FOOD CHEMISTRY
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2022
·
IF 9.231
Yajuan Bai,Yue Zhou,Ruifen Zhang,Yanxia Chen,Fengzhong Wang,Mingwei Zhang
Plant polysaccharides possess many health-promoting properties, which are closely related to the digestion, absorption and utilization of polysaccharides in the host. The characteristic changes in Chinese yam polysaccharide (CYP) during simulated gastrointestinal digestion and faecal fermentation, as well as the intestinal anti-inflammatory effects of CYP and fermented CYP, were studied. The molecular weight of CYP remained unchanged during gastrointestinal digestion. After 24 h of faecal fermentation, free glucose and mannose released from CYP were utilized by gut microbiota, and the production of short-chain fatty acids increased. Simultaneously, CYP improved the growth of Bifidobacterium and Megasphaera. Compared with CYP, faecal fermented CYP exhibited greater suppression of anti-inflammatory mediators and increased intestinal tight junction expression in LPS-stimulated coculture Caco-2/Raw264.7 cells. The obtained results reveal that the role of CYP in promoting gut health is closely related to the interactions between CYP and gut microbes, and CYP has potential as an anti-inflammatory adjuvant in enteritis therapy.
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Food Science and Human Wellness
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2022
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IF 8.022
Menglin Chen,Hong Yao,Huizi Tan,Wenqi Huang,Quanyong Wu,Shaoping Nie
Most scientific investigations regarding inflammatory bowel disease (IBD) pathogenesis or therapeutic strategies use dextran sulfate sodium (DSS)-induced models performed on mice. However, differences between human and animal microbiota may confound the data reproducibility from rodent experiments to clinical trials. In this study, the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis were investigated using mice colonized with either native or humanised microbiota. Disorders in disease activity index (DAI), morphology and histology of colon tissue, intestinal permeability, and secretion of MPO, TNF-α and IL-6 were ameliorated by daily intake of live B. longum NSP001 cells in both conventional and humanised colitis mice. But the abnormal thymus index, and colonic production of ZO-1 and iNOS were improved only in colitis mice treated with B. longum NSP001 and humanised microbiome. The accumulation of acetic acid and propionic acid in colon microbiome, and the optimization of primary bile acid biosynthesis and glycerophospholipid metabolism pathways in cecum commensals were likely to explain the beneficial effects of B. longum NSP001. These data revealed that intestinal microbiome baseline would possibly affect the manifestation features of interventions by probiotics or dietary components and highlighted the necessity to include humanised microbiome while investigating potential therapeutic strategies based on rodent models.
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Food & Function
·
2022
·Vol. 13
·期 22
·11744-11757
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IF 6.317
Panpan Li,Yanjun Liu,Juan Zhao,Wenjie Pan,Yuan He,Shunzhe Fu,Yuanfa Liu,Yong-Jiang Xu
Salecan, a natural β-glucan consisting of seven residues linked by β-(1→3)/α-(1→3) glycosidic bonds, is one of the novel food ingredients approved in China. β-Glucan has a variety of health-improving effects, yet its mechanism against liver injury remains poorly understood. β-Glucan can induce shifts in the gut microbiota and show health benefits; however, whether modulation of the gut microbiota by β-glucan is associated with its benefits remains unclear. Here, the hepatoprotective effect and potential mechanism of salecan supplementation using a model of CCl4-induced liver injury were investigated. After 8 weeks of treatment, salecan alleviated liver injury by regulating oxidative stress and activating the Nrf2 signaling pathway. In addition, salecan treatment modulated the composition of the gut microbiota, and the antibiotic cocktail treatment indicated that the hepatoprotective effect of salecan was dependent on the gut microbiota. Fecal microbiota transplantation was used to further verify this mechanism, and we confirmed that microbial colonization partially alleviated liver injury. Besides, microbiota-derived metabolites of salecan also contributed to the hepatoprotective effect of salecan against liver injury and inhibited oxidative stress. These findings supported that salecan intervention attenuated liver injury by regulating the gut microbiota and its metabolites.
