Advanced Healthcare Materials
·
2025
·
IF 9.6
Yi Liu,Xujie Cui,Minhao Guo,Jinmei Wu,Yulan Zhao,Guangzheng Zhang,Jiahui Xu,Heyou Han,Weihui Li,Zhiyong Song
Drug-resistant bacterial infections pose a significant threat to global health, creating an urgent need for new antimicrobial agents. Reusing approved drugs has gained attention as a strategy to address this issue. In this study, a nano antibacterial platform (DSF@HKUST-1@Dex) that responds to the infection microenvironment is proposed. This platform releases disulfiram (DSF), binds to copper ions in the mildly acidic conditions of infected areas, converting DSF from nontoxic to toxic in situ, thereby inducing bacterial death and enhancing copper ion absorption. Noncatalytic treatment is also initiated for a synergistic antibacterial effect. Excessive copper ions disrupt bacterial metabolism, inhibit the Tricarboxylic acid (TCA) cycle, reduce ATP levels, and induce cuproptosis-like death, significantly enhancing antibacterial efficacy. In a bacterial wound infection model, the platform exhibited excellent antibacterial activity, promoting wound healing and reducing inflammation. Proteomic analysis showed that the platform selectively targeted bacterial peptidoglycan, disrupted the bacterial cell wall, impacted energy metabolism, and inhibited bacterial growth. In conclusion, this nanoplatform offers a promising strategy for treating drug-resistant infections by repurposing old drugs, converting them to toxic forms, and providing a novel antimicrobial approach.
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-21
·
IF 12.6
Zhao Jinchao,Lei Lei,Zeng Cheng,Zhou Xianfei,Ding Junkang,Dai Wenbin,Jiang Angfeng,Zou Shaomin,Jin Qiao,Tang Zhe
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC) has the risk to exacerbate the tumor immunosuppressive microenvironment and promote lung metastasis. There is an urgent need to reverse the immunosuppressive microenvironment and reduce lung metastasis after iRFA. Herein, an iron-based metal-organic framework loaded with capmatinib (Fe-MOF/Cap) is employed to reverse the immunosuppressive microenvironment dominated by M2-like tumor-associated macrophages (TAMs) after iRFA and inhibit lung metastasis of HCC. On one hand, Fe-MOF/Cap repolarizes M2-like TAMs to M1-like TAMs and inhibits the expression of PD-L1 after iRFA, promoting CD8+ T cell infiltration. The infiltration of CD8+ T cells and the decrease of PD-L1 are conducive to enhance the immunotherapy after iRFA. On the other hand, Fe-MOF/Cap can inhibit lung metastasis of HCC via inhibiting the expression of c-MET. In vitro and in vivo experiments confirm that Fe-MOF/Cap is able to significantly inhibit the lung metastasis of HCC after iRFA by inhibiting the c-MET/STAT3/VEGF pathway. Fe-MOF/Cap provides a potentially promising strategy for HCC immunotherapy and anti-metastasis after iRFA, with favorable clinical prospects.Graphical
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PubMed
高影响因子
PETROLEUM CHEMISTRY
·
2025
·
IF 1.1
Jiang Ning,Mao Min,Wang Qingyin,Wang Gongying
MOF-5 is a classic metal-organic framework (MOF) crystal. However, synthesis of high-quality crystals usually requires an expensive N , N ′-diethylformamide (DEF) solvent, and a high molar ratio of a raw material (Zn 2+ : BDC 2– = 3‒5 : 1). More critically, its extreme instability against water vapor has caused researchers to do not use it. In this study, we achieved some important breakthroughs by using inexpensive N , N ′-dimethylformamide (DMF) solvent and meticulously optimizing synthesis parameters combined with a specialized micro-open solvothermal method. With a reduced molar ratio of a raw material (1.47 : 1), we successfully synthesized crystals exhibiting excellent phase structure and morphology, high surface area, out standing water vapor stability, and strong CO 2 adsorption capacity. The results show that the DEF replacement with DMF and reduction of the raw material molar ratio from 3 : 1 to 1.47 : 1 provides an increase of the BET surface area from ~935 to 2388 m 2 /g, and an improvement of the CO 2 adsorption capacity from ~0.8 to 2.5 mmol/g (298 K, 100 kPa). Breakthrough curves reveal that in simulated separation experiments for the flue gas and natural gas containing low CO 2 concentrations (10‒20%), the dynamic separation selectivity for CO 2 /N 2 reaches 22, while that for CO 2 /CH 4 remains stable at 4. Notably, the selectivity remained nearly unaffected by the pressure variation; this phenomenon is promising for enhancing the capture and purification of a low-concentration CO 2 from the flue gas and natural gas. It is important that the improved MOF-5 crystals prepared under optimal synthetic conditions maintained the stable phase structure and morphology even after 14-day exposure to humid air (relative humidity >70%), successfully overcoming the challenge posed by a water vapor.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 123
