JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Yuanyuan Wang,Huan Wang,Zhixian Li,Dongjie Yang,Xueqing Qiu,Yechen Liu,Mengzhen Yan,Qiong Li
Lignin has been demonstrated to be green and effective for the modification of ZnO-based materials. In this work, quaternized lignin/zinc oxide nanostructured hybrid composites (QLS/ZnO NCs) were synthesized with good dispersion and uniform particle size via a facile hydrothermal method . Sodium lignosulfonate (LS) was modified by quaternization to endow the positive charges, which effectively captured bacteria due to the electrostatic interactions. Interestingly, QLS/ZnO NCs show a litchi-like morphology consisting of nanorods with diameters of 5–10 nm, which further resulted in damage to the bacterial cell membrane. Owing to the surface charge and rough surface topology for bacterial capture, QLS/ZnO NCs exhibited greatly enhanced antibacterial activity compared with bare ZnO . After being treated with QLS/ZnO NCs for 90 min, the sterilization rates of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) reached 97.54% and 99.55%, respectively. Due to the reactive oxygen species (ROS) produced by ZnO under light irradiation, the antibacterial activity of QLS/ZnO NCs could be further enhanced. In addition, the minimal inhibition concentrations (MICs) of QLS/ZnO NCs towards E. coli and S. aureus were both 100 μg/mL, and the minimum bactericidal concentrations (MBCs) were 100 μg/mL and 200 μg/mL, respectively. Moreover, with the incorporation of QLS/ZnO NCs into polyurethane films, the composite films showed excellent antibacterial activity, strong tensile strength and enhanced ultraviolet light blocking performance.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 32
·50800
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IF 3.125
Peng Zhu,Xingqun Zhang,Yunlong Wang,Changen Li,Xianzhu Wang,Jiancheng Tie,Ying Wang
Capparis spinosa L. (CSL) is a medicinal plant with high antibacterial activity against a variety of pathogens and antioxidation properties. In this paper, for the first time, nanofiber membranes of polylactic acid (PLA) containing 0, 4, 7,and 10 wt% CSL ethyl acetate extract were fabricated by electrospinning. Scanning electron microscopy showed that the fiber diameter decreased after adding CSL to the PLA nanofibers. Fourier transform infrared spectroscopy confirmed that CSL was successfully incorporated in the matrix. The water contact angle test proved that the addition of CSL improved the hydrophilic properties of the material. Moreover, the addition of CSL improved the oxidation resistance of the composite fiber membrane. A burst drug release from the composite nanofibers occurred within the first 12 hr, followed by slow release over a prolonged period of time. As the concentration of CSL increased, the inhibition ability of nanofibers against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) gradually increased. In summary, due to their good mechanical, antioxidant, and antibacterial properties, CSL/PLA nanofiber membranes may possess potential applications as wound dressing materials.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
·
IF 8.128
Ying Liu,Runxia Wang,Haiyan Wang,Xijuan Yu,Xien Liu,Peng He,Xilin She,Tianrong Zhan
It is established that ultrathin layered double hydroxide nanosheets (LDHNS) and zeolitic imidazole frameworks (ZIF) are desirable electrochemical sensing modifiers owing to their large surface area and abundant catalytic sites. Integration of them is thus an effective solution to maximize their electrocatalytic activity . Herein, a novel reaction–diffusion framework (RDF) technique is applied for the in situ growth of ZIF-67 on ultrathin CoAl-LDHNS (CoAl-LDHNS@ZIF-67). In a confined space of the agar gel matrix of RDF, the coordination reaction between organic ligands and CoAl-LDHNS without an additional Co 2+ source achieves the controllable growth of ZIF-67 crystals through a long vertical diffusion . The prepared composite comprises both CoAl-LDHNS and ZIF-67 components with a certain ratio and provides a large surface area and amply catalytic sites, thus realizing a rapid transfer of electron and mass. The CoAl-LDHNS@ZIF-67 modified electrode is employed for the simultaneous detection of naphthol isomers by differential pulse voltammetry . Naphthol isomers display anodic reactions with a wide peak potential difference, allowing their simultaneous detection feasible. Voltammetric responses of α-naphthol and β-naphthol follow good linearity against the concentration in a wide range from 0.3 to 150 μM with limits of detection of 54 and 82 nM, respectively. The proposed sensor also demonstrates excellent selectivity , stability, reproducibility, and practicability for the simultaneous detection of naphthol isomers.
