Advanced Healthcare Materials
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2026
·
IF 11
Yan Zhang,Song Li,Qiang Li,Ruiyuan Wang,Yue Sun,Yichun Wang,Xiaomin Yan,Xiaojian Wang,Yufeng Wang,Yadong Xue,Chao Ding,Jianfeng Gong,Lin Ding,Huangxian Ju
Conventional targeted therapies for inflammatory bowel disease (IBD) often rely on unstable biological recognition elements. While molecularly imprinted polymers (MIP) offer robust synthetic alternatives, their utility is limited by an “always-on” binding state: even weak non-specific adsorption can significantly compromise their target-binding capacity. We convert static MIP into reactive oxygen species (ROS)-activated therapeutic actuators by conjugating mannose to transferrin-imprinted MIP via a ROS-cleavable linker. The saccharide acts dually as a therapeutic agent and a protective cloak. It sterically blocks non-specific binding during intestinal transit. At inflammatory sites, elevated ROS levels (higher than in healthy tissue) trigger simultaneous mannose release and activation of high-affinity targeting. This enables precise MIP anchoring to the inflamed epithelium for physical barrier formation and localized microbiome modulation. In murine colitis models, this achieved mucosal healing, mitigated inflammation, and microbiota rebalancing using a mannose equivalent dose of 27.2 mg/kg/d, benchmarking against free mannose and non-responsive MIP controls. This work establishes a generalizable paradigm for targeted recognition and drug delivery in complex physiological environments, paving the way for intelligent, disease-responsive nanomedicines.
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Cyborg and Bionic Systems
·
2026
·
IF 20.9
Ming Yang,Jian Hu,Zerui Li,Hanhan Xie,Hongri Gu,Chengzhi Hu
Multimodal nanotherapeutic systems capable of integrating photothermal, catalytic,and gas-mediated strategies offer powerful opportunities to overcome the limitations ofsingle-mode cancer therapies. Here, we develop a near-infrared (NIR) light-activatedbiomimetic nanomotor for targeted NO delivery and synergistic cancer therapy. Thenanomotor is constructed from bowl-shaped mesoporous polydopamine (PDA)nanoparticles loaded with Fe(II) as a Fenton catalyst and BNN6 as a thermallyresponsive NO donor (Denoted as PFB). To endow tumor specificity, the nanomotor isfurther camouflaged with MCF-7 cancer cell membrane (PFB@CM), enablinghomologous recognition and enhanced intratumoral accumulation. Upon NIRirradiation, PFB@CM exhibits strong photothermal conversion efficiency that initiatesthree synergistic processes: (i) self-thermophoretic propulsion that promotes cellularinternalization; (ii) heat-triggered decomposition of BNN6 for precise NO release; and(iii) heat-accelerated Fe(II) release from the PDA matrix. The liberated Fe(II) catalyzesendogenous H2O2 via a Fenton-like reaction to generate reactive oxygen species (ROS),which subsequently react with NO to yield highly cytotoxic reactive nitrogen species(RNS). This cascade amplifies oxidative and nitrosative stress within tumor cells,enabling photothermal, chemodynamic, and NO-mediated synergistic therapy. Thedesign of PFB@CM integrates homologous targeting, autonomous motility, and NIR-responsive multi-mechanism activation, demonstrating a versatile strategy for precisionnanomedicine and highlighting the potential of light-activated nanomotors for safe andeffective multimodal cancer therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
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IF 8.3
Fenglin Li,Chu Cheng,Chaofan Tong,Yinliang Zhang,Rui Xu,Xiaoqing Jiang,Liangliang Tian,Jiawen Jian,Jihong Xia,Jie Zou
The use of NO 2 sensors is a significant measure for reducing NO 2 emissions from industrial plants and vehicles. The performance of these devices considerably depends on the morphology of sensing electrodes, which in turn is directly influenced by the particle size of the raw powder used for gas detection. In this study, the particle size distribution (PSD) of LaCrO 3 powder was optimized through adjustments to calcination temperature, and the influence of such optimization on the morphology of sensing electrodes was considered in the examination of sensing performance. The results indicated that the sensor (S300) fabricated with the optimally calcined powder exhibited the best performance, achieving a high sensitivity of 52.52 mV/decade and a low limit of detection of 16.5 ppb—advantages stemming from the optimized gas diffusion pathways and triple phase boundaries (TPBs) in the sensing electrodes. The sensor also exhibits excellent selectivity, repeatability, and long-term stability. Overall, the PSD-oriented method developed in this research serves as an effective strategy for designing mixed-potential sensors, showing promising applications in high-temperature exhaust gas monitoring.