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JOURNAL OF CATALYSIS
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2022
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IF 8.047
Yuan Yu,Chun-Xiu Liu,Xin-Yue Fan,Yun-Jie Wei,Ru-De Lin,Yao Yao,Ming-Liang Shi,Na Wang,Xiao-Qi Yu
High-efficiency photo-enzymatic synthesis of chalcone chemicals was achieved by tandem catalysis based on the photocatalytic oxidation of porphyrin-based metal organic frameworks (MOFs) confined copper nanoclusters and the non-specific catalytic activity of hydrolases. A series of photocatalysts were successfully synthesized and the Cu nanoparticles (NPs) were loaded on the materials by in-situ reduction of Cu 2+ . Subsequently, in situ oxidation of benzyl alcohol and aldol reaction catalyzed in tandem by Cu@PCN-222(M) and hydrolase were used as template reactions and the reaction conditions were systematically studied. 20 chalcone derivatives were successfully synthesized (yield up to 98 %). Finally, the optical properties difference of photocatalysts were studied by spectroscopic and electrochemical analysis. The reaction system used greener benzyl alcohol as the reaction substrate and was driven by visible light under O 2 . This method has good yield and recovery performance, which provides a new strategy for the construction of MOF-enzyme combined catalytic system.
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Food Bioscience
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2022
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IF 5.318
Xiang Li,Yan Du,Zhaoxin Tu,Chengping Zhang,Li Wang
Highland barley (HB) possesses a series of properties such as regulating lipid metabolism and attenuating liver injury. Our study aimed to investigate the effect of HB, highland barley bran (HBB), whole grain highland barley (WGHB) on lipid metabolism, liver inflammation, gut microbiota and metabolite profiles in high-fat/cholesterol (HFCD) diet mice. 5 treatment groups were fed a normal control diet or a HFCD with or without HB supplementation for 10 weeks. The results showed that HB especially HBB significantly improved lipid parameters, liver function and injury and blood glucose indexes related to hyperlipidemia compared with HFCD group. In addition, HBB recovered the disorder of gut microbiota by increasing Bacteroidetes / Firmicutes ratio and Lactobacillus and Allobaculum abundances, and decreasing Proteobacteria abundance related to lipid metabolism bacteria. HBB enhanced the levels of 6 short chain fatty acids induced by HFCD. Fecal metabolomics analysis showed that the important differential metabolites between HBB group and HFCD group were deoxycholic acid , myclobutanil and cis -4-Hydroxy-D-proline, and the important differential metabolic pathways were arachidonic acid metabolism, tyrosine metabolism and bile secretion . Results suggested that HBB was an effective dietary intervention candidate to ameliorate hyperlipidemia.
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Current Research in Food Science
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2022
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IF 6.269
Renjie Zhao,Zhichang Qiu,Xinyan Bai,Lu Xiang,Yiteng Qiao,Xiaoming Lu
Garlic saccharides have prebiotic activity, but the association between their function and structure is still poorly known. In present study, four different garlic saccharides were obtained from garlic polysaccharides (GPs) after acidolysis by ultrafiltration. Obtained GPs were constituted by different monosaccharides, among which fructose and glucose were the main components, while galactose was a major component of GPs-U6. All four saccharides were partly degraded by the simulated digestive system, and most could reach the large intestine to be utilized by the gut microbiota. Except for GPs-U6, the other three garlic saccharide fractions had good prebiotic activity in vitro and in vivo . Furthermore, GPs-U0.3 with lower molecular weight (Mw) showed better prebiotic activity, including promoting the production of short-chain fatty acids (SCFAs), increasing the abundance of beneficial bacteria such as Bifidobacterium , Lachnospiraceae NK4A136 group and Phoscolarctobacterium , and inhibiting the growth of potentially harmful bacteria. In addition, Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway enrichment analysis showed that GPs-U0.3 could reduce the risk of cancer and cardiovascular diseases. Overall, this findings of the present study revealed the digestive properties of GPs, as well as the potential association between their chemical structures and fermentation characteristics by gut microbiota. Thus, it can be stated that GPs-U0.3 can be used as potential prebiotics in functional foods, which provides a theoretical basis for the targeted preparation of functionalized garlic saccharides.
