International Journal of Pharmaceutics-X
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2026
·
IF 7.9
Le Chang,Jin Zeng,Libo Zhang,Hao Cheng,Bianbian Wang,Jialian Yu,Fang Chen,Deyu Kong,Jianhua Wang,Xiaofan Jiang
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by persistent synovial inflammation and progressive cartilage and bone destruction. Triptolide (TP) exhibits potent anti-inflammatory activity, but its therapeutic application is limited by poor aqueous solubility and a narrow therapeutic window. To address these limitations, we developed dissolving hyaluronic acid (HA) microneedles (MNs) incorporating a TP-loaded microemulsion (mean diameter: 27.6 ± 4.4 nm) for local transdermal delivery. The TP-loaded microneedles (TP MNs) showed a uniform pyramidal morphology (height of ∼500 μm) and adequate mechanical strength (fracture force: 0.098 ± 0.010 N per needle), supporting skin insertion with microchannel depths of approximately 450 μm. In vitro , TP MN-derived preparations reduced the viability, migration, and invasion of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), and decreased inflammatory mediator production, including TNF-α, IL-1β, IL-6, GM-CSF, and CSF-1R. In vivo , TP MNs alleviated joint swelling, synovial hyperplasia, cartilage damage, and bone erosion in a collagen-induced arthritis (CIA) rat model relative to TP HA solution and blank MN controls. At the molecular level, TP-containing treatment was associated with changes in NF-κB-associated downstream readouts in synovial tissues and RA-FLS. Under the present dosing regimen, serum ALT, AST, BUN, and CRE remained comparable among groups, providing preliminary evidence for the absence of overt short-term hepatorenal dysfunction within the study period. Collectively, these results support microemulsion-embedded HA microneedles as a promising local TP delivery platform for inflammatory arthritis, while warranting further investigation of long-term safety, complete pharmacokinetic profiles, and application-site effects.
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高影响因子
MEASUREMENT
·
2026
·
IF 6.1
Yuan Jin,Junyuan Song,Nanke Ma,Guangli Li
NiMoO 4 micro-rods/MWCNT-COOH composite first applied for FLX detection. • Low LOD (0.012 μM), wide range (0.05–20 μM), high sensitivity (μA μM −1 ). • Enrichment via electrostatic attraction, H-bonding, and π‑π stacking (adsorption-controlled). • Good anti-interference, 82% stability over 30 days, recoveries 94–104% in real samples. • Structural and functional complementarity (conductivity + catalysis) of the composite. Fleroxacin (FLX), a commonly utilized fluoroquinolone antibiotic, has been identified as a significant environmental and human health hazard due to its presence and accumulation in the environment. In this study, an electrochemical sensor employing a NiMoO 4 /MWCNT-COOH composite material was devised for the highly selective and highly sensitive detection of FLX in environmental water samples. The nickel molybdate microrod/carboxylated multiwalled carbon nanotube composites (NiMoO 4 /MWCNT COOH) synergistically combines the catalytic properties of NiMoO 4 with the exceptional conductivity and dispersibility of MWCNT-COOH, thereby enhancing electron transfer rates and the effective electroactive surface area. The sensor demonstrated a favorable linear response within the concentration range of 0.05–20 μM, with a limit of detection of 0.012 μM, a sensitivity of 2.988 μA μM −1 , good anti-interference capabilities, and sustained stability (signal retention rate of 82% over 30 days). Furthermore, spiked recovery experiments conducted in authentic water samples (tap water, lake water, serum and bean sprout) yielded recoveries ranging from 94.04% to 103.8% and the relative standard deviations (RSDs) are less than 5%, affirming the method’s suitability for the reliable analysis of FLX in complex matrices. This approach offers a robust sensing platform for environmental antibiotic monitoring.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Liming Wang,Yupeng Liu,Gonghua Hu,Liang Xiong,Yuanfu Ding,Bingzhe Wang,Xiaofeng Lin,Hanqiang Zhang,Qitong Huang,Songnan Qu,Licen Li
