ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Luolan Ouyang,Jia Ke,Shanshan Xiang,Jing Ding,Shufen Zhang,Zixu Wang,Si Chen,Tingting Meng,Hong Yuan,Fangying Yu,Fuqiang Hu
Ulcerative colitis (UC), a chronic inflammatory disorder of the colon, remains challenging to treat due to limited efficacy with current therapies. Ferroptosis, a newly identified form of programmed cell death, contributes significantly to UC pathogenesis and might offer promising therapeutic potential. Herein, we developed an oral synergistic regulation of ferroptosis using a solid lipid nanocomplex-embedded inulin gel (SLN/Que&OA@Gel) for colon-targeted UC therapy; solid lipid was utilized to encapsulate oleic acid (OA) and quercetin (Que) for better intestinal bioavailability, which was further embedded in an inulin gel to realize colon targeting. The system combines OA─which modulates lipid composition to reduce ferroptosis susceptibility─with Que, an antioxidant that scavenges reactive oxygen species (ROS) and suppresses oxidative stress to limit ferroptosis progression. Simultaneously, the incorporation of the inulin gel matrix ensures gastrointestinal tract protection, mucoadhesion, prolonged retention time at the lesion site, and sustained drug release, which promise a better curative effect. In vivo studies demonstrate that SLN/Que&OA@Gel effectively remodels the UC-associated pathological microenvironment by alleviating intestinal damage, restoring intestinal barrier integrity, and reducing inflammation. This strategy of synergistic regulation of ferroptosis and microenvironment remodeling presents a promising therapeutic avenue for UC management.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Huan Tian,Feng-Lei Jiang
Perovskite nanocrystals (NCs) exhibit intrinsic chemical instability due to their ionic nature. This property renders them susceptible to structural degradation and optical performance deterioration upon exposure to various cations (both inorganic and organic ions). For instance, Cs+ can induce phase transformation and photoluminescence quenching in the CsPbBr3 NCs. In this work, we found that externally introduced metal cations exert diverse effects (classified as three types) on the structure and optical properties of CsPbBr3 NCs. Notably, certain cations, such as Zn2+ and Cd2+, can bind to the surface and shield nanocrystals against the detrimental effects of exogenous cations. The protection effects were observed by both optical spectroscopy and transmission electron microscopy. Pretreatment with both ZnBr2 and CdBr2 significantly enhances the resistance of CsPbBr3 NCs to structurally or optically detrimental exogenous cations (Cs+). Moreover, with didodecyldimethylammonium bromide (DDAB) simultaneously incorporated in this pretreatment, the pretreated CsPbBr3 NCs exhibit enhanced resistance to polar solvents (e.g., ethanol), manifesting as keeping stable and bright even when exposed to 20% (volume percentage) of ethanol. These three components (ZnBr2, CdBr2, and DDAB) exhibit complementary functions for chemical stability. This stability-preserving strategy is expected to enhance the robustness of perovskite NCs against complex chemical conditions encountered during the device fabrication process (solution processing and interlayer interface engineering) and operating environments.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Boyu Huang,Ziyi Zhang,Junnan Shen,Weijun Pang
Lipid content in myofibers plays an important role in improving pork quality closely linked to flavor, tenderness, and marbling; however, the molecular mechanisms regulating lipid deposition in myofibers remain elusive. Here, we identify GA-binding protein α (GABPα) as a previously unrecognized transcriptional regulator (TF) of lipid deposition in porcine skeletal myofibers. Functional analyses show that GABPα markedly enhances lipid deposition in myofibers and activates endoplasmic reticulum (ER) stress in skeletal muscle. Mechanistically, GABPα directly binds to the promoter of the ER stress-associated gene activating transcription factor 4 (ATF4), thereby promoting lipid deposition in myofibers. Our findings establish GABPα as a novel key regulator of lipid deposition in myofibers and identify the GABPα–ATF4 regulatory axis as a mechanistic pathway connecting ER stress with porcine myofiber lipid deposition, providing significant implications to boost pork quality in the pig industry.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Shafaat Hussain,Shengyi Yang,Ayesha Zia,Muhammad Qasim,Bingsuo Zou,Yurong Jiang
