INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Cong Xu,Jiahui Guo,Baoyue Chang,Qingyun Wang,Yiming Zhang,Xianhui Chen,Wanyi Zhu,Jiage Ma,Shanshan Qian,Zhanmei Jiang,Juncai Hou
This study was conducted to develop a W/O/W emulsion encapsulated Lactobacillus plantarum 23 – 1 ( LP23 – 1 ) to significantly enhance the survival rate of LP23-1 under simulated digestion and storage conditions. The zein particles and pectin formed a complex through electrostatic interaction and hydrogen bonding. When the proportion of zein particles to pectin was 1:1, the emulsifying stability index (ESI) was 304.17 %. Additionally, when the proportion of the internal aqueous phase to the oil phase was 1:9, the polyglycerol polyricinoleate (PGPR) concentration was 5 %, the proportion of primary emulsion to the external aqueous phase was 5:5, the zein particles concentration was 4 %, and the proportion of zein particles to pectin was 1:1, the encapsulation rate was the highest at 96.27 %. Cryo-scanning electron microscopy and fluorescence microscopy confirmed the morphology of W/O/W emulsion and successful encapsulation of LP23–1 . Furthermore, compared with free LP23–1 , the W/O/W emulsion encapsulation significantly improved the survival rate of LP23–1 to 73.36 % after simulated gastrointestinal digestion and maintained a high survival rate of 78.42 % during the 35-day storage. The W/O/W emulsion was found to effectively improve the survival rate of LP23–1 during simulated digestion and storage, which has implications for the development of probiotic functional foods with elevated survival rates.
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TALANTA
·
2025
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IF 6.1
Xin Xu,Ting Ying,Zhanghuan Yang,Ze Zhang,Liang Hu,Tong Shen,Dejian Li,Rui Zhu,Dong Chang
The development of portable exosome detection platforms is crucial for noninvasive early diagnosis of lung cancer, particularly in resource-limited settings. Herein, we engineered a paper-based colorimetric biosensor utilizing a MnO 2 /CeO 2 heterojunction nanozyme for visual quantification of plasma exosomes. The heterojunction synergistically integrates the high surface area of CeO 2 (45.689 m 2 /g) with the nanorod shaped MnO 2 , generating an interfacial electron transfer pathway that enhances peroxidase-like activity by 1.77 and 5.87 fold (K m = 1.197 mM, V max = 0.884 M/min) compared to individual components. Molecular recognition was achieved through dual-target immobilization: exosome-specific aptamers and anti-CD63/FGG/FGB antibodies conjugated on a chitosan-modified cellulose substrate. A smartphone-based hue-saturation-value (HSV) analysis system embedded in the platform enabled rapid on-site screening within 15 min, followed by microplate scanning of suspected high-risk samples, achieving a detection range of 10 2 –10 8 particles/μL with an ultralow detection limit of ∼2 particles/μL. Integration of a logistic regression model incorporating CD63, FGG, and FGB absorbance values further improved classification robustness. Clinical validation using 194 plasma samples demonstrated exceptional diagnostic accuracy in discriminating malignant from benign pulmonary nodules (AUC = 0.996), with a 95 % confidence interval ranging from 0.797 to 1.05, with 98.51 % sensitivity and 95.52 % specificity. This work establishes a multimodal strategy combining heterojunction nanozyme catalysis, paper-based microfluidics, smartphone-assisted imaging, and machine learning, offering a scalable paradigm for liquid biopsy applications in primary healthcare.
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BIOCHEMICAL PHARMACOLOGY
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2025
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IF 5.6
Suiqing Mai,Jiale Ke,Shiqin Lin,Rongrong Huang,Fengxin Zheng,He Jiao,Hong Wang,Shuqin Zhang,Mengying Mao,Qiuping Li,Zean Zhao,Jianxin Pang,Qun Zhang
A high-purine diet is an important factor in the development of hyperuricemia (HUA), in which the intestinal tract is the main site of dietary purine absorption. Inhibition of intestinal concentrative nucleoside transporter 2 (CNT2) can inhibit dietary purine-induced elevation of serum uric acid (sUA) levels. However, there is a lack of research on CNT2 inhibitors for the treatment of HUA. By using high throughput virtual screening from an in-house natural product database, the natural active component 5-methylvisammioside (MeV) in Saposhnikovia divaricata (Turcz.) Schischk was predicted to be an effective CNT2 inhibitor with the highest docking score. In vitro , MeV showed the strongest inhibitory activity against CNT2, with IC 50 value of 11.22 ± 2.18 μM. Moreover, MeV showed little or almost no inhibitory effect on other nucleoside transporters CNT3 and equilibrative nucleoside transporters (ENTs), as well as on uric acid (UA) transporter-related targets. In vivo , MeV significantly reduced sUA, inhibited adenosine uptake, and had an ameliorative effect on pathological changes in the liver, kidney, and intestinal tract. Moreover, MeV improved serum and intestinal indices related to inflammation and oxidative stress in mice, reduced intestinal permeability. Through our further study, we found that MeV inhibited the activation of reactive oxygen species (ROS) and NF-κB P65, reduced the production of the NOD-like receptor protein 3 (NLRP3) inflammasome, and improved intestinal injury in a high UA environment. The study suggests that MeV is a potent CNT2 inhibitor for the treatment of HUA and also protects intestinal function by inhibiting the ROS/NF-κB/NLRP3 pathway.