Nicotinamide-derived carbon dots (NAM-CDs) display amplified Ki67 binding, conferring potent tumor targeting. • Optimized solvothermal synthesis at 180 °C boosts red fluorescence and photothermal conversion. • Excellent biocompatibility and tight Ki67 binding enable selective nuclear retention of NAM-CDs in cancer cells. • In vivo 660 nm irradiation of NAM-CDs achieves complete tumor regression without recurrence over 30 days. The lack of tumor-specific targeting remains a major bottleneck in photothermal therapy. Here, we exploit the natural affinity of nicotinamide (NAM) for Ki67, a tumor proliferation marker, to design a targeted photothermal nanomaterial. NAM-derived carbon dots (NAM-CDs) were synthesized via a one-step solvothermal method, in which the carbon core serves as a scaffold for the multivalent presentation of NAM moieties. Dynamic molecular docking simulations revealed that NAM-CDs exhibited a markedly enhanced binding affinity toward Ki67, with binding energy of −7.7 kcal/molcompared with −3.8 kcal/mol for free NAM. These results indicate that the multivalent display of NAM not only preserves but also amplifies its intrinsic Ki67-targeting capability. To further optimize the photophysical properties of NAM-CDs, the synthesis temperature was systematically tuned. At 180 °C, the resulting NAM-CDs developed a pyridine-rich surface characterized by maximized pyrrolic-N content and enhanced amide bond formation, facilitating efficient energy transfer from the carbon core to surface states. This optimized electronic structure synergistically enhanced both red fluorescence emission and photothermal conversion efficiency. The pyridine-rich NAM-CDs exhibited excellent biocompatibility, specific nuclear retention through Ki67-mediated interactions in cancer cells, and potent photothermal tumor ablation upon 660 nm laser irradiation in vivo, achieving complete tumor regression without recurrence over a 30-day observation period. By harnessing the inherent Ki67 affinity of NAM, this work provides a facile strategy for imparting tumor-targeting capability to photothermal agents, opening a new avenue for proliferation-marker-directed cancer therapy. In this work, we developed nicotinamide-derived carbon dots that exploit natural Ki67 affinity to amplify binding, with a pyridine-N-rich surface boosting fluorescence and photothermal conversion. They achieve selective nuclear retention in cancer cells and complete tumor regression without recurrence. Download: Download high-res image (119KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Tianxin Zuo,Hengchang Zhang,Kaidi Sun,Hairong Chen,Caiqin Han
AuNPs@BN@AgNR SERS sensor for ultrasensitive salivary BR/BV detection. • Ultra-low LODs of 5 × 10 −8 M for BR and 1 × 10 −7 M for BV in spiked saliva. • FDTD simulations confirm 5.54-fold electric field enhancement via LSPR coupling. • BN layer enables target enrichment and suppressed non-specific adsorption. Bilirubin (BR) and biliverdin (BV) are non-invasive biomarkers for hepatic function assessment. Their detection in saliva is limited by sub-micromolar concentrations and matrix interference. Conventional methods exhibit limits of detection (LODs) ≥ 10 −6 M. Herein, an AuNPs@BN@AgNR SERS sensor is fabricated via oblique angle deposition, wet chemical etching, and chemical reduction. FDTD simulations demonstrate a 5.54-fold local electric field enhancement in the x–z plane relative to the BN@AgNR bilayer, resulting from LSPR coupling between AuNPs and AgNRs. Experimentally, the substrate achieves enhancement factors up to 4.06 × 10 9 with a spatial relative standard deviation (RSD) of ≤7.00%. The sensor yields LODs of 1 × 10 −12 M (BPE), 2.5 × 10 −8 M (R6G), and 1 × 10 −6 M (CV). In spiked saliva, the sensor exhibits quantifiable concentration ranges of 5 × 10 −8 M to 1 × 10 −4 M for BR and 1 × 10 −7 M to 1 × 10 −4 M for BV, with corresponding LODs of 5 × 10 −8 M and 1 × 10 −7 M. This performance is attributed to BN-mediated electrostatic target enrichment and the suppression of non-specific protein adsorption. This study provides an analytical platform for the non-invasive trace analysis of hepatic biomarkers. Download: Download high-res image (112KB) Download: Download full-size image
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MATERIALS CHARACTERIZATION
·
2026
·
IF 6.2
Ehsan Ghasali,Hamidreza Ghadami Karder,Congya Zhu,Ayesha Sadiqa,Li Jie,Yasin Orooji
Novel Dy₂Ho₂Er₂Tm₂Yb₂O₁₅ high-entropy oxide successfully synthesized via conventional sintering. • Single-phase cubic bixbyite structure (Ia-3) formed across all sintering conditions. • Higher sintering time/temperature promoted grain growth, strain relaxation and homogeneity. • Bandgap narrowed to 4.45 eV due to high-entropy induced lattice distortion. characters). • Promising photoluminescence properties indicating potential photocatalytic activity. A bixbyite-structured rare-earth high-entropy oxide with the composition Yb₂Tm₂Er₂Dy₂Ho₂O₁₅ was synthesized by a conventional compaction–sintering route. The effects of sintering temperature and time on phase formation, microstructure, chemical homogeneity, and optical properties were systematically investigated. XRD