ACS Applied Materials & Interfaces
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2025
·
IF 8.2
Wenqiang Liu,Zitong Qi,Tuanning Liu,Yang Zhang
Inorganic halide perovskite nanocrystals (NCs) are regarded as promising emitters for light-emitting diodes due to their bright and narrow emission. However, surface defects often result in trap states and ion migration, which remains a huge challenge for high-quality perovskite NCs. Herein, fluoride ions are introduced into CsPbBr3 perovskite NCs at room temperature through the chelation of ligands. Experimental results demonstrate that these fluoride ions from inorganic salts can improve the average lifetime and crystallinity of CsPbBr3 NCs. Meanwhile, the resulting photoluminescence quantum yield is optimized up to 99.02%, and it has high stability to water, heat, and ultraviolet light. Density functional theory calculations show that fluoride ions have a higher binding energy compared to other ligands, which not only removes the electron trapping center but also increases the halogen ion migration energy. By mixing green-emission CsPbBr3 NCs and red-emission K2SiF6:Mn4+ phosphors on a blue chip, the fabricated white light emitting diode shows a high luminous efficiency of 147.8 lm/W, a wide color gamut (129% for NTSC), and CIE coordinates of (0.3160, 0.3051). Furthermore, the photoluminescence intensity decreased by only 2.9% after 48 h of continuous operation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Nan Ma,Rong Li,Gui-Fang Zhang,Ruo-Han Gao,Dong-Jie Zhang
Quinoa β-glucan (QBG) has shown potential benefits in treating type 2 diabetes mellitus (T2DM); however, comprehensive evaluations of its effects remain limited. This study investigates the impact of QBG—derived from hot water extraction (Q-) and microbial fermentation enrichment (Q+)—on serum glucose levels, lipid profiles, appetite-regulating hormones, fecal short-chain fatty acids (SCFAs), and gut microbiota composition and function in streptozotocin/high-fat diet (STZ/HFD)-induced T2DM mice. The results indicate that QBG treatment significantly reduced fasting blood glucose, insulin levels, triglycerides (TG) and total cholesterol (TC), while concurrently increasing high-density lipoprotein cholesterol (HDL C) levels. Additionally, liver and pancreatic function improved, as evidenced by decreased levels of malondialdehyde (MDA), aspartate transaminase (AST), and alanine transaminase (ALT). SCFA levels were significantly higher in QBG-treated groups compared to MC group. QBG treatment also reduced the abundance of Firmicutes and Patescibacteria, along with the Firmicutes/Bacteroidota ratio, while increasing levels of Bacteroidota and Actinobacteria. These findings suggest that QBG can regulate the dysbiosis of SCFAs production in T2DM mice and may indirectly modulate the secretion of appetite-regulating hormones by influencing gut microbiota composition. Furthermore, PICRUSt analysis revealed that QBG treatment, particularly Q + _H, could enhance disrupted metabolism and improve gut microbiota functions, helping restore normal physiological function.