·101982-101988
·
IF 3.84
Chang Liu,Bing Yan
Heterostructured chemosensors have excellent chemical stability, low contamination and excellent recyclability, and are regarded as a promising new generation of sensors with critical properties related to their sensing sensitivity and selectivity. Our preparation strategy for a heterostructured sensor is to construct it using a luminescent lanthanide complex and metal organic framework (MOF). A heterogeneous sensor is systematically produced using EuTTA and ZIF-8 to cover silica, and thin particles are obtained with small size and uniform morphology. Then, the particles were used as a highly selective and sensitive sensor to detect Cu2+ in aqueous solution. Eventually, we find that the well-structured silica@EuTTA@ZIF-8 microspheres have a good fluorescence stability, low detection limit and broad linear range in aqueous environments. These excellent properties make it a potential chemosensor for sensing of Cu2+ in environmental or biological solution systems.
研究领域:
分析化学
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环境监测
·
生物传感
·
材料科学
·
无机化学
·
纳米技术
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高影响因子
Small
·
2024
·Vol. 21
·期 4
·2410657
·
IF 13
Jia Wang,De Wang,Zelin Zhao,Ganggang Chang,Wei Guo,Jun Xu,Yinyu Xiang,Junrui Li,Junsheng Li
Developing cost-effective ruthenium (Ru)-based HER electrocatalysts as alternatives to commercial Pt/C is crucial for the advancement of proton exchange membrane water electrolysis (PEMWE). However, the strong hydrogen adsorption of Ru-based catalysts restricts its activity. Herein, a strategy is reported to tune the electronic structure and improve mass transfer by implanting Ru atoms onto the (002) facet of two-dimensional zeolitic imidazolate framework-67 (Ru@ L ZIF (002) ) to optimize the d -band center ( ε d ) of Ru and the hydrogen spillover behavior. Benefiting from the ultrathin nanosheet structure and optimized ε d of Ru, the over-strong H adsorption energy is weakened and the electron/mass transfer is facilitated. Ru@ L ZIF (002) exhibits an overpotential of 9.2 mV at 10 mA cm −2 and a long-lasting stability of 35 days at 100 mA cm −2 . The mass activity and price activity of Ru@ L ZIF (002) is 2.9 and 14.7 times higher than Pt/C, respectively. More impressively, Ru@ L ZIF (002) delivers a cell voltage of 2.01 V at a high current density of 4 A cm −2 in PEMWE. The excellent long-term durability of 1200 hours operating at 4 A cm −2 with an ultralow decay rate of 7.5 × 10 −3 mV h −1 has been achieved, making it promising as a cost-effective alternative to Pt/C catalyst for PEMWE applications.
研究领域:
电催化
·
材料科学
·
能源化学
·
纳米材料
·
电化学工程
·
可持续能源技术
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高影响因子
CARBON
·
2018
·
IF 7.082
Xian Wang,Zuju Ma,Lulu Chai,Leqiong Xu,Ziyi Zhu,Yue Hu,Jinjie Qian,Shaoming Huang
Growing demand for clean and renewable energy resources has sparked intensive research on the development of an effective strategy to prepare non-noble metal electrocatalysts for oxygen evolution reaction (OER). Herein, we report a new type of N-doped carbon coated CoP particle/carbon nanotube composite (CNT-NC-CoP) has been synthesized by in situ nucleation and growth of ZIF-67 nanoparticles onto carbon nanotubes, which subsequently is treated with carbonization and phosphorization. Unique hierarchical structure endows as-obtained CNT-NC-CoP with high specific surface area , abundant exposed active sites, quick ion diffusion path , and good electrical conductivity , thus exhibiting the highest electrocatalytic capability with the low overpotential of 251 mV at the current density of 10 mA cm −2 and remaining long-term durability (overlapping LSV curve after 10 h). Besides, density functional theory (DFT) calculations reveal that CoOOH/graphene charged surfaces are more effective for facilitating intermediates adsorption and improving the corresponding catalytic activity .