confirmed the formation of a cubic bixbyite structure with the space group , while Williamson–Hall analysis indicated improved crystallinity and strain relaxation with increasing sintering severity. SEM/TEM observations and EDS mapping revealed progressive grain growth, densification, and homogeneous distribution of the constituent rare-earth elements. XPS results confirmed the predominance of trivalent rare-earth cations and a stable oxygen environment, with no major chemical-state changes after sintering. UV–Vis analysis showed a band gap of 4.45 eV, which is lower than those of the individual constituent oxides, suggesting that lattice distortion and compositional complexity influence the electronic structure. PL results further indicated reduced electron–hole recombination in the UV region. Overall, the results demonstrate that conventional compaction and sintering can produce chemically homogeneous bixbyite-type rare-earth HEOs with tunable microstructural and optical characteristics.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Shucheng Liu,Bo Wang,Ruiheng Lu,Hongxiang Ou,Xuan Zhang
Naringin (NRG) is a bioactive substance with important pharmaceutical and industrial value. However, the major challenges in the separation of NRG arise from the complexity and low concentration of crude extracts. In this work, by integrating the advantages of magnetic separation, MOFs@COFs composite materials, and surface molecular imprinting strategy, a new kind of magnetic MOF@COF-based boronate-affinity molecular imprinted adsorbent (NH2-MIL-68-Fe3O4@COFs@BA-MIPs) was constructed. Magnetic NH2-MIL-68 substrates were prepared by the solvothermal method, aldehyde-functionalized by surface modification with 2,4,6-triformylphloroglucinol (Tp). Then, a covalent organic framework shell was grown on the surface of substrates via the Schiff base reaction. Finally, a boronate-affinity imprinted polymer was prepared via surface-initiated atom transfer radical polymerization (SI-ATRP). The as-prepared adsorbent features rapid magnetic separation. In addition, the high-density boronate-imprinted recognition sites and porous structure endow the material with a fast adsorption rate (reaching equilibrium about 60 min), a high adsorption capacity (57.29 μmol g–1), and good retention performance (92.79%) after six adsorption–desorption cycles at 308 K under pH 8.0. Moreover, the extraction rate of crude NRG by NH2-MIL-68-Fe3O4@COFs@BA-MIPs reached 93.61%. This study provides a design strategy for constructing NRG adsorbents with rapid magnetic response and has important application value in the specific separation and purification of flavonoids.
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ACS Applied Energy Materials
·
2026
·
IF 5.5
Yuyu Ma,Yi Dong,Deng Li,Yi Cao,Yuqin Wang,Juhong Lian,Wei Yu,Ruibin Jiang,Junqing Yan,Shengzhong Liu,Shanshan Chen
Solar-driven CO2 conversion via photovoltaic-powered electrolysis offers a sustainable route for carbon utilization and renewable energy storage, yet its current output is still constrained by the low-value yield of the anodic reaction. Herein, we rationally designed a solar-compatible paired electrolysis system by coupling cathodic CO2 reduction reaction (CO2RR) with anodic off-field H2S oxidation reaction (OFSOR) mediated by the I3−/I− redox couple, enabling synchronous production of high-value formate and elemental sulfur with significantly reduced energy input. An acid-tolerant Bi-based metal−organic framework (Bi-MOF) precursor was fabricated and underwent in situ structural reconstruction to form Bi2O2CO3 as an active phase for CO2RR with a formate faradaic efficiency (FE) exceeding 90% over a wide current density range. In situ Raman spectroscopy confirmed the formation of key *HCOO− intermediates over the Bi2O2CO3, accounting for the superior formate selectivity. By coupling with the carbon cloth anode, a two-electrode CO2RR-OFSOR electrolyzer was assembled, delivering a current density of 50 mA/cm2 at a cell voltage of only 2.91 V and reducing cell voltage by 41% under the tested conditions as compared to the conventional CO2RR-OER configuration. Furthermore, a self-driven solar-powered photovoltaic-electrochemical device was established by directly powering the electrolyzer with commercial silicon photovoltaic cells, which steadily operates with formate FE above 90% and achieves a solar-to-chemical conversion efficiency of 4.6%. This work provides a promising and energy-efficient solar-driven integrated strategy for collaborative CO2 conversion and H2S resource utilization, highlighting the potential of hybrid electrolysis systems in sustainable electrosynthesis.
