Journal of Translational Medicine
·
2024
·Vol. 22
·期 1
·1-13
·
IF 6.1
Li Jing,Wang Xiaochen,Bai Jie,Wei Huangzhao,Wang Wenbo,Wang Shuai
Background Hypertension influences the inflammatory pathological changes in the retina. The function of the inflammasomes is significant. To see if Sirtuin 1 (SIRT1) regulates angiotensin II (Ang II)-induced hypertensive retinopathy and inflammation by modulating NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation and the potential protective effects of fucoidan (FO) in mouse retinal vascular endothelial cells (mRECs) and mice retina. Methods The diagnosis of hypertensive retinopathy was made after three weeks of Ang II infusion (3000 ng/kg/min). One day prior to the commencement of Ang II infusion, the mice were treatment with NLRP3 inhibitor MCC950 (10 mg/kg/day, intraperitoneal injections) or FO (300 mg/kg/day, oral gavage). A blood pressure was recorded. Hematoxylin and eosin (H&E) staining was used to conduct pathological alterations, dihydroethidium bromide (DHE) was utilized to assess oxidative stress damage in the retina, and fluorescence angiography was used to identify vascular disorders in the eye. Using immunohistochemical labeling, NLRP3 expression was found. Reactive protein and mRNA expression levels in mouse retina and cells were assessed using Western blot and real-time quantitative polymerase chain reaction (RT-qPCR). Results NLRP3 inflammasome activation and SIRT1 decrease were brought about by Ang II infusion. Retinopathy and dysfunction were lessened by MCC950 target-induced NLRP3 inflammasome activation, while overexpression of SIRT1 had the opposite impact on NLRP3 inflammasome activation, indicating that SIRT1 functions as an upstream regulator of NLRP3 activity. FO may improve SIRT1 expression and decrease NLRP3 activation in retinopathy and dysfunction brought on by Ang II, and the effects were consistent across both in vivo and in vitro models. Conclusions SIRT1 adversely regulates the NLRP3 inflammasome pathway, which in turn increases Ang II-induced inflammation and hypertensive retinopathy. FO may mitigate Ang II-induced retinopathy and dysfunction via modulating the expression of SIRT1/NLRP3. This implies practical approaches to the management of hypertensive retinopathy.
研究领域:
医学
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Fan Wu,Rishun Li,Anfeng Yao,Zhixin Li,Huiqin An,Hui Ye,Qingping Xin,Yuzhong Zhang,Hong Li,Lizhi Zhao
Liquid-filled porous membranes have been developed for oil-water separation with antifouling properties. However, the degradation of fouling resistance and reduction of separation efficiency may occur due to the poor stability of the liquid layer. Prompted by the mesoporous structure and high porosity characteristics of aerogel , the membrane with aerogel-network-stabilized slippery surfaces was fabricated by in situ growth of silica aerogel coating on the polyethylene terephthalate (PET) fiber membrane and silicone oil filling. Owing to the oil-locking ability of the aerogel coating, the liquid layer of the membrane showed excellent stability against chemical corrosion and high-temperature, improved stability against shear and mechanical abrasion , and good hot water tolerance and self-healing performance. The prepared liquid-filled membrane can efficiently separate water-in-oil emulsion. In filtrating-cleaning cycles, the membrane showed antifouling property and durability with high separation efficiency and flux recovery. The membranes with highly stable liquid-filled surface provide promising prospects in industrial oil treatment and oil spill recovery.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2019
·
IF 3.372
Peng Liu,Mengmeng Chen,Yiqiang Ma,Chuan Hu,Qiugen Zhang,Aimei Zhu,Qinglin Liu
