ACS Applied Energy Materials
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2021
·
IF 6.024
Meiwan Chen,Dechao Niu,Jiayi Mao,Guangyu Jiang,Kaiyuan Li,Gaoxu Huang,Xiaopan Jin,Yongsheng Li
Though great progresses have been made on improving the volume effect and electronic conductivity of anode materials in sodium-ion batteries (SIBs), the electrical performance at high current density for long cycling stability is still a huge challenge. To address this, a facile confined-impregnation/crystallization strategy is developed to construct a movable Fe2O3 core in nitrogen-doped hierarchical porous carbon nanospheres (MFe2O3@N-HCNs) for ultrafast intercalation/deintercalation of SIBs. The as-prepared MFe2O3@N-HCNs not only exhibit a connected and hierarchal porous structure with large surface specific area (∼367 m2 g–1) but also possess a highly dispersed and moveable Fe2O3 core (∼5 nm) for the tolerance of volume expansion during the intercalation/deintercalation process of sodium ions. As SIBs anode materials, the MFe2O3@N-HCNs anode exhibits a capacity of 417 mAh g–1 at 0.1 A g–1 after 100 cycles and of 364 mAh g–1 at 2 A g–1 with 4500 cycles. Especially, a prominent discharge capacity of 102 mAh g–1 is still obtained at 5 A g–1 after 10000 cycles. Such remarkable performances should be attributed to the unique highly dispersed and moveable Fe2O3 core and conductive nitrogen-doped hierarchical porous carbon framework with large surface area. Consequently, this study develops a facile methodology to promote the energy storage and long cycling performance of hierarchically porous carbon@transition-metal oxide (TMO) composite anode materials for SIBs, especially at high current density.
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Food & Function
·
2021
·Vol. 12
·期 16
·7440-7447
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IF 5.396
Ying Li,Bo Chen,Hai-Yan Cao,Jing-En Li,Ling-Li Chen,Qing-Feng Zhang
Bambusa multiplex cv Fernleaf (B. multiplex) is a species of bamboo. In the present study, B. multiplex leaf extract was prepared through the resin absorption/desorption procedure and analyzed by HPLC. C-Glycosyl flavonoids are the main constituents of B. multiplex extract, and the content of isoorientin and vitexin was 51.8 and 23.1 mg g−1, respectively. Besides, the extract exhibited inhibitory activities on pancreatic lipase and α-glucosidase with IC50 values of 0.91 and 1.16 mg mL−1, respectively. The extract could bind to pancreatic lipase and showed mixed-type inhibition. An in vivo study showed that pre-administration of B. multiplex extract significantly reduced the fat absorption in rats and increased fat excretion through feces. The change in the C-glycosyl flavonoid content in feces was the same as that in the triglyceride content. The inhibitory activity of B. multiplex leaf extract on pancreatic lipase was confirmed both in vitro and in vivo.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2021
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IF 7.963
Si-Si Liu,Jin-Ling Li,Lin-Ke Ge,Cai-Lin Li,Jian-Liang Zhao,Qian-Qian Zhang,Guang-Guo Ying,Chang-Er Chen
Fluoroquinolones (FQs) have raised significant concerns due to their ubiquitous occurrence and promoting of antimicrobial resistance (AMR). In this study, a molecularly imprinted polymer-diffusive gradient in thin-films (MIP-DGT) sampler is developed for selective measurement of FQs in waters by using a commercial available MIP material as the binding agent. The MIP-DGT shows selective adsorption of the FQs and linearly accumulates the FQs over the deployment time. MIP-DGT measurement is independent of pH (6–8) and ionic strength (IS) (0.01–0.5 M) but is affected by DOM at higher concentrations (~10 mg•L −1 ), which is due to the altered diffusion coefficients and reduced adsorption on the MIP binding gel. Significant interaction effects of DOM with pH or IS indicate that this is the predominant influence on the MIP-DGT performance, which results in a lower measurement by the MIP-DGT but this is curtailed to some extend with increasing IS or pH. The MIP-DGT measurements, however, correlate well with those by grab sampling in a wastewater treatment plant , suggesting it is reliable for measuring FQs in waters. For the first time, we demonstrate that key water chemistry parameters do have interaction effects on the DGT measurements, which should be considered for the data interpretation. The MIP-DGT is a promising tool to understand the interaction effects of the environmental parameters on the fate, behaviours and bioavailability/toxicity of organic contaminants and improve environmental risk assessments in the environment and modelling.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Hao Xincai,Sun Xiaodong,Zhu Haizhen,Xie Lixia,Wang Xuanbin,Jiang Nan,Fu Pan,Sang Ming
Trans-resveratrol (RES) exhibits a wide range of biological activities. Various methodological approaches have been established to improve the pharmacokinetic properties of RES. Moreover, additional in vivo studies are required to support clinical application. In this study, RES/HP-β-CD (RHSD) inclusion complex was prepared and characterized by FTIR, PXRD, DSC and NMR data. The effect and potential mechanism of RHSD against cervical cancer were investigated in a mouse xenograft tumor model by qPCR assay, Western blot assay, and immunohistochemical assay. Results showed that RHSD significantly decreased tumor growth compared with free RES, while the effect of preventing tumor growth was more prominent in vivo. Notably, RHSD could inhibit tumor development by suppressing the expression of HPV E6 and E7 oncogenes and upregulating P53 and Rb1 protein in cervical cancer. These findings demonstrated that RHSD was safe and potential for development of a new oral administration drug to treat cervical cancer.
