CHIRALITY
·
2019
·Vol. 31
·期 10
·824-834
·
IF 1.927
Shiyu Chen,Xiaoxia Huang,Shun Yao,Wencai Huang,Yin Xin,Minghui Zhu,Hang Song
Several amino acid chiral ionic liquids were introduced as functional monomers to prepare molecularly imprinted polymers for specific recognition of L-phenylalanine. Among them, the imprinted polymers L-Phe@MIPs based on [ViImC3][L-Pro] showed the best selective recognition ability for L-phenylalanine. A series of experiments such as dynamic adsorption, static adsorption, and competitive adsorption were conducted to investigate the specific recognition ability and adsorption capacity of the L-Phe@MIPs. It is found that the adsorption efficiency to L-phenylalanine on L-Phe@MIPs was 3.11 times higher than that to D-phenylalanine. All the results demonstrated that the L-Phe@MIPs possessed good recognition and relatively high adsorption efficiency for L-phenylalanine. Besides, the recovery of L-phenylalanine was above 98%, and the L-Phe@MIPs exhibited good reusability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 15
·2770
·
IF 3.06
Yunchang Fan,Zeyu Niu,Chen Xu,Lei Yang,Tuojie Yang
Rheum palmatumL. (R. palmatumL.) is a traditional Chinese herb and food, in which rhein and emodin are the main bioactive components. The extraction of the two compounds fromR. palmatumL. is, thus, of great importance. In this work, protic ionic liquids (PILs) were applied in the microwave-assisted extraction (MAE) of rhein and emodin fromR. palmatumL., which avoids the toxicity of organic solvents. The results of the present study indicate that PILs possessing higher polarity exhibit higher extraction ability due to their stronger absorption ability for microwave irradiation. Compared with conventional solvents, such as methanol, trichloromethane, and deep eutectic solvents (DESs), the PIL, 1-butyl-3-himidazolium methanesulfonate ([BHim]MeSO3) reported herein is more efficient. The selected extraction conditions of liquid–solid ratio, microwave irradiation time, microwave irradiation power, and PIL concentration were 40 g·g−1, 50 s, 280 W, and 80%, respectively. Under the selected conditions, the extraction yields of rhein and emodin were 7.8 and 4.0 mg·g−1, respectively. These results suggest that PILs are efficient extraction solvents for the separation of active components from natural products.Keywords:microwave-assisted extraction;protic ionic liquids (PILs);polarity;Rheum palmatumL.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 57
·32977-32983
·
IF 3.049
Yuang Mao,Chang Zhao,Shuyan Ge,Tao Luo,Jie Chen,Jiyang Liu,Fengna Xi,Junjie Liu
Sensitive and reliable detection of mercury ions (Hg2+) and L-cysteine (L-Cys) is of great significance for toxicology assessment, environmental protection, food analysis and human health. Herein, we present gram-scale synthesis of nitrogen doped graphene quantum dots (N-GQDs) for sensitive detection of Hg2+ and L-Cys. The N-GQDs are one-step synthesized using bottom-up molecular fusion in a hydrothermal process with gram-scale yield at a single run. N-GQDs exhibit good structural characteristics including uniform size (∼2.1 nm), high crystallinity, and single-layered graphene thickness. Successful doping of N atom enables bright blue fluorescence (absolute photoluminescence quantum yield of 24.8%) and provides unique selectivity towards Hg2+. Based on the fluorescence quenching by Hg2+ (turn-off mode), N-GQDs are able to serve as an effective fluorescent probe for sensitive detection of Hg2+ with low limit of detection (19 nM). As L-Cys could recover the fluorescence of N-GQDs quenched by Hg2+, fluorescent detection of L-Cys is also demonstrated using turn-off-on mode.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 17
·3060
·
IF 3.06
Shuang Gao,Yan-Yan Liu,Jing-Yu Jiang,Ying Fu,Li-Xia Zhao,Chun-Yan Li,Fei Ye
Herbicide safeners selectively protect crops from herbicide injury while maintaining the herbicidal effect on the target weed. To some extent, the detoxification of herbicides is related to the effect of herbicide safeners on the level and activity of herbicide target enzymes. In this work, the expression of the detoxifying enzyme glutathione S-transferase (GST) and antioxidant enzyme activities in maize seedlings were studied in the presence of three potential herbicide safeners: 3-dichloroacetyl oxazolidine and its two optical isomers. Further, the protective effect of chiral herbicide safeners on detoxifying chlorsulfuron in maize was evaluated. All safeners increased the expression levels of herbicide detoxifying enzymes, including GST, catalase (CAT), and peroxidase (POD) to reduce sulfonylurea herbicide phytotoxicity in maize seedlings. Our results indicate that theR-isomer of 3-(dichloroacetyl)-2,2,5-trimethyl-1,3-oxazolidine can induce glutathione (GSH) production, GST activity, and the ability of GST to react with the substrate 1-chloro-2,4-dinitrobenzene (CDNB) in maize, meaning that theR-isomer can protect maize from damage by chlorsulfuron. Information about antioxidative enzyme activity was obtained to determine the role of chiral safeners in overcoming the oxidative stress in maize attributed to herbicides. The interaction of safeners and active target sites of acetolactate synthase (ALS) was demonstrated by molecular docking modeling, which indicated that both isomers could form a good interaction with ALS. Our findings suggest that the detoxification mechanism of chiral safeners might involve the induction of the activity of herbicide detoxifying enzymes as well as the completion of the target active site between the safener and chlorsulfuron.Keywords:chiral safener;biological activity;antioxidative enzyme activity;protection mechanism;chlorsulfuron
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2019
·
IF 2.752
Zhezhe Wang,Yue Yang,Tong Zou,Xinixn Xing,Rongjun Zhao,Yude Wang
In this study, l -aspartic acid stabilized CdS quantum dots (L-Asp-CdS QDs) were synthesized via a one-step hydrothermal method and used for the qualitative identification of Cr 3+ . Cr 3+ could be identified rapidly based on the formation of precipitated floccules using this method. Qualitative assessment indicated the resistance of this method to interference from various metal ions and it can be applied over a wide pH range with a qualitative determination limit of 1 μM. Moreover, we demonstrated that the L-Asp-CdS QDs can be employed for the practical detection of Cr 3+ in water samples.