Pervaporation is a promising membrane technology for separation of aqueous organic solution particularly azeotrope and close-boiling point compounds. However, most of pervaporation membranes are based on hydrophilic polymers that suffer decline of separation performance due to their swelling in aqueous solution. Here we present a copolymer synthetic strategy for preparation of hydrophobic polymer pervaporation membrane with hierarchical porosity via uniting both rigid and flexible segments. The synthesized membrane has well-defined micropores and high free volume faction of 8.03% with cavity size of 0.476 nm, and demonstrate exceptional performance with high permeability and selectivity for dehydration of alcohols. In the pervaporation of ethanol-water azeotrope, the membrane displays the high permeabtion flux of 74.6 μm kg m −2 h −1 and water selectivity of 34 (separation factor of 732) at 30 °C. The developed strategy has excellent potential for synthesizing copolymers for high-efficient pervaporation membranes.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
PLANT PHYSIOLOGY
·
2024
·Vol. 197
·期 1
·
IF 6.5
Song Ru-Feng,Liao Cai-Yi,Wang Lin-Feng,Lu Kai-Kai,Zhang Chi,Wu Run-Xin,Wu Ji-Xiao,Ma Yu-Qing,Kuang Lei,Guo Ning,Yuan Hong-Mei,Liu Wen-Cheng
The plasma membrane (PM)-localized Na+/H+ antiporter Salt Overly Sensitive1 (SOS1) is essential for plant salt tolerance through facilitating Na+ efflux; however, how SOS1 localization and protein accumulation is regulated in plants remains elusive. Here, we report that Sorting Nexin 1 (SNX1) is required for plant salt-stress tolerance through affecting endosomal trafficking of SOS1 in Arabidopsis (Arabidopsis thaliana). Disruption of SNX1 caused salt hypersensitivity with increased Na+ accumulation and decreased Na+ efflux in Arabidopsis when challenged with high salinity stress. SNX1 co-localized and interacted with SOS1 in endosomes, promoting its PM localization and protein stability in plants under saline conditions. SOS1 overexpression promoted salt tolerance in the wild-type, whereas such effect was greatly compromised in the snx1-2 mutant. Pharmaceutical results showed that SOS1 recycling from the cytosol to the PM was largely blocked while its vacuolar degradation was accelerated in the snx1-2 mutant. Furthermore, salt-induced SOS1 phosphorylation enhanced its interaction and co-localization with SNX1, which is required for SOS1 PM localization in plants. Our study elucidates that SNX1 facilitates SOS1 PM localization and protein accumulation through endosomal trafficking, thereby enhancing salt tolerance in plants.
研究领域:
植物学
·
分子生物学
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 48
·8380-8389
·
IF 2.7
Zhuoxing Wu,Bolin Yu,Huien Gong,Yiquan Tang,Jiaxian Chen,Yingying Jian,Danmei Wei,Hongyun Meng,Chunhua Tan
The concentration of formaldehyde in the environment must be precisely monitored, as it is closely linked to human health. In this paper, a decaboryl derivative formaldehyde fluorescent probe (M1) was synthesized for the first time by introducing a 5-amino-isoquinoline group into a decaborane parent. Using theoretical calculations, 1H-NMR, 11B-NMR, HR-MS, and FT-IR, the molecular structure of the probe was determined and its response mechanism to formaldehyde was examined. The fluorescence response of the probe to formaldehyde was then tested, revealing an augmented response to formaldehyde in a solution of 0–600 μM, with a detection limit of 4.18 × 10−6 M. The results show that the formaldehyde fluorescence probe has the advantages of good linearity, strong anti-interference and high sensitivity. On this basis, a fiber optic formaldehyde fluorescence sensor based on an M1/PMMA thin film was constructed in this paper. This fiber optic fluorescence sensor, with its high selectivity, low detection limit, online and remote monitoring, and other advantages, was successfully applied to the detection of formaldehyde in both food and aqueous solutions, with results that were reliable compared to those of acetone. The detection limit of formaldehyde increased to 6.9 × 10−8 M. The potential for its utilization in the chemical, biological, environmental, and other formaldehyde detection fields is quite promising.
