CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Wenlin Li,Qijia Chen,Xin Ning,Jiajun Zheng,Ke Liang,Lei Han
Self-pillared nano-ZSM-5 (SPZ) boosts 1-hexene oligomerization stability for SAF. • Accessible strong Brønsted acid sites promote branching and cyclization reactions. • 2D-GC–MS shows C12–C17 products dominate while aromatization remains minor. • Lower N 2 flow favors deeper oligomerization, enriching heavier and jet-fuel-range products. • Oligomer-derived soft coke drives deactivation and enables partial N 2 reactivation. Developing high-performance catalysts for the oligomerization of bio-derived olefins into sustainable aviation fuels (SAF) is of paramount importance. However, simultaneously achieving high catalytic activity and selectivity while mitigating the rapid deactivation of nano-zeolites remains a formidable challenge. To drive the efficient production of SAF, a novel self-pillared nano-ZSM-5 (SPZ) zeolite featuring an enriched acidic profile was designed in this work, delivering exceptional activity, selectivity, and stability for 1-hexene oligomerization. Compared with nano-sized ZSM-5 featuring intercrystalline mesoporous voids (NSZ), the SPZ catalyst significantly improved catalytic performance, increasing 1-hexene conversion from 20% to 61% at 240 °C while prolonging catalyst lifetime. DTBPy-FTIR, and TEOS passivation collectively support the involvement of external and pore-mouth acid sites in 1-hexene conversion and further indicate that these accessible sites may also promote secondary cracking. Semi-quantitative, area-normalized 2D-GC–MS responses were dominated by C12-C17 oligomer-derived species and showed extensive branching and cyclization, whereas aromatics remained minor. Variation of the N 2 flow rate shifted the recovered product distribution through coupled changes in reactant dilution, nominal contact time, and product stripping. Deactivation was associated mainly with retained oligomer-derived soft coke. These results identify accessible acidity and transport as coupled descriptors for tuning unsaturated jet-fuel-range precursors over hierarchical ZSM-5. Download: Download high-res image (220KB) Download: Download full-size image
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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2026
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IF 4.3
Jingjing Li,Xiaoxia Feng,Ranran Si,Yuanyuan Liu,Zhifang Huo,Huanqing Song,Chuan Zhou
Bronchopulmonary dysplasia (BPD), characterized by inflammation, is a severe pulmonary condition of preterm infants. This study aimed to investigate the role of secreted frizzled related protein 2 (SFRP2) in BPD and to elucidated its underlying mechanisms, focusing on inflammation, apoptosis, and the Nrf2/HO-1 signaling pathway. In vivo neonatal mouse models and in vitro murine lung epithelial-12 (MLE-12) models were established by hyperoxia induction. Administration of recombinant SFRP2 (rSFRP2) aggravated hyperoxia-induced lung injury, reduced alveolation, and increased inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both lung tissues and cells (all P < 0.05). This demonstrated that SFRP2 aggravated hyperoxia-induced inflammation. These results were also evidenced by elevated numbers of inflammatory cells in the BALF and increasing counts of MAC-3 positive cells in the lung tissues of rSFRP2-treated BPD mice (all P < 0.05). rSFRP2 treatment promoted hyperoxia-induced apoptosis of lung tissue in mice and MLE-12 cells, reflected in increased count of TUNEL-positive cells. The Nrf2/HO-1 pathway was inhibited in the lung tissues of mice and MLE-12 cells after hyperoxia induction, and rSFRP2 therapy further suppressed its activity. Rescue experiments demonstrated that the activation of Nrf2 expression mitigated rSFRP2-induced inflammation and apoptosis in MLE-12 cells. Mechanically, SFRP2 promoted competitive binding of BACH1 to the ARE sequence of HO-1, impaired Nrf2 binding, and suppressed antioxidant signaling. We concluded that SFRP2 might exacerbate lung inflammation and apoptosis by inhibiting the Nrf2/HO-1 pathway, thus promoting the progression of BPD.