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JOURNAL OF CATALYSIS
·
2026
·
IF 6
Wenli Wu,Ming Chen,Chuanfu Wang,Yuxin Jin,Gang Xie,Xinyang He,Daiqi Ye,Limin Chen
CO 2 -assisted oxidative dehydrogenation of ethane (CO 2 -ODHE) has attracted growing attention as a promising route for the effective utilization of shale gas and CO 2 to produce ethylene. A 1.5 wt% Co/TiZrO 4 catalyst was identified highly effective for the CO 2 -ODHE reaction, achieving an ethane conversion of 43.7%, an ethylene yield of 27.9% and a CO 2 conversion of 20.1% at 650 ℃ − performances that surpasses many reported non-Cr-based transition metal catalysts. Based upon our recently developed analytical method for quantitative elucidation of ethane-CO 2 reaction pathways, combined characterization using powder X-ray diffraction (XRD), hydrogen temperature-programmed reduction (H 2 -TPR), in-situ Raman, in-situ NO adsorption diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and quasi in-situ X-ray photoelectron spectroscopy (XPS) revealed that Co 3+ species exhibited higher intrinsic activity than Co 2+ for ethane dehydrogenation. More importantly, this study provide first evidence for a temperature dependent reaction mechanism- from a Mars-van Krevelen mechanism at low temperature, to a coupled direct dehydrogenation (DDHE) and reverse water gas shift (RWGS) mechanism at intermediate temperatures, and finally to dry reforming of ethane (DRE) at high temperature. These mechanistic insights establised a robust foundation for the rational design of highly selective and thermally stable catalysts for efficient ethylene production via CO 2 -ODHE.
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IEEE SENSORS JOURNAL
·
2026
·
IF 4.5
Pengxia Li,Zhifei Cao,Bin Xie,Guowei Yang,Yifei Ma,Mei Wang,Suotang Jia,Xuyuan Chen,Zhaomin Tong
Gas sensors play a vital role in human health monitoring, particularly for detecting disease-related biomarkers in exhaled breath. However, conventional metal-oxide semiconductor gas sensors face limitations in wearable respiratory monitoring applications due to their inflexibility and high heat loss. Here, we fabricated an Au-ZnO fibre-based gas sensor for the detection of ammonia (NH3), an indicator of kidney dysfunction. The device is constructed from a composite flexible fibre comprising a liquid-metal core and a silica cladding, onto which an Au-ZnO gas-sensing layer is synthesised in situ. Liquid metal directly conducts thermal energy to the insulating cladding through Joule heating, providing thermal energy to the gas-sensing layer. This design enables low heat loss and low-current operation while generating sufficient thermal energy to enhance the gas-sensing response. The resulting Au-ZnO fibre sensor exhibits a stable high response to NH3 (response of 2.2 to 2 ppm NH3) even under bending (bending radius of 15 mm). The response time and recovery time are 153 s and 156 s at a working temperature of 280 oC. This demonstrates that the Au-ZnO fibre sensor has good flexibility and suitability for wearable respiratory monitoring. To showcase its practical utility, a real-time monitoring sensor system was developed by designing a signal detection circuit, and the concentration of NH3 was monitored in real time through different coloured light-emitting diodes. This work presents a practical, home-based approach for respiratory monitoring of NH3 and offers a simple, effective solution to distinguish between healthy individuals and patients with different stages of kidney disease.
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Advanced Optical Materials
·
2026
·
IF 7.2
Zhifeng Xing,Shuohan Li,Xin Zhang,Fengjun Chun,Yaxin Cao,Shengqiang Liu,Xiaohe Wei,Feng Wang
Thermoresponsive luminescent materials have been developed over the past decades for temperature monitoring in diverse scenarios. However, traditional luminescence thermometers typically require excitation by light sources such as lasers and light-emitting diodes, which may suffer from errors caused by uneven distribution of the excitation light and environmental interference. In this report, ZnS doped with Cu + and Cl − is investigated for electroluminescence thermometry driven by alternating current. The ZnS:Cu/Cl generates blue-green dual emissions, which exhibit dissimilar responses to temperature changes, giving rise to the thermometric property. The thermometric performance is further improved by refining the thermal response of the green emission through Co 2+ tri-doping, registering a relative sensitivity of 1.19% K −1 at around 50°C. The advances in these alternating-current-driven thermoresponsive optical materials offer exciting opportunities for quantitative temperature detection and visualized surface temperature mapping.