研究领域:
环境科学
·
分析化学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Shufeng Li,Zhe Chen,Yinhua Yang,Zhihao Si,Pei Li,Peiyong Qin,Tianwei Tan
The hydrophobicity of porous particles is important for the performance of mixed-matrix membranes for pervaporation separation of n -butanol aqueous solution. Here, a strategy was proposed to further enhance the hydrophobicity of ZIF-8. ZIF-8 particles were first coated by polydopamine (PDA) to create chemically reactive surface and then modified with silane coupling agents n -propyltrimethoxysilane and n -octyltriethoxysilane. The water contact angles of the obtained P-ZIF-8@PDA and O-ZIF-8@PDA separately increased from 132.8° to 137.3° and 151.5°, which demonstrated a remarkable enhancement in hydrophobicity. The silane-modified ZIF-8 particles were subsequently incorporated into PDMS to fabricate mixed-matrix membranes, which exhibited an improved adsorption selectivity for butanol. The best membrane with 1 wt% loading (O-ZIF-8@PDA) exhibited a separation factor of 56 and butanol flux of 480.6 g m −2 h −1 for a 1.5 wt% butanol solution at 55 °C. The separation factor increased by 23% compared with that of a ZIF-8/PDMS membrane. Moreover, compared with those of a pure PDMS membrane, the separation factor and butanol flux increased by 34% and 85%, respectively. Thus, the strategy is an effective method to improve the PV performance of PDMS membranes for butanol separation.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Optical Materials
·
2024
·
IF 0
Min Yang,Xi Wang,Nan Li,Jiatian Cheng,Chengzhi Xue,Ziwei Xu,Depeng Chu,Xiaojie Zhang,Yucheng Liu,Zhou Yang,Shengzhong Frank Liu
Due to their exceptional responses to X-ray exposure, lead halide perovskites are recognized as ideal candidates for high-spatial-resolution X-ray detectors. However, an effective method to deposit a large-area, submillimeter-thick, dense perovskite film for X-ray detection has been lacking. In this study, a strategy that combines saturated-solution-induced epitaxial growth with a large-area blade-coating process has been developed to produce large-size, submillimeter-thick CH3NH3PbBr3 perovskite films. The successive deposition of a saturated precursor film does not dissolve the underlying perovskite film. Instead, it promotes epitaxial crystal growth by controlling the crystal growth rate over the nucleation rate. The obtained films exhibit a columnar grain structure with fewer pinholes and negligible residual lattice strain. As a result, under an X-ray source with a working voltage of 40 kV, the obtained thick CH3NH3PbBr3 film achieves X-ray sensitivity of up to 1938 μC Gyair–1 cm–2 under −3 V bias, a reduced dark current drift of 1.78 × 10–4 nA s–1 V–1, and a detection limit of 47 nGyair s–1 under a −2 V bias; all the above are among the best performances reported for the CH3NH3PbBr3-based X-ray detectors. Using the point-to-point current scanning method, a clear X-ray image could be obtained. This study presents an effective approach for producing thick, dense, and crack-free perovskite films directly on substrates for future X-ray detection applications.
研究领域:
材料科学
·
核医学成像
✓ 已验证
DOI
Nature Water
·
2023
·Vol. 1
·期 3
·281-290
·
IF 0
Dai Ruobin,Zhou Huimin,Wang Tianlin,Qiu Zhiwei,Long Li,Lin Shihong,Tang Chuyang Y.,Wang Zhiwei
Fabricating nanofiltration membranes with high water permeance and selectivity is crucial to efficient water purification. However, achieving such a goal with a simple and cost-effective approach that is compatible with existing membrane manufacturing infrastructure remains a substantial technical challenge. Here we show a strategy of nanoemulsion-regulated interfacial polymerization (NERIP) based on nanovehicle-assisted monomer shuttling for fabricating highly permeable and selective nanofiltration membranes. In NERIP, the nanovehicles, which are surfactant-stabilized oil droplets (in water) enriched with piperazine (PIP), enter and merge into the hexane phase to initiate the polymerization between PIP and trimesoyl chloride. This nanovehicle-assisted monomer shuttling results in the formation of polyamide ‘bubbles’ that later collapse into nanocraters. The nanocrater structure substantially increases the surface area and void fraction of the polyamide layer. The PIP shuttling also accelerates the polymerization reaction, enabling the formation of a thin and highly cross-linked polyamide layer with a more uniform pore size distribution. These structural superiorities yield an unprecedentedly high performance with a water permeance of 36.8 ± 1.9 l m −2 h −1 bar −1 and a Na 2 SO 4 rejection of 99.6 ± 0.1%. NERIP creates a new dimension to fabricate highly permeable and selective nanofiltration membranes for desalination and water purification.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
Journal of Materiomics
·
2024
·
IF 8.4
Zhenfeng Guo,Ze Zhu,Xiaoqian Zhang,Ying Peng,Ziting Huang,Xinqiang Wang,Luyi Zhu,Yongshuai Xie,Guanghui Zhang,Benxue Liu,Dong Xu
High-performance thermally insulating ceramic materials with excellent mechanical and thermal insulation properties are essential for thermal management in extreme environments. In this work, SiO 2 was introduced into the crystalline lattice and grain boundary of TiO 2 to inhibit its phase transition and grain growth. Meanwhile, layered TiO 2 /SiO 2 nanofiber membranes (TS NFMs) were designed and prepared. The TS NFMs had lightweight (44 mg/cm 3 ), high tensile strength (4.55 MPa), ultra-flexibility, and low thermal conductivity (31.5 mW·m −1 ·K −1 ). The prepared TS-1100 NFMs had excellent buckling fatigue resistance, which could undergo 100 buckling-recovery cycles at up to 80% strain. Low density and high diffuse reflectance endow the TS NFMs with excellent thermal insulation effects. A single-layer nanofiber membrane was composed of multiple layers of nanofibers. According to the principle of multi-level reflection, the multilayer structure had a better near-infrared reflection effect. Through the stacking effect of layers, a 10 mm thick sample composed of about 300 layers of nanofiber membranes could reduce the hot surface temperature from 1,200 °C to about 220 °C, demonstrating an excellent comprehensive thermal insulation effect. The layered TS NFMs with ultra-flexibility, high tensile strength and high-temperature resistance (1,100 °C) provide a dominant pathway in producing materials in extremely high-temperature environments.