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Journal of Cleaner Production
·
2021
·
IF 9.297
Yafei Zhang,Hui Liu,Keyong Tang,Jie Liu,Xiumin Li
Large amounts of water and leather chemicals such as sodium sulfide and calcium hydroxide are used in conventional leather production, resulting in huge amount of wastewater and serious environmental pollution . Enzyme is eco-benign, and an ideal alternative to conventional chemicals attributed to its excellent characteristics and high efficiency. In this work, enzymes with different ions are used in beamhouse to remove the interfibrillar substance and open collagen fiber bundles. Analysis of the opened collagen fibers shows that the enzyme with both hydrogen phosphate and magnesium ions have the best effect in opening collagen fiber bundles. Results of wastewater analysis and the staining of hematoxylin-eosin (H&E) and Verhoeff’s Van Gieson (EVG) indicated the excellent removal of interfibrillar substance by all ion-assisted trials, suggesting an improved removal efficiency. The mechanical properties and shrinkage temperature of the leathers are similar to those of the conventional leathers. Since both deliming and bating are no longer required, a large amount of water can be saved, the leather making time can be shortened, and the cost of wastewater treatment can be reduced. Ion-assisted enzyme method is more efficient and environmentally friendly than the conventional one with sodium sulfide. This work presents a promising path for the cleaner leather making.
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RSC Advances
·
2021
·Vol. 11
·期 6
·3770-3776
·
IF 3.361
Guangtao Qian,Fengna Dai,Haiquan Chen,Mengxia Wang,Mengjie Hu,Chunhai Chen,Youhai Yu
5-Amine-2-(4-amino-benzene)-1-phenyl-benzimidazole (N-PhPABZ) was successfully synthesized and polymerized with 3,3′,4,4′-biphenyl tetracarboxylic dianhydride (BPDA) to obtain a novel N-phenyl-poly(benzimidazole imide) (N-Ph-PBII). The successful incorporation of N-phenyl addressed the issue of high H2O-absorption of traditional PBIIs while retained the superheat resistance property. The resulting N-Ph-PBII possessed a high glass-transition temperature (Tg) up to 425 °C and a low affinity for water of 1.4%. Furthermore, the loose molecular packing and noncoplanar structures led to an increase in optical transparency for the modified PBII.
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JOURNAL OF MEMBRANE SCIENCE
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2020
·
IF 7.183
Shuai Wang,Zhong-yang Wang,Jian-zhong Xia,Xiao-mao Wang
Membrane surface properties play important roles in determining the rate and severity of membrane fouling . This paper reported an innovative nanofiltration (NF) membrane called PENF which had a poly(piperazine-amide) active layer formed on a polyethylene (PE) support layer. The PENF membrane was very attractive in that millimeter-sized surface patterns could be automatically formed by the pressing effect of applied pressure for which permeate spacer acted as the in situ imprinter. This was attributed to the thin and tough PE support layer, which could be easily deformed under the applied pressure for NF applications. The surface-patterned PENF membrane (PENF-P) demonstrated greatly enhanced resistance to organic, inorganic and scaling fouling as well as combined fouling, when compared to either the original PENF membrane or commercial NF membranes like NF270. Without surface patterns, the PENF membrane along with other NF membranes followed a same general rule in resisting membrane fouling; a more hydrophilic NF membrane was generally more resistant to fouling. Membrane integrity breaches caused by surface deformation and patterning were negligible in terms of glucose rejection and water permeability coefficient. The PENF-P membrane could reject glucose by >80% at an applied pressure of 3.5 bar and had a water permeability coefficient of >11 L/m 2 /h/bar. A continuous running of a small-size spiral-wound element of the membrane (0.85 m 2 ) for over 3000 h confirmed that the PENF membrane had a long-time consistently high performance in terms of water permeation and solute rejection. The innovative PENF membrane and the involved surface patterning technique are expected to have a bright application prospect for water treatment and wastewater reclamation.
