ACS Nano
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2025
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IF 16
Ziqi Fang,Wenbin Zhong,Huihuang Xiong,Lizhi Zhou,Xinting Xu,Dan Ding,Yiqun Wan,Hao Wan
Bacteria have attracted enormous attention in cancer therapy due to their immunoactivating capabilities and ease of genetic engineering. However, clinical advancement is hindered by off-target toxicity, rapid clearance, and low therapeutic efficiency, demanding additional functionalization. Herein, by leveraging the universal adhesive capacity of iron-tannic acid (Fe-TA) networks, a dual-membrane-camouflaged bacterial therapeutic (VNP-AIF@Fe–TA@RH) was fabricated through fusing red blood cell membrane (RM) and PD-1-overexpressing HEK293T cell membrane (HM) on the surface of an attenuated Salmonella typhimmurium strain genetically engineered with apoptosis-inducing factor (AIF)-encoding plasmids. Camouflaged by RM, VNP-AIF@Fe–TA@RH demonstrated prolonged blood circulation and facilitated selective tumor accumulation together with the intrinsic hypoxic tropism of VNP, presenting a remarkable tumor-to-organ accumulation ratio of up to 3.76 × 107-fold. Upon reaching tumor sites, in situ AIF encoding in tumor cells induced enhanced cell apoptosis and subsequently triggered robust antitumor immune responses, which were powered by T cell dysfunction reversing endowed by HM-mediated PD-L1 immune checkpoint blockade. Consequently, the tumor immune microenvironment was effectively remodeled, as evidenced by dendritic cell maturation, effector T cell activation, macrophage phenotypic repolarization, reduced T regulatory cell infiltration, and enhanced production of pro-inflammatory cytokines. Collectively, effective inhibition of bilateral melanoma tumor growth and metastasis was accomplished. This work presented a potent bacteria-based biohybrid therapeutic, inspiring the design of effective alternatives for cancer therapy.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
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IF 4
Meiijian Wang,Hao Wang,Shiyun Lou,Dexi Tao,Yaolin Tang,Bingfang Zou,Yongqiang Wang
Liquid-phase microextraction (LPME) relies critically on precise solvent control to achieve efficient extractant recovery. To address this, we developed a magnetic microparticle-based dispersive liquid-phase microextraction (MP-DLPME) strategy, employing hydrophobic porous Fe 3 O 4 microparticles (∼1 μm) as solvent-stabilizing microcarriers. These microparticles were functionalized via covalent grafting of 3-chloropropyltriethoxysilane (CPS) and optimized porosity, enabling rigid confinement of organic solvents (e.g., 1-octanol) through dual mechanisms: (I) hydrophobic solvent anchoring to modified surfaces and (II) capillary trapping within mesopores. When applied to hydrophobic polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides (OPPs), the system generates solvent-encapsulated magnetic aggregates that dynamically fragment into microdroplets under vortex-induced shear forces, facilitating efficient analyte extraction via magnetic collection. By integrating the high efficiency of dispersive extraction with the rapid recovery of magnetic separation, the MP-DLPME method provides a robust sample pretreatment solution for environmental water analysis.
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BIOMACROMOLECULES
·
2025
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IF 5.4
Yanyao Wang,Chengcheng Zhao,Taohong He,Weipeng Zhao,Annela M. Seddon,Dave J. Adams,Honghui Yang
Abundant reversible noncovalent interactions contribute greatly to the anisotropy of supramolecular morphologies and the transformation across multiple structures. However, the trigger (group) to drive the transformation remains obscure. Herein, H-bonding between free N-terminal amines of l-tryptophan derivatives (GTCn) and DMSO, triggering a morphological transition is revealed from flat to twisted nanoribbons by tuning DMSO/H2O ratios. Corresponding dynamic macroscopic morphology evolution from an aggregated cluster to a flower-like sphere of gel is observed under an optical microscope. Combined experiments and molecular dynamics (MD) simulations establish this H-bonding as the submolecular trigger, which simultaneously induces the change of π–π stacking, from the J-type to H-type. Alkyl chains at the C-terminus modulate structural dimensions, while gel thixotropy is governed by chiral morphology. These results provide a molecular strategy for precisely triggering twisted ribbon formation in self-assembly alongside the injectable chiral gel systems visible under optical microscopy.