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Cell Reports Medicine
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2026
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IF 14
Pengcheng Zhang,Yahui Gao,Yaxin Wang,Xin Li,Yi Jiang,Yigang Xu,Keliang Xie,Yixuan Ma,Sheng Wang,Hui Zheng,Wen Li,Xu Jin
A critical challenge in sepsis treatment lies in its complex immune microenvironment, characterized by concurrent hyperinflammation and immunosuppression. This imbalance is jointly driven by dysregulated neutrophil programmed death and abnormal activation of the PD-1/PD-L1 immune checkpoint. Therefore, precisely modulating neutrophil fate and blocking this immune checkpoint are highly promising therapeutic strategies. We engineered an artificial exosome nano-decoy (AT@NV-PD1) that homes to senescent-like neutrophils. It comprises a pH-responsive bovine serum albumin core carrying AT7519, a cyclin-dependent kinase inhibitor, cloaked with macrophage membrane presenting PD-1. After intravenous delivery, PD-1 selectively binds PD-L1 on target neutrophils. In the mildly acidic microenvironment, AT7519 release triggers timely neutrophil apoptosis, curbing excessive inflammation. Concurrently, the nano-decoy neutralizes bacterial toxins and inflammatory cytokines. By engaging PD-L1, AT@NV-PD1 also alleviates T cell exhaustion, reduces immunosuppression, and promotes immune homeostasis. In conclusion, AT@NV-PD1 represents a sepsis therapy by precisely regulating neutrophil fate and rebuilding immune balance.
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AICHE JOURNAL
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2026
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IF 4.4
Yaxing Zhang,Liju Bai,Xiaotong Jiang,Yimin Deng,Helei Liu
Mass transfer performance is an important design criterion for the absorption of CO 2 by amines in packed columns. In this paper, the effects of diethylenetriamine (DETA)–1-dimethylamino-2-propanol (1DMA2P)–H 2 O biphasic solvent on the total mass transfer coefficient ( K G a v ) of different operating parameters (liquid flow rate, gas flow rate, liquid temperature, CO 2 partial pressure, and CO 2 loading) were investigated in a mesh-structured (DX) packed column. The mass transfer mechanism of this biphasic solvent to capture CO 2 was assessed by determining the control step of mass transfer. In addition, the experimental data were compared with two empirical models, the Sheng model and the modification, and the results showed that the modification could better fit the experimental results. Further analysis was conducted on the differences in packed column design among several different amine systems and the DETA–1DMA2P–H 2 O system. The findings revealed that the DETA–1DMA2P–H 2 O system required the least column volume, highlighting its strong potential for industrial application.
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Gut Microbes
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2026
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IF 15.3
Shuze Chen,Hanxiao Feng,Ying Wang,Jun Huang,Senbao Xu,Yunying Gong,Xiuying Liu,Ye Ouyang,Qiujuan Ye,Dekai Zheng,Kai Sun,Anjiang Wang,Ye Chen
Despite the rising global incidence of inflammatory bowel disease (IBD), curative therapies remain unavailable. While our previous work implicated the intestinal proteoglycan Syndecan-1 (SDC1) in IBD-associated barrier dysfunction and inflammation, the underlying mechanism was unclear. This study aimed to elucidate how SDC1 maintains intestinal barrier integrity through interactions with the gut microbiome. In DSS-induced colitis, global knockout of Sdc1 (Sdc1-/-) exhibited exacerbated inflammatory infiltration and greater impairment of barrier structure and function than wild-type (WT). Formation of intestinal organoids was independent of genotype, indicating that Sdc1-/- does not impair barrier function via disrupting epithelial development. The heightened colitis susceptibility in Sdc1-/- mice was abolished in the antibiotic-treated pseudo-germ-free models, and transmissible to WT mice via fecal microbiota transplantation. Similar results were reproduced in a germ-free mouse model. Metagenomic sequencing identified Faecalibacterium prausnitzii as the most significantly depleted species upon Sdc1 knockout. In vitro, SDC1-attached glycosaminoglycans (heparan