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Food Bioscience
·
2025
·
IF 5.9
Fei Shen,Huiting Zhu,Zhongyan Bao,Di Han,Juan Du,Minjie Zhao,Fengqin Feng,Guanghua He,Qiufen Mo
Constipation is a common gastrointestinal condition. Lactiplantibacillus plantarum T34 has been demonstrated efficacy in relieving loperamide-induced constipation in mice model. Oral intervention of L. plantarum T34 (1 × 10 8 CFU/mouse/day) resulted in improved defecation and enhanced intestinal morphology. Mechanistic studies revealed that L. plantarum T34 strengthend the intestinal barrier through the upregulation of tight junction protein genes, specifically Claudin-1 , as well as mucosal barrier proteins such as Muc2 and Muc3 . Additionally, L. plantarum T34 modulated gut homeostasis by influencing the expression of aquaporin genes, levels of the gut neurotransmitter serotonin (5-HT), and oxidative stress markers. Furthermore, L. plantarum T34 effectively restored the composition of the gastrointestinal microbiota, addressing dysbiosis linked to constipation. These findings suggested that L. plantarum T34 may serve as a promising probiotic intervention for managing constipation, offering a safe and effective alternative to traditional treatments.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shijiao Fan,Zechuan Lu,Zhenning Yan,Liuyang Hu
In this paper, the interaction of three berberine mid-chain fatty acid salts ([BBR][FAs]), viz. berberine caproate ([BBR][CAP]), berberine heptylate ([BBR][HEP]) and berberine octoate ([BBR][OCT]), with bovine serum albumin (BSA) was studied by means of UV–visible absorption spectroscopy , fluorescence spectroscopy, fourier transform infrared spectroscopy (FT-IR) and molecular docking techniques. Fluorescence experiments revealed that three berberine salts quench the fluorescence of BSA by static quenching mechanism resulted from a stable [BBR][FAs]-BSA complex formation. The stoichiometric numbers of [BBR][FAs]-BSA complexes were found to be 1:1. Synchronous and three-dimensional fluorescence spectra as well as FT-IR demonstrated that the binding of [BBR][FAs] altered the microenvironment and conformation of BSA. The binding average distance from [BBR][FAs] to BSA (3.2–3.5 nm) was determined according to Förster energy transfer theory. Site probe investigation showed that [BBR][FAs] bound to BSA active site I (sub-domain IIA). The binding promotes the esterase-like activity of BSA. The molecular docking results confirmed the fluorescence competition findings and provided the type of binding forces. Furthermore, the relationship between the anionic chain length of [BBR][FAs] and the interaction was explored, and the positive correlation was found.
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JOURNAL OF SEPARATION SCIENCE
·
2025
·Vol. 48
·期 3
·e70116
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IF 2.8
Jinghui Li,Yan Kang,Ying Wang,Jiaxin Liu,Yingting Wang,Sitong Liu,Yunxi Bu,Xiangqun Li,Jiahan Xie,Zhibing Wang
A simple, green, and efficient ultrasound-assisted deep eutectic solvents (DESs) extraction followed by high-performance liquid chromatography-diode array detector was established to detect four liposoluble anthraquinones in Salvia miltiorrhiza Bge. root. In this study, a series of polarity-adjustable DESs were prepared using n -hexanol and tetrabutylammonium chloride, and their structure, density, viscosity, pH, and thermal stability were determined. The conditions for extraction were optimized through single-factor experiments and response surface methodology. The kinetic and thermodynamic properties associated with the ultrasound-assisted extraction of anthraquinones were investigated. The results showed that the standard curves for anthraquinones showed excellent linearity from 0.018 to 150 µg mL −1 ( r > 0.9998). The detection and quantification limits varied from 5.04 to 5.60 ng mL −1 and 16.81 to 18.67 ng mL −1 , respectively. The recoveries were measured as 84.1%–95.1%, and the relative standard deviations were not exceeded 4.6%.