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RSC Advances
·
2021
·Vol. 11
·期 17
·10121-10129
·
IF 3.361
Zhilong Quan,Chunyang Luo,Bitong Zhu,Chungui Zhao,Mingyi Yang,Magnar Bjørås,Kaizheng Zhu,Anna-Lena Kjøniksen
Antibiotic resistance is an emerging threat to public health. The development of a new generation of antimicrobial compounds is therefore currently required. Here we report a novel antimicrobial polymer of chitosan/polypropylene carbonate nanoparticles (CS/PPC NPs). These were designed and synthesized from readily available chitosan and a reactive oligomer polypropylene carbonate (PPC)-derived epoxy intermediate. By employing a simple and efficient functionalized strategy, a series of micelle-like chitosan-graft-polypropylene carbonate (CS-g-PPC) polymers and chitosan–polypropylene carbonate (CS–PPC) microgels were prepared by reacting mono-/bis-epoxy capped PPC with chitosan. The chemical structure, particle size, and surface charge of the newly synthesized polymers were characterized by infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. The antimicrobial activities of these nanoparticles were determined in both Gram-positive bacteria (S. aureus) and Gram-negative bacteria (E. coli). Minimum inhibitory concentration (MIC), the nanoparticle concentration needed to completely inhibit the bacterial growth, was found at 128 μg mL−1 to 1024 μg mL−1, strongly depending both on the nature of the epoxy-imine network formed from the functional groups (mono- or bis-capped epoxy groups reacting with amine groups) and the feed ratio of the functional groups (-epoxy/-NH2) between the functionalized PPC and chitosan. No hemolysis was observed at concentrations well in excess of the effective bacteria-inhibiting concentrations. These findings provide a novel strategy to fabricate a new type of nanoantibiotic for antimicrobial applications.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Huihui Chai,Feng Chen,Zhaoxi Song,Lulu Xiong,Gang Xiao,Zhisong Lu,Ling Yu
Replica molding is a well-established technique to fabricate surfaces with micro-patterns. Double replica molding of polydimethylsiloxane (PDMS) was developed to fabricate bio-inspired structures though challenged by the cross-linking between PDMS and PDMS. In this paper, we report a novel Wax Assisted Replica Molding (WARM) method to rapidly and precisely copy the microstructures from versatile substrates to PDMS and hydrogels. The low phase transition temperature, hydrophobicity and low surface free energy of wax were utilized to assist transferring patterns from an original master to final replicas. The potential of WARM was demonstrated by generating patters from bio-inspired materials, such as plant leaves and loose fibrous scaffolds, the later was not feasible for direct PDMS replicating. Apart from PDMS, transferring the patterns to materials like hydrogels, sodium alginate, silk fibroin, epoxy glue, and chitosan were also explored. More importantly, the proposed WARM was conducted to fabricate silver nanowire functionalized, microstructure patterned-PDMS specimens, which were further used to construct a flexible electronic skin to monitor human physiological signals, highlighting the potential of WARM in developing biosensors and bioelectronics devices. Neither chemical modification nor special equipment was needed, especially in the favoring of a resource-limited experiment setting.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Chenmeizi Wang,Ling Wang,Qingle Zhang,Lu Cheng,Haitao Yue,Xin Xia,Huimin Zhou
Addition of nanomaterials into polymer matrix is a promising avenue to reinforce the mechanical properties of composites. In this work, chitosan-based hydrogels reinforced by cellulose nanofibers (CNFs) have been prepared by chitosan as matrix. The effect of CNFs (1vt%, 1.5vt% and 2vt%) on the structure-property relationship in mechanical, swelling capability, pH sensitivity and antibacterial have been investigated, respectively. Different from normal reinforced particle, CNFs with special fiber shape and abundant hydrogen bonding can form interconnected porous structure with chitosan hydrogel, which can spread stress and defer permanent damage under compressing. And the compressive strength increases nearly 20 % and swelling capacity achieve 140 %, when 1.5vt% CNFs added. Thanks to CNFs which obtained from apocynum venetum generated positive effect on the antibacterial rate against E. coli and S. aureus of composite hydrogel. It proves that CNFs display an excellent mechanical and antibacterial enhancement in composite, and it provided a new prospect for the rational selection of the different shapes and aspect ratio of reinforced materials. The obtained CNFs reinforced composite hydrogels could be potentially applied in antibacterial biological and food packaging area.