研究领域:
材料科学
·
热管理工程
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 21
·期 9
·1352-1357
·
IF 3.382
Jian Yin,Guodong Zhang,Xutang Tao
A facile fractional crystallization technique was developed to prepare single crystalline CsPb2Br5 films using water as the solvent, and the films can be easily transferred onto various substrates for the device fabrication. The obtained films can be up to 600 × 600 μm2 and decrease to 50 nm in thickness with high crystalline quality as well as temperature and air stability.
研究领域:
材料科学
·
晶体学
·
光电子器件
✓ 已验证
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2018
·
IF 2.732
Siqi Fan,Xu Yao,Jingfang Li,Weizuo Li,Guangming Li
In view of the potential application of NIR luminescence in biology, a series of four new 3,5-Heptanedione (β-diketonate) ytterbium complexes, e.g. [Yb(L) 3 (H 2 O) 2 ] ( 1 ), [Yb(L) 3 (2,2′-bpy)] ( 2 ), [Yb(L) 3 (dpq)] ( 3 ) and [Yb(L) 3 (dppz)] ( 4 ) have been designed and isolated. Crystal structures analysis show that all complexes 1 – 4 exhibit the similar mononuclear structure, in which the central Yb 3+ ion is eight-coordinated forming the square-anti-prismatic geometry. NIR luminescence of all complexes 1 – 4 shows strong characteristic emission of Yb 3+ ions. To improve the mechanical and thermal stability, complex 1 was further doped into poly-(methyl methacrylate) (PMMA) for preparing a thin film ( 1 @PMMA). Their thermal stability and NIR luminescence were essentially enhanced in contrast to that for complex 1 . This NIR luminescent thin film may be of potential applications in biological dictation and luminescent probe.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Jin Wang,Longhui Fang,Yutao Ban,Xiangyang Liu,Maogang He
Due to their high global warming potential (GWP), hydrofluorocarbons (HFCs) are included in various regulations as substances to be phased down. Gas separation membrane technology is expected to provide a better choice for refrigerant separation. In this study, a series of metal-organic frameworks (MOFs)/ polydimethylsiloxane (PDMS) mixed matrix membranes (MMMs) were prepared for the separation of the refrigerant blend R454A (GWP = 145), which consists of a near-zeotropic difluoromethane (R32, GWP = 675) and 2,3,3,3-tetrafluoropropene (R1234yf, GWP = 4). ZIF-71-NH 2 was prepared for the first time by solvent-assisted ligand exchange (SALE), and then ZIF-71-NH 2 @ Ionic Liquid (IL) was prepared by embedding [C 2 mim][BF 4 ] into the pores of ZIF-71-NH 2 by capillary action method. The results showed that a hydrogen bonding network was established between the amino group and PDMS, which improved the interfacial compatibility, and reduced the pore size of ZIF-71, which contributed to an excellent gas separation performance of ZIF-71-NH 2 /PDMS MMMs. Restricting [C 2 mim][BF 4 ] to the ZIF-71-NH 2 pore can further reduce its pore size, and enhance R32/R1234yf separation performance due to the high selective solubility for R32 and R1234yf. The selectivity of 10 wt% ZIF-71-NH 2 /PDMS MMM is 25.6 % over that of 10 wt% ZIF-71/PDMS MMM. The selectivity of ZIF-71-NH 2 @IL/PDMS MMM is 38.3 % higher than that of ZIF-71-NH 2 /PDMS MMM. The ZIF-71-NH 2 /PDMS and ZIF-71-NH 2 @IL/PDMS MMMs exhibited the most excellent R32/R1234yf separation performance compared with the data currently published in the literature. Moreover, both designed MMMs demonstrated excellent resistance to ageing.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
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