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ACS Nano
·
2025
·
IF 16
Shujie Li,Houde Wu,Li Guo,Xiaoyi Wang,Gang Shu,Xinxing Li,Shao-Kai Sun
Achieving high resolution while minimizing contrast agent dosage remains a key goal, yet a major challenge in contrast-enhanced computed tomography (CT) imaging. Herein, we propose an artificial intelligence-assisted low-dose high atomic number contrast agent for ultrahigh-resolution CT imaging. As a proof of concept, high-quality PEGylated hafnium oxide nanoparticles (DA-HfO2 NPs) are synthesized, exhibiting superior X-ray attenuation, high hafnium content (36%), excellent water solubility, appropriate hydrodynamic size (13.5 nm), and prolonged circulation half-life (161.9 min). High-dose DA-HfO2 NPs enable extended ultrahigh-resolution vascular imaging with a spatial resolution of 0.15 mm and a time window of at least 60 min. More importantly, by integrating artificial intelligence, the low-dose contrast agent (at 25% of the standard dose) achieves imaging quality comparable to that of the high-dose agent in both contrast density and spatial resolution, while simultaneously enhancing biosafety. This strategy enables high-resolution imaging at reduced contrast agent doses and offers a promising approach for sensitive and safe CT angiography.
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International Journal of Nanomedicine
·
2025
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IF 6.5
Qingyan Li,Weilin Zheng,Jingge Cheng,Bo Li,Yutian Lei,Huilong Guo,Youshan Xv,Jiaming Huang,Xiaoxing Liao
Introduction Diabetic wounds represent a growing clinical challenge worldwide, characterized by persistent immune dysregulation and excessive inflammation that lead to impaired healing and chronic progression.Methods To address this, we developed a composite nanosystem, termed Ru@ACEI, composed of ruthenium-incorporated hollow mesoporous silica nanoparticles loaded with angiotensin-converting enzyme inhibitors (ACEIs).Results The Ru@ACEI nanoparticles exhibit dual enzyme-mimetic activities (superoxide dismutase and catalase), effectively scavenging excess reactive oxygen species (ROS). This activity reduces cellular apoptosis and promotes endothelial cell proliferation. Following cellular uptake, Ru@ACEI catalyzes the decomposition of peroxides into water and oxygen, thereby suppressing the NLRP3/Caspase-3/Caspase-9 apoptosis pathway. The consequent improvement in endothelial cell survival helps reverse local hyperinflammation in diabetic wounds.Conclusion Collectively, these findings demonstrate that the Ru@ACEI nanosystem accelerates diabetic wound healing by mitigating the inflammatory microenvironment and downregulating the expression of pro-inflammatory factors, offering a promising therapeutic strategy for managing chronic diabetic wounds.
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ChemistrySelect
·
2025
·Vol. 10
·期 38
·e04548
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IF 2
Suad Atitalla Ageeb,Aeshah Alrubayyi,Leila Mahmoud Mokhtar,Afkar Qabil Alshammari,Inaam A. Salim,Hamouda Adam Hamouda
An issue confronting supercapacitors is the sustainability of their materials. Consequently, our research has concentrated on creating eco-friendly materials that have elevated energy density. We synthesized and regulated nitrogen-doped activated carbon from wheat husks (NWHC) using urea and FeCl 2 . We used techniques such as XRD, SEM, TEM, TGA, XPS, Raman spectra, and N 2 adsorption–desorption isotherm. The NWHC-800 has a large surface area of 1134.78 m 2 g −1 , a high nitrogen content of 5.25 wt.%, and is excellent at attracting water. The NWHC demonstrates exceptional electrochemical performance as an electrode material for supercapacitors. The symmetric supercapacitor, which is manufactured using the NWHC-800//NWHC-800 configuration, has an energy density of 21.33 Wh kg −1 at a power density of 450 W kg −1 . It also has exceptional cycling stability, with 87.2% retention of specific capacitance after 10,000 cycles. We obtained these results in a voltage range of 1.8 V using a 0.5 M Na 2 SO 4 aqueous solution. These results indicate that using NWHC-800 as the electrode material is a good choice for making high-performance supercapacitors. Graphical Our research focused on developing environmentally friendly materials with high energy density. We fabricated and structured nitrogen-enriched wheat husk activated carbon (NWHC) using urea and iron chloride. We used techniques such as XRD, SEM, TEM, TGA, XPS, Raman spectroscopy, and nitrogen adsorption equation.