sulfate (HS) and chondroitin sulfate (CS)) but not the SDC1 core protein promoted F. prausnitzii growth. Prokaryotic transcriptome profiling indicated that HS/CS induces cobalamin biosynthesis in F. prausnitzii. The critical role of cobalamin as a mediator was confirmed, as its synthetic inhibition significantly diminished the growth-promoting effect of HS/CS. Mechanism studies showed that HS/CS enhanced biofilm formation in F. prausnitzii, thereby facilitating cobalamin biosynthesis. Oral administration of HS ameliorated DSS-induced colitis and promoted mucosal colonization of F. prausnitzii, independent of the host genotype. Finally, human IBD biopsies revealed a positive correlation between epithelial SDC1 and mucosal F. prausnitzii, as well as an inverse correlation with bacterial translocation and the number of LPS‑positive cells. Our study elucidates a novel mechanism in which the glycosaminoglycan chains of SDC1 promote F. prausnitzii colonization and growth through enhanced biofilm formation and cobalamin synthesis, thereby highlighting the therapeutic potential of HS for IBD and offering a new basis for host-directed microbiota regulation.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Ziyu Zhang,Qiannan Duan,Hongfang Zhang
Bilayer heteronanosheets were prepared via self-assembly. • DNA three-way junctions were applied to achieve impedance signal amplification. • The biosensor shows high sensitivity and good reproducibility. Mucin 1 (MUC-1) is a promising biomarker of adenocarcinoma, thus sensitive and simple detection of MUC-1 is significantly important for the early diagnosis of this disease. Herein, an impedimetric biosensor for MUC-1 detection was developed, which was designed to achieve high sensitivity by introducing DNA three-way junctions (3WJ) on the sensor surface. For this purpose, hetero-bilayer nanosheets of reduced graphene oxide (rGO) and MnO 2 were applied to fabricate a stable and conductive sensor surface. PAMAM was modified to attach MUC-1 antibody on the surface. When MUC-1 was present, 3WJ can be introduced to the sensing interface via a DNA tail containing base sequence of MUC-1 aptamer. Because of the unique spatial configuration and negatively charged nature of 3WJ, diffusion of the redox probe [Fe(CN) 6 ] 3−/4– was greatly hindered. Consequently, impedance at the electrode/solution interface induced by MUC-1 was amplified, enabling a biosensor with high sensitivity. Using this biosensor, a detection limit as low as 4.3 pg·mL −1 was achieved. Furthermore, the biosensor also exhibited good specificity and reproducibility, demonstrating potential application in the diagnosis of adenocarcinoma and other related biological purpose. Download: Download high-res image (158KB) Download: Download full-size image
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ACS Catalysis
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2026
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IF 13.6
Xianming Zhao,Mengde Kang,Jian Zhou,Jing Li,Mei Ren,Xinya Zhang,Honghao Liu,Zhongcheng Tian,C. Richard A. Catlow,Songmei Sun,Cheng Lian,Marc Pera-Titus,Yongsheng Li
The direct oxidation of methane to methanol at room temperature is a highly sought-after but challenging reaction due to methane’s inert C−H bond and methanol overoxidation. Conventional approaches often require high temperature and pressure or special oxidants. Here, we report an AuxPdy/TS-1 composite photocatalyst with tunable Au/Pd ratios that achieves highly selective methane-to-methanol conversion at near-room temperature using water as the oxidant. An optimized Au0.1Pd0.05/TS-1 photocatalyst exhibits an activity of 64.7 mmol gAuPd−1 h−1 and a turnover frequency of 19.1 h-1 with 100% methanol selectivity under simulated solar light. This performance arises from the efficient electron-hole generation by encapsulated nanoalloy AuPd clusters, generating ·OH and ·CH3 radicals for methane activation and water oxidation, as evidenced by in situ EPR and DRIFT spectroscopy. DFT calculations show that Au sites preferentially mediate the formation of methanol via surface-bound *CH3 and *OH intermediates. Alloy-induced Pd→Au charge redistribution modulates CH4/H2O activation energetics and weakens methanol binding. This study demonstrates an efficient and mild route for highly selective methane utilization under mild conditions.
