SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Junhao Li,Jiawei Wang,Xinyu Yuan,Zhikun Wang,Shuangqing Sun,Qiang Lyu,Songqing Hu
At present, endocrine-disrupting chemicals (EDCs) and heavy metals (HMs) are increasingly polluting water. In this work, we prepared a sulfhydryl-rich β-cyclodextrin polymer (SH-CDP) for the adsorption of Pb 2+ and bisphenol A (BPA), as the representatives of HMs and EDCs, respectively. SH-CDP have excellent adsorption performance with theoretical maximum adsorption capacity of 604.65 mg/g and 287.88 mg/g for Pb 2+ and BPA, respectively. The adsorption process of Pb 2+ by SH-CDP reaches equilibrium quickly within 60 s because of chelation between Pb 2+ and sulfhydryl group, suggesting an ultra-fast adsorption rate. Since the adsorption sites of Pb 2+ and BPA by SH-CDP are independent, the adsorption performance is still favorable under the coexistence of Pb 2+ and BPA. Furthermore, SH-CDP maintains stable adsorption performance after five consecutive cycles. These results demonstrate that SH-CDP is a potential material capable of effectively treating HMs and EDCs in wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOORGANIC CHEMISTRY
·
2023
·
IF 5.1
Xuchen Feng,Jun Ge,Hui Fu,Lin Miao,Feng Zhao,Jingyu Wang,Yujiao Sun,Yingpeng Li,Yunfei Li
Small molecules directly downregulating β-catenin could potentially offer a more effective therapeutic approach for combating against cancer stem cells, as compared to targeting the downstream components of the Wnt/β-catenin pathway. The challenge, however, lies in the fact that very few β-catenin suppressors have proven clinically effective, leaving a significant gap in medical solutions. Given that E-cadherin has a natural affinity for β-catenin, it stands to reason that agents designed to increase E-cadherin expression might provide an alternative method of regulating β-catenin levels. In this study, we report our discovery of DSS-C12 and DSS-B8, specific ester-based drugs derived from Dan-Shen-Su (DSS) extracted from the herb Salvia miltiorrhiza . Remarkably, these compounds display a potent ability to downregulate β-catenin, while also improving overall survival in post-surgery mice. Additionally, when these drugs are used in combination with PD-L1 checkpoint blockade, they stimulate enhanced systemic immune responses leading to significant suppression of primary tumor growth. In-depth mechanistic studies revealed that DSS-B8 functions as a vitamin D receptor agonist without inducing hypercalcemic effects. Collectively, our findings indicate that DSS-derived small molecules have considerable potential as clinically viable therapeutic strategies for β-catenin deactivation.
研究领域:
肿瘤学
·
药理学
·
免疫学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CRYSTAL GROWTH
·
2021
·
IF 1.797
Qi Pan,Honglei Zhang,Xueyong Guo,Wanjun Zhao,Xuekun Fan
In this study, the effects of dopamine, binder and plasticizer on the crystal transformation of β-HNIW were investigated. By a simple preparation method, dopamine, plasticizer and binder were coated on the surface of β-HNIW. The characterization results of SEM , DSC and XRD show that the four dopamine polymers, three binders and four plasticizers form a stable polymer film on the surface of β-HNIW crystal. The crystal transformation temperature of β-HNIW crystal coated with dopamine polymer is delayed to varying degrees, and the crystal transformation temperature is significantly improved about 40 °C. Dopamine polymers effectively inhibit the crystal transformation of β-HNIW, improving the thermal safety of β-HNIW. The three binders have inhibitory effect on the crystal transformation of β-HNIW, and four plasticizers promote the crystal transformation of β-HNIW. Dopamine and binder have an inhibitory effect on the β-HNIW crystal transformation, while the plasticizer has a promoting effect on the β-HNIW crystal transformation.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2016
·
IF 3.652
Huidong Zheng,Jinliang Chen,Chao Li,Jingjing Chen,Yingshu Wang,Suying Zhao,Yanru Zeng
Myrcene, an important intermediate for the production of fine chemicals and pharmaceuticals, is mainly produced by the pyrolysis of β-pinene in the industry. The study of the direct pyrolysis of β-pinene was carried out without a catalyst and carrier gas at 573–873 K and under low pressure. In order to clarify the reaction mechanism, the primary intermediates of β-pinene pyrolysis including myrcene and limonene were also used as raw materials for further pyrolysis. The identification of some small molecules and C 10 H 16 isomers in the products proves that both decomposition reaction and ene reaction take place during the pyrolysis process. Based on the qualitative and quantitative analysis of reaction products, a reaction scheme for the pyrolysis of β-pinene was proposed. With appropriate simplification of the reaction scheme, a phenomenological kinetic model of the competitive parallel and consecutive first-order reaction was built, and exhibited good agreement with the experimental data. The activation energy ( E a ) and pre-exponential factor ( k 0 ) for each pathway were also determined.