Infrared (IR) photodetectors are crucial for a range of applications, including night vision, optical communication, and environmental monitoring. However, their effectiveness is often hindered by low charge transport and interfacial losses in colloidal quantum dot (CQD)-based designs. MXenes, known for their high metallic conductivity, adjustable surface terminations, and excellent optical transparency, present a unique opportunity to improve interfaces for better optoelectronic performance. In this work, Ti3C2Tx MXene via interface engineering for PbS CQD IR photodetectors, in which it functions as an electrode, transport layer, and interfacial modifier is systematically investigated. As a result, an ultrahigh responsivity of 1032.37 A/W with a specific detectivity of 1.12 × 1013 Jones and an external quantum efficiency of 1.311 × 105 % are obtained from photodetector ITO/ZnO/Ti3C2Tx/PbS/MoO3/Ti3C2Tx under 1 μW/cm2 980 nm illumination. Our finite difference time domain (FDTD) simulations further support and provide a physical basis for our experimental results, indicating that dual MXene incorporation significantly enhances optical field confinement and absorption within the PbS CQD layer. Thus, it illustrates that MXene-enabled interface engineering and optical coupling can establish an effective design paradigm for high-performance, solution-processed infrared photodetectors, effectively bridging the gap between quantum materials and practical optoelectronics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Optical Materials
·
2026
·
IF 3.4
Shichao Rao,Wentao Niu,Zhongwei Man,Xiulin Xie,Zhe Yin,Yue Qin,Shuaibing Wang,Ouyang Lin,Aiwei Tang
The advancement of environmentally benign I–III–VI colloidal quantum dots (QDs) has established a promising materials platform to replace cadmium-based counterparts. However, in practical device architectures, especially blue-emitting devices, abundant surface nonradiative recombination centers and imbalanced carrier injection often lead to suboptimal device performance, thereby hindering their deployment in display technologies. Herein, we employ a zinc iodide (ZnI2) post-treatment for the Cu–Ga–Zn–S (CGZS) QDs film strategy, effectively passivating surface defects and nonradiative sites, thereby enhancing device performance. The treated QDs facilitate the formation of an interface dipole, which effectively elevates the overall energy levels of the QDs while simultaneously reducing the hole injection barrier, leading to an enhanced hole injection efficiency. Working in concert, these effects facilitate balanced carrier injection and optimize exciton recombination, thereby boosting the device efficiency and operational stability. Consequently, the peak external quantum efficiency (EQE) exhibits a favorable improvement, increasing from 1.01% in the pristine device to 1.90% after treatment. This work offers an effective approach to achieving balanced carrier injection in quantum-dot light-emitting diodes (QLEDs) and establishes a solid foundation for the development of high-performance, cadmium-free, blue-emitting QLEDs.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Meidan Que,Xiangwei Bai,Tengjiao Xue,Ziang Liu,Jiaojiao Zheng,Xun Sun,Jun Xu
Barium titanate (BaTiO3) exhibits high chemical stability; however, the relatively rapid recombination of charge carriers severely limits its photocatalytic performance. Meanwhile, electrocatalysis facilitates charge transport by generating a spontaneously polarized electric field, effectively suppressing charge carrier recombination, but the performance of conventional ferroelectric catalysts is inherently constrained by their low surface piezopotential. In this study, a piezo-photocatalytic system triggered by ultrasonic vibration is reported, based on BaTiO3 nanobats. The BaTiO3 structure resembles a nanobat, featuring a thicker lower cylindrical body (∼35 nm diameter) and a thinner upper section (∼20 nm diameter) with a total length of about 250 nm. It can generate a piezo-potential as high as 1.2 V through COMSOL finite element simulation. Under mild vibration, the BaTiO3 nanobats exhibit superior piezo-photocatalytic performance, converting CO2 into CO with a maximum yield of 101.18 μmol·g–1·h–1. The yield is approximately five times higher than that achieved with ultraviolet light irradiation alone. Furthermore, theoretical calculations reveal that the adsorption and desorption of intermediates (*COOH, *CO) on BaTiO3 can be regulated by applying different strains. The piezo-photocatalytic CO2 reduction reaction opens an avenue beyond conventional photocatalysis, expanding energy utilization to pave the way for carbon neutrality.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2026