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Advanced Healthcare Materials
·
2025
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IF 9.6
Huanhuan Wu,Haoyu Wang,Jinwen Wei,Gang Shu,Shao-kai Sun,Cai Zhang,Dong Li
Acquiring multidimensional tumor and tumor-associated vascular information is essential for accurate diagnosis and treatment planning of glioma, yet effective imaging methods are still lacking. Here, ultrasmall manganese ferrite nanoparticles (UMFNs) are developed as a dual contrast-enhanced T 1 -weighted imaging (T1WI) and susceptibility-weighted imaging (SWI) probe for multidimensional diagnosis of glioma. The UMFNs are synthesized through thermal decomposition and functionalized with polyethylene glycol, ensuring excellent water dispersibility and biocompatibility. Characterization studies confirm the nanoparticles’ uniform size (3.8 nm) and high stability in various media. High r 1 (6.8 m m −1 s −1 ) and r 2 * (95.1 m m −1 s −1 ) values demonstrate the superior T 1 and T 2 * enhancement capabilities of UMFNs. In vivo imaging on a 3.0 T magnetic resonance imaging (MRI) scanner demonstrates that UMFN-enhanced SWI clearly delineates tumor margins and provides sustained tumor enhancement in ultrasmall orthotopic glioma (<2 mm). Besides, UMFN-enhanced SWI reveals distinct vascular structures associated with the glioma, including tortuous, thickened vessels indicative of tumor-induced angiogenesis. Whole-brain histological analysis corroborates these findings, demonstrating dense tumor proliferation and vascular remodeling. These results highlight the potential of UMFNs as a dual-enhanced agent for the early detection and high-resolution vascular mapping of glioma, providing an advanced multidimensional method for precise diagnosis of brain tumors.
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Advanced Science
·
2025
·
IF 14.1
Runchao Dong,Hulin Wang,Jia Zhang,Hongxin Yin,Genqiang Liu,Bartosz Orwat,Beata Luszczynska,Weijun Li,Dongdong Zhang,Huan He,Zhentao Du,Shanliang Chen,Weiyou Yang
Manipulating the interfacial and surface carrier dynamics within nanostructured semiconductors is pivotal for advancing the electrical and optical performances of photoelectrochemical (PEC) photodetectors (PDs), particularly for durable underwater optical communication systems. Herein, a highly responsive and robust self-powered PEC UV PDs based on SiC/Au heterojunction nanoarrays is explored, by leveraging the synergistic effect from localized surface plasmon resonance (LSPR) of Au nanoparticles (NPs), heterojunction interfacial engineering, integrated self-supporting photoelectrode architecture, 1D nanoarray benefits, and inherent chemical stability of SiC. SiC nanowire (NW) arrays are fabricated via anodic oxidation and subsequently decorated with tailored densities of Au NPs using controlled sputtering. The as-assembled SiC-based PEC PDs demonstrate exceptional UV (375 nm) photodetection behaviors with rapid response ( τ r / τ d , 86.5/170.95 ms), high responsivity ( R λ , 1244.95 mA W −1 ), excellent detectivity ( D * , 6.35 × 10 11 Jones), and remarkable external quantum efficiency ( EQE , 412.45%). Moreover, they exhibit broad pH tolerance and excellent long-term stability against full aquatic environments. This work provides a strategic approach for designing high-performance self-powered PEC PDs for reliable underwater optical communication, such as liquid environmental monitoring, ocean exploration, and biomedical detection.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Jiamei Fu,Mengqiu Quan,Haiquan Sun,Junyi Zhou,Qingyi Xie,Minghui Cui,Xiaolin Wang,Fenglong Li,Jin Zhu,Jing Chen
In the field of sports medicine, especially in high-intensity sports such as football, basketball, and skiing, ligament injuries are extremely common. However, current artificial ligaments face multiple critical limitations, including suboptimal biocompatibility, limited host tissue integration, insufficient mechanical durability to withstand physiological stresses, and inadequate durability during long-term cyclic loading. To address these challenges, 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone (HCC), which shared structural similarity with naturally occurring chalcones, is employed as the raw material for the chain extender, combined with HMDI and polycaprolactone diol (PCL diol), to synthesize a novel polyurethane (HCMPU). The results showed that the maximum stress of HCMPU-3 reached 42.1 MPa, with an elongation at break of up to 710%. It also demonstrated outstanding durability, maintaining structural integrity without significant degradation after 5000 loading cycles. Additionally, during the initial implantation period, its stability in an enzymatic environment can provide strong support to the human body before new tissue regeneration, making it a promising candidate for an ideal artificial ligament. Moreover, the favorable biocompatibility of HCMPUs is demonstrated through cytotoxicity testing and rat pathological staining sections. Therefore, this work demonstrated the potential of HCMPU to overcome key limitations in current artificial ligaments and advance the development of next-generation materials for ligament repair.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Hao Cui,Chen Ni,Mengmeng Wang,Jie Huang,Danyang Qu,Jinfeng Yang,Xingqi Pan,Zhenbao Liu,Meilin Shi