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Food Bioscience
·
2025
·
IF 5.9
Lin Yuan,Yunjie Li,Liuyan Zheng,Yifan Qin,Xin Zhang,Lijuan Ma,Huan Zhang,Liping Du
Organic acids are critical flavor contributors in light-flavor Baijiu (LFB). The binding of organic acids and volatile compounds may affect the release of flavor in Baijiu. In this study, the effects of different concentrations of lactic acid, hexanoic acid, butyric acid, and acetic acid on the release of key aroma-active compounds in LFB were investigated. Twenty volatile compounds were identified as key aroma-active compounds in four LFB samples using odor activity values combined with aroma recombination, and omission experiment methods. Furthermore, as the concentrations of organic acids were increased in the simulated LFB solution, significant changes in the release of key aroma-active compounds occurred. The addition of lactic acid from 0.5-fold to 5-fold resulted in all key aroma-active compounds exhibiting stronger releases, especially the addition of a 3-fold concentration of lactic increased the release of key esters to about twice. In contrast, the effect of hexanoic acid, butyric acid, and acetic acid on the release of key aroma-active compounds showed a concentration-dependent trend. This suggests that the specific structures of volatiles and organic acids alter the intermolecular interactions between them, thereby altering the aroma release. The results reveal that different organic acids alter the overall aroma profile by affecting the release of volatile compounds in the LFB matrix.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Yiran Bian,Yi Zhang,Taosuo Wang,Chuang Yang,Zhiming Feng,Kheng-Lim Goh,Yibin Zhou,Mingming Zheng
The enzymatic synthesis is essential for the flavor esters in the food and fragrance industries. This paper introduces a novel preparation method for lipase microarrays (CALB@PMHOS-TEOS) with loadings up to 229 ± 1.4 mg/g. Using surfactant-free hydrophobic silica-hybridized mesoporous materials and Candida antarctica lipase, this resulted in the effective synthesis of flavor esters. Using CALB@PMHOS-TEOS a Pickering emulsion system was formed at the oil-water interface for the sustainable synthesis of flavor esters. This resulted in a 93.5 ± 0.5 % conversion of hexanoic acid within 2 h at an optimal temperature of 35 °C, which is the highest level recorded in the literature to date. Furthermore, the conversion of hexanoic acid was maintained at 63.9 ± 1.2 % after 9 cycles of CALB@PMHOS-TEOS reuse. The application of the enzyme to the synthesis in a variety of flavor esters achieved a new benchmark in the existing literature. A molecular docking model was evaluated to understand the molecular mechanism underpinning the immobilized lipase. This work introduces a novel method for the eco-friendly and efficient synthesis of flavor esters for applications across various fields including food and cosmetics.
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Foods
·
2024
·Vol. 13
·期 10
·1561
·
IF 4.7
Qiaoyi Zhou,Jinjing Gao,Xueyan Sun,Yicheng Liang,Minqi Ye,Dongxia Liang,Caijin Ling,Binghu Fang
Tea plants have a long cultivation history in the world, but there are few studies on polysaccharides from fresh tea leaves. In this study, tea polysaccharides (TPSs) were isolated from fresh tea leaves. Then, we investigated the characteristics of TPSs during in vitro simulated digestion and fermentation; moreover, the effects of TPSs on gut microbiota were explored. The results revealed that saliva did not significantly affect TPSs’ molecular weight, monosaccharide composition, and reducing sugar content, indicating that TPSs cannot be digested in the oral cavity. However, TPSs were partially decomposed in the gastrointestinal tract after gastric and intestinal digestion, resulting in the release of a small amount of free glucose monosaccharides. Our in vitro fermentation experiments demonstrated that TPSs are degraded by gut microbiota, leading to short-chain fatty acid (SCFA) production and pH reduction. Moreover, TPSs increased the abundance of Bacteroides, Lactobacillus, and Bifidobacterium but reduced that of Escherichia, Shigella, and Enterococcus, demonstrating that TPSs can regulate the gut microbiome. In conclusion, TPSs are partially decomposed by gut microbiota, resulting in the production of SCFAs and the regulation of gut microbiota composition and function. Therefore, TPSs may be used to develop a prebiotic supplement to regulate the gut microbiome and improve host health.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Yanhui Zhang,Hongbo Li,Xiaoqin Hai,Xiaoli Guo,Xin Di
A green and recyclable switchable supramolecular deep eutectic solvent (SS-DES) was designed and prepared for effective extraction of flavonoids from Scutellariae Radix . The novel SS-DES has both excellent extraction performance of DES and the host guest inclusion of cyclodextrin, thereby showing superior extraction efficiency and selectivity. The characteristic of polarity switching can endow the SS-DES with achieving homogeneous extraction and rapid two-phase separation, shorting per-treatment time largely. Parameters affecting the extraction performance were investigated by the response surface methodology. The results indicated that the SS-DES showed better extraction yield of total flavonoids (157.95 mg/g) compared with pure DES (135 mg/g) and traditional organic solvent (60 % ethanol, 104.87 mg/g). Moreover, the switching mechanism of SS-DES was characterized by FT-IR and 1 H NMR, and the extraction mechanism was studied by density functional theory and molecular docking analysis. After evaluating the ecological impact of the method, the cytotoxicity of SS-DES was investigated and the result displayed that its toxicity was very low or even negligible with the EC 50 >2000 mg/L. After being adsorbed by macroporous AB-8 resin, the regenerated SS-DES was recycled 5 times and the extraction efficiency still remained above 90 %, indicating the desirable reusability. Therefore, the proposed method was efficient and sustainable, and revealed favorable application prospect for the extraction of bio-active compounds from plant materials.