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INORGANIC CHEMISTRY
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2025
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IF 4.7
Xiaoyan Liu,Pengyu Guo,Zhiwei Liu,Borong Zhang,Sijia Li,Xin Liu,Yunling Liu
Although the one-step separation of ethylene from C2 hydrocarbons remains a significant challenge, one-step C2 separation provides a revolutionary breakthrough in cost savings and efficient energy utilization. Recent advances in metal–organic frameworks (MOFs) for achieving one-step C2 separation have been widely recognized. In this work, for the first time, the potential relationship between the structure and properties of MOF materials previously used for one-step C2 separation was revealed from a mathematical statistical perspective. Additionally, the importance of N/O sites in enhancing the selectivity of C2H6/C2H4 separation is elucidated as a supplementary finding. Guided by the above findings, a pillar-layered MOF (JLU-MOF167) was synthesized using a mixed-ligand strategy. The unprecedented layer structure, composed of triazole units and multiple Cd units, provides an optimal thickness that creates a large number of N/O sites. Simultaneously, the tortuous channels between the pillars ensure sufficient interaction space between the molecules and the framework. The excellent structural design enables JLU-MOF167 to exhibit outstanding performance in both C2H2/C2H4 and C2H6/C2H4 separations as well as dynamic separation capabilities. Furthermore, theoretical calculations confirm the critical role of high-density N/O sites in facilitating one-step C2 separation.
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JOURNAL OF CATALYSIS
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2025
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IF 6.5
Qibin Zeng,Yuancai Lv,Meiyan Shi,Ting Pan,Yunhe Xie,Yifan Liu,Minghua Liu
Selective cleavage of C-O bonds is a pivotal step for converting lignin into value-added chemicals, yet the development of efficient catalysts for mild-conversion remains a formidable challenge. Herein, a novel bi-Ni metal catalyst (Ni NPs-SAs /NC) composing of Ni single atoms (SA) and Ni nanoparticles (NP) was synthesized by pyrolysis strategy and employed for lignin hydrogenolysis without external hydrogen gas. Due to the high reactivity of Ni NPs-SAs /NC, various lignin model compounds (α-O-4, β-O-4 and 4-O-5, etc.) were fully converted into aromatic monomers at low temperature (200 ℃) and autogenous pressure, and the selectivity of aromatic monomers was as high as 86.3 %. Structural characterization and theoretical calculations indicated that the excellent catalytic performance of Ni NPs-SAs /NC catalysts was attributed to the synergistic effect of Ni SA and NP sites. Specifically, isopropanol was adsorbed at the Ni NP site and generates active hydrogen, and the Ni SA site adsorbed and activated the C-O bonds. The active hydrogen spillover from the Ni NP site to the Ni SA site enabled the cleavage of the C-O bond of lignin under mild conditions. This work may pave the way for developing high-performance non-noble metal catalysts with exceptional reactivity and selectivity for the valorization of lignin.
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ENVIRONMENTAL RESEARCH
·
2025
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IF 7.7
Yehan Xiong,Tiantian Xu,Bingchang Chen,Jiangkun Du,Lijing Tan,Yujie Zhong,Jianguo Bao
The photocatalytic performance of materials is primarily governed by their band structure, charge carrier transport, and active sites. This study introduces a surface modification strategy for graphitic carbon nitride (g-C 3 N 4 ) using C=O groups to significantly enhance its photocatalytic activity. The C=O-modified g-C 3 N 4 (CNSHQC2) demonstrated exceptional photocatalytic performance. It achieved a degradation rate of over 85 % for tetracycline hydrochloride (TC) in five different real wastewater matrices within 40 min of natural sunlight exposure. By combining quantitative structure-activity relationship analysis with site-specific blocking experiments, the C=O groups were identified as the primary active sites. Traditional functional group modifications typically improve photocatalytic performance by increasing surface area or enhancing charge transfer. In contrast, C=O modification simultaneously optimizes the band structure and introduces active sites that promote PMS activation. The results indicate that this dual modulation of electronic structure and surface chemistry facilitates efficient charge carrier separation and enhances the generation of reactive oxygen species (ROS). Additionally, C=O groups increase triplet exciton generation and promote singlet oxygen formation via energy transfer. These synergistic effects collectively contribute to a significant improvement in the photocatalytic performance of g-C 3 N 4 . This work provides a new strategy for designing high-performance photocatalysts and valuable insights into the role of C=O groups in expanding the potential applications of carbon-based materials in environmental remediation.
