JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Renjie Zhou,Jiahao Yu,Shuo Li,Jian Zhang,Chenqiang Wang,Lianfu Zhang
Amadori compounds (ACs; N-(1-deoxy-d-fructos-1-yl)-amino acid) are superior flavor precursors and potential functional ingredients in food processing. In this study, vacuum dehydration as an excellent and universal method for the formation of ACs in both simulation systems and food processing was revealed. In total, 12 amino acids referring to all six categories were selected to conduct simulated reactions with glucose in aqueous models. At 90 °C, yields of 11 ACs were significantly increased by vacuum dehydration, reaching 4–198 times compared to a heat sealing reaction in aqueous systems, and formation of 5-hydroxymethyl-2-furaldehyde (5-HMF) and browning were slower than that by a dry powder reaction. In particular, the yields of Fru-Arg, Fru-His, and Fru-Glu reached 87.03, 90.73, and 89.88 mol %, respectively. The order of promotion effect was acid ACs > basic ACs > unique ACs > polar neutral ACs > aliphatic ACs > aromatic ACs. The excellent effect was mainly attributed to the control of water activity (Aw) and pH, which enabled the models to reach the optimal reaction state quickly by adjusting the vacuum degree at mild temperatures. The method was also applied to AC enrichment in tomato sauce processing; the AC content could rise to 30.72 mg/g, which was more than 17 times than those in samples without vacuum dehydration and two commercial tomato sauces.
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DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2022
·
IF 9.336
Ruyue Zhang,Yilong Zhang,Yating Sun,Hang Yu,Fangwei Yang,Yahui Guo,Yunfei Xie,Weirong Yao
This study evaluated how the generation of pyrazines was promoted by high-intensity ultrasound (HIU) in a Maillard reaction (MR) model system of glucose-glycine. Carbohydrate module labeling (CAMOLA) technique was adopted using D-glucose- 13 C 6 to elucidate the carbon skeleton of both intermediate and final MR products (MRPs). In the D-glucose- 13 C 6 -glycine HIU-MR model system, the concentration of 11 types of pyrazines was significantly higher than their counterparts in the thermal MR. Results of CAMOLA analysis showed that a significantly lower proportion of [M] + in pyrazines with long-length side chains was observed when compared with the pyrazines generated in thermal MR. This phenomenon may suggest the aldol-type condensation was promoted by the HIU, which is a conversion from pyrazines with short-length side chains to those with long-length side chains involving carbonyl compounds. Furthermore, the analysis of isotopomers distribution in 2,3-dimethyl-quinoxaline as the o-phenylenediamine-derivatized 2,3-butanedione indicated that the increased proportion of [M + 4] + in 2,3-dimethyl-quinoxaline (15.74% ± 0.11%) was attributed to a cleavage of D-glucose- 13 C 6 promoted by the HIU. The above-mentioned findings elucidate that the aldol-type condensation and cleavage of D-glucose contribute to the promoted synthesis of pyrazines. The HIU would generate an extremely high temperature and pressure environment that is favored by the aldol-type condensation as a high-pressure favored reaction. The HIU, therefore, can be further developed as a promising technique to promote flavor generation through the MR.
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DOI
高影响因子
SYNTHETIC METALS
·
2021
·
IF 3.266
Yueqiang Ma,Yuchang Du,Chunxia Li,Yan Zhang,Hongmei Du,Jinsheng Zhao,Junhong Zhang,Yu Xie
In this work, starting from cyclopenta[2,1-b;3,4-b′]dithiophene (CPDT) and tris(thienothiophene) (3TT) as donor units, and diketopyrrolopyrrole (DPP) as the acceptor unit, three new solution-processable donor-acceptor conjugated copolymers (P1, P2, P3) were successfully synthesized through the palladium-catalyzed Stille coupling reaction. The monomer molar feeding ratios (CPDT:DPP:3TT) of the three polymers are 3:2:1, 2:1:1, 3:1:2, respectively, which are named as PCPT-1, PCPT-2, and PCPT-3. For comparison purpose, we also synthesized the binary copolymers between CPDT and DPP (PCP), CPDT and 3TT (PCT), and compared their properties with the ternary copolymers. The optical band gaps of the five polymers were all lower than 1.9 eV, and they all showed abundant color changes. During the oxidation process , PCPT-1 changed from purple to cyan-gray and turned to earthy brown finally, PCPT-2 changed from purple in a neutral state to blue-gray in an oxidized state. Similarly, PCPT-3 turned from purple to cement gray and finally oxidized to light blue. PCP polymer changed from dark green in a neutral state to cement gray in an oxidized state, PCT polymer changed from purple in a neutral state to Light gray purple in an oxidized state. The electrochromic kinetic performance study showed that the response time of the five polymers was about 1 s within a 4-second interval. In the dynamic stability test of 750 cycles (6000 s), the five polymers demonstrated good stability. The contrast retention of polymer PCPT-2 at 570 nm reached to as high as 96.17%.