研究领域:
化学工程
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Yang Liu,Chuang Lang,Yaping Ding,Siyu Sun,Guangwei Sun
Chitosan (CS)/β-sodium glycerophosphate (β-GP) gels have low temperature sensitivity, which limits their biomedical application. The protonation and deprotonation of the CS amino groups are regulated by pH. It is possible to accelerate thermosensitive gelation by increasing the pH of the CS solution to maximize the degree of CS amino deprotonation and enhance hydrophobic interactions. In this study, a CS solution with a higher pH (HpHCS; pH 6.19, close to pKa 6.2) was obtained by means of the consumption of hydrogen ions using excessive chitosan. Raman spectroscopy showed that strong hydrogen bonds might exist in HpHCS. Gelation was accelerated significantly at 37 °C using HpHCS due to the decreased sol–gel transition temperature. Support vector machine and t-distributed stochastic neighbor embedding analyses confirmed that the gel derived from HpHCS was significantly different from that of the other groups. In addition, the HpHCS gel exhibited a low degradation rate and low cytotoxicity. Furthermore, a mathematical equation was established to predict the gelation time of HpHCS/β-GP at 37 °C. A better concentration of HpHCS for in vivo injection was obtained due to the shorter gelation time and lower viscosity. We found that human mesenchymal stem cells survived and proliferated in vitro in the HpHCS/β-GP hydrogel. Therefore, this study provides an optimized HpHCS solution with enhanced deprotonation for accelerated thermosensitive gelation with β-GP.
研究领域:
生物材料
·
医学工程
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Ling Tang,Jinqing Chen,Jiali Luo,Huijuan Wei,Lina Lan,Hailan Qin,Qiumei He,Xiangyu Kong,Liting Lai,Wenya Ding,Jian Xiao
Dihydromyricetin (DMY), the main functional component of vine tea, exhibits multiple biological activities and is widely used in food applications such as dairy products, functional foods, and food additives. However, its poor stability and bioavailability limit its broader utilization. To address this, CCGT-DMY-NPs were successfully prepared using chitosan-grafted-β-cyclodextrin (CS-CD), gelatin-grafted-β-cyclodextrin (Gel-CD), and vitamin E polyethylene glycol succinate (TPGS). The CCGT-DMY-NPs exhibited a particle size of 216.33 ± 7.23 nm, a polydispersity index of 0.207 ± 0.011, a zeta potential of 25.67 ± 4.53 mV, and an encapsulation efficiency of 98.21 ± 2.44 %, with significantly improved stability compared to free DMY. In vitro cellular uptake studies using confocal laser scanning microscopy (CLSM) and flow cytometry (FCM) confirmed enhanced uptake of CCGT-DMY-NPs in Caco-2 cells. In vitro unidirectional intestinal perfusion demonstrated that CCGT-DMY-NPs significantly increased the apparent permeability coefficient (P app ) and absorption rate constant (Ka) across duodenal, jejunal, and ileal segments ( p < 0.01), with jejunal P app reaching 2.47 ± 0.59 × 10 −2 cm/min compared to 0.26 ± 0.06 × 10 −2 cm/min for free DMY. Mechanism studies indicated that the enhanced absorption was attributed to mucoadhesion, tight junction opening, and involvement of multiple endocytic pathways (clathrin-, caveolin-, non-caveolin-, and non-clathrin-mediated) and macropinocytosis. Pharmacokinetic studies confirmed that the area under the curve (AUC 0-t ) of CCGT-DMY-NPs was 2.20 times higher than that of oral DMY, and the relative bioavailability (F rel ) of CCGT-DMY-NPs reached 219.89 %. These findings suggest that CCGT-DMY-NPs significantly enhance the oral bioavailability of DMY through multi-mechanistic promotion of intestinal absorption, providing a promising strategy for its application in functional foods.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2017
·Vol. 28
·期 13
·9464-9470
·
IF 2.019
Xing Yangyang,Zhu Yingchun,Chang Chengkang,Wang Yunli,Wang Yang