·
IF 4.5
Hongyu Lin,Huwei Bian,Junyao Li,Laidi Xu,Tao Jiang,Yong Kong
To enhance the therapeutic efficacy of breast cancer, multimodal therapy with the aid of a pH-responsive controlled release platform is proposed in this work. Indocyanine green (ICG) is loaded in honeycomb MnO2 (hMnO2) synthesized by a template method, which is coencapsulated with 5-fluorouracil (5-FU) in the hydrogels cross-linked between carboxymethyl chitosan (CMCS) and oxidized hyaluronic acid (OHA). The imine linkage (−HC═N−) between CMCS and OHA is hydrolyzed under weakly acidic conditions, leading to the release of 5-FU for chemotherapy and ICG/hMnO2. The hMnO2 can convert the optical energy of near-infrared (NIR) light into heat for photothermal therapy (PTT). Additionally, the hMnO2 can be reduced to Mn2+ at low pH and high glutathione (GSH) level, and the produced Mn2+ can further react with H2O2 to generate hydroxyl radicals (·OH) through a Fenton-like reaction for chemodynamic therapy (CDT). ICG can be simultaneously released during the reduction of hMnO2, which can catalyze the conversion of oxygen to singlet oxygen (1O2) upon exposure to NIR light for photodynamic therapy (PDT). Due to the synergistic effects of chemotherapy, PTT, CDT, and PDT, the developed ICG/hMnO2/5-FU/CMCS/OHA hydrogels can significantly inhibit the growth of the 4T1 mouse breast cancer cell line.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Shirui Zhang,Peng Zhang,Hongyu Wen,Junzheng Niu,Yi Huang,Xuhui Xu,Huaiqiang Ba,Yu Zhang,Ru Zhao
Thermochromic smart windows dynamically regulate sunlight transmittance in response to temperature changes, thereby suppressing indoor temperature increases. The near-infrared light in sunlight is the main band that causes the indoor temperature to rise. However, the smart window materials in existing research have significant limitations in the absorption of this band. To optimize the modulation efficiency of the infrared band, upconversion nanoparticles (UCNPs) were introduced into the poly(N-isopropylacrylamide) (PNIPAm) matrix. This approach effectively blocks sunlight when natural visible light is obstructed due to an increase in temperature, thereby supplementing indoor brightness with the NIR-to-visible light conversion capability of UCNPs. The 1 wt % microcrystalline composite hydrogel exhibits the best solar spectral modulation performance: the visible light transmittance is 80.1% at room temperature, and the value is reduced to 34.7% after phase transition. In addition, the smart window achieves a temperature drop of 23 °C compared to that of the standard glass window during all-day modulation. It provides a novel approach to developing thermochromic smart windows with broadband solar spectrum modulation capability and excellent durability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2026
·Vol. 31
·期 4
·594
·
IF 5.1
Bing Qian,Xuan Zhu,Chulian Su,Hongxing Li,Qiong Wu,Chengyuan Liu,Yang Pan,Bingjun Han
Thermal oxidation of edible oils during high-temperature cooking produces complex fumes containing harmful volatile compounds. However, the role of water, a common co-reactant in practical cooking, remains insufficiently understood. In this study, oleic acid was used as a model compound to investigate thermal oxidation. Online monitoring using synchrotron radiation photoionization mass spectrometry (SR-PIMS) revealed that water significantly increased the emission of volatile acetaldehyde and acrolein, with maximum increases of 164% and 123% at 10% water addition. Complementary offline GC-MS analysis showed enhanced formation of (E)-2-decenal, (E,E)-2,4-decadienal, and (E)-2-undecenal, suggesting these unsaturated aldehydes may be key intermediates. Mechanistically, oleic acid underwent free radical-mediated peroxidation to form (E)-2-decenal, (E)-2-undecenal, and (E,E)-2,4-decadienal. These intermediates subsequently decomposed into acetaldehyde and acrolein via hydration, retro-aldol condensation, and hydroperoxide scission, with water accelerating both processes. Overall, these findings highlight water’s critical role in promoting the generation of harmful volatile aldehydes in oil fumes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Hanqing Liu,Haifeng Zhou,Jing Xu,Le Ding,Guangjun Zhou,Shiwei Chen,Youxin Lou