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Bio-Design and Manufacturing
·
2020
·Vol. 3
·期 4
·373-382
·
IF 4.095
Xuan Chengkai,Liu Xuemin,Lai Chen,Shi Xuetao
There is a consensus that the prevention of wound infection should be achieved in the following ways: (1) closing the wound to protect it from extra infection; (2) an antibacterial agent that could kill endogenous bacteria. However, existing bulk two-dimensional antibacterial materials show inefficient adhesion to wounds with complex morphology and thus cause the prevention of wound closure. Reducing the thickness of bulk two-dimensional materials to less than 100 nanometres endows them with great flexibility, which could allow them to adhere to wounds with complex morphology by only physical adhesion. Herein, a broad-spectrum and efficient antimicrobial peptide (AMP) was introduced to biocompatible methacrylated gelatine (GelMA) with multiple modification sites, which served as an inner antibacterial layer. After being combined with a biodegradable and good mechanical poly-l-lactide (PLLA) outer layer through plasma-treatment-assisted spin coating, we finally constructed bilayered antibacterial nanosheets with a thickness of approximately 80 nm. These bilayered nanosheets possess good adhesion to surfaces with complex topography and thus achieve better wound closure than other bulk two-dimensional materials. Moreover, this AMP-grafted conjugation shows minimal cytotoxicity compared with Ag + antibacterial agents, and the antibacterial rate of nanosheets is dependent on the graft rate of AMP. We suggest that this bilayered antibacterial nanosheet might be an advanced anti-infection dressing for wound treatment in clinical settings.
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Journal of Materials Research and Technology-JMR&T
·
2020
·
IF 5.289
Wenwen Guo,Xin Wang,Jiali Huang,Wei Cai,Junling Wang,Lei Song,Yuan Hu,Zhou Gui
Currently, aluminum phosphide tablets have been extensively used as fumigant for grain storage because they could release phosphine that shows highly efficient anti-microorganism. However, phosphine is highly toxic and flammable which usually causes production accidents. Therefore, this study aimed to develop a novel fumigant based on cinnamaldehyde and study its antimicrobial efficacy for grain storage. The novel fumigant tablet was composed of cinnamaldehyde, silica, citric acid and sodium bicarbonate. Results showed that mesoporous silica with ultra-high specific surface area (1036.5 m 2 /g) served as carrier for cinnamaldehyde. The mixture of citric acid and sodium bicarbonate reacted with moisture to generate carbon dioxide which was helpful to release cinnamaldehyde. As expected, the fumigant tablet displayed a sustained release effect. The in vitro culture experiments showed that cinnamaldehyde had high antimicrobial effect against five fungi including Aspergillus flavus , Aspergillus candidus , Aspergillus niger , Fusarium and Penicillium . In the accelerated mildew simulation experiment (temperature: 35 °C, humidity: 98%), the blank group without mildew preventive began to go mouldy after five days, the control group with only cinnamaldehyde became mildew one week later, whereas there was no visible mildew growth in the experimental group with the fumigant tablet after one week. The number of fungal colonies in the blank group and the control group after one week was 8.3 × 10 4 and 6.5 × 10 3 CFU/g, respectively, while there were no fungi detected in the experimental group. This cinnamaldehyde-based fumigant tablet is a green and safe mildew preventive, which provides an alternative solution to aluminum phosphide tablet for grain storage.
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ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Zhong Wang,Hongfu Gao,Jiwen Cui,Shi Zhou,Yanli Zhao,Cai Ye,Jinlian Li,Dongmei Wu
Establishment of new method for evaluation microbial viability has become an urgent need in the fields of biology, medicine, environment and so on. In this paper, two electrochemical signals of Staphylococcus aureus ( S. aureus ) at + 0.693 and + 0.973 V vs. Ag/AgCl ( sat . KCl) were detected on the multi-walled carbon nanotube modified glassy carbon electrode (MWCNTs/GCE), and attributed to the oxidation of guanine and adenine secreted by S. aureus . For the first time, bacterial viability was evaluated from the perspective of proliferation and purine metabolism. Compared with the plate counting method, the electrochemical signals of guanine and adenine showed an earlier change of viability when S. aureus entered stationary from logarithmic phase and apoptotic from stationary phase during the growth process of S. aureus . There were good linear relationships between electrochemical signals of guanine and adenine and the number of S. aureus cells in different growth phases, but there were different detection thresholds. At the logarithmic phase, S. aureu s had stronger viability and ability to metabolize purines, which resulted in a lower detection threshold. Both electrochemical signals of bacteria could well reflect the inhibition of levofloxacin on S. aureus viability, and the guanine signal peak was closer to the result of plate counting method.