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Frontiers in Cellular Neuroscience
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2020
·
IF 3.921
Xu Yi,Zhang Shuai,Sun Qiang,Wang Xu-Qiao,Chai Ya-Ni,Mishra Chandan,Chandra Shah Ram,Ai Jing
Chronic cerebral hypoperfusion (CCH) is considered a preclinical condition of mild cognitive impairment and thought to precede dementia. However, as the principal cholinergic source of hippocampus, whether the septo-hippocampal neurocircuit was impaired after CCH is still unknown. In this study, we established the CCH rat model by bilateral common carotid artery occlusion (2VO). Under anesthesia, the medial septum (MS) of rats was stimulated to evoke the field excitatory post-synaptic potential (fEPSP) in the pyramidal cell layer of dCA1. Consequently, we observed decreased amplitude of fEPSP and increased paired-pulse ratio (PPR) after 8-week CCH. After tail pinch, we also found decreased peak frequency and shortened duration of hippocampal theta rhythm in 2VO rats, indicating the dysfunction of septo-hippocampal neurocircuit. Besides, by intracerebroventricularly injecting GABAergic inhibitor (bicuculline) and cholinergic inhibitors (scopolamine and mecamylamine), we found that CCH impaired both the pre-synaptic cholinergic release and the post-synaptic nAChR function in MS–dCA1 circuits. These results gave an insight into the role of CCH in the impairment of cholinergic MS–dCA1 neurocircuits. These findings may provide a new idea about the CCH-induced neurodegenerative changes.
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FOOD CHEMISTRY
·
2020
·
IF 6.306
Pengfei Wang,Naiyi Yin,Xiaolin Cai,Huili Du,Yaqi Fu,Ziqi Geng,Sharmin Sultana,Guoxin Sun,Yanshan Cui
Rice, a staple food for half the world’s population, easily accumulates arsenic (As). Research on As distribution in rice protein and starch and its relationship with rice As bioaccessibility remains limited. This study investigated As distribution, chemical composition, As bioaccessibility and speciation in rice by continuous extraction and in vitro digestion. Of the total As, 87.5–94.5% was in rice protein and 5.0–9.8% in rice starch. The As amount in different protein fractions decreased as follows: glutelin > globulin > albumin > prolamin. As(V), As(III) and DMA in rice were more bioaccessible in the small intestinal phase than the gastric phase, and almost all As(V) dissolved in the small intestinal phase. Bioaccessible As in gastrointestinal digestive solution and As mass in protein fractions (albumin, globulin, and glutelin) were significantly positively correlated ( p < 0.05). These results illuminate the bioaccessibility of As to humans consuming As-contaminated rice and avoid overassessment.
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ACTA PHARMACOLOGICA SINICA
·
2020
·Vol. 42
·期 6
·987-997
·
IF 5.064
Liu Qiu-yan,Zhuang Yu,Song Xian-rui,Niu Qun,Sun Qiu-shuang,Li Xiao-nan,Li Ning,Liu Bao-lin,Huang Fang,Qiu Zhi-xia
Metabolic reprogramming is associated with NLRP3 inflammasome activation in activated macrophages, contributing to inflammatory responses. Tanshinone IIA (Tan-IIA) is a major constituent from Salvia miltiorrhiza Bunge, which exhibits anti-inflammatory activity. In this study, we investigated the effects of Tan-IIA on inflammation in macrophages in focus on its regulation of metabolism and redox state. In lipopolysaccharides (LPS)-stimulated mouse bone marrow-derived macrophages (BMDMs), Tan-IIA (10 μM) significantly decreased succinate-boosted IL-1β and IL-6 production, accompanied by upregulation of IL-1RA and IL-10 release via inhibiting succinate dehydrogenase (SDH). Tan-IIA concentration dependently inhibited SDH activity with an estimated IC 50 of 4.47 μM in LPS-activated BMDMs. Tan-IIA decreased succinate accumulation, suppressed mitochondrial reactive oxygen species production, thus preventing hypoxia-inducible factor-1α (HIF-1α) induction. Consequently, Tan-IIA reduced glycolysis and protected the activity of Sirtuin2 (Sirt2), an NAD + -dependent protein deacetylase, by raising the ratio of NAD + /NADH in activated macrophages. The acetylation of α-tubulin was required for the assembly of NLRP3 inflammasome; Tan-IIA increased the binding of Sirt2 to α-tubulin, and thus reduced the acetylation of α-tubulin, thus impairing this process. Sirt2 knockdown or application of Sirt2 inhibitor AGK-2 (10 μM) neutralized the effects of Tan-IIA, suggesting that Tan-IIA inactivated NLRP3 inflammasome in a manner dependent on Sirt2 regulation. The anti-inflammatory effects of Tan-IIA were observed in mice subjected to LPS challenge: pre-administration of Tan-IIA (20 mg/kg, ip) significantly attenuated LPS-induced acute inflammatory responses, characterized by elevated IL-1β but reduced IL-10 levels in serum. The peritoneal macrophages isolated from the mice displayed similar metabolic regulation. In conclusion, Tan-IIA reduces HIF-1α induction via SDH inactivation, and preserves Sirt2 activity via downregulation of glycolysis, contributing to suppression of NLRP3 inflammasome activation. This study provides a new insight into the anti-inflammatory action of Tan-IIA from the respect of metabolic and redox regulation.