✓ 已验证
产品关联
DOI
高影响因子
LUMINESCENCE
·
2018
·Vol. 33
·期 5
·954-961
·
IF 1.671
Penghui Shi,Yan Zhang,Yuhua Li,Liujiao Bian
Both the molecular recognition and interaction of metallo-β-lactamase CcrA with l -captopril were studied by the combined use of fluorescence spectra and molecular dynamic simulation. The results showed that the binding constant was 8.89 × 10 4 L mol −1 at 296 K. Both Zn1 and Zn2 displayed tetrahedral coordination geometries in the CcrA–Lcap complex, the S atom in l -captopril displaced the nucleophilic hydroxide in apo CcrA and occupied the fourth coordination site for each ion, resulting in a competitively inhibited CcrA enzyme. Strong electrostatic interaction between the two zinc ions in CcrA and negatively charged l -captopril provided the main driving force for the binding affinity. Through a partly structural transformation from β-sheet to random coil, loop 1 (residues 24–34) completely opened the binding pocket of CcrA to allow an induced fit of the newly introduced ligand. This study may provide some valuable information for designing and developing a more tightly binding inhibitor to resist superbugs.
✓ 已验证
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2018
·
IF 3.129
Shulan Xiao,Hong Zhuang,Guanghong Zhou,Jianhao Zhang
The objective of the present study was to understand mechanisms of inhibitory effect of l -carnosine on lipid oxidation using an oxidized myoglobin (metMb)-mediated washed cod muscle system. Experiments were conducted to compare l -carnosine with commercial antioxidants, tert-Butylhydroquinone (TBHQ) and α-tocopherol, and metal chelating reagent EDTA for inhibition of lipid oxidation, to compare l -carnosine with TBHQ for scavenging free radicals and to evaluate the effect of l -carnosine on structure of pro-oxidant metMb with spectral methods. Results showed that the inhibitory effect of l -carnosine on lipid oxidation was comparable with TBHQ and better than α-tocopherol. However, 1,1-diphenyl-2-picrylhydrazyl assay showed that TBHQ was much more effective in scavenging free radicals than l -carnosine. Comparing with 1.5% EDTA, 1.5% l -carnosine was much more effective against lipid oxidation. Incubation of l -carnosine with metMb resulted in spectral changes of metMb in wavelengths between 370 nm and 450 nm, Soret band shifted from 409 nm to 420 nm, and reduced molar ellepticity values. These results indicate that the high inhibitory effects of l -carnosine on meat lipid oxidation may result from not only its scavenging and chelating functions but also its effect on pro-oxidant metMb structure.
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2018
·
IF 3.849
Pengfei Zhou,Xuping Wang,Pengzhan Liu,Jing Huang,Chen Wang,Mushui Pan,Zheshi Kuang
It is of great significance to develop green solvents for promoting green and sustainable technology. Deep eutectic solvents (DESs) as new extraction solvents are emerging in the search for efficient the extraction of bioactive compounds or drugs. In this study, twelve types of DESs including choline chloride-, betaine-, and l -proline-based DESs were investigated in combination with ultrasonic-assisted extraction (UAE) for the extraction of phenolic compounds from Morus alba L. leaves. Compared with conventional extraction system, DESs composed of choline chloride/citric acid showed more effective extraction yields (22.66 mg/g vs. 15.29 mg/g). The operation conditions were also optimized systematically. In addition, liquid–liquid extraction was an effective approach to recover the major phenolic compounds in the extracts. The recovery and recyclability of DESs were also evaluated. A broad extractability of phenolic compounds in the certain designed DESs systems was observed according to principal component analysis (PCA). The developed DESs can be an alternative procedure for the green and efficient extraction of phenolic compounds from natural sources.