Breast cancer progression is closely associated with hypoxia, which severely limits the efficacy of conventional therapy. In addition, the lack of real-time imaging hampers accurate monitoring of therapeutic processes, further reducing treatment precision and efficacy. Here, the rational design of a multifunctional nanoplatform that integrates hypoxia relief, dual-modality imaging, and synergistic therapy to overcome these barriers is reported. Mesoporous polydopamine nanoparticles are engineered and sequentially functionalized with the sonosensitizer chlorin e6 (Ce6), oxygen-generating manganese dioxide, and the targeting antibody cetuximab, yielding MPDA-Ce6@MnO 2 -C225 (MCMC NPs). This construct exhibits a uniform nanoflower-like architecture, high Ce6 encapsulation efficiency, and robust oxygen supply capacity. By simultaneously enhancing reactive oxygen species generation and chemodynamic activity, MCMC NPs achieve potent SDT/CDT synergy under ultrasound activation. Importantly, they provide sensitive dual-modality fluorescence and magnetic resonance (MR) imaging, enabling real-time monitoring of nanoparticle distribution and therapeutic response. In vitro studies confirm excellent biocompatibility, targeted uptake by 4T1 breast cancer cells, and significant MRI signal enhancement. In vivo, MCMC NPs effectively alleviate tumor hypoxia, markedly suppress tumor growth, and prolong therapeutic response. This study establishes MCMC NPs as a versatile nanotheranostic platform that integrates imaging with oxygen-augmented SDT/CDT, offering a promising strategy for precise and effective breast cancer treatment.
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ANALYTICAL CHEMISTRY
·
2025
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IF 6.7
Xiaoxuan Ren,Yue Sun,Shengjie Li,Xuwen Gao,Guizheng Zou
The unary nanocrystals (NCs) of copper are frequently employed as a catalyst, sensitizer, and energy transfer mediator of chemiluminescence (CL). Herein, the direct and defect-involved CL of copper NCs (CuNCs) for the semiautomatic immunoassay is proposed with bovine serum albumin (BSA)-stabilized CuNCs (BSA-CuNCs) as luminophores. The biocompatible BSA-CuNCs are a kind of n-type NC that can directly give off flash CL via charge annihilation between its endogenous electrons and exogenously injected holes by the coexisting oxidative activators. Potassium hexacyanoferrate(III) (K3[Fe(CN)6]) can trigger BSA-CuNCs with efficient CL around ∼701 nm, a waveband longer than all commercial-available CL reagent kits. The coexisting citric ion can also directly reduce the hole-injected BSA-CuNCs to further enhance CL emission. The CL of BSA-CuNCs/K3[Fe(CN)6] in citrate buffer is consequently utilized to detect myoglobin on the commercialized and semiautomatic IVD device, which exhibits improved determination performance compared to the commercially available CL reagent kits, with a wide linear response range from 0.25 to 1000 pg/mL and a limit of detection of 0.10 pg/mL (S/N = 3). BSA-CuNCs can be safely stored in pure water and label protein without unintended precipitation, which might provide an alternative to the molecule tagged CL reagent kits.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
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IF 11.3
Tao Luo,Hao Wang,Tao Chen,Jing Xu,Jean-François Boily,Feng Wu,Khalil Hanna
Pyrite, a ubiquitous sulfide mineral, exerts a strong influence on the fate of coexisting As(III) and As(V) species in natural settings, such as gold deposits, sedimentary basins, and hydrothermal systems. However, the As(III) adsorption and oxidation mechanisms on pyrite at neutral pH remain contested. Through oxic and anoxic kinetic experiments using pyrite with varying oxidation degrees, we demonstrate that As(III) adsorbs preferentially to the Fe(III) (oxy)(hydr)oxide coatings rather than to pyrite sites. Contrary to prevailing assumptions, the HO• radicals contribute minimally to As(III) oxidation at circumneutral pH. Spectroscopy and molecular simulations revealed that pyrite-generated H2O2 oxidizes As(III) via an inner-sphere electron transfer process. This heterogeneous oxidation likely proceeds through a ternary surface complexation involving arsenite and Fe sites. These findings challenge both the conventional radical-dominated pathway and the assumed mechanism of natural arsenopyrite formation. By elucidating the dominant As(III) sorption/oxidation pathway on pyrite surfaces, our findings reshape our current understanding of arsenic geochemistry. They also inform risk assessment and remediation strategies for arsenic-impacted environments.
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