiao,Guangcheng Yang,Kaili Zhang
The afterburning effect of aluminized explosives makes them have strong damage ability to soft targets, but the aluminum particles in the composition often cannot achieve proper combustion. The high ignition temperature of micron aluminum powder is one of the main reasons. In this work, we introduce nanothermite reaction with low onset temperature (<660 °C) into aluminized explosives by replacing the base explosives with energetic coordination polymers (ECPs). The decomposition products of many ECPs contain corresponding metal oxides that will react with aluminum via thermite reaction. Three kinds of ECPs ([CoC 2 H 4 N 8 O 4 ] n , [NiC 2 H 4 N 8 O 4 ] n and [CuC 2 H 4 N 8 O 4 ] n ) are constructed and compounded with nano-aluminum (nano-Al) particles to form aluminized ECPs. The influence of metal ion species and Al/Metal (Al/Me) molar ratio on their energetic properties are systematically studied. The results show that the exothermic thermite reaction with low onset temperature plays an important role in the combustion propagation of aluminized ECPs, and the possible mechanism is proposed. When the Al/Me molar ratio is 3–4, the aluminized ECPs have the best peak pressure and pressurization rate. At the optimum molar ratio, the pressure and pressurization rate of aluminized ECP(Co) are much higher than those of aluminized ECP(Ni) and ECP(Cu). Among the three kinds of aluminized ECPs, the aluminized ECP(Co) has the best energetic characteristics and can be used as a preferred choice. However, for the applications that require a long-time heat supply, aluminized ECP(Cu) will be suitable.
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Lin-Chao Yang,Quan Zhou,Jin-Qiu Liu,Zhuo Wang,Yue-Chan Song,Wen-Wen Wu,Peng Liu
Extensive studies on TiO 2 -based colossal permittivity (CP, dielectric constant ε’ >10 3 ) materials have focused on the cation doping of metal elements; however, little attention has been paid to nonmetallic dopants. Compared to metallic elements, nonmetallic atoms with small radii and high activities, such as H, C, B, and N, can be used as anion-doping elements. Their incorporation into the TiO 2 lattice includes interstitial and substitutional doping, which can influence the bandgap of TiO 2 and its electron transport performance differently, thereby exhibiting considerable potential in TiO 2 -based applications. In this study, different N-containing compounds (BN and NH 4 Cl) were doped into rutile TiO 2 , while homogeneous ceramics of single-phase rutile TiO 2 were prepared via solid-state sintering. The effects of co-doping N, Cl, and N, B on the dielectric properties of rutile TiO 2 ceramics were investigated. While N and Cl doping showed no considerable effect on the dielectric properties of rutile TiO 2 ceramics, the co-doping of N and B doping in rutile TiO 2 considerably increased the dielectric constant to >10 4 with suppressed tan δ in a wide frequency range from 1 kHz to 10 MHz. These ceramics exhibited excellent frequency stability (up to 100 MHz) and temperature stability (153–513 K), which outperforms most reported transition metal co-doped TiO 2 ceramics, thereby highlighting the untapped potential of the non-metallic dopants in enhancing dielectric materials.
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2024
·
IF 4.7
Wang Guoqiang,Hui Yunfeng,Wei Deyu,Wang Yueying,Yu Yiheng,Shi Longqing,Zhang Mengke,Hu Jing
Poly(butylene succinate) (PBS), a biodegradable material, has excellent mechanical properties and processing properties. Brassylic acid (BA) is a kind of diacid with long chains derived from biomass. In this study, poly(butylene succinate-co-butylene brassylate) is synthesized to investigate the effects of BA on the structure and properties of PBS. The relationship between the melting temperature of copolyesters and the content of butylene brassylate units is V-shaped, which is typical of isodimorphic random copolyesters. Due to the introduction of BA, the density of unstable ester bonds in copolyesters gradually decreases and the initial thermal decomposition temperature of copolyesters gradually increases with the increase of BA. The dynamic mechanical analysis showed that the glass transition temperature of PBS was reduced by the introduction of BA. When the BA content is 25%, the copolyesters and PBS have the same crystal structure. When the BA content is 50–100%, the copolyesters and poly(butylene brassylate) have the same crystal structure, which indicates that the butylene brassylate units are easier to crystallize than the butylene succinate units. The ductility of copolyesters increases with the addition of BA. When the BA content is 50%, the elongation at break reaches the maximum (> 2000%). The copolyesters are suited for films due to high elongation at break.
✓ 已验证
DOI
高影响因子
Chinese Physics B
·
2023
·Vol. 32
·期 1
·017901
·
IF 1.7
Siwen You,Ziyi Shao,Xiao Guo,Junjie Jiang,Jinxin Liu,Kai Wang,Mingjun Li,Fangping Ouyang,Chuyun Deng,Fei Song,Jiatao Sun,Han Huang
Hybrid organic–inorganic perovskite thin films have attracted much attention in optoelectronic and information fields because of their intriguing properties. Due to quantum confinement effects, ultrathin films in nm scale usually show special properties. Here, we report on the growth of methylammonium lead iodide (MAPbI3) ultrathin films via co-deposition of PbI2 and CH3NH3I (MAI) on chemical-vapor-deposition-grown monolayer MoS2 as well as the corresponding photoluminescence (PL) properties at different growing stages. Atomic force microscopy and scanning electron microscopy measurements reveal the MoS2 tuned growth of MAPbI3 in a Stranski–Krastanov mode. PL and Kelvin probe force microscopy results confirm that MAPbI3/MoS2 heterostructures have a type-II energy level alignment at the interface. Temperaturedependent PL measurements on layered MAPbI3 (at the initial stage) and on MAPbI3 crystals in averaged size of 500 nm (at the later stage) show rather different temperature dependence as well as the phase transitions from tetragonal to orthorhombic at 120 and 150 K, respectively. Our findings are useful in fabricating MAPbI3/transition-metal dichalcogenide based innovative devices for wider optoelectronic applications.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）