Eu 2+ -doped β-Sialon phosphors with a composition of Eu
x
Si 5 Al 1− x
O z+ x
N 8−z− x
( x = 0.05, 0.06, 0.07) were synthesized in a new synthetic route using novel raw materials, such as nano-silicon dioxide (SiO 2 ), nano-carbon (C), and aluminum (Al). This is different from the prevailing method using Si 3 N 4 , AlN, and Al 2 O 3 to obtain β-Sialon phosphors. Compared with the conventional method, lower cost raw materials, simpler pretreatment and a relatively shorter reaction time are achieved. The phosphors show a high purity. All the phosphors exhibit green emission under ultra violet (UV) radiation. A broad band of excitation spectra implies the promising application in UV ray based green light-emitting diode (LED). Chromaticity coordinates of the β-Sialon: Eu 2+ phosphors demonstrate that it is accessible to obtain different green emissions from single phase of Eu 2+ -doped β-Sialon through adjusting Eu 2 O 3 concentration. Furthermore, the Eu
x
Si 5 Al 1− x
O 1 + x
N 7 − x
( x = 0.05) shows a better thermal stability than the commercial green-emitting silicate phosphor. These results indicate a promising prospect for this efficient and economic route in preparing β-Sialon: Eu 2+ phosphors, and the phosphors are a highly promising candidate for LED applications.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 2
·882
·
IF 4.6
Mingjun Wang,Che Li,Bingfang Liu,Wenzhen Qin,Yu Xie
Photocatalysis is a hopeful technology to solve various environmental problems, but it is still a technical task to produce large-scale photocatalysts in a simple and sustainable way. Here, nano-flower β-Bi2O3/TiO2composites were prepared via a facile solvothermal method, and the photocatalytic performances of β-Bi2O3/TiO2composites with different Bi/Ti molar ratios were studied. The nano-flower Bi2O3/TiO2composites were studied by SEM, XRD, XPS, BET, and PL. The PL result proved that the construction of staggered heterojunction enhanced the separation efficiency of carriers. The degradation RhB was applied to study the photocatalytic performances of prepared materials. The results showed that the degradation efficiency of RhB increased from 61.2% to 99.6% when the molar ratio of Bi/Ti was 2.1%. It is a mesoporous approach to enhance photocatalytic properties by forming heterojunction in Bi2O3/TiO2composites, which increases the separation efficiency of the generated carriers and improves photocatalytic properties. The photoactivity of the Bi2O3/TiO2has no evident changes after the fifth recovery, indicating that the Bi2O3/TiO2composite has distinguished stability.Keywords:Bi2O3/TiO2;heterojunction;photocatalysts;degradation RhB
研究领域:
环境科学
·
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 12
·2413-2421
·
IF 2.741
Chao Han,Jianguang Luo,Zhongrui Li,Yingqi Zhang,Huijun Zhao,Lingyi Kong
A biphasic chiral recognition system based on chiral ligand exchange with Cu(II)- N - n -dodecyl-L-proline and hydroxypropyl-β-cyclodextrin as an additive was developed to enantioseparate aromatic β-amino acids by high-speed counter-current chromatography. The biphasic chiral recognition system was established with an n -butanol/water (1:1, v/v) solvent system by adding N - n -dodecyl-L-proline and Cu(II) ions to the organic phase and hydroxypropyl-β-cyclodextrin to the aqueous phase. Several separation parameters, such as temperature, pH value, and chiral selector concentration, were systematically investigated by enantioselective liquid–liquid extraction. Under the optimal separation conditions, 54.5 mg of ( R , S )-β-phenylalanine and 74.3 mg of ( R , S )-β-3,4-dimethoxyphenylalanine were baseline enantioseparated. More importantly, the synergistic enantiorecognition mechanism, based on the Cu(II)- N - n -dodecyl-L-proline and hydroxypropyl-β-cyclodextrin, was discussed for the first time.