研究领域:
材料化学
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电化学
·
纳米材料科学
·
能源催化
·
功能材料
·
计算材料学
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Tao Liu,Yan Zeng,Tao Ma,Feng Liang
Antibiotic contamination in aquatic environments poses increasing environmental and health risks, calling for efficient and sustainable remediation strategies. In this work, a metal organic framework (MOF)-mediated approach is developed to construct iron-doped carbon nitride (CN) nanotubes (Fe-CN-X, X = 0, 65, 135, 200, 270) using MIL-88A(Fe) as both an iron source and a structure-directing precursor. By regulating the amount of MIL-88A(Fe), the Fe content and structural properties of the Fe-CN-X can be precisely tuned, leading to the formation of surface-porous nanotubular structures with well-dispersed active sites. Among the prepared samples, Fe-CN-135 exhibits an optimal combination of visible-light absorption, charge separation efficiency, and surface characteristics. Under visible-light irradiation in a H 2 O 2 -assisted photocatalytic system, Fe-CN-135 achieves 99.3% degradation of tetracycline (TC) within 40 min, with a pseudo-first-order rate constant of 0.1106 min −1 . Mechanistic investigations reveal that Fe incorporation narrows the bandgap, suppresses electron-hole recombination, and promotes Fe 3+ /Fe 2+ redox cycling, leading to a • OH-dominated oxidation pathway. The catalyst also demonstrates excellent stability and effectiveness toward multiple organic pollutants. This work provides a practical and scalable strategy for designing Fe-doped CN photocatalysts through MOF-mediation and offers a unique insight for the efficient degradation of organic pollutants.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Xuejiao Wang,Jing Yang,Ming Zhang,Qian Hu,Bai-Xue Li,Jin Qu,Zhong-Zhen Yu,Dongzhi Yang
We design a spontaneously super-hygroscopic alkaline microreactor by photoinduced integration of Zr-MOF catalyst and alkaline poly(dimethylaminoethyl acrylate) onto LiCl-salinized poly(N-isopropylacrylamide) gel, generating a microenvironment with non-volatile polymeric base and non-bulk water for detoxification of a typical nerve agent simulant, dimethyl 4-nitrophenyl phosphate (DMNP), in atmospheric environments. The super-hygroscopic gel with directional microchannels facilitates the absorption, transport and storage of water under different humidities, and exhibits fast hygroscopic efficiency with a high moisture absorption capacity of 6.4 g g −1 . The integrated microreactor achieves simultaneous water uptake and catalytic hydrolysis of DMNP in an atmospheric environment with an initial half-life of ∼1.9 h and a final conversion of 95.5%, which is attributed to the synergistic catalytic microenvironment of the exposed Zr-MOF catalyst, the polymeric base, and the water from moist air. This work provides a feasible strategy for designing spontaneously hygroscopic microreactors for detoxifying nerve agent simulants in atmospheric environments.