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RARE METALS
·
2026
·Vol. 45
·期 3
·e70187
·
IF 12.1
Xiuxian Zhao,Junhua Sun,Shudi Ying,Rongchuang Geng,Jiajia Feng,Jiachen Ma,Riming Hu,Panpan Zhao,Xuchuan Jiang,Zheng Liu
en This link goes to a English section zh This link goes to a Chinese section Aqueous vanadium dioxide (VO 2 )-based smart thermal insulation coatings represent a viable strategy to decrease building energy consumption and advance sustainable development goals. However, the inherent instability and limited compatibility with polymer matrices of VO 2 hinder its widespread application. Herein, a core-shell structured nanocomposite, VO 2 @poly(hexafluorobutyl methacrylate- block - N , N -dimethylacrylamide) (VO 2 @PHFBMA- b -PDMA), is developed and applied to water-based intelligent coatings. The experimental results show that the designed block copolymer shell PHFBMA- b -PDMA not only has excellent acid and oxidation resistance but also improves the water dispersion stability of VO 2 , ensuring the compatibility between VO 2 and the organic polymer matrix. Moreover, the shell can effectively increase the carrier concentration in VO 2 , thereby significantly enhancing the local surface plasmon resonance effect and giving it excellent optical performance. By optimizing the formula and incorporating the VO 2 @PHFBMA- b -PDMA nanocomposites into water-based polyurethane resins, the resulting coating exhibits excellent adhesion, high hardness, and strong resistance to thermal cycling and ultraviolet aging. In addition, the coating has significant thermochromic properties, which can transmit near-infrared radiation at low temperatures and effectively shield near-infrared radiation at high temperatures. Compared with uncoated glass, the designed coated glass can reduce indoor temperature by approximately 5°C. 摘要 en This link goes to a English section zh This link goes to a Chinese section 二氧化钒(VO 2 )基水性智能隔热涂料,为实现建筑节能与可持续发展提供了可行策略。然而,VO 2 本身的不稳定性及其与聚合物基质相容性较差的问题,限制了其实际应用。为此,本研究制备了一种核壳结构纳米复合材料,VO 2 @聚(甲基丙烯酸六氟丁酯- b - N , N -二甲基丙烯酰胺) (VO 2 @PHFBMA- b -PDMA),并将其用于水性智能涂料体系。结果表明,所设计的嵌段共聚物壳层PHFBMA- b -PDMA不仅具备优异的耐酸和抗氧化性能,还能显著提升VO 2 在水相中的分散稳定性,并改善其与有机聚合物基质之间的相容性。此外,该壳层能够有效增加VO 2 的载流子浓度,从而显著增强其局域表面等离子体共振效应,赋予材料更优的光学性能。通过配方优化,将VO 2 @PHFBMA- b -PDMA纳米复合材料引入水性聚氨酯树脂中,所得涂层表现出良好的附着力、高硬度、优异的抗热循环与抗紫外老化性能。该涂层还具备显著的热致变色性能,能够在低温状态下允许近红外光透过,而在高温条件下有效阻隔近红外光。与未涂覆的玻璃相比,涂覆该涂层的玻璃可使室内温度降低约5°C。
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Jinglin Zhang,Lizhen Chen,Langhuan Huang,Suiping Deng,Jingxian Zhang,Shaozao Tan
Titanium (Ti) stands as a widely used orthopedic implant material, but implant-associated infection remains a formidable and critical contributor to implant failure in clinical practice. To address this intractable challenge, we reported a composite coating comprised of graphene oxide (GO) and ferroferric oxide (Fe3O4) on the Ti matrix surface (denoted as Ti/GO/Fe3O4), which showed synergistically augmented chemodynamic therapy against implant-associated infection. Specifically, the surface hydrophilic and negatively charged coating could physically deter initial bacterial adherence. Moreover, the GO sheet, with sharp-edged architecture, mediated the mechanical nanoknife effect, leading to the physical cleavage of the bacterial membrane. With the help of multienzyme-mimetic activity, GO/Fe3O4 acquired a moderate ROS burst and sustained a relatively high ROS level by glutathione consumption, causing chemical, ferroptosis-like bacterial death. Both in vitro and in vivo assays confirmed that the biocompatible and multifunctional coating was effective in preventing implant-associated infection, which could speed up the implant-tissue integration process. Such work would offer a technical route to design a nonantibiotic, biosafe, and multimodal infection-resistant implant device, which implies considerable potential in clinical application.