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Materials
·
2026
·Vol. 19
·期 14
·2977
·
IF 3.7
Anjie Qi,Yunjia Liang,Bingjie Ge,Guodong Jiang,Shanglin Xiang,Dongyu Cai
HighlightsDeveloped a self-catalytic water/castor oil system for PET depolymerization.Achieved spontaneous precipitation of oligoesters without cooling crystallization.Upcycled the oligoesters into polyurethane adhesives with high peel strength.This study presents a green approach for polyethylene terephthalate (PET) upcycling using a biphasic system of subcritical water and castor oil. This system enables efficient conversion without an external catalyst and facilitates product separation. Hydrolysis of castor oil generates fatty acids in situ, which catalyze PET conversion to selectively produce low-molecular-weight oligoesters (Mn ≈ 1500 g/mol). These oligoesters are inherently immiscible with the bio-medium at room temperature, allowing straightforward separation by centrifugation. Orthogonal experiments show that temperature is the dominant factor affecting PET conversion, with the optimal conditions being 200 °C, a water-to-oil mass ratio of 1:5, and a reaction time of 10 h for complete conversion. Under the practical optimum condition, the castor oil phase remained highly effective over five consecutive depolymerization cycles. The functionalized oligoesters were used in polyurethane synthesis. At 6% loading, they gave adhesives with a T-peel strength of 8.09 N/15 mm and tensile strength of 25.14 MPa, and excellent damp-heat stability (only 0.62% loss in T-peel and 0.47% in 180° peel after aging). Thermogravimetric analysis confirmed enhanced thermal stability, with increases of 19.52 °C in T5%and 16.50 °C in T50%compared with the unmodified system. These results demonstrate the practical potential of the obtained oligoesters in high value adhesive applications.
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高影响因子
JOURNAL OF FLUORESCENCE
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2026
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IF 3.4
Liang Tianmi,Liu Shijian,Ma Wenjin,Tao Xiaoqi
Colla Corii Asini ( CCA ), a traditional food-medicine product, is vulnerable to food safety and market integrity due to frequent adulteration. This study developed a lateral flow assay based on polyethylenimine-functionalized europium metal-organic frameworks (PEI-Eu-MOFs-LFA) for quantitatively detecting donkey DNA to assess the authenticity of CCA , without the need for knowing the types of adulterants. The protonated amino groups on the PEI‑Eu-MOFs surface formed stable complexes with negatively charged single‑stranded DNA (ssDNA) probes. Electrostatic attraction and hydrogen bonding facilitated conjugate formation, leading to fluorescence quenching of the PEI-Eu-MOFs via the inner-filter effect (IFE). This method enables direct analysis after DNA extraction, eliminating the need for additional nucleic acid amplification steps, and completes the entire process in just 60 min. Furthermore, a calibration curve was established between the T/C ratio and the logarithmic value of donkey hide content (2% to 100%). The PEI-Eu-MOFs-LFA exhibited excellent sensitivity and accuracy, with a detection limit of 1.86%, recoveries ranging from 85.70% to 114.63%, and relative standard deviations from 2.48% to 12.59%. Consequently, PEI-Eu-MOFs-LFA demonstrates high sensitivity and accuracy, significantly improving detection efficiency and providing an innovative approach for quality control and market regulation of CCA .
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APPLIED CATALYSIS A-GENERAL
·
2026
·
IF 4.8
Xinyue Chen,Binjian Chen,Yudong Mao,Min Yan,Zhihao Liu,Yuxuan Jiang,Xianqun Jin
FeNiP-CeO 2 /NF heterostructure is designed for efficient oxygen evolution reaction. • Superior OER activity: 231, 304, 390 mV at 100, 500, 1000 mA·cm −2 . • Performance optimized by heterostructure design and interfacial synergistic effect. • The catalyst exhibits outstanding long-term stability of 200 h at 500 mA·cm −2 . Developing efficient and durable non-noble-metal electrocatalysts for the oxygen evolution reaction under industrially relevant conditions remains a significant challenge. Herein, a heterostructured FeNiP-CeO 2 /NF electrocatalyst was rationally designed and synthesized via a two-step hydrothermal–phosphidation strategy. The resulting catalyst features hierarchically assembled FeNiP nanosheets intimately coupled with oxygen-vacancy-rich CeO 2 nanoparticles, forming abundant heterointerfaces. Benefiting from the synergistic interaction between bimetallic Fe–Ni phosphide active sites and CeO 2 -induced interfacial charge redistribution, FeNiP-CeO 2 /NF exhibits markedly enhanced OER activity in alkaline media, delivering low overpotentials of 231, 304, and 390 mV at current densities of 100, 500, and 1000 mA cm −2 , respectively. In addition, the catalyst demonstrates excellent long-term durability, maintaining stable operation for 200 h at 500 mA cm −2 with a Faradaic efficiency of 99.3%. This work demonstrates that rational heterointerface engineering combined with hierarchical structural design is an effective strategy for constructing highly active and robust OER electrocatalysts, highlighting the promising potential of FeNiP-CeO 2 /NF for industrial water electrolysis applications. Download: Download high-res image (256KB) Download: Download full-size image