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ACS Applied Polymer Materials
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2026
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IF 5.2
Ziyi Yuan,Zhihong Lin,Kejing Li,Jian Li,Viatcheslav Freger,Xuezhong He
Polymers of intrinsic microporosity (PIMs) are promising membrane materials for CO2 separation due to their high permeability; however, their limited CO2/N2 selectivity restricts practical application. Herein, mixed-matrix membranes (MMMs) were fabricated by incorporating a CO2-molecularly imprinted UiO-66-NH2 filler (MIP@U) into amidoxime-functionalized PIM-1 (AOPIM-1), followed by thermal treatment at 160 or 250 °C under vacuum to regulate the membrane microstructure. Spectroscopic and porosity analyses (FTIR, XRD, and N2 physisorption) show that thermal treatment at 160 °C promoted oxadiazole-ring formation, leading to enhanced subnanometer microporosity and improved CO2/N2 selectivity. In contrast, treatment at 250 °C partially regenerates nitrile groups and generates larger micropores, resulting in higher CO2 permeability but reduced selectivity. The MIP@U filler introduces CO2-recognition cavities and improves interfacial compatibility, enabling synergistic control of polymer microporosity and interfacial transport pathways. The optimized 3 wt % MIP@U/AOPIM-1-TR160 membrane achieves a CO2 permeability of ∼1600 Barrer and a CO2/N2 selectivity of 50.8. The membrane also demonstrates stable performance under pressures up to 12 bar and during 30 h of continuous operation at 2 bar. This study highlights a dual-approach strategy combining thermally tailored PIM chemistry with molecularly imprinted MOF fillers for designing high-performance MMMs for CO2 capture.
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Journal of Energy Chemistry
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2026
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IF 15.6
Yun Tian,Menghao Jiang,Jinxing Long
Developing in-situ catalysts featuring good activity for lignin hydrogenolysis is highly desirable, yet remains a great challenge. In this work, we proposed an efficient strategy for selective hydrodeoxygenation of lignin to a versatile petrochemical of alkylcyclohexanol (ACH) using the in-situ Ru nanoparticles anchored on MgO-modified TS-1. The results demonstrated that, with HRO 5 -MgO 20 @TS-1 catalyst, a total monomer yield of 36.4% was shown from the one-pot cascade process of lignin hydrogenolysis and phenolics hydrodeoxygenation. Importantly, 55.8% of obtained monomers were identified as ACH (20.2% yield), which has been widely used as an oxygenated fuel, solvent, and intermediate for functionalized materials. Intensive catalyst characterizations using TEM, XPS, and XAFS revealed that the highly dispersed in-situ Ru 0 species, together with the suitable acid-base properties, are responsible for the superior catalytic performance of HRO 5 -MgO 20 @TS-1 in lignin depolymerization. In addition, a plausible reaction pathway for ACH formation has been proposed, according to the results of comparative characterization of raw and regenerated lignin, and the performance of lignin model conversion. Therefore, this work provides a new insight into producing value-added alkylcyclohexanol from the renewable lignin.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Sun Ruize,Liu Xiaonan,Chen Jingge,Chen Zhangguo,Zhou Jicheng,Xu Wentao
Propane direct dehydrogenation (PDH) is an important way for the high-value utilization of propane (C 3 H 8 ). However, the conventional thermal catalytic reaction process is limited by the thermodynamic equilibrium of the strong endothermic reaction, and usually needs to be operated at high temperature, which makes it difficult to balance high conversion and high selectivity. In this study, a new method of microwave catalytic dehydrogenation of C 3 H 8 to propylene (C 3 H 6 ) at low temperature and high efficiency was proposed, and Pt-ZnO/S-1 + SiC microwave catalyst was developed. It was found that microwave significantly improved the conversion and selectivity of the catalyst, and the reaction was carried out efficiently at lower temperatures. Under low temperature microwave catalysis (MCRM) at 450 ° C, the conversion of C 3 H 8 was as high as 46.4%, and the selectivity of C 3 H 6 was as high as 99.3%, which were significantly better than 18.4% conversion and 95.1% selectivity under conventional thermal catalysis (CRM). Further study shows that the microwave action reduces the apparent activation energy of the catalyst from 75.5 kJ·mol −1 under CRM to 48.7 kJ·mol −1 under MCRM. This study provides a new strategy for the low-temperature and efficient conversion of low-carbon alkanes such as C 3 H 8 and provides a new idea for the application of microwave catalytic technology in other catalytic reactions.