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ENERGY
·
2025
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IF 9.4
Fenhong Song,Jiaming Ma,Gang Wang,Ruibo Zhang,Jiawen Li,Jing Fan
Supercapacitors are essential to future energy systems, enabling efficient energy storage and management. Transition metal oxides are pivotal in advancing supercapacitor performance due to their redox activity and conductivity. Here, we synthesize a multi-element transition metal oxide composite (NiO-(NiFeCo)O) via a one-step hydrothermal method, forming self-assembled 3D rough nanorod networks. This architecture enhances ion transport, provides abundant active sites, and delivers a specific capacitance of 1414.54 F g −1 at 1 A g −1 , with 98.35 % capacitance retention after 3000 cycles. We further developed an asymmetric supercapacitor (ASC) using NiO-(NiFeCo)O as the positive electrode and rGO self-assembled on SiO 2 as the negative electrode. The ASC achieved a remarkable energy density of 66.0 Wh·kg −1 at 800 W kg −1 , alongside 88.46 % capacitance retention after 11,000 cycles. This design balances high energy/power density with exceptional stability, addressing critical challenges in next-generation energy storage. Our findings highlight the potential of NiO-(NiFeCo)O//SiO 2 /rGO ASCs for scalable, sustainable applications in advanced energy systems.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Yi Xing,Hanlin Xu,Min Zhang,Faliang Cheng
The excessive use of chlortetracycline (CTC) has the potential to adversely affect ecosystems and threat human health by inducing antibiotic-resistant infections, necessitating a rapid, sensitive and accurate detection method for CTC. Here, an electrochemical sensor based on molecularly imprinted polymer (MIP) has been developed that utilized poly o-phenylenediamine (poly-o-PD) film to specificity detect CTC, which preparation process was low-cost, time-saving and simple. It combines the recognition capabilities of MIP with the outstanding electrochemical performance of electrode modification materials, namely tungsten disulfide (WS 2 ) and carboxylated multi-walled carbon nanotubes (MWCNTs-COOH). And, in order to verified the optimal ratio of CTC (template) and o-PD (monomer), the density functional theory is performed by Vienna Ab Initio Simulation Package (VASP) within the generalized gradient approximation to calculate the interaction energy of CTC-o-PD. The sensor detects CTC by analyzing the current changes of the redox-active probes in response to the binding of CTC to the imprinted sites on the modified electrode surface. The sensor reveals a high affinity toward CTC binding, enabling the detection of CTC concentrations within the range of 0.5 – 425.0 μM, with a detection limit of 18.5 nM (S/N = 3). Meanwhile, the sensor harnesses the advantages of screen-printed electrode (SPE) such as miniaturization, suitability for large-scale production, and cost-effectiveness, to further enhance the practicality. The sensor described herein has been successfully used for specific quantitative detection of CTC in actual water, demonstrating its practical applicability.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Wenxuan Zhou,Xiaoyong Mo,Cham Wah Cheung,Edmund C.M. Tse
At present, over 95 % of H 2 O 2 is produced via the anthraquinone process that requires large infrastructure, generates organic pollution, and poses safety issues. Electrochemical H 2 O 2 generation through oxygen reduction can serve as an alternative, reliable, and decentralized production method if affordable and high-performance electrocatalysts can be developed. Herein, a two-step process is used to prepare an Fe-based complex as a non-precious metal electrocatalyst to facilitate oxygen reduction reaction (ORR) and produce an alkaline H 2 O 2 solution. The Fe complex of benzene-1,3,5-tricarboxylate (FeBTC) is first synthesized using a hydrothermal method and then activated via a pulsed laser treatment process that is optimized via the Taguchi method. The pulse-laser-treated FeBTC (PL-FeBTC) lowers the H 2 O 2 electrosynthesis overpotential by 50 mV at −0.1 mA/cm 2 and exhibits a 25 % increase in H 2 O 2 product selectivity at 0.4 V vs. RHE. The experimental results indicate that the O 2 -to-H 2 O 2 turnover frequency and electrocatalytic yield of the Fe-based metal–organic framework are enhanced simultaneously through solid-to-solid pulsed laser conversion. Through a series of X-ray photoelectron spectroscopy, elemental analysis, Raman spectroscopy, X-ray absorption spectroscopy, and control atmospheric experiments, the origin of the improvement in catalytic performance is rationalized through the formation of an oxo-bridge across the di–Fe active site via an oxygen-doping mechanism, thus providing a systematic laser methodology for precise structure-performance tuning. Beyond H 2 O 2 generation, this study further lays the foundation for the development of cost-effective and scalable electrocatalysts that are central to other commodity manufacturing and sustainable resourcification processes.