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Surfaces and Interfaces
·
2026
·
IF 6
Shiyang Fu,Yuqing Shi,Guowei Yu,Xiao Liang,Nan Gao,Jing Zhang
Co 3 O 4 /Fe 2 O 3 p–n heterojunctions were prepared hydrothermally. • CF-5 shows a 5.6-fold response at a lower optimal temperature. • DFT reveals charge redistribution enhancing n-butanol adsorption. To selectively detect volatile organic compounds at low operating temperatures are highly desirable for industrial safety and environmental monitoring. Herein, we report the high-performance n-butanol gas sensors via interfacial engineering of Co 3 O 4 /Fe 2 O 3 p–n heterojunction composites. Hierarchical architectures composed of Fe 2 O 3 nanoparticles uniformly anchored on Co 3 O 4 nanorods were synthesized through a facile hydrothermal calcination strategy. Among the prepared samples, the optimized composite delivers a markedly enhanced sensing response of 23.08 toward 100 ppm n-butanol, representing a 5.6-fold improvement compared with pristine Co 3 O 4 , and simultaneously reducing the optimal operating temperature to 110°C. The mechanism analyses reveal pronounced interfacial charge transfer from Fe 2 O 3 to Co 3 O 4 , which induces band bending and built-in potential barriers that sensitively regulate carrier transport. The formation of heterointerfaces also significantly enriches chemisorbed oxygen species, thereby accelerating surface oxidation reactions with n-butanol molecules. As a result, the sensor exhibits outstanding selectivity against common interfering gases, fast response/recovery dynamics (42/36 s). Density functional theory calculations further elucidate that the heterojunction facilitates stronger adsorption of n-butanol and its oxidation intermediates, enhanced charge transfer, and favorable electronic-state redistribution near the Fermi level. This work highlights interfacial electronic engineering as an effective strategy for developing energy-efficient and highly reliable metal-oxide gas sensors. Download: Download high-res image (237KB) Download: Download full-size image
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INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Yongliang Ding,Bingbing Shi,Siyu Liu,Jindong Li,Fang Wu,Qingmin Yang,Yuhong Wang,Mengjie Li,Zhongkai Wang,Xiankun Wu
H 2 O 2 -assisted cleavage converts non-edible tung oil into bio-based azelaic acid for polyamide synthesis. • Programmable crystallinity transforms rigid PA69 into tough elastomers with good melt processability. • Crystallinity-engineered polyamide elastomers show strong, reprocessable adhesion on metals. Transforming non-edible plant oils into high-performance engineering polymers offers a promising route toward sustainable materials, yet remains challenged by the inefficient upgrading of structurally complex feedstocks and the difficulty of simultaneously controlling crystallinity, toughness, and processability in the resulting polymers. Tung oil, a renewable resource rich in conjugated polyunsaturated fatty acids, is particularly attractive but has been underutilized because selective conversion into well-defined monomers remains difficult. Here we report an integrated strategy that links feedstock upgrading with molecular structure programming to create bio-based polyamides with designer crystallinity. Through hydrogen peroxide-assisted oxidative cleavage, tung oil is selectively converted into high-purity azelaic acid (AA), which is subsequently copolymerized with hexamethylenediamine and poly(propylene glycol) bis(2-aminopropyl ether) (D400) to construct a family of random copolyamides (PA69 X ). The incorporation of flexible ether-containing segments disrupts chain regularity and hydrogen-bond organization, enabling precise modulation of crystalline order, melting behavior, and lamellar structure while preserving excellent thermal stability. As a result, the materials undergo a transition from rigid semicrystalline polyamides to highly tough elastomers with programmable crystallinity. The optimized copolyamide exhibits a fracture toughness of 141 MJ m −3 together with continuous melt-fiber processability, stretch-induced crystallization behavior, and robust reprocessable adhesion to metal substrates with lap shear strengths exceeding 9 MPa. This work establishes a general framework that integrates renewable feedstock valorization, crystallinity engineering, and multifunctional performance, providing a pathway for converting underutilized plant oils into sustainable engineering polymers. Download: Download high-res image (240KB) Download: Download full-size image Description: A sustainable pathway from tung oil to high-performance polyamide elastomers is established via bio-based azelaic acid, enabling programmable crystallinity, exceptional toughness, stretch-induced crystallization, and multifunctional applications in fibers and reprocessable adhesives
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危险品化学品经营许可证（带存储）