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MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 221
·期 22
·2000237
·
IF 2.335
Xin Han,Mengyu Li,Zewen Fan,Yu Zhang,Huihui Zhang,Qiaoling Li
Traditional self-healing hydrogels have great application prospects in biological engineering because of their extremely high water content, but their durability cannot be easily guaranteed. Therefore, developing a rapid self-healing hydrogel with long-lasting water retention capacity is still a significant challenge. A high-strength and fast self-healing hydrogel with an interpenetrating double network based on polyvinyl alcohol/agar-ethylene glycol (PVA/agar-EG) is proposed. Polyvinyl alcohol (PVA) and agar are designed for the construction of the interpenetrating network. Furthermore, the introduction of a borate-bonding dynamic action mode affords the hydrogel with extraordinary mechanical strength and rapid self-healing. The addition of EG as a traveling solvent enables the sample to retain water and prevents freezing in harsh environments, including at high temperatures of 80 °C and extremely low temperatures of −40 °C. Additionally, owing to the intelligent remolding ability of the PVA/agar-EG hydrogel, the material can be recycled to prolong the service life of the hydrogel. Overall, the PVA/agar-EG hydrogel developed in this study can provide a new general strategy for the development of intelligent self-healing devices, and hydrogels can be applied in complex environmental engineering.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Kun Fang,Rong Wang,Hua Zhang,Linjie Zhou,Ting Xu,Ying Xiao,Yang Zhou,Guorong Gao,Jing Chen,Donglei Liu,Fanrong Ai,Jun Fu
Acute wounds subject to frequent deformations are difficult to be treated because the healing process was easily interfered by external mechanical forces. Traditional wound dressings have limited efficacy because of their poor mechanical properties and skin adhesiveness and difficulty in the delivery of therapeutic drugs effectively. As such, tough and skin-adhesive wound dressings with sustainable and stimuli-responsive drug release properties for treatment of those wounds are highly desirable. For this purpose, we have developed a mechano-responsive poly(sulfobetaine methacrylate) hydrogel which aims to control the delivery of antibiotic drug upon application of mechanical forces. Diacrylated Pluronic F127 micelles were used as a macro-cross-linker of the hydrogel and loaded with hydrophobic antimicrobial drugs. The micelle-cross-linked hydrogel has excellent mechanical properties, with the ultimate tensile strength and tensile strain of up to 112 kPa and 1420%, respectively, and compressive stress of up to 1.41 MPa. Adhesiveness of the hydrogel to the skin tissue was ∼6 kPa, and it did not decrease significantly after repetitive adhesion cycles. Protein adsorption on the hydrogel was significantly inhibited compared to that on commercial wound dressings. Because of the mechano-responsive deformation of micelles, the release of drug from the hydrogel could be precisely controlled by the extent and cycles of mechanical loading and unloading, endowing the hydrogel with superior antibacterial property against both Gram-positive and Gram-negative bacteria. In addition, drug penetration into the skin tissue was enhanced by mechanical stress applied to the hydrogel. The micelle-cross-linked zwitterionic hydrogel also showed good cell biocompatibility, negligible skin irritation, and healing capacity to acute skin wounds in mice. Such a tough mechano-responsive hydrogel holds great promise as wound dressings for acute wounds subjected to frequent movements.
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ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Yuehua Xu,Yan Fang,Yanjing Ou,Liyu Yan,Qinhui Chen,Caixia Sun,Jiang Chen,Haiqing Liu
Uncontrollable bleeding and bacterial infection are the two major challenges in treating hemorrhaging civilian and military traumas. Herein, a novel hemostatic material was designed by in situ growth of zinc imidazolate frameworks (ZIF-8) into a chitin sponge (CTS) for effective hemostasis and anti-infection. ZIF-8 nanocrystals were not only uniformly dispersed throughout the CTS but also firmly anchored onto CTS with a residual mass of over 94% after 10 min of sonication. The resultant composite sponge (ZIF-8–CTS) displayed a hierarchically porous structure with a high specific surface area (∼126.2 m2·g–1) and super-hydrophilicity, accelerating blood absorption to concentrate blood cells and platelets to form a primary blood clot. Meanwhile, upon contact with blood, ZIF-8 nanocrystals could gradually release Zn2+ to activate the blood coagulation cascade reactions. Benefiting from these two synergistic effects, ZIF-8–CTS exhibited superior hemostasis performance than the traditional hemostatic materials (cotton gauze and gelatin sponge) in the rat femoral artery and liver injury models. Furthermore, it displayed excellent cytocompatibility and hemocompatibility. Importantly, it had an outstanding bactericidal effect with antibacterial ratio of up to 100% for Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. These results demonstrated that ZIF-8–CTS is an excellent antibacterial hemostatic material with a high potential in clinical applications.
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