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高影响因子
POLYHEDRON
·
2023
·
IF 2.6
Mengyun Chen,Rong Shao,Qiongqiong Wang,Yan Gao,Ye Ma,Rongfeng Guan,Tao Yang
Metal-organic framework (MOF) fluorescent materials have significant advantages in detecting organic pollutants and metal ion pollution. A zinc metal organic framework nanofiber fluorescent membrane (Zn(Eu)-MOF@PAN NFM) was prepared by doping the lanthanide metal Eu using an electrospinning and impregnation process. The structure and morphology of the membrane was characterized by SEM, XRD, FT-IR and XPS. The results show that the membrane has good fluorescence performance and can successfully and efficiently detect nitrobenzene (NB; detection limit = 0.861 ppm, K sv = 0.143 ppm −1 ), 4-nitrophenol (4-NP; detection limit = 0.631 ppm, K sv = 0.178 ppm −1 ), benzaldehyde (BA; detection limit = 0.981 ppm, K sv = 0.051 ppm −1 ) and Fe 3+ ions (detection limit = 3.418 ppm, K sv = 3.210×10 −3 ppm −1 ) in solution. In terms of repeatability and stability, the test results are obviously better than the property of the powder.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Heming Sun,Xiaonian Tang,Shuo Li,Ye Yao,Li Liu
The construction of the materials with one-dimensional (1D) hollow structure using Metal-organic frameworks (MOFs) as the templates has attracted much attention for applied in various fields. Herein, MOF-derived 1D Ru/Mo co-doped Co 3 O 4 hollow microtubes have been obtained via a simple solvothermal method . The as-synthesized samples are characterized by using XRD, FESEM , TEM , XPS, PL and BET. The sensing measurement reveals that when doping amount of Mo and Ru is 1% and 0.3%, the Co 3 O 4 sample exhibits the best sensing performance. Specially, 0.3% Ru/Mo-Co 3 O 4 sample exhibits high responses of 126–100 ppm TEA at a low operating temperature of 160 °C, which are about 18.5 times than that of pure Co 3 O 4 . Furthermore, it shows rapid response/ recovery speed (5 s/7 s), good selectivity and repeatability as well as excellent long-term stability. The good TEA sensing performance is attributed to the construction of 1D hollow architecture and synergistic effect of Ru/Mo co-doping. Thus, it is expected to be a promising sensing material for high-performance detection of TEA gas. In addition, this work provides an useful inspiration for preparation of MOF-derived materials with 1D hollow architecture for achieving excellent performance in various fields.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Yang Yu,Bo Yue,Jianfei Wu,Zhenyu Fu,Ziwei Cui,Jiafu Qu,Jundie Hu,John Tosin Aladejana,Yun Lu,Jianzhang Li,Dan Tian,Yahui Cai
Oily wastewater discharged from households and industries, especially stable oil-in-water emulsions, causes serious pollution to the human habitat. Thus, it is urgent to find an environmentally friendly, efficient, and low-cost method for separating stable oil-in-water emulsions. In this paper, a superhydrophilic wood-based composite membrane (wood/MIL-100(Fe) membrane) for separating oil-water emulsion was reported. The wood/MIL-100(Fe) membrane was made by in-situ growing MIL-100(Fe) on wood, which enhances the hydrophilic properties and roughness. The vertical micro-nano structure and superhydrophilicity of wood/MIL-100(Fe) membrane determines separation flux and efficiency. Consequently, the wood/MIL-100(Fe) membrane displays high separation flux (more than 1061 L·m −2 ·h −1 ) and efficiency (more than 99.9 %). In addition, the wood/MIL-100(Fe) membrane has good mechanical stability, chemical stability, and anti-fouling properties. The wood/MIL-100(Fe) membrane is expected to replace other filter membranes in water treatment and environmental restoration.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Li Feng,Xiaoyun Lin,Junhui Feng,Xiaoqin Min,Yongnian Ni
This study presents the preparation of a novel electrochemical non-enzymatic sensor for the detection of glucose in natural saliva based on a metal organic framework (MOF) derivative (Cu-MOF-C) and nickel nanoparticle (NiNP) composite modified glassy carbon electrodes (GCE). The morphology and structural evolution were thoroughly characterized using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), ultraviolet and visible spectrum (UV) and Fourier transform infrared spectrum (FTIR). Moreover, the electrocatalytic activity of the NiNPs/Cu-MOF-C/GCE for glucose was investigated using cyclic voltammetry (CV) and the amperometric i-t technique. The NiNPs/Cu-MOF-C/GCE sensor exhibits a wide linear range of 0.3–1150 μM and low detection limit (DL) of 0.090 μM at a signal/noise ratio (S/N) of 3. The average recovery rate of this method is satisfactory between 97.3% and 108.4%. Furthermore, the sensor exhibited excellent repeatability, good stability and reproducibility for glucose detection. Compared with traditional invasive measurement, the detection of glucose in natural saliva can reduce the pain caused by continuous blood collection, which is an ideal method for patients requiring continuous monitoring of glucose.
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高影响因子
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