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FUEL
·
2022
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IF 8.035
Wenran Gao,Yiling Wan,Shanhui Zhao,Muhammad Asif Akhtar,Kuan Ding,Bin Li,Yinlong Wu,Shoujun Zhang,Shu Zhang
Ketonization of biomass-derived oxygenates is promising for sustainable production of platform chemicals, but the catalyst activity will be severely inhibited by furanic compounds. To investigate the mechanism of the inhibition effect, furanic compounds with different side functional groups were chosen for co-ketonization with propanoic acid over CeO 2 . Results from 12 h continuous reaction showed that conversion of propanoic acid changed slightly when furan was co-fed with propanoic acid, while decreased significantly from 100 % for sole propanoic acid feeding to <55 % when co-feeding with furfural and furfuralcohol. Therefore, the inhibition ability followed the order of furfural ≈ furfuralcohol ≫ furan, which agreed well with the coke yield on the spent catalysts (51 %, 47 %, and 22 %, respectively). DFT calculation indicated that furfural and furfuralcohol, with the adsorption energy of 17–19 kJ·mol −1 , were much easier to adsorb on the catalyst than furan (11 kJ·mol −1 ). However, the lack of α-H of these furanic compounds led to their conversion into aromatic coke components. It is evidenced that the oxygenated side groups, rather than the furan ring, are responsible for the inhibition effect. Successive ketonization-combustion-ketonization tests revealed that simple air calcination can hardly recover the activity of the spent CeO 2 . This investigation gives new insights into the inhibitory impact of furans on the ketonization activity.
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Nutrients
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2022
·Vol. 14
·期 19
·3928
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IF 6.706
Guopeng Li,Shugang Li,Huanhuan Liu,Lihua Zhang,Jingzhu Gao,Siteng Zhang,Yue Zou,Xiaodong Xia,Xiaomeng Ren
Plant polysaccharide intervention has shown significant potential to combat obesity. However, studies on animal polysaccharides are indeed rare. The aim of this study was to investigate the potential functions of CIP (IL) on obesity, intestinal microflora dysbiosis, and the possible protection of intestinal barrier in mice fed with high-fat diet (HFD). Our results revealed that after 13 weeks, the HFD+L (high-fat diet + 25 mg/kg CIP) group showed significantly more weight loss and fat accumulation relative to the HFD+H (high-fat diet + 50 mg/kg CIP) group. Furthermore, CIP intervention modulated lipid metabolism and mRNA levels of inflammatory mediators in liver. Overall, CIP clearly improved the intestinal barrier in HFD-fed mice. Additionally, we observed that CIP intervention improved intestinal microbiota community richness and diversity in HFD-fed mice. The CIP intervention mice group showed a relatively lowFirmicutestoBacteroidetesratio compared to the HFD group. This study concluded that CIP could be used as a functional food to prevent adipocyte accumulation, reduce systemic inflammation, and protect the intestinal barrier.Keywords:crude isinglass polysaccharides (CIP);intestinal barrier;inflammation;HO-1/Nrf2 pathway;intestinal flora
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Yafei Guo,Guodong Wang,Jun Yu,Pu Huang,Jian Sun,Ruilin Wang,Tao Wang,Chuanwen Zhao
Transition metal oxides (TMOs) doping is proposed as one effective strategy to improve CO 2 capture and conversion performance of Ni-CaO dual function materials (DFMs). The effect of single and binary TMOs doping on structure–property-activity relationships of Ni-CaO DFMs for integrated CO 2 capture and in-situ reverse water gas shift (RWGS) is investigated. ZrO 2 doping enhances the surface basicity and reducibility of Ni-CaO DFMs for improved CO 2 uptakes and reinforced catalytic activity. ZrO 2 doping also endows Ni-CaO DFMs with improved working stability by forming CaZrO 3 solid solution, which acts as physical barrier to retard the agglomeration and sintering of CaO and NiO species. Doping binary metal oxides of ZrO 2 -CeO 2 further boosts the oxygen vacancy concentration in the DFMs for promoted CO 2 activation and conversion and stabilized CO yield. The desired Ni-CaO-6ZrO 2 -6CeO 2 DFMs shows a higher CO 2 conversion of 72.1% and a lower decay rate of 12.0% for CO yield in consecutive cycles.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Danni Chang,Xinzhong Hu,Zhen Ma
The present study compared the modulatory effects of different resistant starches (RSs) isolated from native (NP-RS), acid-hydrolyzed (AHP-RS), and pullulanase debranched (PDP-RS) pea starches on the corresponding in vivo metabolic responses in high fat (HF)-diet-induced obese mice. The biochemical studies on serum lipid profile and antioxidant enzyme activities were supported by histological and gene expression analyses, which suggested a potential therapeutic role for RS in regulating obesity, possibly through the production of short-chain fatty acids and the proliferation of some beneficial colonic bacteria, including Allobaculum, Bifidobacterium, Odoribacter, Clostridium, and Prevotella. Particularly, a more pronounced effect of AHP-RS with a higher proportion of the crystalline region and a more ordered double-helical alignment on improving the hyperlipidemic symptoms in obese mice induced by a HF diet was observed. Our analysis revealed that the RS3 samples seemed to be more effective than RS2 in terms of attenuating obesity in mice that were fed a HF diet.