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Journal of Environmental Chemical Engineering
·
2025
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IF 7.2
Zhipei Tang,Ju Zhu,Ziqi Zhao,Heming Dong,Qian Du,Dongdong Feng,Yu Zhang,Tianhang Zhang,Yirui Peng,Jianmin Gao,Min Xie
Surface modification of porous biochar is a key strategy for enhancing CO 2 adsorption performance. Herein, HNO 3 solution impregnation, along with concurrent pore structure modulation via KOH chemical activation, was used to functionalize pine nut shell-derived biochar. The influence of HNO 3 concentration on heteroatom doping and pore configuration was also systematically investigated. Combining experimental characterization with density functional theory calculations, the dual contributions of pore structure and heteroatom-induced interactions to the enhanced CO 2 uptake in modified biochars were decoupled. The optimized functionalized porous biochar exhibited N and O doping levels of 1.67 at.% and 11.1 at.%, respectively, a specific surface area of 1498 m 2 g −1 , and an ultra-micropore (<0.7 nm) volume of 0.40 cm 3 g −1 . This material achieved a CO 2 adsorption capacity of 4.82 mmol g −1 at 25 °C and 1 bar. Notably, the ultra-micropore filling rate exceeded 80% at 0 °C and 1 bar. Therefore, the developed synergistic regulation strategy facilitates concurrent optimization of heteroatom functionality and pore structure. This strategy yields superior CO 2 capture performance under ambient conditions (25 °C, 1 bar), and provides insights for advancing carbon capture technologies.
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NEW JOURNAL OF CHEMISTRY
·
2025
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IF 2.5
Sleshi Fentie Tadesse,Worku Lakew Kebede,Dong-Hau Kuo
Visible-light-driven photocatalysis is an efficient and environmentally benign approach to mitigate organic pollutants from waste effluents. A facile one-step precipitation method was used to synthesize Fe–Mo3(O,S)4−x/La4Mo2O11 (FeLaMoOS) nanocomposites. The as-prepared materials were characterized by XRD, SEM, HR-TEM, XPS, PL, EIS, photocurrent, and UV-visible spectroscopy. The type I heterojunction formed between Fe–Mo3(O,S)4−x and La4Mo2O11 exhibited a maximum light absorption response in the visible spectrum. The FeLaMoOS composite (13% Fe and 20% La) demonstrated the highest degradation efficiency, degrading 97.5% MO and 99.2% RhB in 90 min. The removal efficiency of MB was 99.6% after 45 min of magnetic stirring in the dark. The enhanced catalytic efficiency can be attributed to the effective charge separation of photoinduced e−–h+ pairs due to doping and heterojunction formation. Superoxide radicals (O2˙−) played a dominant role, while hydroxyl radicals (˙OH) played only a minor role, in the photocatalytic degradation process. Possible photocatalytic degradation mechanisms of organic dye molecules were proposed, based on the active radical species involved and the band potentials of the photocatalysts. This study can be used to establish a simple and efficient strategy for designing reusable composite photocatalysts for the degradation of organic dyes.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
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IF 15.7
Li Taiguang,Chen Butian,Wang Tenghui,Liu Chong,Yin Wen,Mao Qianjiang,Zhou Dongxu,Hao Yongmei,Liu Xiangfeng
Solid-state sodium metal batteries have attracted great interest because of their improved safety and abundant Na resources. However, the interfacial resistances and instabilities induced by parasitic reactions, together with Na dendrite issues, result in reduced rate capability and poor cycling stability. Here, we address these challenges by intrinsically inhibiting parasitic interfacial redox reactions through enhanced P-O covalency in Na 3 Zr 2 Si 2 PO 12 (NZSP) with Na 2 SiF 6 incorporation, wherein the high electronegativity of F strengthens P-O covalency. Additionally, SnF 2 coating provides a sodiophilic surface and stabilizes the NZSP interface, which is essential for effective electrochemical cycling. This integrated approach significantly reduces interfacial impedance to 2.0 Ω cm 2 , enabling stable Na plating/stripping for 3600 hours at 0.5 mA cm -2 /0.25 mAh cm -2 . The full cell with Na 3 V 2 (PO 4 ) 3 positive electrode demonstrates stable cycling with high-rate capability (87.5% capacity retention after 2500 cycles at 1 C and 96.1% capacity retention after 1200 cycles at 5 C). This study sheds light on the development of high-performance quasi-solid-state sodium batteries.
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危险品化学品经营许可证（带存储）