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LAB ON A CHIP
·
2026
·
IF 6.3
Qikai Wang,Wenwen Shi,Qihang Yang,Feng Teng,Qiuhong Cui
To address the low light-harvesting efficiency, rapid charge recombination, and restricted mass transport in conventional photocatalysts, this study proposes a bio-inspired SiO2@TiO2 photocatalytic microsphere reactor (ST-PCMR), rapidly fabricated via microfluidic technology and confined self-assembly. This reactor employs an ordered macroporous SiO2 framework as a mechanical support and a rapid mass transfer channel, while a high-surface-area interconnected mesoporous TiO2 catalytic network is constructed under spatial confinement. By tuning the size of the SiO2 nanoparticles, the photonic band-gap was precisely matched with the absorption edge of TiO2, significantly enhancing light absorption via the slow-photon effect. The confinement effect further induced the formation of Ti–O–Si bonded interfaces and high-density grain boundaries, which effectively accelerated the separation and suppressed the recombination of photogenerated charge carriers, leading to a significant increase in photocurrent density and a notable reduction in charge-transfer resistance compared to non-confined TiO2. Under identical illumination conditions, the ST-PCMR exhibited excellent hydrogen production performance, showing an activity 8 times higher than that of single-component TiO2, with 86% retention of its initial activity after five cycles. This study provides a new material paradigm for synergistically optimizing light harvesting, charge separation, and reaction transport, offering a promising pathway for highly efficient solar-to-hydrogen conversion.
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Polymers
·
2026
·Vol. 18
·期 4
·
IF 5.8
Tao Zhang,Nan Li,Zhiyang Luo,Zhaoyi Wang,Zhongyi Sheng,Heyang Liu,Likang Zhou,Liqiang Liu
Polydicyclopentadiene (PDCPD), an emerging environmentally friendly material, has been widely applied in lightweight structural shells; however, its extension to high-value electronic applications remains challenging. In this work, we developed a novel vinyl-SiO2@NaNbO3(VSN) core–shell structure with a high surface vinyl concentration (1.26 mmol/g) and excellent thermal stability, making it highly suitable for co-polymerization with polymers. Through ring-opening metathesis polymerization, the influence of VSN on the mechanical, thermal, and dielectric properties of PDCPD composites was systematically investigated. The vinyl groups on the VSN surface provide strong interfacial compatibility with the PDCPD matrix. With only 1.0 wt% loading, the composites show significant performance improvements: the heat deflection temperature and glass transition temperature increased to 139.3 °C and 150.43 °C, respectively, while the dielectric constant at 1 kHz rises to 4.13 with an ultralow dielectric loss of 0.035%. Meanwhile, the composites maintain high mechanical strength and solvent resistance. This study not only establishes a facile strategy for fabricating highly compatible inorganic additives but also offers new opportunities for expanding PDCPD into advanced dielectric and electronic applications.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Yu Bai,Yi Ding,Guoquan Liao,Xiangchun Kong,Yucheng Wang,Mingshuo Dai,Yuandu Hu
Photonic microcapsules with dual stopbands hold great potential in sensing and wearable electronics. However, existing systems face limited deformability and responsiveness to physical stimuli. In this study, we fabricated fully deformable dual-stopband photonic microcapsules using microfluidics-enabled core–shell double-emulsion templates. The core and shell parts of the microcapsules were an aqueous suspension of PNIPAM-co-AAC hydrogel particles and a poly(ethylene glycol) phenyl ether acrylate (PEGPEA) resin suspension of silica particles, respectively. Given that the core and shell parts were both deformable components, the resultant photonic microcapsules featured full deformability. Their structural colors can be regulated by tuning the particles’ diameters and volume fractions. The resultant microcapsules exhibited isotropic reflection spectra, overcoming angle dependence, and showed reversible color changes under mechanical compression. This work offers a scalable approach for multifunctional photonic microcapsules, paving the way for applications in microsensors, stress visualization, and adaptive wearable devices.
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Science Advances
·
2026
·Vol. 12
·期 9
·
IF 13.9
Xinyi Li,Jiyu Liu,Zhongfeng Wang,Hong Huang,Xiaoyuan Sun,Wenting Lu,Xiao Zhao
Coordination engineering is often used to tune the electronic structures of active sites, while their catalytic performances are determined not only by electronic structures but also by microenvironments. Herein, we introduce interfacial functional ligands that not only optimize the electronic structures of active sites but also regulate the interfacial microenvironment for oxygen evolution reaction (OER). Specifically, the pore edge–hosted FeF 3 O 2 sites enable a favorable electronic structure to generate * OOH intermediates and simultaneously promote the interfacial transport of hydroxide for enhanced OER kinetics. The F ligands in FeF 3 O 2 sites interact with interfacial water strongly via H-bonding to promote H-bond network connectivity, thus encouraging the temporally concerted proton transfer during hydroxide diffusion. Consequently, FeF 3 O 2 sites realize the 331.5-fold enhancement in turnover frequency for alkaline OER over the NiOOH and efficient water electrolyzers (1.663 voltage at 1.0 amperes per square centimeter at 60°C, durably operating at 1.0 amperes per square centimeter > 1200 hours).
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危险品化学品经营许可证（带存储）