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CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Ronghua Peng,Xueyou Qin,Jiawei Lin,Lingyu Wang,Songgu Wu,Junbo Gong
We designed a solvent mixture composed of carboxylic acid solvents and water as the crystallization medium for the selective preparation of three distinct γ-aminobutyric acid (GABA) conformational polymorphs (Form-I, Form-II, and the newly discovered Form-IV). By adjusting the carbon chain length and content of carboxylic acid solvents, we were able to finely tune the solvation environment, leading to the formation of the desired polymorphs. Crash-cooling crystallization experiments demonstrated that with the carbon chain length (C1–C6) and content (0–30%) of carboxylic acid increasing, the polymorphic outcomes gradually change from Form-I to Form-II and ultimately to Form-IV. Interestingly, four different conformations were observed within these three polymorphs. DFT calculation indicated that the stability order of these conformations is conformer-IVβ > conformer-IVα > conformer-II > conformer-I. Based on solution FTIR analysis and solvation free energy calculation, the solvation effect on GABA molecules diminishes with an increasing carbon chain length and content of carboxylic acid solvents. A lower solvation effect makes the desolvation process of GABA molecules much easier so that GABA molecules can undergo sufficient conformational rearrangement during the nucleation stage, thereby adopting a more stable conformation during the molecular assembly process. In this crystallization conditions, Form-IV with a more stable conformation in its crystal structure has the potential to replace Form-II and Form-I through preferential crystallization.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Min Wang,Yajie Yue,Jingjing Zhang,Yifan Qin,Liyan Jia,Xu Jing
In this study, magnetic deep eutectic solvent-dispersive liquid-liquid microextraction combined with high-performance liquid chromatography method was developed for the extraction and determination of succinate dehydrogenase inhibitors in water, juice, wine, and vinegar . A new green magnetic deep eutectic solvent was synthesized using quaternary phosphorus salt, metal chloride, and fatty acid. The special self-dispersion magnetic deep eutectic solvent achieved rapid extraction without auxiliary dispersion and separation via neodymium magnets without centrifugation, avoiding the use of toxic disperser solvents and disperser instruments and reducing the separation time. The recovery of succinate dehydrogenase inhibitors under optimal extraction conditions was 76.5–97.8 %, and the limit of detection was 0.0011–0.0029 mg L −1 . The method could be a fast, simple, green, and reliable alternative for the analysis of succinate dehydrogenase inhibitors. The self-dispersion magnetic deep eutectic solvent can facilitate the development of dispersive liquid-liquid microextraction methods of other pesticides in food samples.
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FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Jieyao Yu,Jingzhe Li,Zhi Lin,Yin Zhu,Zhihui Feng,Dejiang Ni,Shengchun Zeng,Xuehong Zeng,Yijun Wang,Jingming Ning,Liang Zhang,Xiaochun Wan,Xiaoting Zhai
As a kind of green tea with unique multiple baking processes, the flavor code of Lu’an Guapian (LAGP) has recently been revealed. To improve and stabilize the quality of LAGP, further insight into the dynamic changes in odorants during the whole processing is required. In this study, 50 odorants were identified in processing tea leaves, 14 of which were selected for absolute quantification to profile the effect of processes. The results showed that spreading is crucial for key aroma generation and accumulation, while these odorants undergo significant changes at the deep baking stage. By adjusting the conditions of the spreading and deep baking, it was found that low-temperature (4 °C) spreading for 6 h and low-temperature with long-time baking (final leaf temperature: 102 °C, 45 min) could improve the overall aroma quality. These results provide a new direction for enhancing the quality of LAGP green tea.
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