✓ 已验证
产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2019
·
IF 4.182
Matteo Ciprian,Karla Hernandez Ruiz,Meruyert Kassymova,Tingting Wang,Serge Zhuiykov,Somboon Chaemchuen,Rong Tu,Francis Verpoort
3D metal N-doped carbon frameworks (M-NCFs) are produced from the direct pyrolysis of 2D zeolitic imidazolate frameworks (ZIF-L Zn and Co) in a reducing atmosphere. The effects of the thermal treatment were studied in order to achieve the desired catalyst. The results show that metal nanoparticles and N-doping species present in the carbon matrix have a direct influence on the catalytic performance. Zn/NCF-1000 displayed quantitative conversion and selectivity towards the chemical fixation of carbon dioxide through the cycloaddition with epoxides. Furthermore, the magnetic property of the newly synthesized Co/NCF-600 was used to demonstrate its superior stability and recyclability, retaining the same catalytic activity for more than 10 cycles.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL ENGINEERING SCIENCE
·
2018
·Vol. 35
·期 4
·279-288
·
IF 1.547
Guanghui Wang,Yao Jiang,Suhang Hu,Yadan Guo
Phytoremediation may be used for remediation of cocontaminated soil with heavy metals and polycyclic aromatic hydrocarbons (PAHs). However, the low bioavailability of heavy metals and PAHs in soils may have adverse effects on the efficiency of phytoremediation; it is necessary to find an effective method for simultaneously improving bioavailability of PAHs and heavy metals in cocontaminated soils. In this study, a novel aspartic acid-β-cyclodextrin (ACD) was synthesized, the structural characteristics of ACD were confirmed by FT-IR spectroscopy, and the complexation of fluorene (Flu) and cadmium (Cd) with ACD was studied. Pot culture experiments were conducted to investigate effects of ACD on phytoremediation of soil cocontaminated with Flu and Cd. Results showed that ACD could enhance uptake of Flu and Cd in alfalfa (Medicago sativa L.), and removal percentages of Flu and Cd in planted soil with ACD increased from 45.78% and 25.62% to 66.96% and 34.88%, respectively. Biological activity of planted soils with ACD was obviously higher than that of planted soils without ACD, which resulted in improvement of phytoremediation efficiency. As a promising remediation strategy, ACD-assisted phytoremediation may be a feasible technology for simultaneous removal of PAHs and heavy metals in cocontaminated soils.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2013
·Vol. 214
·期 7
·824-834
·
IF 2.386
Lidong Feng,Xinchao Bian,Yi Cui,Zhiming Chen,Gao Li,Xuesi Chen
Poly( L -lactide) (PLLA) is melt blended with poly(ether urethane) (PEU) based on poly(ethylene glycol) blocks via a chain-extension reaction by diisocyanate as a chain extender to improve its flexibility without sacrificing comprehensive performance. The elongation at break of the blends with triphenyl phosphate (TPP) as a reactive blending additive is much higher than that without TPP by physical blending. When 10 wt% PEU is blended, the former elongation reaches to 298%, while the latter one is only approximately 20%. The reactive blending forms a PLLA–PEU block copolymer, thus improving their compatibility. When the weight-average molecular weight ( M w ) of PEUs is 18–90 kg mol −1 , the effect of M w is very little on tensile properties of blends. The rheological properties of the blends are modified through the content and molecular weight of PEU. The complex viscosity ( η *) of PLLA/PEU blends increases with increasing M w of PEU. The η * of the PLLA blend containing 5 wt% PEU in M w 73 kg mol −1 is higher than that of neat PLLA. The water absorption of the PLLA/PEU blends enhances because of the hydrophilicity of PEUs versus neat PLLA.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·Vol. 129
·期 2
·767-772
·
IF 1.289
Dagen Zhong,Zonghua Liu,Shasha Xie,Wei Zhang,Yuanming Zhang,Wei Xue
This work is to develop a novel dual drug delivery system that can simultaneously load and release 18β-glycyrrhetinic acid (GA, a hydrophobic drug) and bovine serum albumin (BSA, hydrophilic model drug) in a single formulation. The system consists of poly( D,L -lactic) (PDLLA) microspheres embedded in calcium alginate hydrogel beads. The GA-loaded microspheres were first prepared and then dispersed in the aqueous solution of sodium alginate and BSA. The resulting suspension was dropped into aqueous calcium chloride solution to obtain the dual drug delivery system. The morphology of the microspheres and beads, the drug content and loading efficiency, the interaction between GA and PDLLA, and the drug release behaviors were studied. Scanning electron microscope (SEM) revealed that the PDLLA microspheres were homogeneously distributed in the beads. Differential scanning calorimetry (DSC) measurement suggested certain interaction between GA and PDLLA, and the crystal structure of GA was influenced by the polymer. The dual release in vitro showed a rapid BSA release but a sustained GA release in all the systems. Furthermore, the release rate of BSA was accelerated by increasing PDLLA/alginate ratio, while the release rate of GA was decreased, and the release of both hydrophobic and hydrophilic drugs could be adjusted by changing the ratio of PDLLA/alginate. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 20122
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）