Excessive use of nitrite in food production and preservation causes blood and digestive system diseases, underscoring the need for rapid and accurate quantitative detection of nitrite. In this study, we developed a novel visual method for nitrite detection based on a near-infrared (NIR)-excited ratiometric fluorescent hydrogel sensor. In this sensor, NIR-excited upconversion nanoparticles (UCNPs) and basic fuchsin (BF) served as energy donors and acceptors, respectively, collectively forming an integrated ratiometric nanofluorescent probe. The upconversion optical probe was further embedded into a three-dimensional (3D) porous polyacrylamide (PAM) hydrogel to fabricate a smart hydrogel nanosensor that exhibited specific optical and colorimetric responses to nitrite. The hydrogel nanosensor demonstrated a high loading capacity for upconversion probes and provided a liquid-phase detection environment, thus significantly enhancing both fluorescence signal stability and sensing sensitivity. The NIR-excitation of the UCNPs prevented background fluorescence interference from the hydrogel and real samples. BF acted as a specific recognition unit for nitrite ions. The addition of nitrite altered the green-to-red intensity (G/R) ratio of the hydrogel sensor, facilitating real-time quantitative nitrite detection. Furthermore, the hydrogel sensor was integrated with a smartphone to create a portable platform for practical visual nitrite detection. The detection limits for nitrite using the probe and hydrogel sensor were extremely low (60.7 and 72 nM, respectively). The proposed novel UCNP-based hydrogel nanosensor provides a new sensing approach for detecting harmful substances in food, showing considerable potential to advance the applicability of portable fluorescence sensing devices in food safety monitoring.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Min Luan,Sha Bao,Xueling Zhang,Yuhao Huang,Ruinan Yuan,Pengjun Zhong,Mengyuan Liu,Jue Li,Xuefei Liu,Lei Chen,Qingrong Huang,Rihui Wu
The exact mechanism through which dietary flavonoids alleviate metabolic syndrome (MetS) via the gut microbiota remains fully unclear. This study demonstrates that sinensetin markedly impeded the development of MetS and altered hepatic transcriptomic profiles by activating alternative bile acid biosynthesis signaling cascades both in vivo and in vitro. Importantly, sinensetin administration induced significant shifts in hepatic bile acid composition, notably increasing the relative abundance of non-12-hydroxy bile acids (non-12-OH BAs) in high-fat diet (HFD)-fed mice. Additionally, oral administration of sinensetin significantly relieved intestinal dysbiosis caused by HFD by altering the composition of gut microbiota in mice. The therapeutic efficacy of sinensetin against MetS was microbiota-dependent, as antibiotic-mediated depletion of gut microbiota abolished its beneficial effects, and fecal microbiota transplantation transmited this metabolic improvement. These findings suggest that sinensetin alleviated MetS by reshaping the gut microbiota to enhance non-12-OH BAs synthesis, offering novel mechanistic insights and promising avenues for therapeutic intervention.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Shuanglong Tang,Xi Wang,Jingyu Li,Xiaodan Wen,Hao Chen,Mei Yan,Xi Chen,Chongshen Guo
Although photothermal therapy (PTT) has been deemed as an effective approach for tumor ablation, the ubiquitous overheat over 50 °C in the PTT process would damage surrounding normal tissue. The combination of nutrient depletion at the tumor site with mild PTT seems like an efficient way to overcome this dilemma. In this work, cobalt-doped polydopamine (CP) behaved as both photothermal agent and glucose oxidase (GOx) carrier to achieve a starvation assisted photothermal therapy. CP possesses more weak acid sites than pure polydopamine, and it gives higher encapsulation efficiency and loading capacity of 89.71% and 47.29% towards GOx, respectively. The CPGP was prepared by coating the GOx-loaded CP with a phase change material (PCM) layer. The solidified PCM prevents the binding between the GOx and glucose, thereby inhibiting GOx activity. The PCM melts at 45 °C and then the GOx activity restores to normal level. The CPGP could cause reduction of intracellular levels of NAD + , NADH and ATP, as well as mitochondrial dysfunction and the induction of apoptosis or necrosis. Hence, CPGP-mediated starvation-photothermal combination therapy exhibits an effective tumor-killing effect. In addition, upregulated M1-polarized macrophages, CD4 + T cells and CD8 + T cells were observed in the mouse model.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）