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ACS Nano
·
2026
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IF 17.3
Zhuo Xiqian,Li Yunfeng,Qiu Ling,Aishajiang Reyida,Lei Pengpeng,Wang Tiejun,Yu Duo
Radiotherapy plays a pivotal role in the management of
nonsmall-cell
lung cancer (NSCLC), particularly for patients who are not candidates
for surgical intervention. Despite its significance, the issue of
radioresistance remains a substantial challenge in the treatment of
the NSCLC. Therefore, it is crucial to uncover new targets to enhance
radiotherapy and investigate the mechanisms underlying radioresistance.
Cuproptosis, as an emerging form of cell death dependent on intracellular
copper (Cu) ions, remains unclear in its role in radioresistant NSCLCs.
This study investigates the development of radioresistant NSCLC models,
focusing on the role of the FOS-like antigen 1 (FOSL1) as a significant
factor in mediating radioresistance. The FOSL1 gene is downregulated
in radioresistant cells. Overexpression of FOSL1 induces mitochondrial
damage and dysfunction, causing cuproptosis in radioresistant cells.
To tackle the challenge of radioresistance in NSCLC, we propose an
innovative nanostrategy focused on cuproptosis, aiming to enhance
the efficacy of radiotherapy specifically in radioresistant NSCLC.
This intervention could significantly enhance an increase in intracellular
Cu 2+ concentration and glutathione depletion while also
increasing irradiation (IR)-induced oxidative stress and mitochondrial
damage. The resulting mitochondrial dysfunction leads to tricarboxylic
acid cycle disruption and Fe–S cluster protein destabilization.
These cumulative effects ultimately induced cuproptosis and enhanced
the response of radioresistant NSCLC cells to IR. Our findings highlight
the potential of combining cuproptosis targeting with nanotechnology
to enhance the efficacy of radiotherapy, presenting a promising strategy
to address radioresistance in clinical contexts.
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高影响因子
CHEMICAL PAPERS
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2026
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IF 2.7
Gu Yu-Qing,Fan Cong-Xuan,Xing Shi-Feng,Zhu Hong-Jun
Modified TS-1 catalysts were prepared by treating TS-1 with different alkalis for the nitration of aldoxime, and the effect of alkali treatment on catalytic performance was investigated. TS-1 was modified using organic amines such as ethylamine (EA), triethylamine (TEA), and tetrapropylammonium hydroxide (TPAOH), as well as inorganic bases such as NaOH, KOH. The catalysts were characterized by XRD, FT-IR, UV-vis, N 2 adsorption etc., which showed that the volume of mesopores increased and the skeleton structure remained basically unchanged by the ethylamine-modified TS-1 and the TPAOH-modified TS-1. The highest yield of 1-nitropropane increased 78% when propionaldehyde oxime was catalyzed by the 0.1 mol/L ethylamine treated sample TS-1-EA-0.1. The enhanced catalytic performance of TS-1 after ethylamine treatment may be attributed to the matching between the pore size of modified TS‑1 and the molecular size of propionaldehyde oxime. Subsequently, TS-1-EA-0.1 was used to catalyze acetaldoxime and butyraldehyde oxime. The results revealed that this catalyst was suitable for acetaldehyde oxime as expected, but less effective for the oxidation of butyraldehyde oxime with a larger molecular diameter than propionaldehyde oxime to 1-nitrobutane. Graphical abstract
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