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JOURNAL OF FOOD SCIENCE
·
2021
·Vol. 86
·期 2
·546-562
·
IF 3.167
Yadi Liu,Guoxiao Lai,Yinrui Guo,Xiaocui Tang,Ou Shuai,Yizhen Xie,Qingping Wu,Diling Chen,Xujiang Yuan
Previous research has shown that the extracts from the Ganoderma lucidum spore (GS) have potentially cardioprotective effects, but there is still abundant room for development in determining its mechanism. In this study, the rat model of cardiac dysfunction was established by intraperitoneal injection of trimethylamine- N -oxide (TMAO), and the extracts of GS (oil, lipophilic components, and polysaccharides) were given intragastrically at a dose of 50 mg/kg/day to screen the pharmacological active components of GS. After 50 days of treatments, we found that the extraction from GS reduced the levels of total cholesterol, triglyceride, and low-density lipoprotein; increased the levels of high-density lipoprotein; and reduced the levels of serum TMAO when compared to the model group ( P < 0.05); especially the GS polysaccharides (DT) and GS lipophilic components (XF) exhibited decreases in serum TMAO compared to TMAO-induced control. The results of 16S rRNA sequencing showed that GS could change the gut microbiota, increasing the abundance of Firmicutes and Proteobacteria in the DT-treated group and XF-treated group, while reducing the abundance of Actinobacteria and Tenericutes . Quantitative proteomics analysis showed that GS extracts (DT and XF) could regulate the expression of some related proteins, such as Ucp1 (XF-TMAO/M-TMAO ratio is 2.76), Mpz (8.52), Fasn (2.39), Nefl (1.85), Mtnd5 (0.83), Mtnd2 (0.36), S100a8 (0.69), S100a9 (0.70), and Bdh1 (0.72). The results showed that XF can maintain the metabolic balance and function of the heart by regulating the expression of some proteins related to cardiovascular disease, and DT can reduce the risk of cardiovascular diseases by targeting gut microbiota.
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JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Yifan Li,Hong Sun,Zhen Tian,Yue Li,Xuan Ye,Ruichi Li,Xinyu Li,Shengli Zheng,Jiyuan Liu,Yalin Zhang
The long-term and excessive use of insecticides has led to severe environmental problems and the evolution of insecticide resistance in insects. Carboxylesterases (CarEs) are important detoxification enzymes conferring insecticide resistance on insects. Herein, the detoxification process of Plutella xylostella (L.) carboxylesterase 6 (PxEst-6), one representative P. xylostella carboxylesterase, is investigated with cypermethrin, bifenthrin , cyfluthrin and λ-cyhalothrin. RT-qPCR shows that PxEst-6 is highly expressed in the midgut and cuticles of the third instar larvae. Exposure to pyrethroid insecticides resulted in PxEst-6 up-regulation in a short time. Metabolic assays indicate that PxEst-6 has the capacity to metabolize these pyrethroid insecticides. The combination of molecular docking, binding mode analyses and alanine mutations demonstrated that His451, Lys458 and Gln431 were key residues of PxEst-6 for metabolizing pyrethroids and the acetate groups derived from pyrethroids were key sites for being metabolized by PxEst-6. H451- and K458-derived hydrogen bond (H-bond) interactions with the pyrethroid acetate groups and the polar interactions with the pyrethroid acetate group provided by the Q431 sidechain were crucial to the pyrethroids’ metabolism by PxEst-6. Our study contributes to revealing the reasons for pyrethroid resistance in P. xylostella , and provides a fundamental basis for the development of novel pyrethroid insecticides.
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