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高影响因子
Foods
·
2022
·Vol. 11
·期 14
·2039
·
IF 5.561
Yang Zheng,Yi Wang,Donghui Luo,Lianzhu Lin,Xingyu Lu,Jie Gao,Chuqiao Xiao,Mouming Zhao
The aim of this study was to investigate the effects of bergamot polysaccharide (BP) and Laoxianghuang polysaccharides (LPs, fermented bergamot) on the microbiome and metabolome during the in vitro fermentation of gut microbiota from patients with hyperlipidemia. Results indicated that both BP and LPs were able to increase the production of acetic acid, propionic acid, and butyric acid. However, only LPs could decrease the content of isobutyric acid and isovaleric acid, which are detrimental to gut health. A 16S rRNA analysis showed that both BP and LPs could reduce the proportion ofFusobacterium, whereas they increased theBacteroidescontent in hyperlipidemia. Untargeted UPLC-MS/MS metabolomic profiling found six bio-markers that were significantly changed after BP and LPs intervention, and four of the down-regulated metabolites were long-chain fatty acids associated with vascular diseases. These findings provide new evidence that BP and LPs have the potential to regulate imbalances in the gut microbiota in patients with hyperlipidemia and ameliorate its metabolic abnormalities.Keywords:polysaccharide;hyperlipidemic;gut microbiota;SCFAs;metabolomics
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Journal of CO2 Utilization
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2022
·
IF 8.321
Yupeng Chen,Chong Chen,Xue Li,Nengjie Feng,Lei Wang,Hui Wan,Guofeng Guan
Catalytic fixation of greenhouse gas CO 2 into value-added chemicals under mild conditions was deemed as an effective pathway for carbon emissions mitigation, though facing big challenges. Herein, a novel hydroxyl-ionic liquid functionalized metalloporphyrin (ZnTpyp-IL) catalyst bearing hydrogen bond donor (HBD), Lewis acidic and nucleophilic sites was fabricated and invested in the CO 2 cycloaddition without additive or solvent. The integration of ionic liquid endowed the framework with strong surface affinity to enrich CO 2 molecules, while the cooperative interplay of multiple active sites further promoted the high-selective conversion of epichlorohydrin (ECH). Under optimal conditions (100 °C, 1 MPa, 4 h), the yield of corresponding chloropropene carbonate (CPC) reached 97.1 % (turnover frequency (TOF) = 52.4 h -1 ), far superior to that of bare Tpyp (17.4 %). The preliminary kinetic studies revealed the lower activation energy (59.54 kJ/mol) needed to be overcome in the ring-opening process over ZnTpyp-IL. Moreover, a plausible dual-activation mechanism of hydrogen bonds and Zn centers for epoxides was proposed based on the density functional theory calculation (DFT) to explain the acceleration of rate-determining step. Coupled with the satisfactory reusability and substrate expansibility, the developed ZnTpyp-IL demonstrated its great potential as robust heterogeneous catalyst in the efficient utilization of C 1 resource.
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