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DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 3
·期 7
·3777-3784
·
IF 0
Guojian Tian,Shengyun Cai,Xin Li,Hans Ågren,Qiaochun Wang,Jinhai Huang,Jianhua Su
Two new D–A–π–A configuration metal-free organic sensitizers (T1–T2) based on 5,7-dihexyl-6,12-diphenyl-5,7-dihydroindolo[2,3-b]carbazole and a DPP unit with a bulky branched alkyl chain have been synthesized for dye-sensitized solar cells. Due to a bulky branched alkyl chain being attached to the donor and DPP unit, both compounds obtain high Voc values. Under standard global AM 1.5 solar light conditions, the T1 based-device gives a high conversion efficiency of 8.24% with a Jsc of 15.72 mA cm−2, a Voc of 0.74 V and a FF of 0.71. These excellent performances make the donor dihydroindolo[2,3-b] carbazole and DPP unit promising candidates for further application in DSCs.
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DOI
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Tiantian Wang,Jianhong Wei,Furong Shi,Hejie Wang,Jinye He,Xudong Lv,Yuan Zhou,Pengzhi Guo,Chenglong Wang,Yangjun Xia
In recent years, polymerized small molecule acceptors (PSMAs) have emerged as a promising strategy that combines the strong absorption of small molecules with the film-forming ability and stability of polymers, thereby greatly boosting the performance of all-polymer solar cells (all-PSCs). We designed a non-fused acceptor, DTBT-IC, and its polymeric counterpart, PDTBT-Br-T, by selecting DTBT as the core, bithiophene as the π-bridge, and IC as the terminal group. PDTBT-Br-T was synthesized via Stille coupling and used with PM6 as the donor to fabricate organic solar cells. The PDTBT-Br-T-based device delivered superior performance, with a VOC of 1.050 V, JSC of 9.32 mA cm−2, FF of 45.33%, and a PCE of 4.44%, outperforming the DTBT-IC-based counterpart. Morphological and structural analyses revealed that PDTBT-Br-T exhibits more ordered backbone stacking and defined phase separation, enhancing exciton dissociation and charge transport, and suppressing energy loss. The study highlights that polymerization of DTBT-IC enhances intermolecular packing and microstructure, offering critical design insights for efficient all-PSCs.
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高影响因子
Food & Function
·
2019
·Vol. 10
·期 9
·6009-6019
·
IF 3.241
Yun Yu,Xiu-Yuan Lang,Xi-Xi Li,Run-Ze Gu,Qing-Shan Liu,Rongfeng Lan,Xiao-Yan Qin
The major bioactive ingredient THSG of Polygonum multiflorum is well established for its anti-oxidation, anti-aging and anti-inflammation properties. Increasing evidence supports the capacity of THSG to ameliorate the biochemistry of neurotrophins and their downstream signaling axis in mouse models to attenuate neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In this study, the neuroprotective effects of THSG were studied in vitro and in vivo. In cultured mesencephalic dopamine neurons and SH-SY5Y cell line, it was found that THSG protected the integrity of the cell body and neurite branching from MPP+-induced toxicity by restoring the expression of FGF2 and BDNF and their downstream signaling pathways to inhibit apoptosis and promote cell survival. The inhibition of Akt signaling by LY294002 or TrkB activity by K252a eliminated the neuroprotective effects of THSG. In the MPTP-induced mouse models of Parkinson's disease, THSG ameliorated the animal behaviors against MPTP-induced neurotoxicity, which was demonstrated by the pole test and the tail suspension test. Biochemical and immunohistochemical analysis verified the THSG-mediated restoration of the FGF2-Akt and BDNF-TrkB signaling axis in the substantia nigra and corpus striatum and the recovery of dopaminergic neurons. These results establish the neuroprotective effects of THSG in vitro and in vivo and unravel the underlying mechanism against toxin-induced neural atrophy, providing a new avenue for the use and pharmacological research of edible medicine for anti-neurodegenerative diseases.