研究领域:
分析化学
·
手性化学
✓ 已验证
DOI
PubMed
高影响因子
BIOTECHNOLOGY LETTERS
·
2013
·Vol. 35
·期 8
·1323-1330
·
IF 1.853
Guan Liye,Di Bin,Su Mengxiang,Qian Jie
The aminopropyl-functionalized ethane-bridged bifunctional periodic mesoporous organosilicas (APEPMOs) were synthesized by the co-condensation of 1,2-bis (triethoxysilyl) ethane and 3-aminopropyltriethoxysilane in the presence of cationic surfactants octadecyltrimethylammonium chloride in basic medium. The pores of the APEPMOs were expanded with N , N -dimethyldecylamine and the pore-expanded materials were utilized as supports for β - glucosidase immobilization. A high enzyme loading of 120 mg per g support was achieved in 18 h, and 95.5 % of enzymatic activity was retained. β-Glucosidases were strongly immobilized on APEPMOs with only 5 % desorption in the washing step with buffer solution. The immobilized enzyme had 75 % activity after 20 batch reactions and had improved thermal stability, relative to the free enzyme. These results demonstrate that APEPMOs would be promising supports for β-glucosidases immobilization.
研究领域:
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYTOTHERAPY RESEARCH
·
2019
·Vol. 34
·期 4
·817-824
·
IF 3.766
Mingming Zhu,Xi Yu,Zongmei Zheng,Jiaming Huang,Xuepan Yang,Hongfei Shi
Cancer stem cells (CSCs) are considered as the origin and driving cells of cancer, and play a key role in the progress of cancer. Studies have shown that capsaicin exerted inhibitory effect on prostate cancer cells, however, the effects of capsaicin on prostate CSCs remain undefined. In the present study, we showed that capsaicin could downregulate prostate CSCs markers and inhibit the growth of PC-3 and DU145 prostate cancer stem cells. Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3β and β-catenin, along with downregulation of Wnt/β-catenin pathway target genes c-myc and cyclinD1. Using LiCl, a activator of Wnt/β-catenin pathway, we found activation of Wnt/β-catenin pathway could ameliorate the downregulation of prostate CSCs markers and the growth inhibition induced by capsaicin in prostate cancer stem cells. Those data suggested that the inhibition effect of capsaicin on prostate cancer stem cells and the anti-cancer effect of capsaicin on prostate cancer stem cell may be mediated by Wnt/β-catenin pathway. Findings from this study reveals for the first time the potential role and mechanisms of capsaicin on prostate cancer stem cells.
研究领域:
肿瘤学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DESIGNED MONOMERS AND POLYMERS
·
2023
·
IF 1.6
Yong-Fu Li,Zhu-Xi Tian,Bin Shi,Yang-Bo He,Ming-Xiu Long
β-cyclodextrin butenate was synthesized by using N, N’-Carbonyldiimidazole (CDI) activating reagent and 4-Dimethylaminopyridine (DMAP) as catalyst. The best preparation condition of β-CD butenate was described as below: reaction temperature was 25°C, concentration of 2-butenoic acid was 450 mmol/L, concentration of DMAP was 12.5 mmol/L and reaction time was 20 minutes and at this condition the yield of β-CD butenate was 0.83 mmol/g. According to the results of FT-IR spectrum, NMR spectroscopy and HPLC-QTof-mass spectrum of β-CD butenate, there were four types β-CD butenate synthesized, which were β-CD-2-butenoic acid monoester, β-CD-2-butenoic acid diester, β-CD-2-butenoic acid triester and β-CD-2-butenoic acid tetraester, respectively.
研究领域:
有机化学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）