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DOI
PubMed
高影响因子
Nano Research
·
2014
·Vol. 8
·期 3
·920-930
·
IF 6.963
Zhang Juan,Liu Ying,Lv Jun,Li Genxi
A colorimetric method has been established for α-glucosidase activity assay and its inhibitor screening. The method is based on the specific recognition between 1,4-phenylenediboronic acid (PDBA) and 4-aminophenyl-α- d -glucopyranoside (pAPG), which may induce aggregation of pAPG-functionalized gold nanoparticles (AuNPs) to achieve color change of the test solution. Because pAPG is the substrate of α-glucosidase, the aggregation of AuNPs will be influenced by α-glucosidase since there is no coordination reactivity between PDBA and 4-aminobenzene, the hydrolyzed product of pAPG catalyzed by the enzyme. Therefore, a simple and easily-operated colorimetric method for the assay of α-glucosidase activity can be developed. Under the optimized experimental conditions, the ratios of absorbance at a wavelength of 650 nm to that at 520 nm vary linearly with the α-glucosidase activity within a range from 0.05 to 1.1 U/mL with a lowest detection limit of 0.004 U/mL. Moreover, using the proposed method, the inhibition effect of gallic acid and quercetin on α-glucosidase activity can be tested with IC 50 values of 1.16 mM and 1.82 μM, respectively. Thus, the method has a great potential not only for the detection of α-glucosidase activity, but also for the screening of its inhibitors.
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DOI
高影响因子
Food Analytical Methods
·
2016
·Vol. 10
·期 3
·713-726
·
IF 2.167
Feng Yunzi,Su Guowan,Sun-Waterhouse Dongxiao,Cai Yu,Zhao Haifeng,Cui Chun,Zhao Mouming
The aim of this study was to develop an effective analytical procedure to analyse the aroma-active compounds of soy sauce using headspace solid-phase micro-extraction (HS-SPME) coupled to gas chromatography-mass spectrometry/olfactometry (GC-MS/O). Optimization of SPME focusing on type of fibre, exposure time, extraction temperature and ionic strength was supported by gas chromatography-mass spectrometry (GC-MS). The optimized HS-SPME conditions were as follows: carboxen/polydimethylsiloxane (CAR/PDMS) fibre, NaCl concentration of 270 g/L, extraction temperature of 45 °C and 30-min exposure time. Under these conditions, 25 aroma-active compounds were detected in soy sauce by HS-SPME-GC-O. 2-Methylbutanal (malty), 3-(methylthio)propanal (cooked potato-like), dimethyl trisufide (sulfury, cooked onion), 2-methoxyphenol (smoky) and 2-phenylethanol (flowery) were the most intense. The overall odour impression of the CAR/PDMS-fibre-derived SPME extract detected via human sniffing resembled that of original soy sauce. The intensity of aromas detected by D-GC-O correlated well with the total peak area of GC-MS analysis. Thus, SPME coupled with D-GC-O offers an automated facile method to allow in situ optimization of SPME performance and ultimately effective analysis of aromas.
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DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Rui Hu,Da-Wen Sun,You Tian,Liang Xu,Libin Sun
Natural deep eutectic solvents (NADESs) showing higher cryoprotective effects are attracting concerns, because during the storage, system browning always occurs in aldose/amino acid-based NADESs, which generated brown substances remarkably weaken the cryoprotective effects. In this study, proline/glucose-based (PG) and proline/sorbitol-based (PS) NADESs were prepared, of which storage stability, browning profile, brown substance, and cryoprotective effects were investigated. Results showed that PG at molar ratios of 1:1, 2:1, and 3:1, as well as PS at 1:1, and 2:1 can form NADESs, among which only the PG-based ones could get browning after storage. The predominant brown substance was identified as 1-deoxy-1-L-proline- d -fructose (C 11 H 19 O 7 N, 278 m / z ), which was subsequently verified to show cytotoxicity and decrease Saccharomyces cerevisiae cells viability after cryopreservation, suggesting that the brown substance could take a negative effect on cryopreservation. This study may help to attract more concerns to the storage and cryopreservation stabilities of the NADESs in food-related applications.
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DOI
PubMed
高影响因子
Discover Nano
·
2026
·Vol. 21
·期 1
·334
·
IF 6.7
Xuan Shaoyan,Yang Shenglei,Mao Yuqin,Chen Zhiyong,Zhu Yue,Zhou Ying,Huang Jie,Zhu Xiuliang,Wang Zuhua
Lung cancer remains one of the most prevalent and lethal malignancies worldwide. Oridonin (ORI) exhibits remarkable anti-lung cancer activity. Nevertheless, its clinical application in lung cancer therapy is severely hindered by poor solubility, fast metabolism, insufficient tumor penetration, and low selectivity. In this study, we developed a redox-responsive polymeric micelle (HA-cys-TOS) targeting the CD44 receptor to improve ORI bioavailability and tumor targeting. The polymer was synthesized via esterification and verified by 1 H NMR. Our data showed that ORI@HA-cys-TOS exhibited good stability, biosafety and redox-responsive sustained release. Compared to HepG2 cells, ORI@HA-cys-TOS exhibited significantly enhanced internalization ability in A549 cells, likely due to HA binding to the CD44 receptor overexpressed on A549 cells. Unexpectedly, the enhanced targeted accumulation of ORI@HA-cys-TOS micelles in vivo was also observed in both subcutaneous and in situ lung cancer tissues. In vivo and in vitro antitumor studies demonstrated that ORI@HA-cys-TOS micelles exhibited significantly greater antitumor activity compared to free ORI. Notably, no side-effects were observed during the 21 days experimental period. This study provides an experimental basis for advancing ORI toward clinical personalized lung cancer therapy by targeting CD44 and responding to the tumor redox microenvironment.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Weiwei Zhang,Jiawen Shao,Xuanjun Zhang,Wanzhen Li,Longbao Zhu,Dongdong Sun,Lisandra L. Martin,Zuchun Zhao,Fei Ge
Glucose oxidase and CuS nanoparticles synergise with NIR photothermal therapy for antibacterial activity. • ROS-responsive GS 128 @HPQ hydrogel generates hydroxyl radicals to trigger controlled drug release. • GS 128 @HPQ hydrogel is self-healing, adhesive and mechanically stable for irregular wound treatment. • GS 128 @HPQ hydrogel accelerates diabetic infected wound healing with excellent biocompatibility. Diabetic chronic wounds are plagued by hyperglycemic microenvironments, multidrug-resistant (MDR) bacterial colonization and biofilm formation. In this study, glucose oxidase (GOx)/ 60 nm CuS nanoparticles were incorporated into an adhesive phenylboronic acid-modified, hyaluronic acid/quaternized chitosan (HA-PBA/QCS) dynamic boronate hydrogel (GS 128 @HPQ). GOx catalyzes glucose to generate H 2 O 2 , and CuS, under 808 nm near-infrared irradiation, acts as a Fenton-like catalyst to generate ·OH and also displays photothermal activity that elevates local temperatures to 45–65 °C in vitro, resulting in a synergistic antibacterial effect. The hydrogel has a porous structure with a pore size of approximately 50 μm, exhibits reactive oxygen species (ROS)-responsive drug release, possesses excellent mechanical properties including favorable rheological behavior, a tensile strength of 140 kPa, and self-healing capacity, and demonstrates adhesion properties ideal for wound dressing applications. In vitro, HA-PBA/QCS showed >98% MDR bacterial and more than 85% biofilm clearance. In diabetic mouse infected wound models, the wound area was <5% on Day21, with a > 70% downregulation of inflammation biomarkers IL-6/TNF-α and upregulation of VEGF/CD31, enables rapid re-epithelialization and collagen maturation, while the hydrogel has a hemolysis rate of less than 5%. This hydrogel provides a safe, efficient, and multifunctional platform for treating chronically infected diabetic wounds. Schematic diagram illustrating the synthesis pathway of the GS 128 @HPQ hydrogel and its application in diabetic wound repair through a combined chemo-photothermal antibacterial strategy. (Created in BioGDP). Download: Download high-res image (169KB) Download: Download full-size image
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高影响因子
ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 29
·21624-21633
·
IF 7.3
Zong Ziang,Qu Chaomin,Ding Leping,Ma Xiao,Abulipizi Gulizhabaier,Fang Yanlun,Li Li,Xie Wei,Wang Jiajia,Zhou Juanjuan,Li Zhanjun
Chemi-
or bioluminescence assays have broad applications
in biomedical
analysis, yet they still suffer from a flash effect or difficulty
in maintaining time synchronization during high-throughput assays.
Persistent luminescence (PersL) nanoprobes are able to emit photons
for a rather long time without any chemical reactions and have promising
applications in developing a physi-luminescence assay. Herein, SiO 2 /Zn 2 SiO 4 :Mn,Yb,Ge nanoparticles (MYG,
Zn/Si/Mn/Yb/Ge molar ratio, 2/15/0.003/0.060/0.100) were synthesized
with PersL properties at 525 nm. Mesoporous silica nanoparticles were
used as a nanotemplate to control the size and morphology, which allowed
for gram-scale production (1.1277 g). Ge was found to be an efficient
codopant to realize the enhanced PersL of MYG. A hydrophobic azo dye,
Sudan III, was loaded onto the MYG surface to form a quenched MYG-S
nanoprobe. Under 254 nm UV illumination, Sudan III was oxidized by
H 2 O 2 , and PersL was recovered. The “OFF–ON”
PersL property of MYG-S was applied to develop a physi-luminescence
assay method for H 2 O 2 , glucose, and glucose
oxidase in serum. As the PersL of the samples in a 96-well plate was
activated by simultaneous UV illumination rather than by adding chemicals,
high-throughput photographic luminescence analysis was realized with
accuracy and repeatability. Our research indicates the promising applications
of PersL nanoprobes in developing a physi-luminescence assay.
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PubMed
高影响因子
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